STRINGSTRING
AEE13881.1 AEE13881.1 AEE15452.1 AEE15452.1 AEE15441.1 AEE15441.1 ndk ndk AEE15438.1 AEE15438.1 bioD bioD AEE15431.1 AEE15431.1 thiM thiM metK metK AEE15402.1 AEE15402.1 alaS alaS AEE15377.1 AEE15377.1 folE folE AEE15368.1 AEE15368.1 AEE15340.1 AEE15340.1 AEE15335.1 AEE15335.1 glyQ glyQ glyS glyS AEE15103.1 AEE15103.1 AEE15102.1 AEE15102.1 pstB pstB AEE15072.1 AEE15072.1 AEE15067.1 AEE15067.1 AEE15055.1 AEE15055.1 AEE15044.1 AEE15044.1 AEE15042.1 AEE15042.1 AEE15041.1 AEE15041.1 AEE15036.1 AEE15036.1 hemL hemL lpxK lpxK AEE15008.1 AEE15008.1 AEE15006.1 AEE15006.1 AEE14998.1 AEE14998.1 aspS aspS hisS hisS AEE14992.1 AEE14992.1 AEE14989.1 AEE14989.1 obg obg proB proB nadD nadD AEE14974.1 AEE14974.1 accD accD accA accA AEE14969.1 AEE14969.1 lon lon pyrH pyrH hisI hisI AEE14952.1 AEE14952.1 valS valS AEE14938.1 AEE14938.1 dnaJ dnaJ guaA guaA coaE coaE AEE14897.1 AEE14897.1 AEE14895.1 AEE14895.1 AEE14891.1 AEE14891.1 AEE14883.1 AEE14883.1 era era codY codY AEE14866.1 AEE14866.1 AEE14863.1 AEE14863.1 AEE14861.1 AEE14861.1 AEE14843.1 AEE14843.1 AEE14838.1 AEE14838.1 AEE14836.1 AEE14836.1 priA priA clpX clpX miaA miaA groS-2 groS-2 argB argB AEE14796.1 AEE14796.1 AEE14792.1 AEE14792.1 AEE14767.1 AEE14767.1 lolD lolD AEE14751.1 AEE14751.1 thrS thrS AEE14734.1 AEE14734.1 AEE14733.1 AEE14733.1 AEE14731.1 AEE14731.1 AEE14725.1 AEE14725.1 AEE14716.1 AEE14716.1 AEE14714.1 AEE14714.1 AEE14709.1 AEE14709.1 AEE14708.1 AEE14708.1 AEE14707.1 AEE14707.1 AEE14680.1 AEE14680.1 AEE14673.1 AEE14673.1 AEE14670.1 AEE14670.1 AEE14661.1 AEE14661.1 AEE14660.1 AEE14660.1 AEE14648.1 AEE14648.1 AEE14647.1 AEE14647.1 fhs fhs nadE nadE AEE14626.1 AEE14626.1 nadK nadK dxs dxs AEE14621.1 AEE14621.1 AEE14618.1 AEE14618.1 AEE14617.1 AEE14617.1 AEE14609.1 AEE14609.1 trmFO trmFO moaA moaA rho rho hflX hflX AEE14565.1 AEE14565.1 AEE14557.1 AEE14557.1 AEE14534.1 AEE14534.1 purA purA AEE14532.1 AEE14532.1 AEE14522.1 AEE14522.1 ruvB ruvB ruvA ruvA tyrS tyrS leuS leuS AEE14487.1 AEE14487.1 kdpB kdpB kdpC kdpC AEE14457.1 AEE14457.1 AEE14455.1 AEE14455.1 AEE14451.1 AEE14451.1 ileS ileS AEE14433.1 AEE14433.1 uvrB uvrB AEE14430.1 AEE14430.1 nnrE nnrE AEE14421.1 AEE14421.1 gmk gmk AEE14417.1 AEE14417.1 AEE14415.1 AEE14415.1 dnaK dnaK AEE14406.1 AEE14406.1 ftsE ftsE cmk cmk secA secA tmk tmk AEE14388.1 AEE14388.1 lysS lysS mutS2 mutS2 AEE14383.1 AEE14383.1 AEE14376.1 AEE14376.1 cysS cysS ftsH ftsH tilS tilS carB carB carA carA argS argS AEE14353.1 AEE14353.1 proS proS dxr dxr hisG hisG AEE14333.1 AEE14333.1 pheT pheT pheS pheS AEE14324.1 AEE14324.1 AEE14320.1 AEE14320.1 AEE14318.1 AEE14318.1 AEE14315.1 AEE14315.1 ftsZ ftsZ ddl ddl murB murB murC murC murD murD AEE14296.1 AEE14296.1 murE murE AEE14294.1 AEE14294.1 cbiA cbiA gatB gatB gatA gatA gatC gatC purD purD purM purM hisC hisC AEE14249.1 AEE14249.1 infB infB atpC atpC atpD atpD atpG atpG atpA atpA AEE14203.1 AEE14203.1 AEE14187.1 AEE14187.1 AEE14183.1 AEE14183.1 AEE14180.1 AEE14180.1 AEE14177.1 AEE14177.1 tuf tuf fusA fusA thiL thiL AEE14135.1 AEE14135.1 argG argG pckA pckA AEE14086.1 AEE14086.1 AEE14078.1 AEE14078.1 pgk pgk AEE14066.1 AEE14066.1 AEE14051.1 AEE14051.1 AEE14047.1 AEE14047.1 AEE14037.1 AEE14037.1 glyA glyA AEE13999.1 AEE13999.1 AEE13991.1 AEE13991.1 AEE13988.1 AEE13988.1 AEE13987.1 AEE13987.1 AEE13980.1 AEE13980.1 AEE13979.1 AEE13979.1 AEE13978.1 AEE13978.1 ppk ppk gltX gltX AEE13952.1 AEE13952.1 AEE13951.1 AEE13951.1 pyrK pyrK panC panC AEE13938.1 AEE13938.1 mfd mfd dnaG dnaG AEE13913.1 AEE13913.1 lig lig AEE13908.1 AEE13908.1 coaX coaX dnaX dnaX prs prs AEE13888.1 AEE13888.1 AEE13887.1 AEE13887.1 AEE13882.1 AEE13882.1 AEE13878.1 AEE13878.1 thrB thrB AEE13874.1 AEE13874.1 metG metG AEE13865.1 AEE13865.1 lepA lepA AEE13836.1 AEE13836.1 AEE13835.1 AEE13835.1 AEE13827.1 AEE13827.1 AEE13826.1 AEE13826.1 AEE13825.1 AEE13825.1 AEE13814.1 AEE13814.1 AEE13812.1 AEE13812.1 AEE13811.1 AEE13811.1 AEE13809.1 AEE13809.1 recA recA lysA lysA AEE13786.1 AEE13786.1 AEE13785.1 AEE13785.1 AEE13775.1 AEE13775.1 purC purC AEE13769.1 AEE13769.1 AEE13756.1 AEE13756.1 AEE13749.1 AEE13749.1 AEE13737.1 AEE13737.1 AEE13733.1 AEE13733.1 AEE13731.1 AEE13731.1 AEE13723.1 AEE13723.1 AEE13702.1 AEE13702.1 groL groL groS groS AEE13689.1 AEE13689.1 AEE13661.1 AEE13661.1 AEE13659.1 AEE13659.1 AEE13658.1 AEE13658.1 recF recF dnaA dnaA pyrG pyrG aroK aroK AEE15267.1 AEE15267.1 AEE15263.1 AEE15263.1 serS serS AEE15253.1 AEE15253.1 AEE15252.1 AEE15252.1 AEE15251.1 AEE15251.1 AEE15249.1 AEE15249.1 AEE15242.1 AEE15242.1 pgk-2 pgk-2 AEE15234.1 AEE15234.1 AEE15218.1 AEE15218.1 adk adk AEE15211.1 AEE15211.1 AEE15195.1 AEE15195.1 AEE15194.1 AEE15194.1 AEE15190.1 AEE15190.1 queC queC AEE15178.1 AEE15178.1 selD selD AEE15165.1 AEE15165.1 AEE15164.1 AEE15164.1 coaD coaD AEE15156.1 AEE15156.1 ribBA ribBA AEE15149.1 AEE15149.1 thyX thyX AEE15136.1 AEE15136.1 ispE ispE AEE15126.1 AEE15126.1 AEE15124.1 AEE15124.1 AEE15113.1 AEE15113.1 AEE15112.1 AEE15112.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEE13881.11-phosphofructokinase; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR017583:IPR011611; KEGG: mtp:Mthe_0686 1-phosphofructokinase; PFAM: Carbohydrate/purine kinase; PRIAM: 1-phosphofructokinase; SPTR: 1-phosphofructokinase; TIGRFAM: 1-phosphofructokinase; IMG reference gene:2504783600; PFAM: pfkB family carbohydrate kinase; TIGRFAM: 1-phosphofructokinase; hexose kinase, 1-phosphofructokinase family. (309 aa)
AEE15452.1Molybdate-transporting ATPase; COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003593:IPR003439; KEGG: gwc:GWCH70_1739 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Molybdate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2504785263; PFAM: ABC transporter. (218 aa)
AEE15441.1Cobyrinic acid ac-diamide synthase; COGs: COG1192 ATPase involved in chromosome partitioning; InterPro IPR002586; KEGG: cth:Cthe_2377 chromosome segregation ATPase; PFAM: Cobyrinic acid a,c-diamide synthase; SPTR: Chromosome segregation ATPase; IMG reference gene:2504785252; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain. (250 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (152 aa)
AEE15438.18-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: ddf:DEFDS_1301 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase, class I/II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: 8-amino-7-oxononanoate synthase; IMG reference gene:2504785249; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase. (383 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (188 aa)
AEE15431.1Adenosylmethionine--8-amino-7-oxononanoate transaminase; COGs: COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; InterPro IPR005814; KEGG: ddf:DEFDS_1299 adenosylmethionine--8-amino-7-oxononanoate transaminase; PFAM: Aminotransferase class-III; PRIAM: Adenosylmethionine--8-amino-7-oxononanoate transaminase; SPTR: Adenosylmethionine--8-amino-7-oxononanoate transaminase; IMG reference gene:2504785242; PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase [...] (440 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (269 aa)
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa)
AEE15402.1Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (720 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (854 aa)
AEE15377.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: bld:BLi00095 hypothetical protein; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine); TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; IMG reference gene:2504785187; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyroph [...] (168 aa)
folECOGs: COG0302 GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; InterPro IPR001474:IPR020602; KEGG: ttm:Tthe_0381 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; IMG reference gene:2504785185; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (188 aa)
AEE15368.1Flavodoxin/nitric oxide synthase; COGs: COG0426 flavoprotein; InterPro IPR008254; KEGG: mba:Mbar_A3353 flavoprotein A; PFAM: Flavodoxin/nitric oxide synthase; SPTR: Flavoprotein A; IMG reference gene:2504785178; PFAM: Flavodoxin; Metallo-beta-lactamase superfamily. (391 aa)
AEE15340.1CRISPR-associated protein, Csm1 family; COGs: COG1353 hydrolase of the HD superfamily (permuted catalytic motifs); InterPro IPR013408:IPR006674; KEGG: cni:Calni_1613 crispr-associated protein, csm1 family; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; SPTR: CRISPR-associated protein; TIGRFAM: CRISPR-associated protein Csm1; IMG reference gene:2504785149; PFAM: HD domain; TIGRFAM: CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. (907 aa)
AEE15335.1DNA primase small subunit; COGs: COG4951 conserved hypothetical protein; KEGG: cni:Calni_1598 DNA primase small subunit; SPTR: DNA primase small subunit; IMG reference gene:2504785144. (620 aa)
glyQCOGs: COG0752 Glycyl-tRNA synthetase alpha subunit; HAMAP: Glycyl-tRNA synthetase, class IIc, alpha subunit; InterPro IPR002310; KEGG: cni:Calni_0744 glycyl-tRNA synthetase alpha chain; PFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase alpha chain; TIGRFAM: Glycyl-tRNA synthetase, class IIc, alpha subunit; manually curated; IMG reference gene:2504784904; PFAM: Glycyl-tRNA synthetase alpha subunit; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, alpha subunit. (293 aa)
glySCOGs: COG0751 Glycyl-tRNA synthetase beta subunit; InterPro IPR015944:IPR002311:IPR008909; KEGG: aar:Acear_0683 glycyl-tRNA synthetase beta chain; PFAM: Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal; DALR anticodon binding; PRIAM: Glycine--tRNA ligase; SPTR: Glycyl-tRNA synthetase beta subunit; TIGRFAM: Glycyl-tRNA synthetase, class IIc, beta subunit; IMG reference gene:2504784903; PFAM: Glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain; TIGRFAM: glycyl-tRNA synthetase, tetrameric type, beta subunit. (691 aa)
