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| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | ADZ78140.1 | Conserved hypothetical protein CHP00147; TIGRFAM: Diacylglycerol/lipid kinase; PFAM: Diacylglycerol kinase, catalytic domain; KEGG: phe:Phep_4093 diacylglycerol kinase catalytic region; SMART: Diacylglycerol kinase, catalytic domain. (291 aa) |
| | ADZ78138.1 | KEGG: phe:Phep_0218 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (297 aa) |
| | ADZ78104.1 | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (264 aa) |
| | lpxC | UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (470 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (345 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (188 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (191 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: phe:Phep_0267 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (426 aa) |
| | ADZ78013.1 | Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: phe:Phep_4118 metallophosphoesterase. (255 aa) |
| | ADZ77977.1 | Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: phe:Phep_4032 metallophosphoesterase. (282 aa) |
| | ADZ77951.1 | KEGG: cpi:Cpin_0620 thiamine biosynthesis protein ThiS; TIGRFAM: ThiS, thiamine-biosynthesis; PFAM: ThiamineS. (66 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (622 aa) |
| | ADZ77949.1 | PFAM: Thiamine monophosphate synthase; KEGG: pmz:HMPREF0659_A5801 thiamine monophosphate synthase/TenI. (216 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (215 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (220 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (257 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (225 aa) |
| | ADZ77930.1 | TIGRFAM: Hypoxanthine phosphoribosyl transferase; KEGG: phe:Phep_0044 hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa) |
| | folE | PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; TIGRFAM: GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; KEGG: phe:Phep_4149 GTP cyclohydrolase I. (218 aa) |
| | ADZ77872.1 | Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa) |
| | ADZ77868.1 | PFAM: Phosphatidate cytidylyltransferase; KEGG: phe:Phep_0020 phosphatidate cytidylyltransferase; Belongs to the CDS family. (266 aa) |
| | ADZ77860.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (528 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (331 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (345 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | dacA | Conserved hypothetical protein CHP00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (263 aa) |
| | ADZ77721.1 | KEGG: phe:Phep_0090 thiamine pyrophosphokinase. (189 aa) |
| | ADZ77719.1 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (548 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (331 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa) |
| | ADZ77688.1 | KEGG: phe:Phep_0121 NAD metabolism ATPase/kinase-like protein. (179 aa) |
| | ADZ77642.1 | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (282 aa) |
| | ADZ77640.1 | Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: phe:Phep_0369 metallophosphoesterase. (435 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (499 aa) |
| | araB | Ribulokinase; PFAM: Carbohydrate kinase, FGGY, C-terminal; Carbohydrate kinase, FGGY, N-terminal; TIGRFAM: L-ribulokinase; HAMAP: L-ribulokinase; KEGG: phe:Phep_2729 ribulokinase. (563 aa) |
| | ADZ77581.1 | KEGG: zpr:ZPR_1683 hypothetical protein. (619 aa) |
| | ADZ77406.1 | PFAM: Monooxygenase, FAD-binding; KEGG: sli:Slin_2326 monooxygenase FAD-binding protein. (387 aa) |
| | ADZ77299.1 | PFAM: Phosphoribosyltransferase; KEGG: phe:Phep_4038 uracil phosphoribosyltransferase. (214 aa) |
| | ADZ77258.1 | KEGG: phe:Phep_0227 deoxycytidine triphosphate deaminase; TIGRFAM: Deoxycytidine triphosphate deaminase. (178 aa) |
| | ADZ77189.1 | TIGRFAM: L-ribulokinase; KEGG: phe:Phep_2729 ribulokinase; PFAM: Carbohydrate kinase, FGGY, C-terminal; Carbohydrate kinase, FGGY, N-terminal; Belongs to the ribulokinase family. (553 aa) |
| | ADZ77143.1 | KEGG: phe:Phep_4164 diacylglycerol kinase catalytic region; PFAM: Diacylglycerol kinase, catalytic domain; SMART: Diacylglycerol kinase, catalytic domain. (300 aa) |
| | ADZ77133.1 | Riboflavin biosynthesis protein RibF; SMART: Riboflavin kinase; TIGRFAM: Riboflavin kinase/FAD synthetase; KEGG: phe:Phep_3549 riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (323 aa) |
| | ADZ76960.1 | KEGG: fjo:Fjoh_3798 hypothetical protein. (184 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (346 aa) |
| | ADZ76922.1 | KEGG: cpi:Cpin_1975 ribonucleoside-diphosphate reductase; PFAM: Ribonucleotide reductase. (323 aa) |
| | carA | TIGRFAM: Carbamoyl-phosphate synthase, small subunit; KEGG: phe:Phep_0705 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (366 aa) |
| | ADZ76843.1 | KEGG: phe:Phep_0893 phospholipase D/transphosphatidylase. (1185 aa) |
