STRINGSTRING
AEJ20681.1 AEJ20681.1 AEJ20703.1 AEJ20703.1 AEJ20704.1 AEJ20704.1 AEJ20709.1 AEJ20709.1 AEJ20710.1 AEJ20710.1 AEJ20725.1 AEJ20725.1 AEJ20730.1 AEJ20730.1 AEJ20747.1 AEJ20747.1 AEJ20753.1 AEJ20753.1 AEJ20792.1 AEJ20792.1 AEJ20794.1 AEJ20794.1 AEJ20802.1 AEJ20802.1 AEJ20813.1 AEJ20813.1 AEJ20819.1 AEJ20819.1 AEJ20820.1 AEJ20820.1 AEJ20822.1 AEJ20822.1 uvrC uvrC dnaJ dnaJ uppP uppP AEJ20844.1 AEJ20844.1 cheB-3 cheB-3 AEJ20872.1 AEJ20872.1 AEJ20885.1 AEJ20885.1 AEJ20887.1 AEJ20887.1 AEJ20891.1 AEJ20891.1 AEJ20932.1 AEJ20932.1 AEJ20959.1 AEJ20959.1 gyrA gyrA recF recF AEJ18188.1 AEJ18188.1 AEJ18191.1 AEJ18191.1 AEJ18193.1 AEJ18193.1 AEJ18197.1 AEJ18197.1 hcp hcp AEJ18204.1 AEJ18204.1 AEJ18205.1 AEJ18205.1 AEJ18220.1 AEJ18220.1 AEJ18235.1 AEJ18235.1 AEJ18236.1 AEJ18236.1 AEJ18254.1 AEJ18254.1 AEJ18290.1 AEJ18290.1 AEJ18291.1 AEJ18291.1 AEJ18318.1 AEJ18318.1 AEJ18319.1 AEJ18319.1 AEJ18353.1 AEJ18353.1 AEJ18366.1 AEJ18366.1 recR recR AEJ18370.1 AEJ18370.1 AEJ18381.1 AEJ18381.1 AEJ18382.1 AEJ18382.1 AEJ18397.1 AEJ18397.1 AEJ18404.1 AEJ18404.1 AEJ18461.1 AEJ18461.1 AEJ18470.1 AEJ18470.1 AEJ18474.1 AEJ18474.1 AEJ18498.1 AEJ18498.1 AEJ18501.1 AEJ18501.1 AEJ18590.1 AEJ18590.1 polA polA AEJ18622.1 AEJ18622.1 AEJ18635.1 AEJ18635.1 AEJ18637.1 AEJ18637.1 AEJ18698.1 AEJ18698.1 AEJ18753.1 AEJ18753.1 AEJ18797.1 AEJ18797.1 AEJ18810.1 AEJ18810.1 AEJ18811.1 AEJ18811.1 AEJ18821.1 AEJ18821.1 AEJ18841.1 AEJ18841.1 AEJ18848.1 AEJ18848.1 AEJ18862.1 AEJ18862.1 AEJ18887.1 AEJ18887.1 AEJ18888.1 AEJ18888.1 AEJ18897.1 AEJ18897.1 AEJ18920.1 AEJ18920.1 AEJ18921.1 AEJ18921.1 AEJ18934.1 AEJ18934.1 AEJ18952.1 AEJ18952.1 cheB cheB AEJ18955.1 AEJ18955.1 AEJ18956.1 AEJ18956.1 AEJ18966.1 AEJ18966.1 AEJ18986.1 AEJ18986.1 AEJ18999.1 AEJ18999.1 AEJ19000.1 AEJ19000.1 AEJ19015.1 AEJ19015.1 AEJ19034.1 AEJ19034.1 AEJ19094.1 AEJ19094.1 cheD cheD AEJ19108.1 AEJ19108.1 AEJ19109.1 AEJ19109.1 AEJ19110.1 AEJ19110.1 AEJ19111.1 AEJ19111.1 AEJ19117.1 AEJ19117.1 AEJ19118.1 AEJ19118.1 AEJ19122.1 AEJ19122.1 AEJ19124.1 AEJ19124.1 AEJ19150.1 AEJ19150.1 AEJ19168.1 AEJ19168.1 AEJ19202.1 AEJ19202.1 AEJ19265.1 AEJ19265.1 mutS2 mutS2 AEJ19315.1 AEJ19315.1 AEJ19320.1 AEJ19320.1 AEJ19322.1 AEJ19322.1 nth nth msrA msrA AEJ19338.1 AEJ19338.1 AEJ19339.1 AEJ19339.1 dacA dacA uvrA uvrA AEJ19372.1 AEJ19372.1 AEJ19387.1 AEJ19387.1 AEJ19392.1 AEJ19392.1 AEJ19395.1 AEJ19395.1 AEJ19421.1 AEJ19421.1 ruvC ruvC ruvA ruvA ruvB ruvB mutS mutS recA recA AEJ19557.1 AEJ19557.1 ligA ligA AEJ19627.1 AEJ19627.1 AEJ19635.1 AEJ19635.1 AEJ19652.1 AEJ19652.1 AEJ19653.1 AEJ19653.1 AEJ19654.1 AEJ19654.1 AEJ19659.1 AEJ19659.1 AEJ19661.1 AEJ19661.1 AEJ19675.1 AEJ19675.1 AEJ19676.1 AEJ19676.1 AEJ19677.1 AEJ19677.1 AEJ19678.1 AEJ19678.1 AEJ19679.1 AEJ19679.1 AEJ19697.1 AEJ19697.1 AEJ19718.1 AEJ19718.1 AEJ19730.1 AEJ19730.1 AEJ19734.1 AEJ19734.1 rex rex AEJ19750.1 AEJ19750.1 AEJ19751.1 AEJ19751.1 mfd mfd mutL mutL AEJ19784.1 AEJ19784.1 AEJ19785.1 AEJ19785.1 AEJ19793.1 AEJ19793.1 AEJ19795.1 AEJ19795.1 AEJ19809.1 AEJ19809.1 AEJ19812.1 AEJ19812.1 AEJ19874.1 