AEE15103.1Phosphotransferase ydiA; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (270 aa)
AEE15102.1Pyruvate, phosphate dikinase; COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR010121:IPR002192:IPR008279:IPR000121; KEGG: chy:CHY_0443 pyruvate phosphate dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile region; PEP-utilising enzyme; PRIAM: Pyruvate, phosphate dikinase; SPTR: Pyruvate, phosphate dikinase; TIGRFAM: Pyruvate, phosphate dikinase; IMG reference gene:2504784901; PFAM: PEP-utilising enzyme, mobile domain; PEP-utilising enzyme, TIM barrel domain; Pyruvate phosphate dikinase, PEP/pyruvate binding [...] (883 aa)
pstBPhosphate ABC transporter, ATPase subunit; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (250 aa)
AEE15072.1Helicase domain-containing protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR014001:IPR001650:IPR006935; KEGG: aco:Amico_1337 helicase domain protein; PFAM: DNA/RNA helicase, C-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; SPTR: Helicase domain protein; IMG reference gene:2504784870; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain. (1080 aa)
AEE15067.1Indolepyruvate ferredoxin oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (576 aa)
AEE15055.1MOSC domain containing protein; COGs: COG2258 conserved hypothetical protein; KEGG: kol:Kole_0698 MOSC domain containing protein; SPTR: MOSC domain containing protein; IMG reference gene:2504784851; PFAM: MOSC domain. (149 aa)
AEE15044.1D-lactate dehydrogenase (cytochrome); COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113; KEGG: dhd:Dhaf_4518 FAD linked oxidase domain protein; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: Putative uncharacterized protein; IMG reference gene:2504784840; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD. (468 aa)
AEE15042.1D-lactate dehydrogenase (cytochrome); COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113; KEGG: chy:CHY_0432 putative glycolate oxidase, GlcD subunit; PFAM: FAD linked oxidase, N-terminal; FAD-linked oxidase, C-terminal; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: Putative glycolate oxidase, GlcD subunit; IMG reference gene:2504784838; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain. (413 aa)
AEE15041.1Acetyl coenzyme A synthetase (ADP forming), alpha domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR014089:IPR003781; KEGG: cag:Cagg_3834 acetyl coenzyme A synthetase (ADP forming), alpha domain-containing protein; PFAM: CoA-binding; SPTR: Strongly similar to acetyl-CoA synthetase (ADP-forming) gene; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; IMG reference gene:2504784837; PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain. (702 aa)
AEE15036.1Protein of unknown function DUF814; COGs: COG0482 tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain; KEGG: dtu:Dtur_1496 protein of unknown function DUF814; SPTR: Putative uncharacterized protein; IMG reference gene:2504784832; PFAM: Thiamine biosynthesis protein (ThiI). (324 aa)
hemLCOGs: COG0001 Glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; InterPro IPR004639:IPR005814; KEGG: tmt:Tmath_0437 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; PRIAM: Glutamate-1-semialdehyde 2,1-aminomutase; SPTR: Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; IMG reference gene:2504784829; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (427 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (356 aa)
AEE15008.1COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: vpr:Vpar_0539 ABC transporter related protein; PFAM: ABC transporter-like; ABC transporter, transmembrane region; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2504784804; PFAM: ABC transporter; ABC transporter transmembrane region. (587 aa)
AEE15006.1Phosphonate-transporting ATPase; COGs: COG1126 ABC-type polar amino acid transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: dhd:Dhaf_1042 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2504784802; PFAM: ABC transporter. (244 aa)
AEE14998.1Phosphonate-transporting ATPase; COGs: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems ATPase components; InterPro IPR003593:IPR003439; KEGG: tte:TTE1867 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; IMG reference gene:2504784794; PFAM: ABC transporter. (248 aa)
aspSaspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa)
hisSCOGs: COG0124 Histidyl-tRNA synthetase; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; InterPro IPR015807:IPR002314:IPR004154; KEGG: kol:Kole_0376 histidyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; Anticodon-binding; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; IMG reference gene:2504784788; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase. (419 aa)
AEE14992.1UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: dth:DICTH_0581 ATP-dependent DNA helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase; IMG reference gene:2504784786; PFAM: UvrD/REP helicase. (610 aa)
AEE14989.1COGs: COG0482 tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain; InterPro IPR018318; KEGG: tye:THEYE_A1631 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; PFAM: tRNA methyl transferase-like; SPTR: tRNA-specific 2-thiouridylase mnmA; IMG reference gene:2504784783; PFAM: tRNA methyl transferase; TIGRFAM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. (337 aa)
obgGTPase obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (336 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (199 aa)
AEE14974.1Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (930 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (271 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
AEE14969.1COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: aoe:Clos_0321 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Polyamine-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2504784762; PFAM: ABC transporter. (296 aa)
lonAnti-sigma H sporulation factor, LonB; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (786 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (234 aa)
hisICOGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: dtu:Dtur_1127 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; PRIAM: Phosphoribosyl-AMP cyclohydrolase., Phosphoribosyl-ATP diphosphatase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504784751; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophospho [...] (216 aa)
AEE14952.1FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645:IPR013221:IPR004101; KEGG: sul:SYO3AOP1_1510 FolC bifunctional protein; PFAM: Mur ligase, C-terminal; Mur ligase, central; SPTR: FolC bifunctional protein; TIGRFAM: Folylpolyglutamate synthetase; IMG reference gene:2504784745; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (427 aa)
valSValyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (875 aa)
AEE14938.1Twitching motility protein; COGs: COG2805 Tfp pilus assembly protein pilus retraction ATPase PilT; InterPro IPR006321:IPR001482; KEGG: aae:aq_745 twitching motility protein PilT; PFAM: Type II secretion system protein E; SPTR: Twitching motility protein PilT; TIGRFAM: Pilus retraction protein PilT; IMG reference gene:2504784731; PFAM: Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT. (375 aa)
dnaJChaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (371 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (515 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (197 aa)
AEE14897.1KEGG: ddf:DEFDS_1165 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504784689. (40 aa)
AEE14895.1Fe(3+)-transporting ATPase; COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003593:IPR003439; KEGG: mac:MA0282 sulfate/molybdate ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Sulfate/molybdate ABC transporter, ATP-binding protein; IMG reference gene:2504784687; PFAM: ABC transporter; Belongs to the ABC transporter superfamily. (362 aa)
AEE14891.1COGs: COG1171 Threonine dehydratase; InterPro IPR005789:IPR001926:IPR002912; KEGG: chy:CHY_2459 threonine dehydratase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; Amino acid-binding ACT; SPTR: Threonine dehydratase; TIGRFAM: Threonine dehydratase II; IMG reference gene:2504784683; PFAM: ACT domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine ammonia-lyase, biosynthetic, long form; threonine dehydratase, medium form. (402 aa)
AEE14883.1Xenobiotic-transporting ATPase; COGs: COG4178 ABC-type uncharacterized transport system permease and ATPase components; InterPro IPR003593:IPR010509:IPR003439; KEGG: hya:HY04AAS1_0152 ABC transporter domain protein; PFAM: ABC transporter, N-terminal; ABC transporter-like; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter domain protein; IMG reference gene:2504784674; PFAM: ABC transporter; ABC transporter transmembrane region 2. (584 aa)
eraGTP-binding protein Era-like-protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (287 aa)
codYGTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (276 aa)
AEE14866.1CBS domain containing protein; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR000644:IPR001667:IPR003156:IPR002646; KEGG: tjr:TherJR_1640 polynucleotide adenylyltransferase region; PFAM: Cystathionine beta-synthase, core; Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; Polynucleotide adenylyltransferase region; SMART: Cystathionine beta-synthase, core; SPTR: Polynucleotide adenylyltransferase region; IMG reference gene:2504784656; PFAM: DHH family; DHHA1 domain; CBS domain; Poly A polymerase head domain. (867 aa)
