STRINGSTRING
glpK glpK AEJ20067.1 AEJ20067.1 AEJ20077.1 AEJ20077.1 adk adk AEJ20115.1 AEJ20115.1 AEJ20132.1 AEJ20132.1 AEJ20186.1 AEJ20186.1 aroK aroK AEJ20192.1 AEJ20192.1 pfkA-2 pfkA-2 AEJ20203.1 AEJ20203.1 AEJ20241.1 AEJ20241.1 AEJ20254.1 AEJ20254.1 AEJ20270.1 AEJ20270.1 AEJ20316.1 AEJ20316.1 AEJ20331.1 AEJ20331.1 AEJ20362.1 AEJ20362.1 AEJ20364.1 AEJ20364.1 AEJ20371.1 AEJ20371.1 AEJ20395.1 AEJ20395.1 AEJ20432.1 AEJ20432.1 AEJ20443.1 AEJ20443.1 AEJ20454.1 AEJ20454.1 AEJ20455.1 AEJ20455.1 ackA-2 ackA-2 AEJ20478.1 AEJ20478.1 AEJ20481.1 AEJ20481.1 AEJ20513.1 AEJ20513.1 AEJ20576.1 AEJ20576.1 AEJ20629.1 AEJ20629.1 AEJ20635.1 AEJ20635.1 AEJ20637.1 AEJ20637.1 AEJ20662.1 AEJ20662.1 AEJ20665.1 AEJ20665.1 hprK hprK AEJ20680.1 AEJ20680.1 ppk ppk AEJ20704.1 AEJ20704.1 AEJ20722.1 AEJ20722.1 AEJ20730.1 AEJ20730.1 buk buk AEJ20802.1 AEJ20802.1 udk udk xylB xylB AEJ20845.1 AEJ20845.1 AEJ20872.1 AEJ20872.1 AEJ20876.1 AEJ20876.1 srkA srkA AEJ20932.1 AEJ20932.1 AEJ18319.1 AEJ18319.1 AEJ18204.1 AEJ18204.1 AEJ18221.1 AEJ18221.1 AEJ18228.1 AEJ18228.1 AEJ18240.1 AEJ18240.1 AEJ18246.1 AEJ18246.1 AEJ18280.1 AEJ18280.1 AEJ18290.1 AEJ18290.1 AEJ18298.1 AEJ18298.1 AEJ19998.1 AEJ19998.1 AEJ19983.1 AEJ19983.1 pgk pgk nadK nadK AEJ19808.1 AEJ19808.1 AEJ19759.1 AEJ19759.1 AEJ19724.1 AEJ19724.1 cmk-2 cmk-2 AEJ19702.1 AEJ19702.1 AEJ19690.1 AEJ19690.1 AEJ19654.1 AEJ19654.1 AEJ19548.1 AEJ19548.1 AEJ19525.1 AEJ19525.1 cmk cmk AEJ19520.1 AEJ19520.1 tmk tmk coaX-2 coaX-2 AEJ19466.1 AEJ19466.1 AEJ19459.1 AEJ19459.1 AEJ19450.1 AEJ19450.1 AEJ19388.1 AEJ19388.1 AEJ19338.1 AEJ19338.1 AEJ19290.1 AEJ19290.1 AEJ19239.1 AEJ19239.1 AEJ19195.1 AEJ19195.1 AEJ19170.1 AEJ19170.1 AEJ19150.1 AEJ19150.1 AEJ19142.1 AEJ19142.1 AEJ19126.1 AEJ19126.1 AEJ19117.1 AEJ19117.1 AEJ19108.1 AEJ19108.1 AEJ19097.1 AEJ19097.1 AEJ19083.1 AEJ19083.1 argB argB proB proB AEJ18988.1 AEJ18988.1 AEJ18986.1 AEJ18986.1 AEJ18973.1 AEJ18973.1 AEJ18955.1 AEJ18955.1 AEJ18952.1 AEJ18952.1 ispE ispE AEJ18930.1 AEJ18930.1 AEJ18920.1 AEJ18920.1 AEJ18909.1 AEJ18909.1 AEJ18897.1 AEJ18897.1 AEJ18888.1 AEJ18888.1 ackA ackA coaX coaX AEJ18848.1 AEJ18848.1 AEJ18817.1 AEJ18817.1 pfp pfp AEJ18780.1 AEJ18780.1 AEJ18727.1 AEJ18727.1 AEJ18712.1 AEJ18712.1 ndk ndk AEJ18639.1 AEJ18639.1 AEJ18617.1 AEJ18617.1 coaE coaE AEJ18609.1 AEJ18609.1 AEJ18602.1 AEJ18602.1 AEJ18516.1 AEJ18516.1 AEJ18513.1 AEJ18513.1 AEJ18441.1 AEJ18441.1 AEJ18439.1 AEJ18439.1 AEJ18417.1 AEJ18417.1 AEJ18382.1 AEJ18382.1 AEJ18353.1 AEJ18353.1 pfkA pfkA AEJ18349.1 AEJ18349.1 thiM thiM AEJ18338.1 AEJ18338.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (498 aa)
AEJ20067.1Histidine kinase. (385 aa)
AEJ20077.1Signal transduction histidine kinase. (616 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (209 aa)
AEJ20115.1Carbohydrate kinase, FGGY. (503 aa)
AEJ20132.1Integral membrane sensor signal transduction histidine kinase. (588 aa)
AEJ20186.1Phosphatidate cytidylyltransferase. (197 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (191 aa)
AEJ20192.1Putative signal transduction histidine kinase. (354 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (368 aa)
AEJ20203.1ROK family protein. (403 aa)
AEJ20241.1Tetratricopeptide TPR_1 repeat-containing protein. (983 aa)
AEJ20254.1GAF sensor signal transduction histidine kinase. (609 aa)
AEJ20270.1Multi-sensor signal transduction histidine kinase. (596 aa)
AEJ20316.1KWG Leptospira repeat protein. (342 aa)
AEJ20331.1Multi-sensor signal transduction histidine kinase. (594 aa)
AEJ20362.11-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (322 aa)