AEJ19874.1 AEJ19895.1 AEJ19895.1 AEJ19899.1 AEJ19899.1 AEJ19900.1 AEJ19900.1 AEJ19905.1 AEJ19905.1 AEJ19923.1 AEJ19923.1 AEJ19936.1 AEJ19936.1 AEJ19941.1 AEJ19941.1 AEJ19944.1 AEJ19944.1 AEJ19949.1 AEJ19949.1 AEJ19974.1 AEJ19974.1 AEJ19975.1 AEJ19975.1 clpB clpB AEJ19998.1 AEJ19998.1 AEJ19999.1 AEJ19999.1 AEJ20016.1 AEJ20016.1 cas2-2 cas2-2 cas1 cas1 AEJ20055.1 AEJ20055.1 AEJ20058.1 AEJ20058.1 AEJ20059.1 AEJ20059.1 msrB msrB uvrB uvrB AEJ20067.1 AEJ20067.1 AEJ20074.1 AEJ20074.1 lon-2 lon-2 AEJ20087.1 AEJ20087.1 recG recG AEJ20092.1 AEJ20092.1 AEJ20099.1 AEJ20099.1 recO recO AEJ20122.1 AEJ20122.1 AEJ20129.1 AEJ20129.1 AEJ20132.1 AEJ20132.1 AEJ20133.1 AEJ20133.1 AEJ20134.1 AEJ20134.1 AEJ20139.1 AEJ20139.1 AEJ20140.1 AEJ20140.1 AEJ20146.1 AEJ20146.1 AEJ20191.1 AEJ20191.1 AEJ20207.1 AEJ20207.1 AEJ20220.1 AEJ20220.1 AEJ20231.1 AEJ20231.1 nth-2 nth-2 AEJ20251.1 AEJ20251.1 AEJ20253.1 AEJ20253.1 AEJ20254.1 AEJ20254.1 AEJ20269.1 AEJ20269.1 AEJ20270.1 AEJ20270.1 AEJ20326.1 AEJ20326.1 AEJ20327.1 AEJ20327.1 AEJ20331.1 AEJ20331.1 AEJ20332.1 AEJ20332.1 AEJ20374.1 AEJ20374.1 AEJ20394.1 AEJ20394.1 AEJ20395.1 AEJ20395.1 AEJ20396.1 AEJ20396.1 tpx tpx AEJ20406.1 AEJ20406.1 AEJ20407.1 AEJ20407.1 AEJ20415.1 AEJ20415.1 AEJ20432.1 AEJ20432.1 AEJ20433.1 AEJ20433.1 cheB-2 cheB-2 cheD-2 cheD-2 AEJ20452.1 AEJ20452.1 AEJ20453.1 AEJ20453.1 AEJ20454.1 AEJ20454.1 AEJ20455.1 AEJ20455.1 AEJ20456.1 AEJ20456.1 AEJ20457.1 AEJ20457.1 AEJ20461.1 AEJ20461.1 AEJ20462.1 AEJ20462.1 AEJ20473.1 AEJ20473.1 AEJ20480.1 AEJ20480.1 AEJ20481.1 AEJ20481.1 ychF ychF AEJ20509.1 AEJ20509.1 AEJ20513.1 AEJ20513.1 AEJ20520.1 AEJ20520.1 AEJ20521.1 AEJ20521.1 AEJ20583.1 AEJ20583.1 AEJ20590.1 AEJ20590.1 AEJ20625.1 AEJ20625.1 AEJ20635.1 AEJ20635.1 AEJ20636.1 AEJ20636.1 AEJ20637.1 AEJ20637.1 AEJ20647.1 AEJ20647.1 AEJ20648.1 AEJ20648.1 AEJ20665.1 AEJ20665.1 AEJ20666.1 AEJ20666.1 radA radA rex-2 rex-2 hprK hprK AEJ20680.1 AEJ20680.1 lexA lexA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AEJ20681.1Putative two component, sigma54 specific, transcriptional regulator. (466 aa)
AEJ20703.1Two component transcriptional regulator, winged helix family. (227 aa)
AEJ20704.1Integral membrane sensor signal transduction histidine kinase. (439 aa)
AEJ20709.1Methyl-accepting chemotaxis sensory transducer. (717 aa)
AEJ20710.1Metal dependent phosphohydrolase. (566 aa)
AEJ20725.1DNA-3-methyladenine glycosylase I. (192 aa)
AEJ20730.1Integral membrane sensor signal transduction histidine kinase. (486 aa)
AEJ20747.1Hypothetical protein. (500 aa)
AEJ20753.1Diguanylate cyclase with PAS/PAC sensor. (1148 aa)
AEJ20792.1Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1073 aa)
AEJ20794.1Restriction modification system DNA specificity domain protein. (395 aa)
AEJ20802.1Signal transduction histidine kinase regulating citrate/malate metabolism. (650 aa)
AEJ20813.1Lysylphosphatidylglycerol synthetase/UPF0104. (352 aa)
AEJ20819.1FAD-dependent pyridine nucleotide-disulfide oxidoreductase. (418 aa)
AEJ20820.1FAD dependent oxidoreductase. (498 aa)
