(40 nodes) Protein transmembrane import into intracellular organelle network (Heterobasidion irregulare)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	W4K1V1_9AGAM	Mitochondrial import inner membrane translocase. (214 aa)
	W4JMD8_9AGAM	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (438 aa)
	W4JMI2_9AGAM	CHY-type domain-containing protein. (169 aa)
	W4JPN5_9AGAM	AAA family ATPase, CDC48 subfamily. (1015 aa)
	W4JS82_9AGAM	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (605 aa)
	W4JS86_9AGAM	Molecular chaperone, DnaJ superfamily. (472 aa)
	W4JT24_9AGAM	Peroxisomal biogenesis protein Pex13. (298 aa)
	W4JT85_9AGAM	Mitochondrial outer membrane translocase receptor, subunit TOM70. (575 aa)
	W4JZY3_9AGAM	WD_REPEATS_REGION domain-containing protein. (344 aa)
	W4K0K7_9AGAM	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (460 aa)
	W4K149_9AGAM	Sulfhydryl oxidase. (175 aa)
	W4K1K0_9AGAM	Molecular chaperone, DnaJ superfamily. (504 aa)
	W4K217_9AGAM	DNL-type domain-containing protein. (90 aa)
	W4K3F8_9AGAM	Lactamase_B domain-containing protein. (363 aa)
	W4K462_9AGAM	Peroxisome targeting sequence binding protein Pex5. (287 aa)
	W4K4U5_9AGAM	Mitochondrial intermembrane space protein Mia40. (61 aa)
	W4K575_9AGAM	Mitochondrial import inner membrane translocase. (161 aa)
	W4K603_9AGAM	Mitochondrial import inner membrane translocase. (162 aa)
	W4K733_9AGAM	Peroxisome targeting signal receptor Pex5. (379 aa)
	W4K7U5_9AGAM	Uncharacterized protein. (155 aa)
	W4KB17_9AGAM	Uncharacterized protein; Belongs to the GroES chaperonin family. (107 aa)
	W4KBT2_9AGAM	Mitochondrial import inner membrane translocase. (79 aa)
	W4KD74_9AGAM	Translocase of outer mitochondrial membrane complex, subunit TOM7. (51 aa)
	W4KFM2_9AGAM	ClpB_D2-small domain-containing protein. (499 aa)
	W4KFQ6_9AGAM	Peroxisomal biogenesis factor 2 Pex2. (460 aa)
	W4KFR6_9AGAM	Pex14_N domain-containing protein. (384 aa)
	W4KG20_9AGAM	Translocase of outer mitochondrial membrane complex, subunit TOM20. (563 aa)
	W4KHD6_9AGAM	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (382 aa)
	W4KI79_9AGAM	AAA ATPase. (896 aa)
	W4KJ83_9AGAM	Uncharacterized protein. (357 aa)
	W4KK33_9AGAM	Uncharacterized protein. (168 aa)
	W4KLI5_9AGAM	Translocase of outer mitochondrial membrane complex, subunit TOM40. (355 aa)
	W4KLJ9_9AGAM	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (216 aa)
	W4KM51_9AGAM	Uncharacterized protein. (164 aa)
	W4KN94_9AGAM	GRIP domain-containing protein. (621 aa)
	W4KNM1_9AGAM	Peroxisomal membrane anchor protein Pex14. (311 aa)
	MED5	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (912 aa)
	W4KP20_9AGAM	Uncharacterized protein. (375 aa)
	W4KPG4_9AGAM	Uncharacterized protein. (123 aa)
	W4KRK5_9AGAM	Peroxisome biogenesis factor Pex10. (315 aa)

Your Current Organism:

Heterobasidion irregulare

NCBI taxonomy Id: 747525
Other names: H. irregulare TC 32-1, Heterobasidion irregulare TC 32-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MED5	W4JPN5_9AGAM	W4KNM5	W4JPN5	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	AAA family ATPase, CDC48 subfamily.	0.694
MED5	W4JT24_9AGAM	W4KNM5	W4JT24	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Peroxisomal biogenesis protein Pex13.	0.910
MED5	W4JZY3_9AGAM	W4KNM5	W4JZY3	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	WD_REPEATS_REGION domain-containing protein.	0.828
MED5	W4K462_9AGAM	W4KNM5	W4K462	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Peroxisome targeting sequence binding protein Pex5.	0.766
MED5	W4K733_9AGAM	W4KNM5	W4K733	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Peroxisome targeting signal receptor Pex5.	0.766
MED5	W4KHD6_9AGAM	W4KNM5	W4KHD6	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.780
MED5	W4KI79_9AGAM	W4KNM5	W4KI79	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	AAA ATPase.	0.756
MED5	W4KRK5_9AGAM	W4KNM5	W4KRK5	Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Peroxisome biogenesis factor Pex10.	0.779
W4JMD8_9AGAM	W4JS82_9AGAM	W4JMD8	W4JS82	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Uncharacterized protein; Belongs to the chaperonin (HSP60) family.	0.434
W4JMD8_9AGAM	W4JT85_9AGAM	W4JMD8	W4JT85	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Mitochondrial outer membrane translocase receptor, subunit TOM70.	0.695
W4JMD8_9AGAM	W4K0K7_9AGAM	W4JMD8	W4K0K7	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.	0.844
W4JMD8_9AGAM	W4K149_9AGAM	W4JMD8	W4K149	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Sulfhydryl oxidase.	0.564
W4JMD8_9AGAM	W4K1V1_9AGAM	W4JMD8	W4K1V1	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Mitochondrial import inner membrane translocase.	0.993
W4JMD8_9AGAM	W4K3F8_9AGAM	W4JMD8	W4K3F8	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Lactamase_B domain-containing protein.	0.439
W4JMD8_9AGAM	W4K4U5_9AGAM	W4JMD8	W4K4U5	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Mitochondrial intermembrane space protein Mia40.	0.599
W4JMD8_9AGAM	W4K575_9AGAM	W4JMD8	W4K575	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Mitochondrial import inner membrane translocase.	0.966
W4JMD8_9AGAM	W4K603_9AGAM	W4JMD8	W4K603	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Mitochondrial import inner membrane translocase.	0.895
W4JMD8_9AGAM	W4K7U5_9AGAM	W4JMD8	W4K7U5	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Uncharacterized protein.	0.685
W4JMD8_9AGAM	W4KBT2_9AGAM	W4JMD8	W4KBT2	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Mitochondrial import inner membrane translocase.	0.760
W4JMD8_9AGAM	W4KD74_9AGAM	W4JMD8	W4KD74	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	Translocase of outer mitochondrial membrane complex, subunit TOM7.	0.539