AEE14863.1COGs: COG0180 Tryptophanyl-tRNA synthetase; InterPro IPR002306:IPR002305; KEGG: dtu:Dtur_1469 tryptophanyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class Ib; PRIAM: Tryptophan--tRNA ligase; SPTR: Tryptophanyl-tRNA synthetase; TIGRFAM: Tryptophanyl-tRNA synthetase, class Ib; IMG reference gene:2504784653; PFAM: tRNA synthetases class I (W and Y); TIGRFAM: tryptophanyl-tRNA synthetase. (329 aa)
AEE14861.1Chromosome segregation and condensation protein, ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (167 aa)
AEE14843.1InterPro IPR002847; KEGG: ttm:Tthe_1948 protein of unknown function DUF129; PFAM: F420-0:gamma-glutamyl ligase-related; SPTR: Putative uncharacterized protein; IMG reference gene:2504784632; PFAM: F420-0:Gamma-glutamyl ligase. (207 aa)
AEE14838.1COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015794:IPR008279; KEGG: tjr:TherJR_2325 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; PEP-utilising enzyme, mobile region; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; IMG reference gene:2504784627; PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase. (583 aa)
AEE14836.1ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (257 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (731 aa)
clpXATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (413 aa)
miaAtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (303 aa)
groS-210 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (87 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (288 aa)
AEE14796.1(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (957 aa)
AEE14792.1InterPro IPR006935; KEGG: tal:Thal_1286 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; SPTR: Type III restriction protein res subunit; IMG reference gene:2504784579; PFAM: Type III restriction enzyme, res subunit. (181 aa)
AEE14767.1COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR004099; KEGG: sua:Saut_0554 pyridine nucleotide-disulfide oxidoreductase dimerization region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; PRIAM: Dihydrolipoyl dehydrogenase; SPTR: Pyridine nucleotide-disulfide oxidoreductase dimerization region; IMG reference gene:2504784553; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation [...] (450 aa)
lolDPhosphonate-transporting ATPase; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. (246 aa)
AEE14751.1AAA ATPase central domain protein; COGs: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; InterPro IPR003593:IPR003959; KEGG: chy:CHY_2201 recombination factor protein RarA; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; SPTR: ATPase, AAA family; IMG reference gene:2504784537; PFAM: MgsA AAA+ ATPase C terminal; Holliday junction DNA helicase ruvB N-terminus. (420 aa)
thrSCOGs: COG0441 Threonyl-tRNA synthetase; InterPro IPR002320:IPR012947:IPR002314:IPR004154; KEGG: ddf:DEFDS_1504 threonyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; Threonyl/alanyl tRNA synthetase, SAD; Anticodon-binding; SPTR: Threonyl-tRNA synthetase; TIGRFAM: Threonyl-tRNA synthetase, class IIa; IMG reference gene:2504784533; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II amino [...] (606 aa)
AEE14734.1COGs: COG1132 ABC-type multidrug transport system ATPase and permease components; InterPro IPR003593:IPR001140:IPR003439; KEGG: sfu:Sfum_3555 ABC transporter related; PFAM: ABC transporter-like; ABC transporter, transmembrane region; PRIAM: Xenobiotic-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2504784517; PFAM: ABC transporter transmembrane region; ABC transporter. (564 aa)
AEE14733.1Hypothetical protein; KEGG: cyj:Cyan7822_4851 RimK domain-containing protein ATP-grasp; SPTR: Putative uncharacterized protein; IMG reference gene:2504784516. (315 aa)
AEE14731.1IstB domain protein ATP-binding protein; COGs: COG1484 DNA replication protein; InterPro IPR003593:IPR002611; KEGG: sku:Sulku_2743 IstB domain protein ATP-binding protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core; SPTR: IstB domain protein ATP-binding protein; IMG reference gene:2504784511; PFAM: IstB-like ATP binding protein. (258 aa)
AEE14725.1Helicase domain-containing protein; InterPro IPR014001:IPR001650:IPR006935; KEGG: tal:Thal_0495 helicase domain protein; PFAM: DNA/RNA helicase, C-terminal; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504784502; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain. (1119 aa)
AEE14716.12-oxoglutarate synthase; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: toc:Toce_1203 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; IMG reference gene:2504784493; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (275 aa)
AEE14714.1succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (365 aa)
AEE14709.1COGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR004636:IPR005814; KEGG: mfs:MFS40622_1451 acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine and succinylornithine aminotransferase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; IMG reference gene:2504784486; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases. (396 aa)
AEE14708.1Putative transcriptional regulator, GntR family; COGs: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; InterPro IPR004839; KEGG: aminotransferase; PFAM: Aminotransferase, class I/II; SPTR: Putative transcriptional regulator, GntR family; IMG reference gene:2504784485; PFAM: Aminotransferase class I and II. (389 aa)
AEE14707.1COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR012833:IPR005144; KEGG: hya:HY04AAS1_1401 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone; PRIAM: Ribonucleoside-triphosphate reductase; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic; IMG reference gene:2504784484; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase. (758 aa)
AEE14680.1COGs: COG1122 ABC-type cobalt transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: mta:Moth_1861 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Sulfate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related; IMG reference gene:2504784450; PFAM: ABC transporter. (268 aa)
AEE14673.1Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: cst:CLOST_1222 aminotransferase class I and II; PFAM: Aminotransferase, class I/II; SPTR: Aminotransferase class I and II; IMG reference gene:2504784442; PFAM: Aminotransferase class I and II. (444 aa)
AEE14670.1NADH dehydrogenase (quinone); COGs: COG1894 NADH:ubiquinone oxidoreductase NADH-binding (51 kD) subunit; InterPro IPR011538:IPR019554:IPR019575; KEGG: dth:DICTH_0769 NADH:ubiquinone oxidoreductase, nadh-binding (51 kd) subunit; PFAM: NADH:ubiquinone oxidoreductase, 51kDa subunit; Soluble ligand binding domain; NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding; PRIAM: NADH dehydrogenase (quinone); SPTR: NADH:ubiquinone oxidoreductase, nadh-binding (51 kd) subunit; IMG reference gene:2504784438; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Respiratory- [...] (537 aa)
AEE14661.1Oligopeptide/dipeptide ABC transporter, ATPase subunit; COGs: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system ATPase component; InterPro IPR010066:IPR003593:IPR003439:IPR013563; KEGG: trq:TRQ2_0437 oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter-like; Oligopeptide/dipeptide ABC transporter, C-terminal; PRIAM: Nickel-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Oligopeptide/dipeptide ABC transporter, ATPase subunit; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; IMG reference gene:2504784429; [...] (325 aa)
AEE14660.1Oligopeptide/dipeptide ABC transporter, ATPase subunit; COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR010066:IPR003593:IPR003439:IPR013563; KEGG: tle:Tlet_0198 oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter-like; Oligopeptide/dipeptide ABC transporter, C-terminal; PRIAM: Nickel-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Oligopeptide/dipeptide ABC transporter, ATPase subunit; TIGRFAM: Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; IMG reference gene:250 [...] (319 aa)
AEE14648.1UvrD/REP helicase; COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR000212; KEGG: tye:THEYE_A1137 UvrD/REP helicase domain protein, putative; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase domain protein, putative; IMG reference gene:2504784416; PFAM: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1040 aa)
AEE14647.1KEGG: tye:THEYE_A1135 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504784415. (949 aa)
fhsFormate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; HAMAP: Formate-tetrahydrofolate ligase, FTHFS; InterPro IPR000559; KEGG: aco:Amico_1546 formate--tetrahydrofolate ligase; PFAM: Formate-tetrahydrofolate ligase, FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase 2; IMG reference gene:2504784408; PFAM: Formate--tetrahydrofolate ligase. (548 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (552 aa)
AEE14626.1SMC domain protein; May be involved in recombinational repair of damaged DNA. (561 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (265 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa)
AEE14621.1SMC domain protein; COGs: COG1196 Chromosome segregation ATPase; InterPro IPR003395:IPR010935; KEGG: cdf:CD1250 chromosome partition protein; PFAM: RecF/RecN/SMC protein, N-terminal; SMCs flexible hinge; SPTR: Chromosome segregation protein Smc; manually curated; IMG reference gene:2504784389; PFAM: RecF/RecN/SMC N terminal domain; SMC proteins Flexible Hinge Domain. (1059 aa)
