STRINGSTRING
AEE15321.1 AEE15321.1 AEE13765.1 AEE13765.1 AEE13766.1 AEE13766.1 lysA lysA AEE13837.1 AEE13837.1 AEE13843.1 AEE13843.1 AEE13878.1 AEE13878.1 AEE13991.1 AEE13991.1 AEE14105.1 AEE14105.1 AEE14133.1 AEE14133.1 AEE14135.1 AEE14135.1 AEE14250.1 AEE14250.1 asd asd dapA dapA AEE15377.1 AEE15377.1 AEE14339.1 AEE14339.1 AEE15376.1 AEE15376.1 AEE14342.1 AEE14342.1 aroA aroA AEE14498.1 AEE14498.1 AEE14522.1 AEE14522.1 AEE14529.1 AEE14529.1 AEE14530.1 AEE14530.1 AEE14531.1 AEE14531.1 AEE14539.1 AEE14539.1 AEE14565.1 AEE14565.1 AEE14716.1 AEE14716.1 AEE14730.1 AEE14730.1 dapF dapF aroQ aroQ dapB dapB aroE aroE AEE15270.1 AEE15270.1 aroK aroK aroC aroC AEE15319.1 AEE15319.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AEE15321.1Nicotinate-nucleotide diphosphorylase (carboxylating); COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR002638; KEGG: dth:DICTH_0588 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleotide pyrophosphorylase; IMG reference gene:2504785128; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (283 aa)
AEE13765.1COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: pth:PTH_0734 glutamate synthase domain-containing 2; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase domain 2; IMG reference gene:2504783480; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1517 aa)
AEE13766.1Glutamate synthase, NADH/NADPH, small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR006005:IPR013027; KEGG: hmo:HM1_1039 glutamate synthase (nadph) small chain; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase, NADH/NADPH, small subunit; TIGRFAM: Glutamate synthase, NADH/NADPH, small subunit 1; IMG reference gene:2504783481; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. (488 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (427 aa)
AEE13837.1Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: adg:Adeg_1793 beta-lactamase domain protein; SPTR: Beta-lactamase domain protein; IMG reference gene:2504783554; PFAM: Metallo-beta-lactamase superfamily. (285 aa)
AEE13843.1COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027; KEGG: glutamate synthase (NADPH) small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase (NADPH), homotetrameric; IMG reference gene:2504783560; PFAM: Pyridine nucleotide-disulphide oxidoreductase. (449 aa)
AEE13878.1COGs: COG0527 Aspartokinase; InterPro IPR005260:IPR001341:IPR001048:IPR002912; KEGG: adg:Adeg_0884 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartate kinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; IMG reference gene:2504783596; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (410 aa)
AEE13991.12-oxoglutarate synthase; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: tit:Thit_1912 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding; IMG reference gene:2504783722; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (249 aa)
AEE14105.1Glutamate synthase (NADPH); COGs: COG1148 Heterodisulfide reductase subunit A and related polyferredoxins; InterPro IPR003953:IPR001450:IPR013027; KEGG: abi:Aboo_0977 FAD-dependent pyridine nucleotide-disulfide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; PRIAM: Glutamate synthase (NADPH); SPTR: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; IMG reference gene:2504783843; PFAM: Pyridine nucleotide-disulphide oxidoredu [...] (861 aa)
AEE14133.1COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR011898:IPR001450; KEGG: pmo:Pmob_0586 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate; IMG reference gene:2504783872; PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family. (119 aa)
AEE14135.1COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: tye:THEYE_A0910 pyruvate synthase subunit PorB; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: Pyruvate synthase; SPTR: Pyruvate synthase subunit PorB; IMG reference gene:2504783874; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (327 aa)
AEE14250.1COGs: COG4401 Chorismate mutase; InterPro IPR008243; KEGG: afl:Aflv_1100 chorismate mutase; PFAM: Chorismate mutase, AroH class; SPTR: AroH; TIGRFAM: Chorismate mutase, AroH class; IMG reference gene:2504783993; PFAM: Chorismate mutase type I; TIGRFAM: monofunctional chorismate mutase, gram positive type, clade 1. (127 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (334 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa)