AEJ20822.1Putative signal transduction protein. (287 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (642 aa)
dnaJChaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (373 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (272 aa)
AEJ20844.1Putative PAS/PAC sensor protein. (437 aa)
cheB-3Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (372 aa)
AEJ20872.1ATP-binding region ATPase domain protein. (182 aa)
AEJ20885.1Response regulator receiver protein. (125 aa)
AEJ20887.1Hypothetical protein. (245 aa)
AEJ20891.1Protein of unknown function DUF262. (587 aa)
AEJ20932.1Integral membrane sensor signal transduction histidine kinase. (662 aa)
AEJ20959.1Hypothetical protein. (81 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (837 aa)
recFDNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (355 aa)
AEJ18188.1Metal dependent phosphohydrolase. (501 aa)
AEJ18191.1Methyl-accepting chemotaxis sensory transducer. (287 aa)
AEJ18193.1NGG1p interacting factor 3 protein, NIF3. (253 aa)
AEJ18197.1Domain of unknown function DUF1848. (272 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (553 aa)
AEJ18204.1Signal transduction histidine kinase, LytS. (496 aa)
AEJ18205.1Two component transcriptional regulator, AraC family. (496 aa)
AEJ18220.1Methyl-accepting chemotaxis sensory transducer with Cache sensor. (620 aa)
AEJ18235.1UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1177 aa)
AEJ18236.1Hypothetical protein. (957 aa)
AEJ18254.1Response regulator receiver protein. (242 aa)
AEJ18290.1Integral membrane sensor signal transduction histidine kinase. (445 aa)
AEJ18291.1Two component transcriptional regulator, LuxR family. (221 aa)
AEJ18318.1Two component transcriptional regulator, LuxR family. (227 aa)
AEJ18319.1Integral membrane sensor signal transduction histidine kinase. (409 aa)
AEJ18353.1Integral membrane sensor signal transduction histidine kinase. (434 aa)
AEJ18366.1PAS/PAC sensor hybrid histidine kinase. (905 aa)
recRRecombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (195 aa)
AEJ18370.1UPF0133 protein ybaB; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (105 aa)
AEJ18381.1Two component transcriptional regulator, LuxR family. (226 aa)
AEJ18382.1Integral membrane sensor signal transduction histidine kinase. (408 aa)
AEJ18397.1Response regulator receiver protein. (192 aa)
AEJ18404.1Putative two component, sigma54 specific, transcriptional regulator. (371 aa)
AEJ18461.1Response regulator receiver protein. (211 aa)
AEJ18470.1Manganese/iron superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (208 aa)
AEJ18474.1Two component transcriptional regulator, LuxR family. (216 aa)
AEJ18498.1RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
AEJ18501.1Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (166 aa)
AEJ18590.1Hypothetical protein. (180 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (984 aa)
AEJ18622.1Hypothetical protein. (222 aa)
AEJ18635.1Response regulator receiver protein. (121 aa)
AEJ18637.1Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (158 aa)