AEE14618.1Signal recognition particle-docking protein FtsY; COGs: COG0552 Signal recognition particle GTPase; InterPro IPR004390:IPR003593:IPR000897; KEGG: dhd:Dhaf_3767 signal recognition particle-docking protein FtsY; PFAM: Signal recognition particle, SRP54 subunit, GTPase; SMART: ATPase, AAA+ type, core; SPTR: Signal recognition particle-docking protein FtsY; TIGRFAM: Cell division transporter substrate-binding protein FtsY; IMG reference gene:2504784386; PFAM: SRP54-type protein, GTPase domain; TIGRFAM: signal recognition particle-docking protein FtsY. (291 aa)
AEE14617.1GTP-binding signal recognition particle SRP54 G- domain protein; COGs: COG0541 Signal recognition particle GTPase; InterPro IPR003593:IPR013822:IPR000897:IPR004125; KEGG: chy:CHY_1434 signal recognition particle protein; PFAM: Signal recognition particle, SRP54 subunit, GTPase; Signal recognition particle, SRP54 subunit, helical bundle; Signal recognition particle, SRP54 subunit, M-domain; SMART: ATPase, AAA+ type, core; SPTR: Signal recognition particle protein; IMG reference gene:2504784385; PFAM: SRP54-type protein, GTPase domain; SRP54-type protein, helical bundle domain; Signal pe [...] (437 aa)
AEE14609.1Mg chelatase, subunit ChlI; COGs: COG0606 ATPase with chaperone activity; InterPro IPR004482:IPR003593:IPR000523; KEGG: Mg chelatase subunit ChlI; PFAM: Magnesium chelatase, ChlI subunit; SMART: ATPase, AAA+ type, core; SPTR: Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein; IMG reference gene:2504784377; PFAM: Magnesium chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein. (508 aa)
trmFOMethylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (446 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (324 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (533 aa)
hflXGTP-binding proten HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (418 aa)
AEE14565.1COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: toc:Toce_1019 LL-diaminopimelate aminotransferase apoenzyme; PFAM: Aminotransferase, class I/II; PRIAM: LL-diaminopimelate aminotransferase; SPTR: LL-diaminopimelate aminotransferase apoenzyme; IMG reference gene:2504784333; PFAM: Aminotransferase class I and II. (405 aa)
AEE14557.1Flavoprotein WrbA; COGs: COG0655 Multimeric flavodoxin WrbA; InterPro IPR010089:IPR008254; KEGG: dak:DaAHT2_0413 flavoprotein WrbA; PFAM: Flavodoxin/nitric oxide synthase; SPTR: Flavoprotein wrbA; TIGRFAM: Flavoprotein WrbA; IMG reference gene:2504784323; PFAM: NADPH-dependent FMN reductase; TIGRFAM: NAD(P)H:quinone oxidoreductase, type IV; Belongs to the WrbA family. (219 aa)
AEE14534.1COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: aae:aq_1731 hypothetical protein; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; IMG reference gene:2504784298; PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase. (190 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (435 aa)
AEE14532.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (441 aa)
AEE14522.1COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766:IPR011896; KEGG: tye:THEYE_A0983 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoacid:ferredoxin oxidoreductase subunit beta; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; IMG reference gene:2504784286; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal [...] (280 aa)
ruvBHolliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (319 aa)
ruvAHolliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (194 aa)
tyrSTyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (393 aa)
leuSCOGs: COG0495 Leucyl-tRNA synthetase; InterPro IPR015413:IPR013155:IPR002302; KEGG: csc:Csac_1819 leucyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class I (M); Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding; PRIAM: Valine--tRNA ligase; SPTR: Leucyl-tRNA synthetase; TIGRFAM: Leucyl-tRNA synthetase, class Ia, bacterial/mitochondrial; IMG reference gene:2504784273; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family. (826 aa)
AEE14487.1D-lactate dehydrogenase (cytochrome); COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113; KEGG: dhd:Dhaf_4518 FAD linked oxidase domain protein; PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: Putative uncharacterized protein; IMG reference gene:2504784250; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD. (467 aa)
kdpBPotassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (685 aa)
kdpCPotassium-transporting ATPase C chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (193 aa)
AEE14457.1KEGG: thx:Thet_1100 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504784218. (499 aa)
AEE14455.1IstB domain protein ATP-binding protein; COGs: COG1484 DNA replication protein; InterPro IPR002611:IPR003593; KEGG: ddf:DEFDS_0282 transposase IS21 family; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core; SPTR: Transposase, IS21 family; IMG reference gene:2504784216; PFAM: IstB-like ATP binding protein; Belongs to the DnaA family. (257 aa)
AEE14451.1CRISPR-associated HD domain protein; COGs: COG1203 helicase; InterPro IPR001650:IPR014001:IPR006483:IPR006474; KEGG: tit:Thit_2284 CRISPR-associated helicase Cas3; PFAM: DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: CRISPR-associated HD domain; Helicase Cas3, CRISPR-associated, core; IMG reference gene:2504784211; PFAM: Helicase conserved C-terminal domain; HD domain; Type III restriction enzyme, res subunit; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD. (783 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (918 aa)
AEE14433.1Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (222 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (684 aa)
AEE14430.1COGs: COG0050 GTPase - translation elongation factors; InterProIPR000795:IPR004161:IPR004160:IPR004541:IPR 005225; KEGG: dth:DICTH_0835 elongation factor Tu; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFTu/EF1A, C-terminal; SPTR: Elongation factor Tu 1; TIGRFAM: Translation elongation factor EFTu/EF1A, bacterial/organelle; Small GTP-binding protein; IMG reference gene:2504784189; PFAM: Elongation factor Tu C-terminal domain; Elongation factor Tu domain 2; Elongation factor Tu GTP binding domain; TIGRFAM: [...] (405 aa)
nnrEYjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (478 aa)
AEE14421.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (392 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (215 aa)
AEE14417.1ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR004176:IPR003959:IPR013093:IPR019489:IPR 003593; KEGG: ATP-dependent Clp protease ATP-binding subunit; PFAM: ATPase associated with various cellular activities, AAA-2; ATPase, AAA-type, core; Clp, N-terminal; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: ATPase AAA-2 domain protein; IMG reference gene:2504784172; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular [...] (800 aa)
AEE14415.1Heat shock protein DnaJ domain protein; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623:IPR002939; KEGG: dra:DR_0126 DnaJ protein; PFAM: Heat shock protein DnaJ, N-terminal; Chaperone DnaJ, C-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Septum site-determining protein MinC; IMG reference gene:2504784170; PFAM: DnaJ domain; DnaJ C terminal region. (301 aa)
dnaKChaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (635 aa)
AEE14406.1Protein of unknown function DUF214; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (298 aa)
ftsEPhosphonate-transporting ATPase; Part of the ABC transporter FtsEX involved in cellular division. (231 aa)
cmkCOGs: COG0283 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR000623:IPR011994:IPR003136; KEGG: taf:THA_1828 cytidylate kinase; PFAM: Cytidylate kinase region; Shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase; IMG reference gene:2504784156; PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. (224 aa)
secAProtein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (838 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (214 aa)
AEE14388.1Single-stranded nucleic acid binding R3H domain-containing protein; COGs: COG3854 conserved hypothetical protein; InterPro IPR011703:IPR001374:IPR003593; KEGG: dth:DICTH_0629 single-stranded nucleic acid binding R3H; PFAM: Single-stranded nucleic acid binding R3H; ATPase associated with various cellular activities, AAA-3; SMART: ATPase, AAA+ type, core; Single-stranded nucleic acid binding R3H; SPTR: Single-stranded nucleic acid binding R3H; IMG reference gene:2504784140; PFAM: ATPase family associated with various cellular activities (AAA); R3H domain. (520 aa)
lysSCOGs: COG1190 Lysyl-tRNA synthetase (class II); HAMAP: Lysyl-tRNA synthetase; InterPro IPR004365:IPR004364:IPR002313; KEGG: cow:Calow_0536 lysyl-tRNA synthetase; PFAM: Aminoacyl-tRNA synthetase, class II (D/K/N); Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: Lysine--tRNA ligase; SPTR: Lysyl-tRNA synthetase; TIGRFAM: Lysyl-tRNA synthetase, class II; IMG reference gene:2504784139; PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA syn [...] (500 aa)
mutS2Smr protein/MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (774 aa)
AEE14383.1CoA-disulfide reductase; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterPro IPR013027:IPR004099:IPR001763; KEGG: afu:AF0400 NADH oxidase (NoxA-3); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; Rhodanese-like; PRIAM: CoA-disulfide reductase; SMART: Rhodanese-like; SPTR: NADH oxidase (NoxA-3); IMG reference gene:2504784135; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Rhodanese-like domain. (565 aa)
