STRINGSTRING
lysA lysA thrB thrB AEE13878.1 AEE13878.1 AEE13879.1 AEE13879.1 AEE13880.1 AEE13880.1 argG argG argH argH AEE14269.1 AEE14269.1 asd asd dapA dapA ahcY ahcY AEE14498.1 AEE14498.1 AEE14536.1 AEE14536.1 AEE14605.1 AEE14605.1 AEE14628.1 AEE14628.1 AEE14709.1 AEE14709.1 argC argC argJ argJ argB argB dapF dapF metE metE AEE15003.1 AEE15003.1 AEE15004.1 AEE15004.1 AEE15005.1 AEE15005.1 AEE15006.1 AEE15006.1 dapB dapB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (285 aa)
AEE13878.1COGs: COG0527 Aspartokinase; InterPro IPR005260:IPR001341:IPR001048:IPR002912; KEGG: adg:Adeg_0884 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartate kinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; IMG reference gene:2504783596; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (410 aa)
AEE13879.1Protein of unknown function DUF39; COGs: COG1900 conserved hypothetical protein; InterPro IPR002708; KEGG: tjr:TherJR_1173 protein of unknown function DUF39; PFAM: Protein of unknown function DUF39; SPTR: Putative uncharacterized protein; IMG reference gene:2504783597; PFAM: Domain of unknown function DUF39. (384 aa)
AEE13880.1NIL domain-containing protein; InterPro IPR018449:IPR001450; KEGG: det:DET0920 iron-sulfur cluster-binding protein; PFAM: NIL domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Iron-sulfur cluster-binding protein; IMG reference gene:2504783598; PFAM: 4Fe-4S binding domain; NIL domain. (138 aa)
argGCOGs: COG0137 Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; InterPro IPR001518; KEGG: toc:Toce_0156 argininosuccinate synthase; PFAM: Argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; IMG reference gene:2504783864; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
argHCOGs: COG0165 Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; InterPro IPR009049:IPR000362; KEGG: dap:Dacet_2886 argininosuccinate lyase; PFAM: Fumarate lyase; PRIAM: Argininosuccinate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase; IMG reference gene:2504783865; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (486 aa)
AEE14269.1InterPro IPR001450; KEGG: apo:Arcpr_1028 RNA polymerase insert; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: DNA-directed RNA polymerase subunit D; IMG reference gene:2504784012; PFAM: 4Fe-4S binding domain. (71 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (334 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (411 aa)
AEE14498.1COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; HAMAP: Dihydrodipicolinate synthase; InterPro IPR002220; KEGG: gvg:HMPREF0421_20691 dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; PRIAM: Dihydrodipicolinate synthase; SPTR: Dihydrodipicolinate synthase; IMG reference gene:2504784261; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: dihydrodipicolinate synthase. (298 aa)
AEE14536.1COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR004450; KEGG: cce:Ccel_1450 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: Threonine synthase; IMG reference gene:2504784300; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (498 aa)
AEE14605.1COGs: COG0078 Ornithine carbamoyltransferase; HAMAP: Ornithine carbamoyltransferase; InterPro IPR002292:IPR006132:IPR006131; KEGG: cow:Calow_1320 ornithine carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; PRIAM: Ornithine carbamoyltransferase; SPTR: Ornithine carbamoyltransferase; TIGRFAM: Ornithine carbamoyltransferase; IMG reference gene:2504784373; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn bind [...] (309 aa)
AEE14628.1COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342:IPR002912; KEGG: aar:Acear_1069 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; SPTR: Homoserine dehydrogenase; IMG reference gene:2504784396; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (421 aa)
AEE14709.1COGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR004636:IPR005814; KEGG: mfs:MFS40622_1451 acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine and succinylornithine aminotransferase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; IMG reference gene:2504784486; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases. (396 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (396 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (288 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa)
AEE15003.1Polar amino acid ABC transporter, inner membrane subunit; COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR010065:IPR000515; KEGG: dhd:Dhaf_1045 polar amino acid ABC transporter, inner membrane subunit; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Putative uncharacterized protein; TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine; IMG reference gene:2504784799; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, perme [...] (216 aa)
AEE15004.1Polar amino acid ABC transporter, inner membrane subunit; COGs: COG0765 ABC-type amino acid transport system permease component; InterPro IPR010065:IPR000515; KEGG: dsy:DSY4276 hypothetical protein; PFAM: Binding-protein-dependent transport systems inner membrane component; SPTR: Putative uncharacterized protein; TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine; IMG reference gene:2504784800; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/ [...] (225 aa)
AEE15005.1COGs: COG0834 ABC-type amino acid transport/signal transduction systems periplasmic component/domain; InterPro IPR001320:IPR001638; KEGG: dhd:Dhaf_1043 extracellular solute-binding protein family 3; PFAM: Extracellular solute-binding protein, family 3; SMART: Extracellular solute-binding protein, family 3; Ionotropic glutamate receptor; SPTR: Putative uncharacterized protein; IMG reference gene:2504784801; PFAM: Bacterial extracellular solute-binding proteins, family 3. (270 aa)
AEE15006.1Phosphonate-transporting ATPase; COGs: COG1126 ABC-type polar amino acid transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: dhd:Dhaf_1042 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2504784802; PFAM: ABC transporter. (244 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa)
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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