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| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (399 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa) |
| | AEJ20652.1 | Aspartate carbamoyltransferase regulatory subunit. (144 aa) |
| | AEJ20653.1 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (450 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (334 aa) |
| | AEJ20655.1 | Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein. (257 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (308 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (207 aa) |
| | AEJ20666.1 | Adenylate/guanylate cyclase. (770 aa) |
| | AEJ20747.1 | Hypothetical protein. (500 aa) |
| | AEJ20749.1 | Hypothetical protein. (754 aa) |
| | udk | Uridine kinase. (204 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa) |
| | AEJ20876.1 | Putative cytidylate kinase, putative. (221 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (499 aa) |
| | AEJ20434.1 | Butyrate--CoA ligase. (572 aa) |
| | thyX | Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (286 aa) |
| | AEJ18302.1 | Oxidoreductase FAD/NAD(P)-binding domain protein. (287 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (274 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | AEJ18416.1 | Phospholipid/glycerol acyltransferase. (279 aa) |
| | AEJ18425.1 | Metal dependent phosphohydrolase. (253 aa) |
| | AEJ18439.1 | Diacylglycerol kinase catalytic region. (382 aa) |
| | AEJ18442.1 | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (410 aa) |
| | AEJ18469.1 | Beta-lactamase domain protein. (315 aa) |
| | AEJ18602.1 | Transport-associated protein. (273 aa) |
| | AEJ18605.1 | CDP-alcohol phosphatidyltransferase. (262 aa) |
| | AEJ18606.1 | CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (192 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (221 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NAD(P)+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (356 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (147 aa) |
| | AEJ18817.1 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (260 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa) |
| | AEJ18909.1 | Cytidyltransferase-related domain protein. (184 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (177 aa) |
| | nadD | Metal dependent phosphohydrolase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (395 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D- erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (307 aa) |
| | AEJ18988.1 | Nucleoside diphosphate kinase. (394 aa) |
| | AEJ19029.1 | Carbamoyl-phosphate synthase, large subunit. (1117 aa) |
| | carA | Carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (381 aa) |
| | AEJ19053.1 | ATP-grasp fold domain protein, DUF201-type. (418 aa) |
| | pdxS | Pyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (195 aa) |
| | AEJ19182.1 | Phosphoribosyl transferase domain protein. (200 aa) |
| | AEJ19195.1 | Thymidine kinase. (388 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | folE2 | Protein of unknown function DUF198; Converts GTP to 7,8-dihydroneopterin triphosphate. (271 aa) |
| | AEJ19293.1 | Phosphate acetyltransferase. (332 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa) |
| | dacA | Conserved hypothetical protein CHP00159; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (274 aa) |
| | AEJ19388.1 | ATP:guanido phosphotransferase, catalytic domain protein. (363 aa) |
| | thiI | tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (394 aa) |
| | coaX-2 | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (253 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (218 aa) |
| | AEJ19518.1 | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (366 aa) |
| | cmk | Cytidylate kinase. (210 aa) |
| | AEJ19525.1 | Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (572 aa) |
| | AEJ19548.1 | Thiamine pyrophosphokinase. (216 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (183 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (381 aa) |
| | AEJ19612.1 | CDP-alcohol phosphatidyltransferase. (236 aa) |
| | AEJ19639.1 | Phosphoribosyl transferase domain-containing protein. (353 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (372 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (200 aa) |
| | atpB | V-type ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (432 aa) |
| | atpA | V-type ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (586 aa) |
| | AEJ19649.1 | V-type ATP synthase subunit E. (204 aa) |
| | AEJ19659.1 | Adenylate/guanylate cyclase. (514 aa) |
| | AEJ19685.1 | Metallophosphoesterase. (355 aa) |
| | cmk-2 | Cytidylate kinase. (177 aa) |
| | AEJ19748.1 | CinA domain protein; Belongs to the CinA family. (159 aa) |
| | AEJ19750.1 | Tetratricopeptide TPR_2 repeat-containing protein. (73 aa) |
| | AEJ19760.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (247 aa) |
| | AEJ19776.1 | ATP-dependent carboxylate-amine ligase domain protein ATP-grasp. (535 aa) |
| | AEJ19784.1 | Hypothetical protein. (324 aa) |
| | AEJ19785.1 | Hypothetical protein. (307 aa) |
| | AEJ19808.1 | AAA ATPase. (552 aa) |
| | AEJ19810.1 | ATPase, FliI/YscN family. (451 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (281 aa) |
| | atpD-2 | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (207 aa) |
| | atpB-2 | V-type ATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (487 aa) |
| | atpA-2 | V-type ATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (597 aa) |
| | AEJ19957.1 | ATP synthase subunit c. (107 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (289 aa) |
| | AEJ19984.1 | GMP synthase, large subunit. (553 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (408 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (478 aa) |
| | AEJ19987.1 | Adenylosuccinate lyase. (488 aa) |
| | AEJ20026.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (492 aa) |
| | AEJ20086.1 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (326 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (209 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (264 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (309 aa) |
| | AEJ20172.1 | Metallophosphoesterase. (364 aa) |
| | AEJ20232.1 | 4-diphosphocytidyl-2C-methyl-D- erythritolsynthase; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (241 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa) |
| | ackA-2 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (445 aa) |
| | AEJ20508.1 | Phosphoribosylformylglycinamidine synthase. (1472 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (574 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (236 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (469 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (399 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | purH | Bifunctional purine biosynthesis protein purH. (575 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (460 aa) |