AEE14376.1PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR011611; KEGG: PfkB domain protein; PFAM: Carbohydrate/purine kinase; SPTR: PfkB domain protein; IMG reference gene:2504784128; PFAM: pfkB family carbohydrate kinase; Belongs to the carbohydrate kinase PfkB family. (318 aa)
cysSCOGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803:IPR015273:IPR002308; KEGG: cni:Calni_0407 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase, class Ia, N-terminal; Cysteinyl-tRNA synthetase, class Ia, DALR; PRIAM: Cysteine--tRNA ligase; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: Cysteinyl-tRNA synthetase, class Ia; IMG reference gene:2504784122; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (489 aa)
ftsHATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (627 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (438 aa)
carBCOGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005481:IPR005479:IPR005480:IPR011607:IPR 006275; KEGG: apo:Arcpr_0660 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like; PRIAM: Carbamoyl-phosphate synthase (ammonia); SPTR: Carbamoyl-phosphate synthase, large subunit; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; IMG reference gene:2 [...] (1076 aa)
carACOGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR002474:IPR000991:IPR006274; KEGG: pca:Pcar_1613 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase small chain; TIGRFAM: Carbamoyl phosphate synthase, small subunit; IMG reference gene:2504784113; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphat [...] (372 aa)
argSCOGs: COG0018 Arginyl-tRNA synthetase; HAMAP: Arginyl-tRNA synthetase, class Ic; InterPro IPR005148:IPR015945:IPR008909:IPR001278; KEGG: dtu:Dtur_1486 arginyl-tRNA synthetase; PFAM: Arginyl-tRNA synthetase, class Ic, core; Arginyl tRNA synthetase, class Ic, N-terminal; DALR anticodon binding; PRIAM: Arginine--tRNA ligase; SPTR: Arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; IMG reference gene:2504784109; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase. (541 aa)
AEE14353.1Penicillin-binding protein, 1A family; COGs: COG0744 Membrane carboxypeptidase (penicillin-binding protein); InterPro IPR001264:IPR001460:IPR011816; KEGG: dtu:Dtur_1128 penicillin-binding protein, 1A family; PFAM: Glycosyl transferase, family 51; Penicillin-binding protein, transpeptidase; SPTR: Penicillin-binding protein, 1A family; TIGRFAM: Penicillin-binding protein 1A; IMG reference gene:2504784104; PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase; TIGRFAM: penicillin-binding protein 1B; penicillin-binding protein 1C; penicillin-binding protein, 1A family. (700 aa)
proSProlyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (572 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (376 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (211 aa)
AEE14333.1Histidine--tRNA ligase; COGs: COG0124 Histidyl-tRNA synthetase; InterPro IPR002314; KEGG: dsy:DSY3916 hypothetical protein; PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; PRIAM: Histidine--tRNA ligase; SPTR: Histidine--tRNA ligase; IMG reference gene:2504784079; PFAM: tRNA synthetase class II core domain (G, H, P, S and T). (406 aa)
pheTCOGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; HAMAP: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; InterProIPR002547:IPR005146:IPR005147:IPR005121:IPR 004532; KEGG: dtu:Dtur_1309 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/B4 tRNA-binding domain; tRNA-binding region; tRNA synthetase, B5; Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding; SPTR: Phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, beta subunit, bacterial; IMG reference gene:2504784074; PFAM: tRNA synthetase B5 dom [...] (807 aa)
pheSCOGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; HAMAP: Phenylalanyl-tRNA synthetase alpha chain; InterPro IPR004188:IPR002319:IPR004529; KEGG: toc:Toce_1397 phenylalanyl-tRNA synthetase, alpha subunit; PFAM: Phenylalanyl-tRNA synthetase alpha chain; Phenylalanyl-tRNA synthetase, class II, N-terminal; SPTR: Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: Phenylalanyl-tRNA synthetase, class IIc, alpha subunit; IMG reference gene:2504784073; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synth [...] (340 aa)
AEE14324.1Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR006555; KEGG: nth:Nther_1106 helicase C2; SMART: Helicase, ATP-dependent, c2 type; SPTR: Helicase c2; IMG reference gene:2504784070. (659 aa)
AEE14320.1Septum site-determining protein MinD; COGs: COG2894 Septum formation inhibitor-activating ATPase; InterPro IPR002586:IPR010223; KEGG: ctc:CTC02069 septum site-determining protein MinD; PFAM: Cobyrinic acid a,c-diamide synthase; SPTR: Septum site-determining protein MinD; TIGRFAM: Septum site-determining protein MinD; IMG reference gene:2504784066; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; TIGRFAM: septum site-determining protein MinD. (269 aa)
AEE14318.1Penicillin-binding protein 2; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR005311:IPR001460:IPR017790; KEGG: dtu:Dtur_1401 penicillin-binding protein 2; PFAM: Penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Penicillin-binding protein 2; TIGRFAM: Penicillin-binding protein 2; IMG reference gene:2504784064; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain; TIGRFAM: penicillin-binding protein 2. (567 aa)
AEE14315.1Cell shape determining protein, MreB/Mrl family; COGs: COG1077 Actin-like ATPase involved in cell morphogenesis; InterPro IPR004753; KEGG: rod shape-determining protein MreB; PFAM: Cell shape determining protein MreB/Mrl; SPTR: Rod shape-determining protein MreB; TIGRFAM: Cell shape determining protein MreB/Mrl; IMG reference gene:2504784061; PFAM: MreB/Mbl protein; TIGRFAM: cell shape determining protein, MreB/Mrl family. (337 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (361 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (308 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (295 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (478 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (464 aa)
AEE14296.1UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. (477 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (487 aa)
AEE14294.1Peptidoglycan glycosyltransferase; COGs: COG0768 Cell division protein FtsI/penicillin-binding protein 2; InterPro IPR005311:IPR001460; KEGG: lip:LI1098 cell division protein FtsI/penicillin-binding protein 2; PFAM: Penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; PRIAM: Peptidoglycan glycosyltransferase; SPTR: Peptidoglycan glycosyltransferase; IMG reference gene:2504784040; PFAM: Penicillin binding protein transpeptidase domain; Penicillin-binding Protein dimerisation domain. (539 aa)
cbiACobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa)
gatBAspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (483 aa)
gatAGlutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (481 aa)
gatCAspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (99 aa)
purDCOGs: COG0151 Phosphoribosylamine-glycine ligase; HAMAP: Phosphoribosylglycinamide synthetase; InterPro IPR020562:IPR020561:IPR020560:IPR000115; KEGG: aae:aq_742 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; PRIAM: Phosphoribosylamine--glycine ligase; SPTR: Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; IMG reference gene:2504784004; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribos [...] (410 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728:IPR010918:IPR004733; KEGG: ckn:Calkro_1263 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; IMG reference gene:2504784001; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal do [...] (338 aa)
hisCCOGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR005861:IPR004839; KEGG: pth:PTH_2537 histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; PFAM: Aminotransferase, class I/II; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: Histidinol-phosphate aminotransferase; IMG reference gene:2504783995; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-ph [...] (349 aa)
AEE14249.1Riboflavin biosynthesis protein RibF; COGs: COG0196 FAD synthase; InterPro IPR004821:IPR002606:IPR015864:IPR015865; KEGG: mtt:Ftrac_0781 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; PRIAM: FAD synthetase., Riboflavin kinase; SPTR: Riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase; Cytidyltransferase-related; IMG reference gene:2504783992; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (307 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (688 aa)
atpCATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (473 aa)
atpGATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (504 aa)
AEE14203.1Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012846:IPR012001:IPR012000:IPR011766; KEGG: hor:Hore_10830 acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; IMG reference gene:25047839 [...] (562 aa)
AEE14187.1Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (665 aa)
AEE14183.1NADPH dehydrogenase; COGs: COG1902 NADH:flavin oxidoreductase Old Yellow Enzyme family; InterPro IPR001155; KEGG: mma:MM_2395 NADH:flavin oxidoreductase; PFAM: NADH:flavin oxidoreductase/NADH oxidase, N-terminal; PRIAM: NADPH dehydrogenase; SPTR: NADH:flavin oxidoreductase/NADH oxidase; IMG reference gene:2504783922; PFAM: NADH:flavin oxidoreductase / NADH oxidase family. (349 aa)