AEJ18698.1Protein of unknown function DUF262. (562 aa)
AEJ18753.1Protein of unknown function DUF34. (267 aa)
AEJ18797.1Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein. (154 aa)
AEJ18810.1Methyl-accepting chemotaxis sensory transducer. (632 aa)
AEJ18811.1Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen. (154 aa)
AEJ18821.1RNA polymerase, sigma-24 subunit, ECF subfamily; Belongs to the sigma-70 factor family. ECF subfamily. (170 aa)
AEJ18841.1Hypothetical protein. (747 aa)
AEJ18848.1PAS/PAC sensor signal transduction histidine kinase. (573 aa)
AEJ18862.1Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (215 aa)
AEJ18887.1Two component transcriptional regulator, winged helix family. (235 aa)
AEJ18888.1Integral membrane sensor signal transduction histidine kinase. (455 aa)
AEJ18897.1Two component transcriptional regulator, LuxR family. (883 aa)
AEJ18920.1Multi-sensor signal transduction histidine kinase. (582 aa)
AEJ18921.1Two component transcriptional regulator, winged helix family. (236 aa)
AEJ18934.1Multi-copper polyphenol oxidoreductase, laccase. (264 aa)
AEJ18952.1CheA signal transduction histidine kinase. (710 aa)
cheBResponse regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (359 aa)
AEJ18955.1Response regulator receiver protein. (124 aa)
AEJ18956.1CheW protein. (152 aa)
AEJ18966.1Water Stress and Hypersensitive response domain-containing protein. (321 aa)
AEJ18986.1Signal transduction histidine kinase. (555 aa)
AEJ18999.1Thioredoxin reductase. (312 aa)
AEJ19000.1Methyl-accepting chemotaxis sensory transducer. (662 aa)
AEJ19015.1Methyl-accepting chemotaxis sensory transducer with Cache sensor. (683 aa)
AEJ19034.1Response regulator receiver protein. (145 aa)
AEJ19094.1Hypothetical protein. (588 aa)
cheDCheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family. (213 aa)
AEJ19108.1CheA signal transduction histidine kinase. (802 aa)
AEJ19109.1MCP methyltransferase, CheR-type. (451 aa)
AEJ19110.1CheC domain protein. (154 aa)
AEJ19111.1Response regulator receiver protein. (149 aa)
AEJ19117.1Multi-sensor signal transduction histidine kinase. (751 aa)
AEJ19118.1Two component, sigma54 specific, transcriptional regulator, Fis family. (479 aa)
AEJ19122.1Thioredoxin-disulfide reductase. (411 aa)
AEJ19124.1Water Stress and Hypersensitive response domain-containing protein. (310 aa)
AEJ19150.1Adenylate/guanylate cyclase with integral membrane sensor. (589 aa)
AEJ19168.1Methyl-accepting chemotaxis sensory transducer. (644 aa)
AEJ19202.1Protein serine/threonine phosphatase with extracellular sensor. (1523 aa)
AEJ19265.1Metal dependent phosphohydrolase. (365 aa)
mutS2MutS2 protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (821 aa)
AEJ19315.1Methyl-accepting chemotaxis sensory transducer with Cache sensor. (612 aa)
AEJ19320.1Restriction endonuclease. (461 aa)
AEJ19322.1Tetratricopeptide TPR_2 repeat-containing protein. (673 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (224 aa)
