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| | AZKH_2560 | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (529 aa) |
| | AZKH_2483 | Putative selenophosphate synthetase-related protein. (342 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (391 aa) |
| | lpxA | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa) |
| | fabA/fabZ-3 | 3-hydroxyacyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (145 aa) |
| | lpxD | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (341 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (399 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (274 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa) |
| | AZKH_2355 | Hypothetical protein. (234 aa) |
| | AZKH_2286 | Hypothetical protein. (251 aa) |
| | AZKH_2273 | Dihydrolipoyllysine-residue succinyltransferase. (254 aa) |
| | AZKH_2272 | Hypothetical protein. (76 aa) |
| | AZKH_2233 | Hypothetical protein. (89 aa) |
| | AZKH_2189 | Hypothetical protein. (726 aa) |
| | npy1 | NTP pyrophosphohydrolase; Belongs to the Nudix hydrolase family. NudC subfamily. (274 aa) |
| | bclA | benzoate-CoA ligase. (533 aa) |
| | oah/bzdY | 6-oxo-cyclohex-1-ene-carbonyl-CoA hydrolase. (376 aa) |
| | folE | GTP cyclohydrolase I. (213 aa) |
| | AZKH_2067 | MazG nucleotide pyrophosphohydrolase. (120 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1310 aa) |
| | AZKH_2045 | Glycosyltransferase family protein. (351 aa) |
| | AZKH_2044 | Glycosyltransferase family protein. (518 aa) |
| | AZKH_1923 | HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (273 aa) |
| | abmG | 2-aminobenzoate-CoA ligase. (535 aa) |
| | guaA | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (521 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa) |
| | moaE | Molybdenum cofactor biosynthesis protein E. (151 aa) |
| | moaD | Molybdopterin (MPT) converting factor, subunit 1. (84 aa) |
| | moeA-2 | Molybdopterin-guanine dinucleotide biosynthesis protein A; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (401 aa) |
| | mobB-2 | Molybdopterin-guanine dinucleotide biosynthesis protein B. (201 aa) |
| | sucB/odhB | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (397 aa) |
| | AZKH_1813 | Hypothetical protein. (297 aa) |
| | pyrD | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (342 aa) |
| | AZKH_1782 | AMP forming CoA ligase. (453 aa) |
| | AZKH_1772 | Glycosyltransferase family protein. (272 aa) |
| | AZKH_1771 | Putative phospholipid biosynthesis acyltransferase. (271 aa) |
| | AZKH_1738 | 5-carboxymethyl-2-hydroxymuconate delta-isomerase. (280 aa) |
| | acsB-3 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa) |
| | AZKH_1686 | Hypothetical protein. (474 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (166 aa) |
| | AZKH_1618 | thiamineS protein. (83 aa) |
| | mdcB | Malonate decarboxylase, beta subunit. (304 aa) |
| | AZKH_1582 | Metal dependent phosphohydrolase, putative. (197 aa) |
| | AZKH_1578 | Hypothetical protein. (132 aa) |
| | pdhC | Pyruvate dehydrogenase E2 component; Dihydrolipoamide acetyltransferase. (374 aa) |
| | ascB | acetyl-CoA synthetase. (587 aa) |
| | AZKH_1496 | Ribose-phosphate pyrophosphokinase. (328 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | aceE | Pyruvate dehydrogenase E1 component (alpha subunit) oxidoreductase protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (889 aa) |
| | aceF | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (563 aa) |
| | AZKH_1381 | Organic radical activating enzyme family protein. (159 aa) |
| | AZKH_1362 | Hypothetical protein. (450 aa) |
| | AZKH_1341 | 5'-nucleotidase. (309 aa) |
| | bclA-2 | benzoate-CoA ligase. (529 aa) |
| | thiS-3 | Thiamine biosynthesis protein. (67 aa) |
| | thiG-3 | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (294 aa) |
| | AZKH_4450 | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (291 aa) |
| | AZKH_4404 | 5-carboxymethyl-2-hydroxymuconate delta-isomerase. (280 aa) |
| | prsA-2 | Ribose-phosphate pyrophosphokinase. (313 aa) |
| | AZKH_4361 | Glyoxalase/bleomycin resistance protein/dioxygenase. (181 aa) |
| | AZKH_4356 | Hypoxanthine phosphoribosyltransferase. (185 aa) |
| | pyrD-2 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa) |
| | AZKH_4321 | CinA-related protein; Belongs to the CinA family. (162 aa) |
| | thiL | Thiamine-monophosphate kinase protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa) |
| | AZKH_4291 | Hypothetical protein; Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety; Belongs to the PagL family. (172 aa) |
