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| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (293 aa) |
| | ADZ76596.1 | PFAM: Thioesterase superfamily; KEGG: phe:Phep_2327 thioesterase superfamily protein. (148 aa) |
| | ADZ76598.1 | Phosphoglycerate dehydrogenase; KEGG: phe:Phep_3811 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (324 aa) |
| | ADZ76600.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: phe:Phep_3813 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (351 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (312 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (329 aa) |
| | ADZ76605.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | ADZ76643.1 | Glycine C-acetyltransferase; KEGG: phe:Phep_3321 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase, class I/classII. (413 aa) |
| | ADZ76717.1 | Methylglyoxal reductase (NADPH-dependent); KEGG: gbm:Gbem_3980 aldo/keto reductase YvgN; PFAM: NADP-dependent oxidoreductase domain. (283 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa) |
| | carA | TIGRFAM: Carbamoyl-phosphate synthase, small subunit; KEGG: phe:Phep_0705 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (366 aa) |
| | ADZ76961.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa) |
| | ADZ76980.1 | KEGG: phe:Phep_1138 enoyl-(acyl-carrier-protein) reductase (NADH). (272 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (246 aa) |
| | ADZ77016.1 | Phosphoglycerate dehydrogenase; KEGG: dfe:Dfer_3130 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (328 aa) |
| | ADZ77019.1 | KEGG: dfe:Dfer_3133 phosphoglycerate mutase; PFAM: Histidine phosphatase superfamily, clade-1; SMART: Histidine phosphatase superfamily, clade-1; Belongs to the phosphoglycerate mutase family. (199 aa) |
| | ADZ77030.1 | KEGG: sli:Slin_0084 3-dehydroquinate synthase; PFAM: 3-dehydroquinate synthase AroB. (396 aa) |
| | ADZ77031.1 | PFAM: UbiA prenyltransferase; KEGG: sli:Slin_0160 UbiA prenyltransferase. (294 aa) |
| | ADZ77124.1 | PFAM: GCN5-related N-acetyltransferase (GNAT) domain; KEGG: cpi:Cpin_4589 GCN5-related N-acetyltransferase. (169 aa) |
| | ADZ77133.1 | Riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: phe:Phep_3549 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (323 aa) |
| | ADZ77138.1 | TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase. (269 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (404 aa) |
| | ADZ77187.1 | PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; KEGG: gct:GC56T3_1152 cobalamin synthesis protein P47K. (357 aa) |
| | ADZ77245.1 | KEGG: sli:Slin_5139 glutamate--ammonia ligase; PFAM: Glutamine synthetase, catalytic domain. (452 aa) |
| | ADZ77251.1 | Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; KEGG: phe:Phep_0273 amidohydrolase; PFAM: Peptidase M20; Peptidase M20, dimerisation. (394 aa) |
| | pgi | HAMAP: Phosphoglucose isomerase (PGI); KEGG: phe:Phep_0280 glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase (PGI); Belongs to the GPI family. (548 aa) |
| | ADZ77281.1 | KEGG: phe:Phep_0239 L-serine dehydratase 1; TIGRFAM: Iron-sulphur-dependent L-serine dehydratase single chain form; PFAM: Serine dehydratase-like, alpha subunit; Serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (475 aa) |
| | ADZ77318.1 | PFAM: Amino acid-binding ACT; KEGG: phe:Phep_0261 HAD-superfamily hydrolase, subfamily IB (PSPase-like). (430 aa) |
| | ADZ77320.1 | TIGRFAM: Branched-chain amino acid aminotransferase II; KEGG: phe:Phep_0259 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV. (384 aa) |
| | ADZ77362.1 | KEGG: sli:Slin_1050 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (274 aa) |
| | ADZ77389.1 | KEGG: mxa:MXAN_0342 hypothetical protein. (316 aa) |
| | ADZ77406.1 | PFAM: Monooxygenase, FAD-binding; KEGG: sli:Slin_2326 monooxygenase FAD-binding protein. (387 aa) |
| | ADZ77440.1 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: dfe:Dfer_1784 bifunctional deaminase-reductase domain protein. (193 aa) |
| | ADZ77444.1 | PFAM: Nucleoside phosphorylase domain; KEGG: fjo:Fjoh_3241 nucleoside phosphorylase-like protein. (210 aa) |