| | ADZ76760.1 | Metallophosphoesterase; PFAM: Metallo-dependent phosphatase; KEGG: cpi:Cpin_2675 metallophosphoesterase. (407 aa) |
| | ADZ76732.1 | PFAM: Molybdopterin biosynthesis MoaE; KEGG: rbi:RB2501_05280 molybdopterinconverting factor, subunit. (146 aa) |
| | ADZ76727.1 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (190 aa) |
| | ADZ76632.1 | PFAM: Diacylglycerol kinase, prokaryotic; KEGG: efa:EF2411 diacylglycerol kinase. (124 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (312 aa) |
| | purA-2 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa) |
| | ADZ81433.1 | KEGG: ara:Arad_12002 hypothetical protein; PFAM: Phospholipase D/Transphosphatidylase; SMART: Phospholipase D/Transphosphatidylase. (376 aa) |
| | ADZ81441.1 | KEGG: cbt:CLH_2146 hypothetical protein. (181 aa) |
| | ADZ81543.1 | Hypothetical protein; KEGG: dfe:Dfer_1328 3-demethylubiquinone-9 3-methyltransferase. (148 aa) |
| | ADZ81020.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: dfe:Dfer_5411 glyoxalase/bleomycin resistance protein/dioxygenase. (140 aa) |
| | ADZ81587.1 | PFAM: Molybdopterin biosynthesis MoaE; KEGG: rbi:RB2501_05280 molybdopterinconverting factor, subunit. (142 aa) |
| | ADZ81595.1 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH-like; KEGG: dfe:Dfer_3127 myo-inositol-1-phosphate synthase. (400 aa) |
| | ADZ81625.1 | KEGG: phe:Phep_3185 dihydroorotase, multifunctional complex type; TIGRFAM: Dihydroorotase; PFAM: Amidohydrolase 1. (423 aa) |
| | ADZ81645.1 | TIGRFAM: Phosphoribosyl pyrophosphokinase; KEGG: phe:Phep_0582 ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyltransferase. (318 aa) |
| | ADZ81664.1 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (379 aa) |
| | ADZ81668.1 | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (639 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (296 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (547 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (295 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (524 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (178 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (68 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (390 aa) |
| | ADZ81175.1 | KEGG: phe:Phep_2916 uridine kinase; PFAM: Phosphoribulokinase/uridine kinase. (210 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (670 aa) |
| | ADZ78710.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: ote:Oter_1479 CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (188 aa) |
| | ADZ78642.1 | KEGG: phe:Phep_1632 hypothetical protein. (436 aa) |
| | ADZ78376.1 | TIGRFAM: Sialic acid O-acyltransferase, NeuD; KEGG: aar:Acear_2113 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family. (207 aa) |
| | ADZ78324.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (279 aa) |
| | ADZ80965.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: zpr:ZPR_3304 glyoxalase/bleomycin resistance protein. (137 aa) |
| | ADZ80794.1 | Putative adenylate/guanylate cyclase; KEGG: fbc:FB2170_10279 adenylate cyclase-related protein. (369 aa) |
| | ADZ80596.1 | KEGG: cpi:Cpin_5776 phosphoesterase PA-phosphatase related; PFAM: Phosphatidic acid phosphatase type 2/haloperoxidase; SMART: Phosphatidic acid phosphatase type 2/haloperoxidase. (192 aa) |
| | ADZ80563.1 | Phospholipase D/Transphosphatidylase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa) |
| | ADZ80554.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: phe:Phep_3071 CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (235 aa) |
| | pyrF | KEGG: lby:Lbys_3332 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase domain; TIGRFAM: Orotidine 5'-phosphate decarboxylase, type 2; HAMAP: Orotidine 5'-phosphate decarboxylase, type 2; SMART: Orotidine 5'-phosphate decarboxylase domain; Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa) |
| | ADZ80533.1 | KEGG: phe:Phep_1410 phosphoesterase PA-phosphatase related; PFAM: Phosphatidic acid phosphatase type 2/haloperoxidase; SMART: Phosphatidic acid phosphatase type 2/haloperoxidase. (194 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (280 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (233 aa) |
| | ADZ80518.1 | KEGG: cpi:Cpin_6522 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal. (391 aa) |
| | ADZ80420.1 | Allantoinase; KEGG: phe:Phep_3229 dihydroorotase; PFAM: Amidohydrolase 1. (445 aa) |
| | gpsA | HAMAP: Glycerol-3-phosphate dehydrogenase, NAD-dependent; KEGG: phe:Phep_0664 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal; Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (344 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1219 aa) |
| | ADZ80334.1 | KEGG: bac:BamMC406_6277 FRG domain-containing protein; PFAM: FRG domain; SMART: FRG domain. (239 aa) |
| | ADZ80288.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (390 aa) |
| | ADZ80274.1 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa) |
| | ADZ80273.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (399 aa) |
| | ADZ80271.1 | PFAM: ThiamineS; KEGG: dfe:Dfer_3068 thiamineS protein. (77 aa) |