msrAPeptide methionine sulfoxide reductase msrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (181 aa)
AEJ19338.1Integral membrane sensor signal transduction histidine kinase. (424 aa)
AEJ19339.1Two component, sigma54 specific, transcriptional regulator, Fis family. (470 aa)
dacAConserved hypothetical protein CHP00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (274 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (961 aa)
AEJ19372.1Hypothetical protein. (1099 aa)
AEJ19387.1UvrB/UvrC protein. (179 aa)
AEJ19392.1Peroxiredoxin; Belongs to the glutathione peroxidase family. (161 aa)
AEJ19395.1DEAD/DEAH box helicase domain protein. (783 aa)
AEJ19421.1Acid phosphatase/vanadium-dependent haloperoxidase related protein. (162 aa)
ruvCCrossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (179 aa)
ruvAHolliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (232 aa)
ruvBHolliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (385 aa)
mutSDNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (890 aa)
recAProtein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (431 aa)
AEJ19557.1DNA-directed DNA polymerase. (414 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (665 aa)
AEJ19627.1DNA photolyase FAD-binding protein. (463 aa)
AEJ19635.1Hypothetical protein. (1661 aa)
AEJ19652.1Heat shock protein DnaJ domain protein. (162 aa)
AEJ19653.1Two component, sigma54 specific, transcriptional regulator, Fis family. (455 aa)
AEJ19654.1PAS/PAC sensor signal transduction histidine kinase. (405 aa)
AEJ19659.1Adenylate/guanylate cyclase. (514 aa)
AEJ19661.1CheW protein. (168 aa)
AEJ19675.1Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (413 aa)
AEJ19676.1Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (343 aa)
AEJ19677.1Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (185 aa)
AEJ19678.1OmpA/MotB domain protein. (244 aa)
AEJ19679.1MotA/TolQ/ExbB proton channel. (260 aa)
AEJ19697.1Phage SPO1 DNA polymerase-related protein. (240 aa)
AEJ19718.1Helix-hairpin-helix motif protein. (279 aa)
AEJ19730.1ComEC/Rec2-related protein. (485 aa)
AEJ19734.1Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen. (196 aa)
rexRedox-sensing transcriptional repressor rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (214 aa)
AEJ19750.1Tetratricopeptide TPR_2 repeat-containing protein. (73 aa)
AEJ19751.1Response regulator receiver protein. (241 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1133 aa)
mutLDNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (618 aa)
AEJ19784.1Hypothetical protein. (324 aa)
AEJ19785.1Hypothetical protein. (307 aa)
AEJ19793.1Carbon starvation protein CstA. (562 aa)
AEJ19795.1Arsenite-transporting ATPase. (305 aa)
AEJ19809.1Flagellar export protein FliJ. (149 aa)
AEJ19812.1Flagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (356 aa)
AEJ19874.1Restriction endonuclease. (305 aa)
AEJ19895.1Restriction endonuclease. (305 aa)
AEJ19899.1TfoX domain-containing protein. (107 aa)
AEJ19900.1Restriction endonuclease. (305 aa)
AEJ19905.1Hypothetical protein. (442 aa)