| | ADZ77479.1 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: cpi:Cpin_4632 bifunctional deaminase-reductase domain protein. (183 aa) |
| | ADZ77488.1 | Manually curated; PFAM: Chorismate mutase, type II; KEGG: bth:BT_3934 putative phospho-2-dehydro-3-deoxyheptonate aldolase/chorismate mutase; SMART: Chorismate mutase. (101 aa) |
| | ADZ77553.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; KEGG: phe:Phep_0523 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (346 aa) |
| | ADZ77554.1 | KEGG: phe:Phep_0522 dihydrodipicolinate synthetase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (312 aa) |
| | ADZ77562.1 | KEGG: lby:Lbys_1774 dihydrodipicolinate synthetase; HAMAP: Dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (309 aa) |
| | ADZ77603.1 | KEGG: phe:Phep_4210 hypothetical protein. (231 aa) |
| | ADZ77604.1 | TIGRFAM: Argininosuccinate synthase; KEGG: phe:Phep_4209 argininosuccinate synthase; PFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (395 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | ADZ77607.1 | Acetylornithine transaminase; KEGG: phe:Phep_4207 aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (379 aa) |
| | ADZ77608.1 | KEGG: phe:Phep_4206 N-acetylornithine carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (332 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (281 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | ADZ77611.1 | PFAM: Peptidase M20; Peptidase M20, dimerisation; KEGG: phe:Phep_4203 peptidase M20. (355 aa) |
| | argH | PFAM: Lyase 1, N-terminal; TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: phe:Phep_4202 argininosuccinate lyase. (443 aa) |
| | ADZ77635.1 | NADPH:quinone reductase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: ote:Oter_3807 alcohol dehydrogenase; SMART: Polyketide synthase, enoylreductase. (332 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (263 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | ADZ77721.1 | KEGG: phe:Phep_0090 thiamine pyrophosphokinase. (189 aa) |
| | comB | KEGG: phe:Phep_0407 2-phosphosulfolactate phosphatase; HAMAP: 2-phosphosulpholactate phosphatase ComB; PFAM: 2-phosphosulpholactate phosphatase; Belongs to the ComB family. (240 aa) |
| | ADZ77790.1 | KEGG: dfe:Dfer_1829 alcohol dehydrogenase zinc-binding domain protein; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; SMART: Polyketide synthase, enoylreductase. (314 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (238 aa) |
| | ADZ77818.1 | Gluconolactonase; KEGG: rba:RB12740 gluconolactonase [precursor]; PFAM: SMP-30/Gluconolaconase/LRE-like region. (330 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (345 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (331 aa) |
| | ADZ77880.1 | SMART: Polyketide synthase, acyl transferase domain; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; KEGG: phe:Phep_4148 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase. (295 aa) |
| | ADZ77882.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase-related; KEGG: phe:Phep_4150 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. (137 aa) |
| | mqnB | Futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (216 aa) |
| | mqnD | Protein of unknown function DUF191; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (285 aa) |
| | ADZ77901.1 | Phosphosulfolactate synthase; Manually curated; KEGG: phe:Phep_4158 phosphosulfolactate synthase; PFAM: (2R)-phospho-3-sulpholactate synthase, ComA. (253 aa) |
| | ADZ77902.1 | KEGG: cpi:Cpin_1671 shikimate dehydrogenase substrate binding domain protein; PFAM: Shikimate dehydrogenase substrate binding, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase. (259 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | ADZ77920.1 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (417 aa) |
| | ADZ77930.1 | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: phe:Phep_0044 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa) |
| | ADZ77946.1 | TIGRFAM: Thiazole biosynthesis ThiH; PFAM: Biotin/thiamin synthesis-associated protein; Radical SAM; KEGG: dfe:Dfer_2462 thiazole biosynthesis protein ThiH; SMART: Biotin/thiamin synthesis-associated protein. (370 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (257 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (220 aa) |