| | ADZ80269.1 | TIGRFAM: Molybdenum cofactor synthesis; PFAM: Molybdopterin cofactor biosynthesis C (MoaC) domain; Molybdopterin binding; KEGG: dfe:Dfer_3066 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; SMART: Molybdopterin binding. (303 aa) |
| | ADZ80267.1 | KEGG: dfe:Dfer_0362 CinA domain protein; TIGRFAM: CinA, C-terminal; PFAM: CinA, C-terminal; Belongs to the CinA family. (171 aa) |
| | ADZ80219.1 | PFAM: NUDIX hydrolase domain; KEGG: phe:Phep_0649 NUDIX hydrolase. (156 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa) |
| | ADZ80175.1 | PFAM: NUDIX hydrolase domain; TIGRFAM: Isopentenyl-diphosphate delta-isomerase, type 1; HAMAP: Isopentenyl-diphosphate delta-isomerase, type 1; KEGG: cpi:Cpin_4731 isopentenyl-diphosphate delta-isomerase, type 1. (172 aa) |
| | ADZ80158.1 | TIGRFAM: Adenylosuccinate lyase; KEGG: phe:Phep_2933 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal/plant; Lyase 1, N-terminal; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (445 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (345 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (536 aa) |
| | ADZ80055.1 | KEGG: phe:Phep_2579 phospholipid/glycerol acyltransferase; PFAM: Phospholipid/glycerol acyltransferase; SMART: Phospholipid/glycerol acyltransferase. (245 aa) |
| | ADZ80051.1 | KEGG: phe:Phep_2581 deoxynucleoside kinase; PFAM: Deoxynucleoside kinase. (204 aa) |
| | ADZ80037.1 | KEGG: cro:ROD_26251 hypothetical protein. (201 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | coaA | TIGRFAM: Bacterial pantothenate kinase; HAMAP: Bacterial pantothenate kinase; KEGG: cpi:Cpin_2317 pantothenate kinase. (318 aa) |
| | ADZ79884.1 | PFAM: Protein of unknown function DUF179; KEGG: phe:Phep_1896 protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (188 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (217 aa) |
| | ADZ79863.1 | KEGG: dfe:Dfer_0406 diacylglycerol kinase catalytic region; PFAM: Diacylglycerol kinase, catalytic domain; SMART: Diacylglycerol kinase, catalytic domain. (298 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | ADZ79706.1 | PFAM: WbqC-like protein family; KEGG: phe:Phep_2171 WbqC-like family protein. (205 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (155 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa) |
| | cmk | TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: phe:Phep_1190 cytidylate kinase; PFAM: Cytidylate kinase domain. (225 aa) |
| | ADZ79668.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: aas:Aasi_1686 hypothetical protein. (155 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (394 aa) |
| | ADZ79589.1 | KEGG: phe:Phep_1567 hypothetical protein. (398 aa) |
| | ADZ79578.1 | KEGG: dfe:Dfer_2547 hypothetical protein. (195 aa) |
| | ADZ79576.1 | KEGG: phe:Phep_3094 hypothetical protein. (242 aa) |
| | ADZ78769.1 | KEGG: rbi:RB2501_07515 amidophosphoribosyltransferase; PFAM: Glutamine amidotransferase, class-II. (636 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase, eukaryotic; KEGG: phe:Phep_1173 aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (516 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa) |
| | atpC | ATPase, F1 complex, delta/epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (97 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (501 aa) |
| | tdk | HAMAP: Thymidine kinase, subgroup; KEGG: phe:Phep_0802 thymidine kinase; PFAM: Thymidine kinase. (193 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (425 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: phe:Phep_0809 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain. (508 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa) |
| | ADZ78985.1 | Phosphoesterase PA-phosphatase related protein; KEGG: aas:Aasi_0568 hypothetical protein; PFAM: Phosphatidic acid phosphatase type 2/haloperoxidase; SMART: Phosphatidic acid phosphatase type 2/haloperoxidase. (195 aa) |
| | purC | HAMAP: SAICAR synthetase; KEGG: phe:Phep_1864 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (318 aa) |
| | ADZ79089.1 | TIGRFAM: Competence-induced protein CinA; CinA, C-terminal; PFAM: CinA, C-terminal; Molybdopterin binding; KEGG: phe:Phep_1871 competence/damage-inducible protein CinA; SMART: Molybdopterin binding; Belongs to the CinA family. (416 aa) |
| | ADZ79152.1 | KEGG: sli:Slin_1206 glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal; Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (328 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (206 aa) |
| | ADZ79237.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: dfe:Dfer_2551 CDP-alcohol phosphatidyltransferase. (314 aa) |
| | ADZ79461.1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (327 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (273 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (274 aa) |
| | ADZ79535.1 | TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; KEGG: phe:Phep_1198 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal; Belongs to the NadC/ModD family. (292 aa) |
