STRINGSTRING
proS proS pheT pheT pheS pheS AEJ18355.1 AEJ18355.1 aspS aspS AEJ18460.1 AEJ18460.1 trpS trpS serS serS AEJ18722.1 AEJ18722.1 AEJ18765.1 AEJ18765.1 AEJ18766.1 AEJ18766.1 glnS glnS cysS cysS argS argS tilS tilS AEJ19014.1 AEJ19014.1 AEJ19029.1 AEJ19029.1 carA carA AEJ19035.1 AEJ19035.1 argG argG gltX gltX glyQS glyQS alaS alaS asnA asnA AEJ19127.1 AEJ19127.1 AEJ19128.1 AEJ19128.1 ddl ddl murE murE AEJ19137.1 AEJ19137.1 gatA gatA gatB gatB aspS-2 aspS-2 AEJ19223.1 AEJ19223.1 AEJ19228.1 AEJ19228.1 AEJ19230.1 AEJ19230.1 ileS ileS AEJ19337.1 AEJ19337.1 AEJ19384.1 AEJ19384.1 AEJ19409.1 AEJ19409.1 AEJ19410.1 AEJ19410.1 metG metG AEJ19457.1 AEJ19457.1 hisS hisS ligA ligA atpD atpD atpB atpB atpA atpA AEJ19649.1 AEJ19649.1 AEJ19687.1 AEJ19687.1 murC murC AEJ19723.1 AEJ19723.1 asnS asnS AEJ19789.1 AEJ19789.1 AEJ19810.1 AEJ19810.1 murF murF atpD-2 atpD-2 atpB-2 atpB-2 atpA-2 atpA-2 AEJ19957.1 AEJ19957.1 valS valS AEJ19984.1 AEJ19984.1 purA purA AEJ20026.1 AEJ20026.1 tyrS tyrS AEJ20168.1 AEJ20168.1 AEJ20169.1 AEJ20169.1 accD accD accA accA AEJ20204.1 AEJ20204.1 rtcB rtcB AEJ20434.1 AEJ20434.1 AEJ20441.1 AEJ20441.1 AEJ20488.1 AEJ20488.1 AEJ20489.1 AEJ20489.1 thrS thrS AEJ20508.1 AEJ20508.1 nadE nadE AEJ20950.1 AEJ20950.1 purC purC purM purM purD purD AEJ20537.1 AEJ20537.1 purK purK fhs fhs AEJ20612.1 AEJ20612.1 lysS lysS AEJ20691.1 AEJ20691.1 leuS leuS pyrG pyrG AEJ20875.1 AEJ20875.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
proSProlyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (609 aa)
pheTPhenylalanyl-tRNA synthetase beta chain. (580 aa)
pheSPhenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (537 aa)
AEJ18355.1Threonyl/alanyl tRNA synthetase SAD. (416 aa)
aspSaspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (624 aa)
AEJ18460.1Long-chain-fatty-acid--CoA ligase. (637 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (332 aa)
serSSeryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa)
AEJ18722.1biotin/acetyl-CoA-carboxylase ligase. (289 aa)
AEJ18765.1FdrA family protein. (418 aa)
AEJ18766.1Protein of unknown function DUF1116. (554 aa)
glnSGlutaminyl-tRNA synthetase. (573 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (480 aa)
argSArginyl-tRNA synthetase. (586 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (500 aa)
AEJ19014.1Hypothetical protein. (365 aa)
AEJ19029.1Carbamoyl-phosphate synthase, large subunit. (1117 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (381 aa)
AEJ19035.1Hypothetical protein. (377 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (419 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (492 aa)
glyQSglycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (463 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (595 aa)
asnAAspartate--ammonia ligase. (344 aa)
AEJ19127.1Lysine--tRNA ligase. (337 aa)
AEJ19128.1UDP-N-acetylmuramoylalanine/D-glutamate ligase; Belongs to the MurCDEF family. (517 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (376 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (556 aa)
AEJ19137.1Hypothetical protein. (120 aa)
gatAGlutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (508 aa)
gatBAspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (495 aa)
aspS-2Aspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (458 aa)
AEJ19223.1Hypothetical protein. (363 aa)
AEJ19228.1Hypothetical protein. (361 aa)
AEJ19230.1Hypothetical protein. (346 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1055 aa)
AEJ19337.1Hypothetical protein. (314 aa)
AEJ19384.1Protein of unknown function DUF214. (436 aa)
AEJ19409.1Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (454 aa)
AEJ19410.1Phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (433 aa)
metGMethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (767 aa)
AEJ19457.1biotin/acetyl-CoA-carboxylase ligase. (263 aa)
hisSHistidyl-tRNA synthetase. (434 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (665 aa)
atpDV-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (200 aa)
atpBV-type ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (432 aa)
atpAV-type ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (586 aa)
AEJ19649.1V-type ATP synthase subunit E. (204 aa)
AEJ19687.1PfkB domain protein. (635 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (490 aa)
AEJ19723.1FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (462 aa)
asnSAsparaginyl-tRNA synthetase. (465 aa)
AEJ19789.1Glutamine synthetase catalytic region. (707 aa)
AEJ19810.1ATPase, FliI/YscN family. (451 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (468 aa)
atpD-2V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (207 aa)
atpB-2V-type ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (487 aa)
atpA-2V-type ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (597 aa)
AEJ19957.1ATP synthase subunit c. (107 aa)
valSValyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (886 aa)
AEJ19984.1GMP synthase, large subunit. (553 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (408 aa)
AEJ20026.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (492 aa)
tyrSTyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (418 aa)
AEJ20168.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (173 aa)
AEJ20169.1Biotin carboxylase. (443 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (264 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (309 aa)
AEJ20204.1UBA/THIF-type NAD/FAD binding protein. (249 aa)
rtcBProtein of unknown function UPF0027; Belongs to the RtcB family. (475 aa)
AEJ20434.1Butyrate--CoA ligase. (572 aa)
AEJ20441.1Long-chain-fatty-acid--CoA ligase. (587 aa)
AEJ20488.1Von Willebrand factor type A. (327 aa)
AEJ20489.1Von Willebrand factor type A. (333 aa)
thrSthreonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (584 aa)
AEJ20508.1Phosphoribosylformylglycinamidine synthase. (1472 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (574 aa)
AEJ20950.1Long-chain-fatty-acid--CoA ligase. (641 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (236 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (399 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (460 aa)
AEJ20537.1Long-chain-fatty-acid--CoA ligase. (556 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (399 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (584 aa)
AEJ20612.1Von Willebrand factor type A. (579 aa)
lysSLysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (527 aa)
AEJ20691.1Asn/Gln amidotransferase. (800 aa)
leuSleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (819 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa)
AEJ20875.1Long-chain-fatty-acid--CoA ligase. (570 aa)
Your Current Organism:
Treponema caldarium
NCBI taxonomy Id: 744872
Other names: Spirochaeta caldaria DSM 7334, Spirochaeta caldaria H1, T. caldarium DSM 7334, Treponema caldaria DSM 7334, Treponema caldaria H1, Treponema caldaria str. DSM 7334, Treponema caldaria strain DSM 7334, Treponema caldarium DSM 7334
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