AEJ19923.1TfoX domain-containing protein. (107 aa)
AEJ19936.1NGG1p interacting factor 3 protein, NIF3. (286 aa)
AEJ19941.1DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (565 aa)
AEJ19944.1CheW protein. (159 aa)
AEJ19949.1Heat shock protein DnaJ domain protein. (261 aa)
AEJ19974.1Desulfoferrodoxin. (124 aa)
AEJ19975.1Rubrerythrin. (191 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (856 aa)
AEJ19998.1Signal transduction histidine kinase, LytS. (494 aa)
AEJ19999.1Two component transcriptional regulator, AraC family. (436 aa)
AEJ20016.1Methyl-accepting chemotaxis sensory transducer. (664 aa)
cas2-2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (96 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (343 aa)
AEJ20055.1CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (228 aa)
AEJ20058.1CRISPR-associated protein Cas5 family. (222 aa)
AEJ20059.1Metal dependent phosphohydrolase. (1080 aa)
msrBPeptide methionine sulfoxide reductase msrB. (192 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (673 aa)
AEJ20067.1Histidine kinase. (385 aa)
AEJ20074.1Methyl-accepting chemotaxis sensory transducer. (534 aa)
lon-2Anti-sigma H sporulation factor, LonB; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (855 aa)
AEJ20087.1Flagellar motor switch protein FliG, C-terminal. (459 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (704 aa)
AEJ20092.1Response regulator receiver modulated diguanylate cyclase. (415 aa)
AEJ20099.1single-stranded-DNA-specific exonuclease RecJ. (716 aa)
recODNA repair protein recO; Involved in DNA repair and RecF pathway recombination. (252 aa)
AEJ20122.1Methyl-accepting chemotaxis sensory transducer. (506 aa)
AEJ20129.1Protein of unknown function DUF214. (459 aa)
AEJ20132.1Integral membrane sensor signal transduction histidine kinase. (588 aa)
AEJ20133.1Two component transcriptional regulator, winged helix family. (255 aa)
AEJ20134.1Methyl-accepting chemotaxis sensory transducer with Cache sensor. (697 aa)
AEJ20139.1Two component transcriptional regulator, AraC family. (519 aa)
AEJ20140.1Signal transduction histidine kinase, LytS. (490 aa)
AEJ20146.1Exodeoxyribonuclease III Xth. (258 aa)
AEJ20191.1Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). (686 aa)
AEJ20207.1SMC domain protein. (557 aa)
AEJ20220.1Metal dependent phosphohydrolase. (430 aa)
AEJ20231.1Transcriptional regulator, CarD family. (166 aa)
nth-2DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (229 aa)
AEJ20251.1Methyl-accepting chemotaxis sensory transducer. (427 aa)
AEJ20253.1Two component transcriptional regulator, LuxR family. (212 aa)
AEJ20254.1GAF sensor signal transduction histidine kinase. (609 aa)
AEJ20269.1Two component transcriptional regulator, AraC family. (542 aa)
AEJ20270.1Multi-sensor signal transduction histidine kinase. (596 aa)
AEJ20326.1Protein of unknown function DUF1722. (329 aa)
AEJ20327.1Hypothetical protein. (381 aa)
AEJ20331.1Multi-sensor signal transduction histidine kinase. (594 aa)
AEJ20332.1Two component transcriptional regulator, AraC family. (404 aa)
