STRINGSTRING
lysA lysA thrB thrB AEE13878.1 AEE13878.1 AEE13879.1 AEE13879.1 AEE13880.1 AEE13880.1 AEE14269.1 AEE14269.1 asd asd dapA dapA ahcY ahcY AEE14498.1 AEE14498.1 AEE14536.1 AEE14536.1 AEE14628.1 AEE14628.1 dapF dapF metE metE dapB dapB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (285 aa)
AEE13878.1COGs: COG0527 Aspartokinase; InterPro IPR005260:IPR001341:IPR001048:IPR002912; KEGG: adg:Adeg_0884 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartate kinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; IMG reference gene:2504783596; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (410 aa)
AEE13879.1Protein of unknown function DUF39; COGs: COG1900 conserved hypothetical protein; InterPro IPR002708; KEGG: tjr:TherJR_1173 protein of unknown function DUF39; PFAM: Protein of unknown function DUF39; SPTR: Putative uncharacterized protein; IMG reference gene:2504783597; PFAM: Domain of unknown function DUF39. (384 aa)
AEE13880.1NIL domain-containing protein; InterPro IPR018449:IPR001450; KEGG: det:DET0920 iron-sulfur cluster-binding protein; PFAM: NIL domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Iron-sulfur cluster-binding protein; IMG reference gene:2504783598; PFAM: 4Fe-4S binding domain; NIL domain. (138 aa)
AEE14269.1InterPro IPR001450; KEGG: apo:Arcpr_1028 RNA polymerase insert; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: DNA-directed RNA polymerase subunit D; IMG reference gene:2504784012; PFAM: 4Fe-4S binding domain. (71 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (334 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (411 aa)
AEE14498.1COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; HAMAP: Dihydrodipicolinate synthase; InterPro IPR002220; KEGG: gvg:HMPREF0421_20691 dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; PRIAM: Dihydrodipicolinate synthase; SPTR: Dihydrodipicolinate synthase; IMG reference gene:2504784261; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: dihydrodipicolinate synthase. (298 aa)
AEE14536.1COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR004450; KEGG: cce:Ccel_1450 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: Threonine synthase; IMG reference gene:2504784300; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (498 aa)
AEE14628.1COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342:IPR002912; KEGG: aar:Acear_1069 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; SPTR: Homoserine dehydrogenase; IMG reference gene:2504784396; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (421 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteinemethyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa)
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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