STRINGSTRING
hemA hemA AEE13981.1 AEE13981.1 AEE13987.1 AEE13987.1 AEE14044.1 AEE14044.1 AEE14045.1 AEE14045.1 AEE14069.1 AEE14069.1 AEE14130.1 AEE14130.1 AEE14176.1 AEE14176.1 AEE14791.1 AEE14791.1 AEE15288.1 AEE15288.1 aroE aroE AEE15237.1 AEE15237.1 dapB dapB AEE15049.1 AEE15049.1 AEE15041.1 AEE15041.1 AEE15002.1 AEE15002.1 AEE14967.1 AEE14967.1 AEE14910.1 AEE14910.1 argC argC AEE14753.1 AEE14753.1 sucD sucD AEE14687.1 AEE14687.1 AEE14654.1 AEE14654.1 AEE14628.1 AEE14628.1 AEE14603.1 AEE14603.1 AEE13838.1 AEE13838.1 AEE13706.1 AEE13706.1 gpsA gpsA ilvC ilvC AEE14218.1 AEE14218.1 folD folD asd asd AEE13936.1 AEE13936.1 dxr dxr AEE14379.1 AEE14379.1 AEE14409.1 AEE14409.1 proC proC ahcY ahcY AEE14495.1 AEE14495.1 AEE14558.1 AEE14558.1
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second shell of interactors
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proteins of unknown 3D structure
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hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (431 aa)
AEE13981.1ADP-L-glycero-D-manno-heptose-6-epimerase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR011912:IPR001509; KEGG: aae:aq_344 ADP-L-glycero-D-manno-heptose-6-epimerase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: ADP-glyceromanno-heptose 6-epimerase; SPTR: ADP-L-glycero-D-manno-heptose-6-epimerase; TIGRFAM: ADP-L-glycero-D-manno-heptose-6-epimerase; IMG reference gene:2504783712; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: ADP-L-glycero-D-manno-heptose-6-epimerase. (306 aa)
AEE13987.1CoA-binding domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR003781; KEGG: mja:MJ_0590 hypothetical protein; PFAM: CoA-binding; SPTR: Uncharacterized protein MJ0590; IMG reference gene:2504783718; PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain. (711 aa)
AEE14044.1Nucleotide sugar dehydrogenase; COGs: COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; InterPro IPR017476:IPR001732:IPR014026:IPR014027; KEGG: bhy:BHWA1_01693 UDP-glucose/GDP-mannose dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: UDP-glucose/GDP-mannose dehydrogenase; TIGRFAM: Nucleotide sugar dehydrogenase; IMG reference gene:2504783778; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; U [...] (393 aa)
AEE14045.1NAD-dependent epimerase/dehydratase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: bhy:BHWA1_01692 UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: UDP-glucose 4-epimerase; IMG reference gene:2504783779; PFAM: NAD dependent epimerase/dehydratase family. (340 aa)
AEE14069.1COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR006424:IPR020828:IPR020829; KEGG: saf:SULAZ_0209 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: Strongly similar to glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; IMG reference gene:2504783805; PFAM: Glyceraldehyde 3-phosphate [...] (333 aa)
AEE14130.1Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR000683; KEGG: dth:DICTH_0431 oxidoreductase, Gfo/Idh/MocA family/transferase hexapeptide repeat protein; PFAM: Oxidoreductase, N-terminal; SPTR: Putative uncharacterized protein; IMG reference gene:2504783869; PFAM: Oxidoreductase family, NAD-binding Rossmann fold. (307 aa)
AEE14176.1COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006236:IPR006139:IPR006140:IPR002912; KEGG: chy:CHY_2698 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Amino acid-binding ACT; PRIAM: Phosphoglycerate dehydrogenase; SPTR: D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; IMG reference gene:2504783915; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific [...] (528 aa)
AEE14791.1COGs: COG1832 CoA-binding protein; InterPro IPR003781; KEGG: kcr:Kcr_0283 CoA-binding domain-containing protein; PFAM: CoA-binding; SPTR: CoA-binding domain protein; tmRNA as predicted by Rfam (RF00023), score 218.46; IMG reference gene:2504784578; PFAM: CoA binding domain. (137 aa)
AEE15288.1Enoyl-(acyl-carrier-protein) reductase (NADH); COGs: COG0623 Enoyl-(acyl-carrier-protein); KEGG: tal:Thal_0538 short-chain dehydrogenase/reductase SDR; PRIAM: Enoyl-[acyl-carrier-protein] reductase (NADH); SPTR: Short-chain dehydrogenase/reductase SDR; IMG reference gene:2504785094; PFAM: short chain dehydrogenase. (262 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (268 aa)
AEE15237.1COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR006424:IPR020828:IPR020829; KEGG: cpc:Cpar_1570 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); SPTR: Glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: Glyceraldehyde-3-phosphate dehydrogenase, type I; IMG reference gene:2504785043; PFAM: Glyceraldehyde 3-phosphate dehydrogenase [...] (335 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa)
AEE15049.13-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
AEE15041.1Acetyl coenzyme A synthetase (ADP forming), alpha domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR014089:IPR003781; KEGG: cag:Cagg_3834 acetyl coenzyme A synthetase (ADP forming), alpha domain-containing protein; PFAM: CoA-binding; SPTR: Strongly similar to acetyl-CoA synthetase (ADP-forming) gene; TIGRFAM: Acetyl coenzyme A synthetase (ADP forming), alpha domain; IMG reference gene:2504784837; PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain. (702 aa)
AEE15002.12-hydroxy-3-oxopropionate reductase; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115; KEGG: bao:BAMF_1472 putative beta-hydroxyacid dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; PRIAM: 2-hydroxy-3-oxopropionate reductase; SPTR: Putative beta-hydroxyacid dehydrogenase; IMG reference gene:2504784798; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. (292 aa)