AEJ20364.1Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (572 aa)
AEJ20371.1Fructokinase. (323 aa)
AEJ20395.1Integral membrane sensor signal transduction histidine kinase. (428 aa)
AEJ20432.1Integral membrane sensor signal transduction histidine kinase. (514 aa)
AEJ20443.1PASTA domain containing protein. (343 aa)
AEJ20454.1Response regulator receiver protein. (123 aa)
AEJ20455.1CheA signal transduction histidine kinase. (750 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (445 aa)
AEJ20478.1PfkB domain protein. (342 aa)
AEJ20481.1Hpt sensor hybrid histidine kinase. (837 aa)
AEJ20513.1Multi-sensor hybrid histidine kinase. (869 aa)
AEJ20576.1ROK family protein. (397 aa)
AEJ20629.1Hypothetical protein. (337 aa)
AEJ20635.1Response regulator receiver protein. (124 aa)
AEJ20637.1CheA signal transduction histidine kinase. (657 aa)
AEJ20662.1Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (597 aa)
AEJ20665.1Response regulator receiver protein. (138 aa)
hprKHPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (329 aa)
AEJ20680.1Integral membrane sensor signal transduction histidine kinase. (582 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (697 aa)
AEJ20704.1Integral membrane sensor signal transduction histidine kinase. (439 aa)
AEJ20722.1PfkB domain protein. (370 aa)
AEJ20730.1Integral membrane sensor signal transduction histidine kinase. (486 aa)
bukButyrate kinase; Belongs to the acetokinase family. (355 aa)
AEJ20802.1Signal transduction histidine kinase regulating citrate/malate metabolism. (650 aa)
udkUridine kinase. (204 aa)
xylBXylulokinase. (495 aa)
AEJ20845.1Putative signal transduction histidine kinase. (135 aa)
AEJ20872.1ATP-binding region ATPase domain protein. (182 aa)
AEJ20876.1Putative cytidylate kinase, putative. (221 aa)
srkAAminoglycoside phosphotransferase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (335 aa)
AEJ20932.1Integral membrane sensor signal transduction histidine kinase. (662 aa)
AEJ18319.1Integral membrane sensor signal transduction histidine kinase. (409 aa)
AEJ18204.1Signal transduction histidine kinase, LytS. (496 aa)
AEJ18221.1Xylulokinase. (491 aa)
AEJ18228.1Carbohydrate kinase, FGGY. (532 aa)
AEJ18240.1PfkB domain protein. (303 aa)
AEJ18246.1Signal transduction histidine kinase. (272 aa)
AEJ18280.1Hypothetical protein. (671 aa)
AEJ18290.1Integral membrane sensor signal transduction histidine kinase. (445 aa)
AEJ18298.1PfkB domain protein. (397 aa)
AEJ19998.1Signal transduction histidine kinase, LytS. (494 aa)
AEJ19983.1Signal transduction histidine kinase. (544 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (419 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (281 aa)
AEJ19808.1AAA ATPase. (552 aa)
AEJ19759.1RelA/SpoT domain protein. (413 aa)
AEJ19724.1Signal transduction histidine kinase. (384 aa)
cmk-2Cytidylate kinase. (177 aa)
AEJ19702.1Cobalbumin biosynthesis protein. (178 aa)
AEJ19690.1Aspartate kinase; Belongs to the aspartokinase family. (456 aa)
AEJ19654.1PAS/PAC sensor signal transduction histidine kinase. (405 aa)
AEJ19548.1Thiamine pyrophosphokinase. (216 aa)
AEJ19525.1Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (572 aa)
cmkCytidylate kinase. (210 aa)
AEJ19520.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (172 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (218 aa)
coaX-2Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (253 aa)
AEJ19466.1Aspartate kinase. (817 aa)
AEJ19459.1Galactokinase; Belongs to the GHMP kinase family. (395 aa)
