(82 nodes) Protein folding, and HSP20-like chaperone network (Heterobasidion irregulare)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	W4JM73_9AGAM	Methyltransf_25 domain-containing protein. (303 aa)
	W4JNH1_9AGAM	Uncharacterized protein. (572 aa)
	W4JNI8_9AGAM	Uncharacterized protein. (178 aa)
	W4JQH9_9AGAM	Uncharacterized protein. (815 aa)
	W4JRE5_9AGAM	Uncharacterized protein. (94 aa)
	W4JRM4_9AGAM	Uncharacterized protein. (57 aa)
	W4JS82_9AGAM	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (605 aa)
	W4JT16_9AGAM	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family. (561 aa)
	W4JTU1_9AGAM	Uncharacterized protein. (111 aa)
	W4JUE2_9AGAM	DUF775 domain-containing protein. (245 aa)
	W4JUH3_9AGAM	J domain-containing protein. (320 aa)
	W4JW70_9AGAM	Uncharacterized protein. (1145 aa)
	W4JWV7_9AGAM	Mitoc_mL59 domain-containing protein. (257 aa)
	W4JXA7_9AGAM	PPIase cyclophilin-type domain-containing protein. (369 aa)
	W4JYD5_9AGAM	Methyltransf_25 domain-containing protein. (314 aa)
	W4JYI8_9AGAM	Uncharacterized protein. (743 aa)
	W4JYU8_9AGAM	Molecular chaperone, DnaJ superfamily. (444 aa)
	W4JZ75_9AGAM	Uncharacterized protein. (749 aa)
	W4JZK9_9AGAM	Molecular chaperone, DnaJ superfamily. (187 aa)
	W4K038_9AGAM	Uncharacterized protein; Belongs to the heat shock protein 70 family. (634 aa)
	W4K0A9_9AGAM	Molecular chaperone, DnaJ superfamily. (398 aa)
	TRX7_PDI	Thioredoxin protein disulfide isomerase. (428 aa)
	W4K0H9_9AGAM	Flavin_Reduct domain-containing protein. (208 aa)
	W4K0S6_9AGAM	Uncharacterized protein. (519 aa)
	W4K121_9AGAM	Uncharacterized protein. (472 aa)
	W4K1R7_9AGAM	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (158 aa)
	W4K1W3_9AGAM	Uncharacterized protein. (709 aa)
	W4K1Z5_9AGAM	Uncharacterized protein. (281 aa)
	W4K258_9AGAM	Lon protease homolog; Belongs to the peptidase S16 family. (926 aa)
	W4K2B1_9AGAM	Uncharacterized protein; Belongs to the heat shock protein 70 family. (675 aa)
	W4K2W1_9AGAM	Uncharacterized protein. (192 aa)
	W4K2X6_9AGAM	Uncharacterized protein. (350 aa)
	W4K435_9AGAM	Serine/threonine-protein phosphatase. (541 aa)
	W4K448_9AGAM	Uncharacterized protein. (780 aa)
	W4K4Z4_9AGAM	Uncharacterized protein. (544 aa)
	W4K4Z5_9AGAM	Uncharacterized protein. (595 aa)
	W4K586_9AGAM	BZIP domain-containing protein. (360 aa)
	W4K5V6_9AGAM	Uncharacterized protein. (774 aa)
	W4K847_9AGAM	CVNH domain-containing protein. (124 aa)
	W4K863_9AGAM	HpcH_HpaI domain-containing protein. (358 aa)
	W4K911_9AGAM	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (202 aa)
	W4K9A2_9AGAM	Uncharacterized protein. (506 aa)
	W4KAW8_9AGAM	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (192 aa)
	W4KB17_9AGAM	Uncharacterized protein; Belongs to the GroES chaperonin family. (107 aa)
	TRX8_PDI	Thioredoxin protein disulfide isomerase; Belongs to the protein disulfide isomerase family. (369 aa)
	W4KBI6_9AGAM	TPR_REGION domain-containing protein. (196 aa)
	W4KBS8_9AGAM	Uncharacterized protein. (606 aa)
	W4KC31_9AGAM	Molecular chaperone, DnaJ superfamily. (391 aa)
	W4KC33_9AGAM	Uncharacterized protein. (657 aa)
	PIM1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1081 aa)
	W4KCT4_9AGAM	Uncharacterized protein. (415 aa)
	W4KD98_9AGAM	Molecular chaperone, DnaJ superfamily. (373 aa)
	TRX10_PDI	Protein disulfide-isomerase. (499 aa)
	W4KE38_9AGAM	Uncharacterized protein. (219 aa)
	W4KE74_9AGAM	Uncharacterized protein. (812 aa)
	W4KEB9_9AGAM	J domain-containing protein. (355 aa)
	W4KFM2_9AGAM	ClpB_D2-small domain-containing protein. (499 aa)
	W4KGQ1_9AGAM	Uncharacterized protein. (587 aa)
	TRX5_PDI	Thioredoxin protein disulfide isomerase. (585 aa)
	W4KH61_9AGAM	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (877 aa)
	W4KHT2_9AGAM	Uncharacterized protein. (324 aa)
	W4KHU8_9AGAM	Uncharacterized protein. (538 aa)
	W4KI26_9AGAM	Uncharacterized protein; Belongs to the heat shock protein 70 family. (612 aa)
	W4KI93_9AGAM	Uncharacterized protein. (398 aa)
	W4KJD9_9AGAM	Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
	W4KJG7_9AGAM	HATPase_c domain-containing protein. (701 aa)
	W4KJW9_9AGAM	Uncharacterized protein. (886 aa)
	W4KK91_9AGAM	Uncharacterized protein. (332 aa)
	W4KL06_9AGAM	Uncharacterized protein. (357 aa)
	W4KLH5_9AGAM	AAA domain-containing protein. (403 aa)
	W4KLJ0_9AGAM	Uncharacterized protein. (371 aa)
	W4KLL2_9AGAM	J domain-containing protein. (355 aa)
	W4KLX7_9AGAM	Uncharacterized protein. (239 aa)
	W4KMB7_9AGAM	Aha1_N domain-containing protein. (333 aa)
	W4KMN2_9AGAM	HSF_DOMAIN domain-containing protein. (183 aa)
	W4KMT0_9AGAM	Uncharacterized protein. (565 aa)
	W4KN49_9AGAM	TPR_REGION domain-containing protein. (539 aa)
	W4KNB6_9AGAM	Molecular chaperone, DnaJ superfamily. (214 aa)
	W4KP90_9AGAM	Uncharacterized protein; Belongs to the ClpA/ClpB family. (907 aa)
	W4KPA7_9AGAM	ATP-dependent Clp protease proteolytic subunit. (178 aa)
	W4KQ82_9AGAM	Uncharacterized protein. (204 aa)
	W4KRL4_9AGAM	CS domain-containing protein. (222 aa)