| | ADZ77949.1 | PFAM: Thiamine monophosphate synthase; KEGG: pmz:HMPREF0659_A5801 thiamine monophosphate synthase/TenI. (216 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (622 aa) |
| | ADZ77951.1 | KEGG: cpi:Cpin_0620 thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiamineS. (66 aa) |
| | ADZ77991.1 | TIGRFAM: Threonine synthase; KEGG: phe:Phep_3802 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (437 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (325 aa) |
| | ADZ77993.1 | TIGRFAM: Aspartate kinase domain; KEGG: phe:Phep_3804 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding. (815 aa) |
| | ADZ78053.1 | PFAM: GCN5-related N-acetyltransferase (GNAT) domain; KEGG: lby:Lbys_1078 gcn5-related N-acetyltransferase. (152 aa) |
| | trpC | KEGG: phe:Phep_4168 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | lpxC | UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (470 aa) |
| | ADZ78167.1 | KEGG: cpi:Cpin_1939 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (280 aa) |
| | ADZ78168.1 | KEGG: cpi:Cpin_1938 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII. (386 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | ADZ78306.1 | KEGG: phe:Phep_0632 hypothetical protein. (399 aa) |
| | ADZ78308.1 | KEGG: cpi:Cpin_2236 HAD-superfamily hydrolase, subfamily IA, variant 3; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase. (201 aa) |
| | ADZ78310.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | ADZ78502.1 | PFAM: Membrane bound O-acyl transferase, MBOAT; KEGG: fps:FP1411 sugar O-acetyltransferase precursor; Belongs to the membrane-bound acyltransferase family. (484 aa) |
| | ADZ78520.1 | TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: zpr:ZPR_0543 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (463 aa) |
| | ADZ78544.1 | Hypothetical protein; KEGG: sli:Slin_4776 pyridoxal-5'-phosphate-dependent protein beta subunit. (224 aa) |
| | ADZ78564.1 | TIGRFAM: Nucleotide sugar dehydrogenase; KEGG: zpr:ZPR_0543 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (463 aa) |
| | ADZ78590.1 | PFAM: Bacterial transferase hexapeptide repeat; KEGG: dge:Dgeo_0348 serine O-acetyltransferase. (183 aa) |
| | ADZ78636.1 | Beta-ketoacyl-acyl-carrier-protein synthase III; KEGG: vha:VIBHAR_00675 3-oxoacyl-(acyl-carrier protein) synthase; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal. (336 aa) |
| | ADZ78681.1 | KEGG: gfo:GFO_2876 3-oxoacyl-[acyl-carrier-protein] synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal. (354 aa) |
| | ADZ78718.1 | PFAM: Asp/Glu/hydantoin racemase; KEGG: dfe:Dfer_2141 Asp/Glu/hydantoin racemase. (220 aa) |
| | ADZ78760.1 | KEGG: pdi:BDI_0987 pyruvate dehydrogenase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Belongs to the TPP enzyme family. (578 aa) |
| | ADZ78773.1 | PFAM: Carboxylyase-related; KEGG: phe:Phep_2913 carboxylyase-related protein; Belongs to the UbiD family. (612 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa) |
| | ADZ78827.1 | KEGG: phe:Phep_1518 HAD-superfamily hydrolase, subfamily IA, variant 3; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase. (210 aa) |
| | ADZ78830.1 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (412 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa) |
| | ADZ78834.1 | (R)-citramalate synthase; PFAM: Pyruvate carboxyltransferase; 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; KEGG: phe:Phep_3427 pyruvate carboxyltransferase; SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Belongs to the alpha-IPM synthase/homocitrate synthase family. (504 aa) |
| | ADZ78835.1 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (464 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (493 aa) |
| | ADZ78841.1 | KEGG: phe:Phep_3420 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Amino acid-binding ACT; Acetolactate synthase, small subunit, C-terminal. (196 aa) |