AEE14180.1COGs: COG2187 conserved hypothetical protein; KEGG: tye:THEYE_A1962 Uma3; SPTR: Uma3; IMG reference gene:2504783919; PFAM: Zeta toxin. (517 aa)
AEE14177.1Phosphoglycerate mutase; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: phosphoglycerate mutase; PFAM: Phosphoglycerate mutase; SPTR: Phosphoglycerate mutase; IMG reference gene:2504783916; PFAM: Phosphoglycerate mutase family. (209 aa)
tufTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (405 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (692 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa)
AEE14135.1COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: tye:THEYE_A0910 pyruvate synthase subunit PorB; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate synthase; SPTR: Pyruvate synthase subunit PorB; IMG reference gene:2504783874; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (327 aa)
argGCOGs: COG0137 Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; InterPro IPR001518; KEGG: toc:Toce_0156 argininosuccinate synthase; PFAM: Argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; IMG reference gene:2504783864; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (511 aa)
AEE14086.14-vinyl reductase 4VR; InterPro IPR004096; KEGG: dds:Ddes_0419 4-vinyl reductase 4VR; PFAM: 4-vinyl reductase, 4VR; SPTR: 4-vinyl reductase 4VR; IMG reference gene:2504783823. (179 aa)
AEE14078.1Heavy metal translocating P-type ATPase; COGs: COG2217 Cation transport ATPase; InterProIPR006403:IPR006416:IPR001757:IPR006121:IPR 008250:IPR005834; KEGG: hor:Hore_04850 heavy metal translocating P-type ATPase; PFAM: ATPase, P-type, ATPase-associated region; Heavy metal transport/detoxification protein; Haloacid dehalogenase-like hydrolase; PRIAM: Copper-exporting ATPase; SPTR: Heavy metal translocating P-type ATPase; TIGRFAM: ATPase, P-type, heavy metal translocating; ATPase, P type, cation/copper-transporter; ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter; IMG reference gene:2 [...] (736 aa)
pgkCOGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: chy:CHY_0281 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; IMG reference gene:2504783806; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa)
AEE14066.1Phosphoribulokinase; COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: adg:Adeg_1862 phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; PRIAM: Phosphoribulokinase; SPTR: Phosphoribulokinase/uridine kinase; IMG reference gene:2504783802; PFAM: Phosphoribulokinase / Uridine kinase family. (298 aa)
AEE14051.1IstB domain protein ATP-binding protein; COGs: COG1484 DNA replication protein; InterPro IPR003593:IPR002611; KEGG: sku:Sulku_2743 IstB domain protein ATP-binding protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core; SPTR: IstB domain protein ATP-binding protein; IMG reference gene:2504783786; PFAM: IstB-like ATP binding protein. (258 aa)
AEE14047.1Hypothetical protein; COGs: COG1106 ATPase; KEGG: mar:MAE_11800 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504783781. (374 aa)
AEE14037.1Teichoic-acid-transporting ATPase; COGs: COG1134 ABC-type polysaccharide/polyol phosphate transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: toc:Toce_0489 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Teichoic-acid-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2504783771; PFAM: ABC transporter. (245 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
AEE13999.1SUA5/yciO/yrdC domain protein; COGs: COG0009 Putative translation factor (SUA5); InterPro IPR006070; KEGG: tad:TRIADDRAFT_35031 hypothetical protein; PFAM: Sua5/YciO/YrdC, N-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504783730; PFAM: yrdC domain; TIGRFAM: Sua5/YciO/YrdC/YwlC family protein. (203 aa)
AEE13991.12-oxoglutarate synthase; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: tit:Thit_1912 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding; IMG reference gene:2504783722; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (249 aa)
AEE13988.1KEGG: kol:Kole_2162 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504783719. (221 aa)
AEE13987.1CoA-binding domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR003781; KEGG: mja:MJ_0590 hypothetical protein; PFAM: CoA-binding; SPTR: Uncharacterized protein MJ0590; IMG reference gene:2504783718; PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain. (711 aa)
AEE13980.1ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR003593:IPR004176:IPR003959:IPR001943:IPR 013093:IPR019489; KEGG: cya:CYA_0656 Clp protease, ATP-binding subunit ClpC; PFAM: ATPase associated with various cellular activities, AAA-2; Clp, N-terminal; ATPase, AAA-type, core; UvrB/UvrC protein; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: Clp protease, ATP-binding subunit ClpC; IMG reference gene:2504783711; PFAM: AAA domain (Cdc48 subfamily); Clp amino terminal domain; C-terminal, D2-small domain, of ClpB protein; A [...] (812 aa)
AEE13979.1DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (456 aa)
AEE13978.1DNA integrity scanning, DisA, linker region; COGs: COG1623 nucleic-acid-binding protein (contains the HHH domain); InterPro IPR003390:IPR018906; KEGG: tjr:TherJR_0249 DNA integrity scanning, DisA, linker region; PFAM: DNA integrity scanning, DisA, linker region; DNA integrity scanning protein, DisA, N-terminal; SPTR: DNA integrity scanning, DisA, linker region; IMG reference gene:2504783709; PFAM: DisA bacterial checkpoint controller nucleotide-binding; DisA bacterial checkpoint controller linker region; Belongs to the DisA family. (362 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (721 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (468 aa)
AEE13952.1Twitching motility protein; COGs: COG2805 Tfp pilus assembly protein pilus retraction ATPase PilT; InterPro IPR006321:IPR001482:IPR003593; KEGG: dth:DICTH_0722 type IV pilus retraction protein PilT; PFAM: Type II secretion system protein E; SMART: ATPase, AAA+ type, core; SPTR: Type IV pilus retraction protein PilT; TIGRFAM: Pilus retraction protein PilT; IMG reference gene:2504783676; PFAM: Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT. (352 aa)
AEE13951.1COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR007831:IPR001482:IPR003593; KEGG: ddf:DEFDS_1109 type IV pilus assembly protein PilB; PFAM: Type II secretion system protein E; General secretory system II, protein E, N-terminal; SMART: ATPase, AAA+ type, core; SPTR: Type IV pilus assembly protein PilB; IMG reference gene:2504783675; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain. (574 aa)
pyrKOxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (241 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa)
AEE13938.1ABC transporter related protein; COGs: COG0396 ABC-type transport system involved in Fe-S cluster assembly ATPase component; InterPro IPR003439:IPR003593; KEGG: tye:THEYE_A0164 ABC transporter, ATP-binding protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter, ATP-binding protein; IMG reference gene:2504783660; PFAM: ABC transporter; TIGRFAM: FeS assembly ATPase SufC. (246 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1111 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (560 aa)
AEE13913.1Protein of unknown function DUF933; COGs: COG0012 GTPase probable translation factor; InterPro IPR013029; KEGG: sti:Sthe_0322 GTP-binding protein YchF; PFAM: Protein of unknown function DUF933; SPTR: GTP-binding protein YchF; IMG reference gene:2504783634; PFAM: Protein of unknown function (DUF933); TIGRFAM: GTP-binding protein YchF. (347 aa)
ligDNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (624 aa)
AEE13908.1Small GTP-binding protein; COGs: COG0480 Translation elongation factors (GTPase); InterPro IPR005225:IPR000795:IPR005517:IPR000640; KEGG: nth:Nther_0010 translation elongation factor 2 (EF-2/EF-G); PFAM: Translation elongation factor EFG/EF2, domain IV; Protein synthesis factor, GTP-binding; Translation elongation factor EFG/EF2, C-terminal; SPTR: Elongation factor G 2; TIGRFAM: Small GTP-binding protein; IMG reference gene:2504783629; PFAM: Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation factor G, domain IV; TIGRFAM: translation elongation factor EF [...] (689 aa)
coaXPutative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (275 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (493 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (314 aa)
AEE13888.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (352 aa)
AEE13887.1GTP-binding protein TypA; COGs: COG1217 membrane GTPase involved in stress response; InterProIPR005225:IPR006298:IPR000795:IPR004161:IPR 000640; KEGG: vpr:Vpar_1324 GTP-binding protein TypA; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFG/EF2, C-terminal; SPTR: GTP-binding protein TypA; TIGRFAM: GTP-binding protein TypA; Small GTP-binding protein; IMG reference gene:2504783607; PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; TIGRFAM: GTP-bindin [...] (597 aa)
AEE13882.1COGs: COG3276 Selenocysteine-specific translation elongation factor; InterProIPR005225:IPR004535:IPR000795:IPR004161:IPR 015191; KEGG: nth:Nther_1114 selenocysteine-specific translation elongation factor; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor SelB, winged helix, type 3; SPTR: Selenocysteine-specific translation elongation factor; TIGRFAM: Translation elongation factor, selenocysteine-specific; Small GTP-binding protein; IMG reference gene:2504783602; PFAM: Elongation factor Tu domain 2; Elongation f [...] (626 aa)