AEE14967.1TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR013099:IPR003148; KEGG: tye:THEYE_A0825 potassium uptake protein, TrkA family; PFAM: Regulator of K+ conductance, N-terminal; Ion transport 2; SPTR: Potassium uptake protein, TrkA family; IMG reference gene:2504784760; PFAM: TrkA-N domain; Ion channel. (310 aa)
AEE14910.1NAD-dependent epimerase/dehydratase; COGs: COG0702 nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: cni:Calni_0358 nad-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase; IMG reference gene:2504784702; PFAM: NAD dependent epimerase/dehydratase family. (281 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
AEE14753.1Ketopantoate reductase ApbA/PanE domain protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (341 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (319 aa)
AEE14687.12-hydroxy-3-oxopropionate reductase; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115; KEGG: rcu:RCOM_1211530 3-hydroxyisobutyrate dehydrogenase, putative; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; PRIAM: 2-hydroxy-3-oxopropionate reductase; SPTR: Putative uncharacterized protein; IMG reference gene:2504784463; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase. (285 aa)
AEE14654.1COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006097:IPR006096; KEGG: dae:Dtox_3997 Glu/Leu/Phe/Val dehydrogenase; PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; PRIAM: Glutamate dehydrogenase (NAD(P)(+)); SPTR: Glu/Leu/Phe/Val dehydrogenase; IMG reference gene:2504784422; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (415 aa)
AEE14628.1COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342:IPR002912; KEGG: aar:Acear_1069 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; SPTR: Homoserine dehydrogenase; IMG reference gene:2504784396; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (421 aa)
AEE14603.1COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: tmt:Tmath_0434 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: Sirohaem synthase, N-terminal; IMG reference gene:2504784371; TIGRFAM: siroheme synthase, N-terminal domain. (206 aa)
AEE13838.1Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302; KEGG: bbe:BBR47_13780 NAD-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; PRIAM: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); SPTR: Probable NAD-dependent malic enzyme; IMG reference gene:2504783555; PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain. (409 aa)
AEE13706.1dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (277 aa)
gpsACOGs: COG0240 Glycerol-3-phosphate dehydrogenase; HAMAP: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; InterPro IPR011128:IPR006109; KEGG: afl:Aflv_1086 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal; NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal; SPTR: Glycerol-3-phosphate dehydrogenase [NAD(P)+]; IMG reference gene:2504783492; PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; TIGRFAM: glycerol-3-phosphate dehydrogenase [...] (327 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
AEE14218.1COGs: COG1260 Myo-inositol-1-phosphate synthase; InterPro IPR002587:IPR013021; KEGG: tbi:Tbis_3568 inositol 1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH-like; SPTR: Inositol 1-phosphate synthase; IMG reference gene:2504783961; PFAM: Myo-inositol-1-phosphate synthase. (354 aa)
folDBifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (334 aa)
AEE13936.1UDP-glucose 4-epimerase; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: kol:Kole_0202 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: UDP-glucose 4-epimerase; SPTR: RmlD substrate binding domain protein; IMG reference gene:2504783658; PFAM: NAD dependent epimerase/dehydratase family. (322 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (376 aa)
AEE14379.1COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099; KEGG: tmt:Tmath_1029 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; PRIAM: Prephenate dehydrogenase; SPTR: Prephenate dehydrogenase; IMG reference gene:2504784131; PFAM: Prephenate dehydrogenase. (281 aa)
AEE14409.1dTDP-glucose 4,6-dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR001509:IPR005888; KEGG: hya:HY04AAS1_1572 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: dTDP-glucose 4,6-dehydratase; SPTR: dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; IMG reference gene:2504784163; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (331 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (265 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (411 aa)
AEE14495.1Zinc-binding alcohol dehydrogenase family protein; COGs: COG1064 Zn-dependent alcohol dehydrogenase; InterPro IPR013154:IPR014187; KEGG: dtu:Dtur_0630 zinc-binding alcohol dehydrogenase family protein; PFAM: Alcohol dehydrogenase GroES-like; SPTR: Zinc-binding alcohol dehydrogenase family protein; TIGRFAM: Alcohol dehydrogenase, zinc-binding type 2; IMG reference gene:2504784258; PFAM: Alcohol dehydrogenase GroES-like domain; TIGRFAM: zinc-binding alcohol dehydrogenase family protein. (337 aa)
AEE14558.1Glyoxylate reductase; COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140; KEGG: bmd:BMD_3518 glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; PRIAM: Glyoxylate reductase; SPTR: Glyoxylate reductase; IMG reference gene:2504784324; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (322 aa)
Your Current Organism:
Thermodesulfobium narugense
NCBI taxonomy Id: 747365
Other names: T. narugense DSM 14796, Thermodesulfobium narugense DSM 14796, Thermodesulfobium narugense Na82, Thermodesulfobium narugense str. DSM 14796, Thermodesulfobium narugense strain DSM 14796, sulfate-reducing bacterium Na82
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