AEJ20374.1Aminoglycoside N(3')-acetyltransferase. (271 aa)
AEJ20394.1Hypothetical protein. (106 aa)
AEJ20395.1Integral membrane sensor signal transduction histidine kinase. (428 aa)
AEJ20396.1Two component transcriptional regulator, LuxR family. (224 aa)
tpxThiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (170 aa)
AEJ20406.1Radical SAM domain protein. (443 aa)
AEJ20407.1Hypothetical protein. (300 aa)
AEJ20415.1DNA polymerase beta domain protein region. (131 aa)
AEJ20432.1Integral membrane sensor signal transduction histidine kinase. (514 aa)
AEJ20433.1Two component transcriptional regulator, AraC family. (541 aa)
cheB-2Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (363 aa)
cheD-2CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family. (172 aa)
AEJ20452.1Methyl-accepting chemotaxis sensory transducer. (569 aa)
AEJ20453.1CheW protein. (161 aa)
AEJ20454.1Response regulator receiver protein. (123 aa)
AEJ20455.1CheA signal transduction histidine kinase. (750 aa)
AEJ20456.1Hypothetical protein. (453 aa)
AEJ20457.1Response regulator receiver protein. (133 aa)
AEJ20461.1DNA mismatch repair protein MutS domain protein. (534 aa)
AEJ20462.1DNA mismatch repair protein MutS domain protein. (499 aa)
AEJ20473.1methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (188 aa)
AEJ20480.1Response regulator receiver protein. (424 aa)
AEJ20481.1Hpt sensor hybrid histidine kinase. (837 aa)
ychFGTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (369 aa)
AEJ20509.1Methyl-accepting chemotaxis sensory transducer. (742 aa)
AEJ20513.1Multi-sensor hybrid histidine kinase. (869 aa)
AEJ20520.1Putative cache sensor protein. (169 aa)
AEJ20521.1Methyl-accepting chemotaxis sensory transducer. (598 aa)
AEJ20583.1OsmC family protein. (138 aa)
AEJ20590.1Two component, sigma54 specific, transcriptional regulator, Fis family. (457 aa)
AEJ20625.1Diguanylate cyclase. (337 aa)
AEJ20635.1Response regulator receiver protein. (124 aa)
AEJ20636.1CheC domain protein. (159 aa)
AEJ20637.1CheA signal transduction histidine kinase. (657 aa)
AEJ20647.1Nitroreductase. (180 aa)
AEJ20648.1Methyl-accepting chemotaxis sensory transducer with Cache sensor. (699 aa)
AEJ20665.1Response regulator receiver protein. (138 aa)
AEJ20666.1Adenylate/guanylate cyclase. (770 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (457 aa)
rex-2Redox-sensing transcriptional repressor rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (203 aa)
hprKHPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (329 aa)
AEJ20680.1Integral membrane sensor signal transduction histidine kinase. (582 aa)
lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (204 aa)
Your Current Organism:
Treponema caldarium
NCBI taxonomy Id: 744872
Other names: Spirochaeta caldaria DSM 7334, Spirochaeta caldaria H1, T. caldarium DSM 7334, Treponema caldaria DSM 7334, Treponema caldaria H1, Treponema caldaria str. DSM 7334, Treponema caldaria strain DSM 7334, Treponema caldarium DSM 7334
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