| | ADZ78843.1 | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: phe:Phep_3419 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (583 aa) |
| | ilvD | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: phe:Phep_3418 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (564 aa) |
| | ADZ78854.1 | PFAM: Dihydrodipicolinate synthetase; KEGG: phe:Phep_2814 dihydrodipicolinate synthetase; Belongs to the DapA family. (313 aa) |
| | ADZ78982.1 | KEGG: phe:Phep_0858 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (272 aa) |
| | ADZ79043.1 | PFAM: GCN5-related N-acetyltransferase (GNAT) domain; KEGG: npu:Npun_R0931 GCN5-related N-acetyltransferase. (139 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (376 aa) |
| | ADZ79137.1 | KEGG: cpi:Cpin_3630 cobalamin synthesis protein P47K; PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal; SMART: Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal. (399 aa) |
| | ADZ79253.1 | KEGG: phe:Phep_0658 hypothetical protein. (138 aa) |
| | ADZ79291.1 | PFAM: GCN5-related N-acetyltransferase (GNAT) domain; KEGG: cpi:Cpin_5800 peptidyl-dipeptidase DCP. (166 aa) |
| | ADZ79372.1 | PFAM: Transcriptional coactivator/pterin dehydratase; KEGG: phe:Phep_0475 transcriptional coactivator/pterin dehydratase. (76 aa) |
| | ADZ79400.1 | PFAM: Dihydrodipicolinate synthetase; KEGG: phe:Phep_1691 hypothetical protein; Belongs to the DapA family. (385 aa) |
| | ADZ79449.1 | Hypothetical protein; KEGG: aba:Acid345_2649 haloacid dehalogenase-like hydrolase. (316 aa) |
| | ADZ79518.1 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa) |
| | ADZ79597.1 | TIGRFAM: FO synthase, subunit 2; PFAM: Radical SAM; KEGG: phe:Phep_1588 radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (381 aa) |
| | ADZ79616.1 | KEGG: chu:CHU_1073 thioesterase; TIGRFAM: 4-hydroxybenzoyl-CoA thioesterase; PFAM: Thioesterase superfamily. (138 aa) |
| | ADZ79620.1 | PFAM: Acyl-ACP thioesterase; KEGG: phe:Phep_1852 thioesterase. (138 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa) |
| | ADZ79634.1 | Phosphoglycerate dehydrogenase; KEGG: phe:Phep_1858 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (315 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa) |
| | trpF | KEGG: phe:Phep_3025 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (207 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa) |
| | ADZ79648.1 | Beta-Ala-His dipeptidase; KEGG: phe:Phep_1438 peptidase M20; PFAM: Peptidase M20; Peptidase M20, dimerisation. (456 aa) |
| | ADZ79668.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: aas:Aasi_1686 hypothetical protein. (155 aa) |
| | fbp | HAMAP: Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase; KEGG: phe:Phep_2970 inositol phosphatase/fructose-16-bisphosphatase; PFAM: Fructose-1,6-bisphosphatase class 1/Sedoheputulose-1,7-bisphosphatase. (347 aa) |
| | ADZ79701.1 | KEGG: phe:Phep_3020 glutamate synthase (NADPH); PFAM: Glutamate synthase, central-C; Belongs to the glutamate synthase family. (547 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | ADZ79714.1 | TIGRFAM: Aspartate kinase domain; KEGG: phe:Phep_2333 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (438 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (392 aa) |
| | ADZ79726.1 | KEGG: cpi:Cpin_0730 glutamate synthase (ferredoxin); PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal. (1499 aa) |
| | ADZ79727.1 | TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; KEGG: cpi:Cpin_0731 glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (488 aa) |
| | ADZ79734.1 | TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Belongs to the precorrin methyltransferase family. (260 aa) |
| | ADZ79735.1 | KEGG: phe:Phep_3090 siroheme synthase; TIGRFAM: Sirohaem synthase, N-terminal; PFAM: Protein of unknown function DUF81. (507 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (415 aa) |
| | ADZ79765.1 | KEGG: phe:Phep_1513 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (286 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (230 aa) |
| | ADZ79833.1 | PFAM: Aminoglycoside phosphotransferase; KEGG: bfs:BF0850 putative desulfatase. (373 aa) |
