STRINGSTRING
AEJ18302.1 AEJ18302.1 AEJ18305.1 AEJ18305.1 AEJ18534.1 AEJ18534.1 AEJ18587.1 AEJ18587.1 AEJ18771.1 AEJ18771.1 AEJ18817.1 AEJ18817.1 AEJ18914.1 AEJ18914.1 apt apt AEJ19029.1 AEJ19029.1 carA carA AEJ19169.1 AEJ19169.1 AEJ19193.1 AEJ19193.1 AEJ19195.1 AEJ19195.1 tmk tmk AEJ19639.1 AEJ19639.1 cmk-2 cmk-2 AEJ19808.1 AEJ19808.1 AEJ19982.1 AEJ19982.1 AEJ19984.1 AEJ19984.1 purA purA guaB guaB AEJ19987.1 AEJ19987.1 AEJ20086.1 AEJ20086.1 AEJ20100.1 AEJ20100.1 AEJ20103.1 AEJ20103.1 adk adk surE surE AEJ20508.1 AEJ20508.1 purC purC purF purF purM purM purN purN purH purH purD purD purK purK purE purE pyrB pyrB AEJ20652.1 AEJ20652.1 AEJ20653.1 AEJ20653.1 pyrF pyrF AEJ20655.1 AEJ20655.1 pyrD pyrD pyrE pyrE udk udk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEJ18302.1Oxidoreductase FAD/NAD(P)-binding domain protein. (287 aa)
AEJ18305.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (619 aa)
AEJ18534.1Purine nucleoside phosphorylase deoD-type. (234 aa)
AEJ18587.1Adenosine deaminase. (403 aa)
AEJ18771.1Uracil-xanthine permease. (417 aa)
AEJ18817.1Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa)
AEJ18914.1Purine nucleoside phosphorylase. (254 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa)
AEJ19029.1Carbamoyl-phosphate synthase, large subunit. (1117 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (381 aa)
AEJ19169.1CMP/dCMP deaminase zinc-binding protein. (163 aa)
AEJ19193.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
AEJ19195.1Thymidine kinase. (388 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (218 aa)
AEJ19639.1Phosphoribosyl transferase domain-containing protein. (353 aa)
cmk-2Cytidylate kinase. (177 aa)
AEJ19808.1AAA ATPase. (552 aa)
AEJ19982.12',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (637 aa)
AEJ19984.1GMP synthase, large subunit. (553 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (408 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (478 aa)
AEJ19987.1Adenylosuccinate lyase. (488 aa)
AEJ20086.1Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (326 aa)
AEJ20100.1Pyrimidine-nucleoside phosphorylase. (435 aa)
AEJ20103.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1235 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (209 aa)
surEMultifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (262 aa)
AEJ20508.1Phosphoribosylformylglycinamidine synthase. (1472 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (236 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (469 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (399 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa)
purHBifunctional purine biosynthesis protein purH. (575 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (460 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (399 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa)
AEJ20652.1Aspartate carbamoyltransferase regulatory subunit. (144 aa)
AEJ20653.1Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (450 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (334 aa)
AEJ20655.1Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein. (257 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (308 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (207 aa)
udkUridine kinase. (204 aa)
Your Current Organism:
Treponema caldarium
NCBI taxonomy Id: 744872
Other names: Spirochaeta caldaria DSM 7334, Spirochaeta caldaria H1, T. caldarium DSM 7334, Treponema caldaria DSM 7334, Treponema caldaria H1, Treponema caldaria str. DSM 7334, Treponema caldaria strain DSM 7334, Treponema caldarium DSM 7334
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