AEJ19450.1Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (887 aa)
AEJ19388.1ATP:guanido phosphotransferase, catalytic domain protein. (363 aa)
AEJ19338.1Integral membrane sensor signal transduction histidine kinase. (424 aa)
AEJ19290.1Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (877 aa)
AEJ19239.1ATP-binding region ATPase domain protein. (182 aa)
AEJ19195.1Thymidine kinase. (388 aa)
AEJ19170.1PfkB domain protein. (318 aa)
AEJ19150.1Adenylate/guanylate cyclase with integral membrane sensor. (589 aa)
AEJ19142.1Hexokinase. (452 aa)
AEJ19126.1Regulatory protein MarR. (391 aa)
AEJ19117.1Multi-sensor signal transduction histidine kinase. (751 aa)
AEJ19108.1CheA signal transduction histidine kinase. (802 aa)
AEJ19097.1Aspartate kinase; Belongs to the aspartokinase family. (443 aa)
AEJ19083.1Pyruvate phosphate dikinase PEP/pyruvate-binding protein. (894 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (267 aa)
AEJ18988.1Nucleoside diphosphate kinase. (394 aa)
AEJ18986.1Signal transduction histidine kinase. (555 aa)
AEJ18973.1Ribokinase. (290 aa)
AEJ18955.1Response regulator receiver protein. (124 aa)
AEJ18952.1CheA signal transduction histidine kinase. (710 aa)
ispE4-diphosphocytidyl-2-C-methyl-D- erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (307 aa)
AEJ18930.1Pyruvate kinase; Belongs to the pyruvate kinase family. (599 aa)
AEJ18920.1Multi-sensor signal transduction histidine kinase. (582 aa)
AEJ18909.1Cytidyltransferase-related domain protein. (184 aa)
AEJ18897.1Two component transcriptional regulator, LuxR family. (883 aa)
AEJ18888.1Integral membrane sensor signal transduction histidine kinase. (455 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
coaXPutative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (260 aa)
AEJ18848.1PAS/PAC sensor signal transduction histidine kinase. (573 aa)
AEJ18817.1Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa)
pfpDiphosphate/fructose-6-phosphate1-phosphotransfe rase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (551 aa)
AEJ18780.1PfkB domain protein. (345 aa)
AEJ18727.1Hypothetical protein. (519 aa)
AEJ18712.1Signal transduction histidine kinase. (576 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (147 aa)
AEJ18639.1Hypothetical protein. (182 aa)
AEJ18617.1Galactokinase; Belongs to the GHMP kinase family. (441 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (221 aa)
AEJ18609.1Hypothetical protein. (234 aa)
AEJ18602.1Transport-associated protein. (273 aa)
AEJ18516.1ROK family protein. (388 aa)
AEJ18513.1Death-on-curing family protein. (132 aa)
AEJ18441.1Carbohydrate kinase, FGGY. (468 aa)
AEJ18439.1Diacylglycerol kinase catalytic region. (382 aa)
AEJ18417.1Glycerate kinase; Belongs to the glycerate kinase type-1 family. (379 aa)
AEJ18382.1Integral membrane sensor signal transduction histidine kinase. (408 aa)
AEJ18353.1Integral membrane sensor signal transduction histidine kinase. (434 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (455 aa)
AEJ18349.1SlyX family protein. (67 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (274 aa)
AEJ18338.1Phosphomethylpyrimidine kinase. (285 aa)
Your Current Organism:
Treponema caldarium
NCBI taxonomy Id: 744872
Other names: Spirochaeta caldaria DSM 7334, Spirochaeta caldaria H1, T. caldarium DSM 7334, Treponema caldaria DSM 7334, Treponema caldaria H1, Treponema caldaria str. DSM 7334, Treponema caldaria strain DSM 7334, Treponema caldarium DSM 7334
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