| | ADZ79848.1 | TIGRFAM: Asparagine synthase, glutamine-hydrolyzing; KEGG: fba:FIC_01692 asparagine synthetase B; PFAM: Asparagine synthase; Glutamine amidotransferase, class-II. (561 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (226 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa) |
| | ADZ79857.1 | TIGRFAM: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; KEGG: phe:Phep_2566 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | ADZ79868.1 | SMP-30/Gluconolaconase/LRE-like region-containing protein; PFAM: SMP-30/Gluconolaconase/LRE-like region; KEGG: dfe:Dfer_2979 ATP/GTP-binding. (274 aa) |
| | ADZ79872.1 | PFAM: Membrane bound O-acyl transferase, MBOAT; KEGG: pph:Ppha_2479 membrane bound O-acyl transferase MBOAT family protein; Belongs to the membrane-bound acyltransferase family. (552 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (217 aa) |
| | mqnA | Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (239 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (773 aa) |
| | mqnE | Putative menaquinone biosynthesis protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (398 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (352 aa) |
| | ADZ79921.1 | KEGG: phe:Phep_1873 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding. (393 aa) |
| | ADZ79928.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (348 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | ADZ80053.1 | ATP/cobalamin adenosyltransferase; TIGRFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, PduO-type, N-terminal; KEGG: phe:Phep_2576 ATP/cobalamin adenosyltransferase; PFAM: Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase, EutT/PduO type. (215 aa) |
| | queG | Iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (311 aa) |
| | ADZ80087.1 | Aminodeoxychorismate lyase; KEGG: phe:Phep_1220 aminotransferase class IV; PFAM: Aminotransferase, class IV. (288 aa) |
| | ADZ80091.1 | NAD(P)H quinone oxidoreductase, PIG3 family; SMART: Polyketide synthase, enoylreductase; TIGRFAM: Quinone oxidoreductase putative, PIG3; KEGG: ote:Oter_0170 PIG3 family NAD(P)H quinone oxidoreductase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like. (323 aa) |
| | ADZ80099.1 | KEGG: dsy:DSY0804 hypothetical protein. (190 aa) |
| | ADZ80154.1 | PFAM: Methyltransferase type 11; KEGG: pjd:Pjdr2_2112 methyltransferase type 11. (274 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa) |
| | ADZ80218.1 | PFAM: Iron sulphur-containing domain, CDGSH-type; KEGG: phe:Phep_2426 zinc finger CDGSH-type domain protein. (73 aa) |
| | ADZ80285.1 | Hypothetical protein; KEGG: lby:Lbys_1791 uroporphyrinogeN-III C-methyltransferase. (239 aa) |
| | ADZ80286.1 | TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; KEGG: lby:Lbys_1791 uroporphyrinogeN-III C-methyltransferase; PFAM: Tetrapyrrole methylase. (240 aa) |
| | ADZ80407.1 | KEGG: phe:Phep_3063 beta-lactamase domain protein; PFAM: Beta-lactamase-like; SMART: Beta-lactamase-like. (255 aa) |
| | ADZ80431.1 | Riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; KEGG: phe:Phep_3288 riboflavin synthase subunit alpha; PFAM: Lumazine-binding protein. (201 aa) |
| | ADZ80454.1 | Acetylornithine transaminase; KEGG: phe:Phep_0869 aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (396 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (349 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (280 aa) |
| | ADZ80555.1 | TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: phe:Phep_3073 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (161 aa) |
| | ADZ80571.1 | PFAM: SMP-30/Gluconolaconase/LRE-like region; KEGG: sli:Slin_0076 SMP-30/gluconolaconase/LRE domain protein. (307 aa) |
| | ADZ80601.1 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: lic:LIC10659 hypothetical protein. (205 aa) |
| | ADZ80609.1 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | ADZ80645.1 | KEGG: phe:Phep_1163 acyl-(acyl-carrier-protein) desaturase; PFAM: Fatty acid desaturase, type 2. (340 aa) |
| | ADZ80659.1 | TIGRFAM: Cysteine synthase B; Cysteine synthase K/M; KEGG: phe:Phep_2362 cysteine synthase B; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (289 aa) |
