(53 nodes) Dicarboxylic acid metabolic process network (Heterobasidion irregulare)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	W4K4W5_9AGAM	Shikimate_dh_N domain-containing protein. (337 aa)
	W4K5J2_9AGAM	Transket_pyr domain-containing protein. (1001 aa)
	W4K7H6_9AGAM	Mur_ligase_M domain-containing protein. (493 aa)
	W4K7S7_9AGAM	Malic enzyme. (538 aa)
	W4KEP4_9AGAM	Aspartate-semialdehyde dehydrogenase. (369 aa)
	W4K8F4_9AGAM	Uncharacterized protein. (279 aa)
	W4K8H3_9AGAM	Uncharacterized protein. (279 aa)
	W4K8I7_9AGAM	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1052 aa)
	W4K9G1_9AGAM	Uncharacterized protein. (292 aa)
	oxd3	Oxalate decarboxylase. (437 aa)
	oxd2	Oxalate decarboxylase. (437 aa)
	W4KAH7_9AGAM	Uncharacterized protein. (146 aa)
	W4KB06_9AGAM	Glutamine amidotransferase type-2 domain-containing protein. (2152 aa)
	W4KB12_9AGAM	FtsJ domain-containing protein. (354 aa)
	W4KC22_9AGAM	Glutamine amidotransferase type-1 domain-containing protein. (779 aa)
	oxd1	CUPIN, Germin, oxalate decarboxylase. (466 aa)
	W4KD73_9AGAM	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (333 aa)
	W4KDU5_9AGAM	Succinate-semialdehyde dehydrogenase. (492 aa)
	W4KEH1_9AGAM	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (547 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (174 aa)
	W4JPI5_9AGAM	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family. (1615 aa)
	W4JPI9_9AGAM	Uncharacterized protein. (124 aa)
	W4JQM1_9AGAM	Uncharacterized protein. (661 aa)
	W4KQV1_9AGAM	Uncharacterized protein. (271 aa)
	W4KQT1_9AGAM	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (497 aa)
	W4KPS4_9AGAM	Uncharacterized protein. (353 aa)
	W4KPM1_9AGAM	Uncharacterized protein. (500 aa)
	W4KNH2_9AGAM	Aspartate aminotransferase. (425 aa)
	W4KMK8_9AGAM	Malic enzyme. (570 aa)
	W4KLE7_9AGAM	Uncharacterized protein. (260 aa)
	W4KKF2_9AGAM	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (542 aa)
	W4KJI6_9AGAM	Chorismate synthase. (402 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (452 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (502 aa)
	W4KIS7_9AGAM	Aspartate aminotransferase. (411 aa)
	W4KIA2_9AGAM	CN hydrolase domain-containing protein. (303 aa)
	W4KI67_9AGAM	Uncharacterized protein. (563 aa)
	MDH1	Malate dehydrogenase. (337 aa)
	W4KHQ2_9AGAM	Uncharacterized protein. (299 aa)
	W4KFG1_9AGAM	GTP_cyclohydroI domain-containing protein. (212 aa)
	W4JQP9_9AGAM	WAPL domain-containing protein. (271 aa)
	W4JSM5_9AGAM	Uncharacterized protein. (254 aa)
	W4JW94_9AGAM	Pterin-binding domain-containing protein. (722 aa)
	W4JXU6_9AGAM	Malic enzyme. (543 aa)
	W4JZ04_9AGAM	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (218 aa)
	W4JZD2_9AGAM	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (509 aa)
	W4K0J6_9AGAM	Uncharacterized protein. (222 aa)
	W4K1N5_9AGAM	FolB domain-containing protein. (265 aa)
	W4K300_9AGAM	Uncharacterized protein. (295 aa)
	W4K337_9AGAM	Uncharacterized protein. (506 aa)
	W4K3A7_9AGAM	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
	W4K414_9AGAM	CN hydrolase domain-containing protein. (335 aa)
	MDH2	Malate dehydrogenase. (334 aa)

Your Current Organism:

Heterobasidion irregulare

NCBI taxonomy Id: 747525
Other names: H. irregulare TC 32-1, Heterobasidion irregulare TC 32-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	W4JPD4	W4KIV8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.861
BNA1	BNA5	W4JPD4	W4KIW7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.987
BNA1	W4KD73_9AGAM	W4JPD4	W4KD73	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.652
BNA4	BNA1	W4KIV8	W4JPD4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.861
BNA4	BNA5	W4KIV8	W4KIW7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.996
BNA4	W4KD73_9AGAM	W4KIV8	W4KD73	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.572
BNA5	BNA1	W4KIW7	W4JPD4	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.987
BNA5	BNA4	W4KIW7	W4KIV8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.996
BNA5	W4KD73_9AGAM	W4KIW7	W4KD73	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.616
MDH1	MDH2	W4KHW3	W4K4D3	Malate dehydrogenase.	Malate dehydrogenase.	0.902
MDH1	W4JPI5_9AGAM	W4KHW3	W4JPI5	Malate dehydrogenase.	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family.	0.457
MDH1	W4JXU6_9AGAM	W4KHW3	W4JXU6	Malate dehydrogenase.	Malic enzyme.	0.944
MDH1	W4K3A7_9AGAM	W4KHW3	W4K3A7	Malate dehydrogenase.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.906
MDH1	W4K5J2_9AGAM	W4KHW3	W4K5J2	Malate dehydrogenase.	Transket_pyr domain-containing protein.	0.487
MDH1	W4K7S7_9AGAM	W4KHW3	W4K7S7	Malate dehydrogenase.	Malic enzyme.	0.944
MDH1	W4K8I7_9AGAM	W4KHW3	W4K8I7	Malate dehydrogenase.	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.869
MDH1	W4KB06_9AGAM	W4KHW3	W4KB06	Malate dehydrogenase.	Glutamine amidotransferase type-2 domain-containing protein.	0.833
MDH1	W4KDU5_9AGAM	W4KHW3	W4KDU5	Malate dehydrogenase.	Succinate-semialdehyde dehydrogenase.	0.849
MDH1	W4KIA2_9AGAM	W4KHW3	W4KIA2	Malate dehydrogenase.	CN hydrolase domain-containing protein.	0.808
MDH1	W4KIS7_9AGAM	W4KHW3	W4KIS7	Malate dehydrogenase.	Aspartate aminotransferase.	0.971