(17 nodes) Homologous recombination network (Heterobasidion irregulare)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W4JWI4_9AGAM	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (600 aa)
	W4JWK1_9AGAM	Uncharacterized protein. (108 aa)
	W4JYZ8_9AGAM	Uncharacterized protein. (193 aa)
	W4K1G8_9AGAM	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3066 aa)
	W4K1J4_9AGAM	DNA polymerase. (989 aa)
	W4K3X2_9AGAM	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (674 aa)
	W4K5T1_9AGAM	Uncharacterized protein. (1037 aa)
	W4K7C4_9AGAM	AAA_23 domain-containing protein. (1322 aa)
	W4KBR9_9AGAM	Uncharacterized protein. (379 aa)
	W4KBU5_9AGAM	Uncharacterized protein. (101 aa)
	W4KDG0_9AGAM	Uncharacterized protein. (449 aa)
	W4KJ15_9AGAM	Uncharacterized protein. (819 aa)
	W4KJQ1_9AGAM	Uncharacterized protein. (510 aa)
	W4KKG5_9AGAM	Uncharacterized protein. (282 aa)
	W4KMS5_9AGAM	Uncharacterized protein. (483 aa)
	W4KNF8_9AGAM	Uncharacterized protein. (361 aa)
	W4KPC9_9AGAM	Uncharacterized protein; Belongs to the RecA family. (268 aa)

Your Current Organism:

Heterobasidion irregulare

NCBI taxonomy Id: 747525
Other names: H. irregulare TC 32-1, Heterobasidion irregulare TC 32-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
W4JWI4_9AGAM	W4JYZ8_9AGAM	W4JWI4	W4JYZ8	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.829
W4JWI4_9AGAM	W4K1G8_9AGAM	W4JWI4	W4K1G8	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.976
W4JWI4_9AGAM	W4K1J4_9AGAM	W4JWI4	W4K1J4	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA polymerase.	0.655
W4JWI4_9AGAM	W4K3X2_9AGAM	W4JWI4	W4K3X2	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.821
W4JWI4_9AGAM	W4K5T1_9AGAM	W4JWI4	W4K5T1	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.498
W4JWI4_9AGAM	W4K7C4_9AGAM	W4JWI4	W4K7C4	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	AAA_23 domain-containing protein.	0.999
W4JWI4_9AGAM	W4KBR9_9AGAM	W4JWI4	W4KBR9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.844
W4JWI4_9AGAM	W4KJ15_9AGAM	W4JWI4	W4KJ15	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.498
W4JWI4_9AGAM	W4KKG5_9AGAM	W4JWI4	W4KKG5	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.531
W4JWI4_9AGAM	W4KMS5_9AGAM	W4JWI4	W4KMS5	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.811
W4JWI4_9AGAM	W4KNF8_9AGAM	W4JWI4	W4KNF8	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.781
W4JWI4_9AGAM	W4KPC9_9AGAM	W4JWI4	W4KPC9	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein; Belongs to the RecA family.	0.935
W4JWK1_9AGAM	W4KKG5_9AGAM	W4JWK1	W4KKG5	Uncharacterized protein.	Uncharacterized protein.	0.917
W4JYZ8_9AGAM	W4JWI4_9AGAM	W4JYZ8	W4JWI4	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.829
W4JYZ8_9AGAM	W4K1G8_9AGAM	W4JYZ8	W4K1G8	Uncharacterized protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.890
W4JYZ8_9AGAM	W4K1J4_9AGAM	W4JYZ8	W4K1J4	Uncharacterized protein.	DNA polymerase.	0.720
W4JYZ8_9AGAM	W4K3X2_9AGAM	W4JYZ8	W4K3X2	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.843
W4JYZ8_9AGAM	W4K5T1_9AGAM	W4JYZ8	W4K5T1	Uncharacterized protein.	Uncharacterized protein.	0.648
W4JYZ8_9AGAM	W4K7C4_9AGAM	W4JYZ8	W4K7C4	Uncharacterized protein.	AAA_23 domain-containing protein.	0.915
W4JYZ8_9AGAM	W4KBR9_9AGAM	W4JYZ8	W4KBR9	Uncharacterized protein.	Uncharacterized protein.	0.898