| | ADZ80660.1 | KEGG: phe:Phep_2363 serine O-acetyltransferase. (278 aa) |
| | ADZ80687.1 | SMART: Polyketide synthase, enoylreductase; TIGRFAM: Alcohol dehydrogenase, zinc-binding type 1; KEGG: fjo:Fjoh_3309 alcohol dehydrogenase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (336 aa) |
| | ADZ80727.1 | NADPH:quinone reductase; PFAM: Alcohol dehydrogenase, C-terminal; Alcohol dehydrogenase GroES-like; KEGG: dfe:Dfer_2330 alcohol dehydrogenase zinc-binding domain protein; SMART: Polyketide synthase, enoylreductase. (319 aa) |
| | ADZ80743.1 | PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; KEGG: lby:Lbys_0789 bifunctional deaminase-reductase domain protein. (177 aa) |
| | ADZ80884.1 | PFAM: Domain of unknown function DUF336; KEGG: cpi:Cpin_4361 protein of unknown function DUF336. (135 aa) |
| | ADZ80965.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: zpr:ZPR_3304 glyoxalase/bleomycin resistance protein. (137 aa) |
| | ADZ81017.1 | TIGRFAM: Phosphomethylpyrimidine kinase type-2; KEGG: zpr:ZPR_1974 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (288 aa) |
| | ADZ81020.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: dfe:Dfer_5411 glyoxalase/bleomycin resistance protein/dioxygenase. (140 aa) |
| | ADZ81066.1 | KEGG: phe:Phep_2476 thioesterase-like protein. (141 aa) |
| | ADZ81081.1 | KEGG: fbc:FB2170_11766 hypothetical protein. (133 aa) |
| | ADZ81101.1 | KEGG: phe:Phep_2213 N-acetylneuraminate lyase; PFAM: Dihydrodipicolinate synthetase; Belongs to the DapA family. (311 aa) |
| | ADZ81103.1 | PFAM: Dihydrodipicolinate synthetase; KEGG: phe:Phep_2224 dihydrodipicolinate synthetase; Belongs to the DapA family. (320 aa) |
| | ADZ81106.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (320 aa) |
| | ADZ81148.1 | Cysteine synthase; KEGG: phe:Phep_1609 pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit. (359 aa) |
| | ADZ81185.1 | TIGRFAM: Aspartate kinase domain; KEGG: phe:Phep_2925 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (422 aa) |
| | ADZ81186.1 | KEGG: fbc:FB2170_09831 hypothetical protein. (393 aa) |
| | ADZ81188.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (820 aa) |
| | ADZ81363.1 | KEGG: cpi:Cpin_3609 hypothetical protein. (139 aa) |
| | ADZ81380.1 | KEGG: cpi:Cpin_3609 hypothetical protein. (134 aa) |
| | ADZ81505.1 | KEGG: fjo:Fjoh_4439 hypothetical protein. (169 aa) |
| | ADZ81511.1 | Peptidase dimerization domain protein; PFAM: Peptidase M20, dimerisation; KEGG: sli:Slin_4763 amidohydrolase. (535 aa) |
| | ADZ81543.1 | Hypothetical protein; KEGG: dfe:Dfer_1328 3-demethylubiquinone-9 3-methyltransferase. (148 aa) |
| | ADZ81561.1 | KEGG: lbf:LBF_0121 dihydrofolate reductase. (97 aa) |
| | ADZ81595.1 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH-like; KEGG: dfe:Dfer_3127 myo-inositol-1-phosphate synthase. (400 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | hisC | PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: cpi:Cpin_1819 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (354 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; HAD-superfamily hydrolase, subfamily IIIA; HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: phe:Phep_3194 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (381 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: phe:Phep_3196 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imid azole-4-carboxamideisomerase; PFAM: Histidine biosynthesis. (249 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (262 aa) |
| | hisI | PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; KEGG: phe:Phep_3198 phosphoribosyl-ATP diphosphatase; In the N-terminal section; belongs to the PRA-CH family. (195 aa) |
| | ADZ81691.1 | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (246 aa) |
| | menG | Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (244 aa) |
| | ADZ81701.1 | Manually curated; TIGRFAM: 4-hydroxybenzoate polyprenyltransferase-related; KEGG: phe:Phep_0975 4-hydroxybenzoate polyprenyltransferase; PFAM: UbiA prenyltransferase; Belongs to the UbiA prenyltransferase family. (284 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (164 aa) |