AEE13878.1COGs: COG0527 Aspartokinase; InterPro IPR005260:IPR001341:IPR001048:IPR002912; KEGG: adg:Adeg_0884 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartate kinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; IMG reference gene:2504783596; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (410 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (285 aa)
AEE13874.1Phosphonate-transporting ATPase; COGs: COG1127 ABC-type transport system involved in resistance to organic solvents ATPase component; InterPro IPR003439:IPR003593; KEGG: saf:SULAZ_1668 methionine import ATP-binding protein MetN; PFAM: ABC transporter-like; PRIAM: Phosphonate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Methionine import ATP-binding protein MetN; IMG reference gene:2504783592; PFAM: ABC transporter. (250 aa)
metGMethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (508 aa)
AEE13865.1KEGG: cwo:Cwoe_0009 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504783583. (134 aa)
lepAGTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (600 aa)
AEE13836.1COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; HAMAP: NAD-dependent deacetylase; InterPro IPR003000; KEGG: aco:Amico_1280 silent information regulator protein Sir2; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; SPTR: Silent information regulator protein Sir2; IMG reference gene:2504783553; PFAM: Sir2 family. (240 aa)
AEE13835.1COGs: COG0226 ABC-type phosphate transport system periplasmic component; InterPro IPR005673:IPR006059; KEGG: pstS; phosphate ABC transporter phosphate-binding protein PstS; PFAM: Bacterial extracellular solute-binding, family 1; SPTR: Phosphate ABC transporter, periplasmic phosphate-binding protein; TIGRFAM: Periplasmic phosphate binding protein; IMG reference gene:2504783552; PFAM: Bacterial extracellular solute-binding protein; TIGRFAM: phosphate ABC transporter, phosphate-binding protein; Belongs to the PstS family. (360 aa)
AEE13827.1Cobyrinic acid ac-diamide synthase; COGs: COG0455 ATPase involved in chromosome partitioning; InterPro IPR002586; KEGG: slp:Slip_0975 cobyrinic acid ac-diamide synthase; PFAM: Cobyrinic acid a,c-diamide synthase; SPTR: Cobyrinic acid ac-diamide synthase; IMG reference gene:2504783544; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain. (328 aa)
AEE13826.1GTP-binding signal recognition particle SRP54 G- domain protein; COGs: COG1419 Flagellar GTP-binding protein; InterPro IPR000897:IPR003593; KEGG: ddf:DEFDS_0415 flagellar biosynthesis protein FlhF; PFAM: Signal recognition particle, SRP54 subunit, GTPase; SMART: ATPase, AAA+ type, core; SPTR: Flagellar biosynthesis protein FlhF; IMG reference gene:2504783543; PFAM: SRP54-type protein, GTPase domain. (352 aa)
AEE13825.1ATPase, FliI/YscN family; COGs: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; InterPro IPR005714:IPR004100:IPR000194:IPR003593; KEGG: cth:Cthe_0468 flagellar protein export ATPase FliI; PFAM: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain; ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal; PRIAM: H(+)-transporting two-sector ATPase; SMART: ATPase, AAA+ type, core; SPTR: Type III secretion system ATPase, FliI/YscN; TIGRFAM: ATPase, type III secretion system, FliI/YscN; IMG reference gene:2504783542; PFAM: ATP synthase alpha/beta family [...] (435 aa)
AEE13814.1Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (182 aa)
AEE13812.1KEGG: aav:Aave_4332 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504783528; PFAM: Protein of unknown function, DUF482. (349 aa)
AEE13811.1Cell division protein FtsK/SpoIIIE; COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR002543:IPR018541; KEGG: tte:TTE1378 DNA segregation ATPase FtsK/SpoIIIE and related proteins; PFAM: Cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SPTR: DNA translocase ftsK; IMG reference gene:2504783527; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family; Belongs to the FtsK/SpoIIIE/SftA family. (678 aa)
AEE13809.1Acetylornithine transaminase; COGs: COG0160 4-aminobutyrate aminotransferase and related aminotransferase; InterPro IPR005814; KEGG: sul:SYO3AOP1_0347 aminotransferase class-III; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Aminotransferase class-III; IMG reference gene:2504783525; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
recAProtein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (343 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa)
AEE13786.1ABC transporter related protein; COGs: COG0410 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: gct:GC56T3_0529 ABC transporter related protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: Branched-chain amino acid ABC transporter (ATP-binding protein); IMG reference gene:2504783502; PFAM: ABC transporter. (235 aa)
AEE13785.1Monosaccharide-transporting ATPase; COGs: COG0411 ABC-type branched-chain amino acid transport systems ATPase component; InterPro IPR003439:IPR003593; KEGG: tth:TTC0969 branched-chain amino acid transport ATP-binding protein LivG; PFAM: ABC transporter-like; PRIAM: Monosaccharide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Branched-chain amino acid transport ATP-binding protein livG; IMG reference gene:2504783501; PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter. (260 aa)
AEE13775.1Ribosome-associated GTPase EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (425 aa)
purCCOGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; InterPro IPR001636; KEGG: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: SAICAR synthetase; IMG reference gene:2504783488; PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (231 aa)
AEE13769.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
AEE13756.1COGs: COG2025 Electron transfer flavoprotein alpha subunit; InterPro IPR014730:IPR014731; KEGG: chy:CHY_2477 electron transfer flavoprotein subunit alpha; PFAM: Electron transfer flavoprotein, alpha subunit, C-terminal; Electron transfer flavoprotein, alpha/beta-subunit, N-terminal; SPTR: Electron transfer flavoprotein, alpha subunit; IMG reference gene:2504783468; PFAM: Electron transfer flavoprotein domain; Electron transfer flavoprotein FAD-binding domain. (343 aa)
AEE13749.1COGs: COG0426 flavoprotein; KEGG: mem:Memar_1933 beta-lactamase domain-containing protein; SPTR: Beta-lactamase domain protein; IMG reference gene:2504783461; PFAM: Metallo-beta-lactamase superfamily. (390 aa)
AEE13737.1Type I secretion system ATPase; COGs: COG2274 ABC-type bacteriocin/lantibiotic exporter contain an N-terminal double-glycine peptidase domain; InterProIPR010132:IPR005074:IPR001140:IPR003439:IPR 003593; KEGG: sdl:Sdel_0984 type I secretion system ATPase; PFAM: ABC transporter-like; ABC transporter, transmembrane region; Peptidase C39, bacteriocin processing; PRIAM: Peptide-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: Type I secretion system ATPase; TIGRFAM: ATPase, type I secretion system, HlyB; IMG reference gene:2504783449; PFAM: ABC transporter transmembrane region; AB [...] (701 aa)
AEE13733.1IstB domain protein ATP-binding protein; COGs: COG1484 DNA replication protein; InterPro IPR002611:IPR003593; KEGG: sku:Sulku_2743 IstB domain protein ATP-binding protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core; SPTR: IstB domain protein ATP-binding protein; IMG reference gene:2504783444; PFAM: IstB-like ATP binding protein. (258 aa)
AEE13731.1IstB domain protein ATP-binding protein; COGs: COG1484 DNA replication protein; InterPro IPR002611:IPR003593; KEGG: ddf:DEFDS_0282 transposase IS21 family; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core; SPTR: Transposase, IS21 family; IMG reference gene:2504783442; PFAM: IstB-like ATP binding protein; Belongs to the DnaA family. (257 aa)
AEE13723.1Peptidase S16 lon domain protein; COGs: COG1067 ATP-dependent protease; InterPro IPR008269; KEGG: tye:THEYE_A1753 ATP-dependent protease La; PFAM: Peptidase S16, lon C-terminal; SPTR: ATP-dependent protease La; IMG reference gene:2504783434; PFAM: Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: lon-related putative ATP-dependent protease. (793 aa)
AEE13702.1D-lactate dehydrogenase (cytochrome); COGs: COG0277 FAD/FMN-containing dehydrogenase; InterPro IPR006094:IPR004113; KEGG: dps:DP0059 glycolate oxidase subunit (GlcD); PFAM: FAD-linked oxidase, C-terminal; FAD linked oxidase, N-terminal; PRIAM: D-lactate dehydrogenase (cytochrome); SPTR: Glycolate oxidase subunit glcD; IMG reference gene:2504783413; PFAM: FAD binding domain; FAD linked oxidases, C-terminal domain; TIGRFAM: glycolate oxidase, subunit GlcD. (764 aa)
groL60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa)
groS10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
AEE13689.1MOSC domain containing protein; COGs: COG2258 conserved hypothetical protein; InterPro IPR005302; KEGG: tye:THEYE_A1201 MOSC domain protein; PFAM: Molybdenum cofactor sulfurase, C-terminal; SPTR: Mosc domain protein; IMG reference gene:2504783400; PFAM: MOSC domain. (143 aa)
AEE13661.1Type IV pilus assembly PilZ; COGs: COG5581 glycosyltransferase; InterPro IPR009875; KEGG: ate:Athe_2150 type IV pilus assembly PilZ; PFAM: Type IV pilus assembly PilZ; SPTR: Type IV pilus assembly PilZ; IMG reference gene:2504783371; PFAM: PilZ domain. (246 aa)
AEE13659.1COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterPro IPR005743:IPR002205:IPR006691; KEGG: DNA gyrase subunit A; PFAM: DNA topoisomerase, type IIA, subunit A or C-terminal; DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase, type IIA, subunit A or C-terminal; SPTR: DNA gyrase, A subunit; TIGRFAM: DNA gyrase, subunit A; IMG reference gene:2504783369; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal domain, beta-propeller; TIGRFAM: DNA gyrase, A [...] (804 aa)