Your Current Organism:

Heterobasidion irregulare

NCBI taxonomy Id: 747525
Other names: H. irregulare TC 32-1, Heterobasidion irregulare TC 32-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIM1	W4JNH1_9AGAM	W4KC98	W4JNH1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4JS82_9AGAM	W4KC98	W4JS82	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.643
PIM1	W4JYI8_9AGAM	W4KC98	W4JYI8	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.599
PIM1	W4JZ75_9AGAM	W4KC98	W4JZ75	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4K0H9_9AGAM	W4KC98	W4K0H9	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Flavin_Reduct domain-containing protein.	0.452
PIM1	W4K121_9AGAM	W4KC98	W4K121	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4K2X6_9AGAM	W4KC98	W4K2X6	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4K448_9AGAM	W4KC98	W4K448	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4KB17_9AGAM	W4KC98	W4KB17	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein; Belongs to the GroES chaperonin family.	0.616
PIM1	W4KC33_9AGAM	W4KC98	W4KC33	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4KE74_9AGAM	W4KC98	W4KE74	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4KFM2_9AGAM	W4KC98	W4KFM2	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	ClpB_D2-small domain-containing protein.	0.689
PIM1	W4KJG7_9AGAM	W4KC98	W4KJG7	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	HATPase_c domain-containing protein.	0.452
PIM1	W4KJW9_9AGAM	W4KC98	W4KJW9	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4KLH5_9AGAM	W4KC98	W4KLH5	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	AAA domain-containing protein.	0.599
PIM1	W4KMT0_9AGAM	W4KC98	W4KMT0	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein.	0.452
PIM1	W4KP90_9AGAM	W4KC98	W4KP90	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	Uncharacterized protein; Belongs to the ClpA/ClpB family.	0.599
PIM1	W4KPA7_9AGAM	W4KC98	W4KPA7	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	ATP-dependent Clp protease proteolytic subunit.	0.700
TRX10_PDI	TRX5_PDI	W4KDU6	W4KGZ2	Protein disulfide-isomerase.	Thioredoxin protein disulfide isomerase.	0.630
TRX10_PDI	TRX7_PDI	W4KDU6	W4K0H1	Protein disulfide-isomerase.	Thioredoxin protein disulfide isomerase.	0.626