AEE15377.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: bld:BLi00095 hypothetical protein; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine); TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; IMG reference gene:2504785187; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyroph [...] (168 aa)
AEE14339.1COGs: COG0506 Proline dehydrogenase; InterPro IPR002872; KEGG: ddf:DEFDS_1068 proline dehydrogenase; PFAM: Proline dehydrogenase; PRIAM: Proline dehydrogenase; SPTR: Proline dehydrogenase; IMG reference gene:2504784085; PFAM: Proline dehydrogenase. (299 aa)
AEE15376.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (279 aa)
AEE14342.1Beta-lactamase domain protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: adg:Adeg_1793 beta-lactamase domain protein; SPTR: Beta-lactamase domain protein; IMG reference gene:2504784091; PFAM: Metallo-beta-lactamase superfamily. (278 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa)
AEE14498.1COGs: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; HAMAP: Dihydrodipicolinate synthase; InterPro IPR002220; KEGG: gvg:HMPREF0421_20691 dihydrodipicolinate synthase; PFAM: Dihydrodipicolinate synthetase; PRIAM: Dihydrodipicolinate synthase; SPTR: Dihydrodipicolinate synthase; IMG reference gene:2504784261; PFAM: Dihydrodipicolinate synthetase family; TIGRFAM: dihydrodipicolinate synthase. (298 aa)
AEE14522.1COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766:IPR011896; KEGG: tye:THEYE_A0983 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoacid:ferredoxin oxidoreductase subunit beta; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; IMG reference gene:2504784286; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal [...] (280 aa)
AEE14529.1Glutamine amidotransferase class-II; COGs: COG0067 Glutamate synthase domain 1; InterPro IPR000583; KEGG: chy:CHY_0706 hypothetical protein; PFAM: Glutamine amidotransferase, class-II; SPTR: Putative uncharacterized protein; IMG reference gene:2504784293; PFAM: Glutamine amidotransferases class-II. (363 aa)
AEE14530.1COGs: COG0069 Glutamate synthase domain 2; InterPro IPR001450:IPR002932; KEGG: chy:CHY_0707 glutamate synthase,-like protein; PFAM: Glutamate synthase, central-C; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase, homolog; IMG reference gene:2504784294; PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (504 aa)
AEE14531.1COGs: COG0070 Glutamate synthase domain 3; InterPro IPR002489; KEGG: tmt:Tmath_1316 glutamate synthase alpha subunit domain protein; PFAM: Glutamate synthase, alpha subunit, C-terminal; SPTR: Glutamate synthase alpha subunit domain protein; IMG reference gene:2504784295; PFAM: GXGXG motif. (244 aa)
AEE14539.1Amidohydrolase; COGs: COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase; InterPro IPR002933:IPR011650:IPR010168; KEGG: ckr:CKR_0577 hypothetical protein; PFAM: Peptidase M20; Peptidase M20, dimerisation; PRIAM: N-acetyldiaminopimelate deacetylase; SPTR: Amidohydrolase; TIGRFAM: Peptidase M20D, amidohydrolase; IMG reference gene:2504784304; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: amidohydrolase. (388 aa)
AEE14565.1COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: toc:Toce_1019 LL-diaminopimelate aminotransferase apoenzyme; PFAM: Aminotransferase, class I/II; PRIAM: LL-diaminopimelate aminotransferase; SPTR: LL-diaminopimelate aminotransferase apoenzyme; IMG reference gene:2504784333; PFAM: Aminotransferase class I and II. (405 aa)
AEE14716.12-oxoglutarate synthase; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: toc:Toce_1203 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoglutarate ferredoxin oxidoreductase, beta subunit; IMG reference gene:2504784493; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (275 aa)
AEE14730.1Beta-lactamase domain-containing protein; COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: ppd:Ppro_1945 beta-lactamase domain-containing protein; SPTR: Beta-lactamase domain protein; IMG reference gene:2504784509; PFAM: Metallo-beta-lactamase superfamily. (277 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (268 aa)
AEE15270.13-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (353 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (401 aa)
AEE15319.1Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (383 aa)
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.