AEE13658.1COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterProIPR003594:IPR013506:IPR006171:IPR002288:IPR 001241; KEGG: tit:Thit_0010 DNA gyrase, B subunit; PFAM: DNA topoisomerase, type IIA, subunit B, region 2; ATP-binding region, ATPase-like; Toprim domain; DNA topoisomerase, type IIA, subunit B, C-terminal; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase, type IIA, subunit B or N-terminal; ATP-binding region, ATPase-like; SPTR: DNA gyrase, B subunit; IMG reference gene:2504783368; PFAM: Toprim domain; Histidine kinase-, DNA gyras [...] (632 aa)
recFDNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (323 aa)
dnaAChromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (442 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa)
AEE15267.1COGs: COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; InterPro IPR004435; KEGG: sfu:Sfum_3074 molybdopterin-guanine dinucleotide biosynthesis MobB region; PFAM: Molybdopterin-guanine dinucleotide biosynthesis MobB region; SPTR: Molybdopterin-guanine dinucleotide biosynthesis protein B; TIGRFAM: Molybdopterin-guanine dinucleotide biosynthesis MobB region; IMG reference gene:2504785073; PFAM: Molybdopterin guanine dinucleotide synthesis protein B; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein MobB. (212 aa)
AEE15263.1Sigma54 specific transcriptional regulator with PAS/PAC sensor, Fis family; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR000014:IPR013656:IPR002078:IPR002197; KEGG: pca:Pcar_1580 transcriptional regulator; PFAM: RNA polymerase sigma factor 54, interaction; PAS fold-4; Helix-turn-helix, Fis-type; SMART: PAS; SPTR: Transcriptional regulator; TIGRFAM: PAS; IMG reference gene:2504785069; PFAM: Bacterial regulatory protein, Fis family; PAS fold; TIGRFAM: PAS domain S-box. (417 aa)
serSSeryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
AEE15253.1LamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (253 aa)
AEE15252.1Conserved hypothetical protein CHP00370; COGs: COG2049 Allophanate hydrolase subunit 1; InterPro IPR010016:IPR003833; KEGG: tba:TERMP_01041 allophanate hydrolase 2 subunit 1; PFAM: Allophanate hydrolase subunit 1; SMART: Allophanate hydrolase subunit 1; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP00370; IMG reference gene:2504785058; PFAM: Allophanate hydrolase subunit 1; TIGRFAM: TIGR00370 family protein. (221 aa)
AEE15251.1COGs: COG1984 Allophanate hydrolase subunit 2; InterPro IPR003778; KEGG: aar:Acear_0492 UreA amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; PRIAM: Allophanate hydrolase; SMART: Allophanate hydrolase subunit 2; SPTR: Urea amidolyase related protein; IMG reference gene:2504785057; PFAM: Allophanate hydrolase subunit 2; TIGRFAM: biotin-dependent carboxylase uncharacterized domain. (352 aa)
AEE15249.1Sulfate-transporting ATPase; COGs: COG1137 ABC-type (unclassified) transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: cpi:Cpin_0868 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Sulfate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2504785055; PFAM: ABC transporter. (236 aa)
AEE15242.1(S)-2-hydroxy-acid oxidase; COGs: COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenase; InterPro IPR000262; KEGG: drm:Dred_1257 FMN-dependent alpha-hydroxy acid dehydrogenase; PFAM: FMN-dependent dehydrogenase; PRIAM: (S)-2-hydroxy-acid oxidase; SPTR: FMN-dependent alpha-hydroxy acid dehydrogenase; IMG reference gene:2504785048; PFAM: FMN-dependent dehydrogenase. (339 aa)
pgk-2COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: tnp:Tnap_0485 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; IMG reference gene:2504785044; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (396 aa)
AEE15234.1UPF0042 nucleotide-binding protein yhbJ; Displays ATPase and GTPase activities. (292 aa)
AEE15218.1ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (397 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
AEE15211.1COGs: COG2046 ATP sulfurylase (sulfate adenylyltransferase); InterPro IPR002650; KEGG: dau:Daud_1078 sulfate adenylyltransferase; PFAM: Sulphate adenylyltransferase; PRIAM: Sulfate adenylyltransferase; SPTR: Sulfate adenylyltransferase; TIGRFAM: Sulphate adenylyltransferase; IMG reference gene:2504785017; PFAM: ATP-sulfurylase; TIGRFAM: ATP sulphurylase. (419 aa)
AEE15195.1COGs: COG1038 Pyruvate carboxylase; InterPro IPR000891:IPR003379:IPR000089; KEGG: cts:Ctha_2637 oxaloacetate decarboxylase; PFAM: Biotin/lipoyl attachment; Pyruvate carboxyltransferase; Conserved carboxylase region; PRIAM: Pyruvate carboxylase; SPTR: Oxaloacetate decarboxylase; IMG reference gene:2504785000; PFAM: HMGL-like; Conserved carboxylase domain; Biotin-requiring enzyme. (672 aa)
AEE15194.1Pyruvate carboxylase; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR005481:IPR005479:IPR005482; KEGG: rca:Rcas_2955 carbamoyl-phosphate synthase L chain ATP-binding; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Biotin carboxylase, C-terminal; PRIAM: Pyruvate carboxylase; SPTR: Carbamoyl-phosphate synthase L chain ATP-binding; IMG reference gene:2504784999; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synth [...] (485 aa)
AEE15190.1Sulfate-transporting ATPase; COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: mpd:MCP_2512 ABC transporter ATP binding protein; PFAM: ABC transporter-like; PRIAM: Sulfate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter ATP binding protein; IMG reference gene:2504784995; PFAM: ABC transporter. (291 aa)
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (216 aa)
AEE15178.1KEGG: adg:Adeg_0110 nucleoside recognition domain protein; SPTR: Nucleoside recognition domain protein; IMG reference gene:2504784979. (148 aa)
selDSelenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (353 aa)
AEE15165.1Sulfate-transporting ATPase; COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: csc:Csac_2189 ABC transporter related; PFAM: ABC transporter-like; PRIAM: Sulfate-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2504784966; PFAM: ABC transporter. (245 aa)
AEE15164.1Fe(3+)-transporting ATPase; COGs: COG1131 ABC-type multidrug transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: slp:Slip_0728 ABC transporter related protein; PFAM: ABC transporter-like; PRIAM: Fe(3+)-transporting ATPase; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter related protein; IMG reference gene:2504784965; PFAM: ABC transporter. (298 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (168 aa)
AEE15156.1DEAD/DEAH box helicase domain protein; COGs: COG1200 RecG-like helicase; InterPro IPR014001:IPR001650:IPR011545; KEGG: dtu:Dtur_1140 ATP-dependent DNA helicase RecG; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: ATP-dependent DNA helicase RecG; IMG reference gene:2504784957; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecG. (667 aa)
ribBAGTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (401 aa)
AEE15149.1DEAD/DEAH box helicase domain protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR014001:IPR001650:IPR011545:IPR005580; KEGG: dhd:Dhaf_3118 DEAD/DEAH box helicase domain protein; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; DbpA, RNA-binding; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: DEAD/DEAH box helicase domain protein; IMG reference gene:2504784950; PFAM: Helicase conserved C-terminal domain; DbpA RNA binding domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (531 aa)
thyXThymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (216 aa)
AEE15136.1InterPro IPR011719; KEGG: cyc:PCC7424_4385 hypothetical protein; PFAM: Conserved hypothetical protein CHP02058; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP02058; IMG reference gene:2504784937; PFAM: Conserved hypothetical protein (Lin0512_fam); TIGRFAM: conserved hypothetical protein. (121 aa)
ispE4-diphosphocytidyl-2-C-methyl-D- erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (276 aa)
AEE15126.1Nitrogenase; COGs: COG1348 Nitrogenase subunit NifH (ATPase); InterPro IPR000392; KEGG: clj:CLJU_c23120 nitrogenase iron protein; PFAM: Nitrogenase iron protein, subunit NifH/Protochlorophyllide reductase, subunit ChlL; PRIAM: Nitrogenase; SPTR: Nitrogenase iron protein; IMG reference gene:2504784926; PFAM: 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; TIGRFAM: nitrogenase iron protein; Belongs to the NifH/BchL/ChlL family. (251 aa)
AEE15124.1Small GTP-binding protein; COGs: COG1160 GTPase; InterPro IPR005225:IPR002917; KEGG: sat:SYN_01372 GTPase; PFAM: GTP-binding protein, HSR1-related; SPTR: GTPase; TIGRFAM: Small GTP-binding protein; IMG reference gene:2504784924; PFAM: GTPase of unknown function; TIGRFAM: hydrogenase maturation GTPase HydF; small GTP-binding protein domain. (418 aa)
AEE15113.1COGs: COG0818 Diacylglycerol kinase; InterPro IPR000829; KEGG: cow:Calow_1066 diacylglycerol kinase; PFAM: Diacylglycerol kinase, prokaryotic; SPTR: Diacylglycerol kinase; IMG reference gene:2504784912; PFAM: Prokaryotic diacylglycerol kinase. (134 aa)
AEE15112.1Protein of unknown function DUF21; COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR000644:IPR002550:IPR005170; KEGG: aar:Acear_0620 protein of unknown function DUF21; PFAM: Protein of unknown function DUF21; Cystathionine beta-synthase, core; Transporter-associated region; SMART: Cystathionine beta-synthase, core; SPTR: Putative uncharacterized protein; IMG reference gene:2504784911; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain. (434 aa)
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.