| | yciA | acyl-CoA thioesterase. (135 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (271 aa) |
| | dgt1 | Deoxyguanosinetriphosphate triphosphohydrolase-like protein; Belongs to the dGTPase family. Type 2 subfamily. (395 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa) |
| | pta | Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase. (470 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa) |
| | icmF | methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1092 aa) |
| | AZKH_3904 | Hypothetical protein. (193 aa) |
| | pyrX | Dihydroorotase. (426 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (324 aa) |
| | algH | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (188 aa) |
| | thiD-2 | Phosphomethylpyrimidine kinase, putative. (322 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa) |
| | AZKH_3820 | Hypothetical protein. (175 aa) |
| | thiS-2 | Thiamine biosynthesis protein. (67 aa) |
| | thiG-2 | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (276 aa) |
| | thiC | Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (638 aa) |
| | thiD | Phosphomethylpyrimidine kinase. (278 aa) |
| | plsC | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (235 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (131 aa) |
| | accC | acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (198 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa) |
| | lpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (306 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa) |
| | accA | acetyl-CoA carboxylase carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) |
| | AZKH_3677 | cAMP phosphodiesterase. (271 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (231 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (256 aa) |
| | moeA-3 | Nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme. (250 aa) |
| | surE | Stationary phase survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (247 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (226 aa) |
| | AZKH_3493 | Putative endonuclease. (195 aa) |
| | pssA | CDP-diacylglycerol-serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (256 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (216 aa) |
| | AZKH_3458 | Deoxynucleoside kinase. (213 aa) |
| | AZKH_3454 | Haloacid dehalogenase domain protein hydrolase. (220 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase. (348 aa) |
| | AZKH_3400 | Metallophosphoesterase. (306 aa) |
| | dfp | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (198 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B. (171 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (197 aa) |
| | fdhD | Putative formate dehydrogenase accessory protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (278 aa) |
| | AZKH_0070 | Hypothetical protein. (155 aa) |
| | AZKH_0084 | Pyruvate aminotransferase. (371 aa) |
| | atpB | F-type H+-transporting ATPase, subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (276 aa) |
| | atpE | F-type H+-transporting ATPase, subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa) |
| | atpF | F-type H+-transporting ATPase, subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (157 aa) |
| | atpH | F-type H+-transporting ATPase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa) |
| | atpA | F-type H+-transporting ATPase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (512 aa) |
| | atpG | F-type H+-transporting ATPase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa) |
| | atpD | F-type H+-transporting ATPase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (466 aa) |
| | atpC | F-type H+-transporting ATPase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (141 aa) |
| | AZKH_0156 | Glyoxalase/bleomycin resistance protein/dioxygenase. (153 aa) |
| | AZKH_0158 | Hypothetical protein. (237 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | spoT | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrol; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (733 aa) |
| | napA | Nitrate reductase; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (848 aa) |
| | AZKH_0372 | Glycosyltransferase family protein. (250 aa) |
| | AZKH_0458 | thiamineS protein. (88 aa) |
| | acsB | acetyl-CoA synthetase. (662 aa) |
| | yceF | Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (206 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (227 aa) |
| | AZKH_0607 | Putative alpha-ribazole phosphatase. (183 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (210 aa) |
| | coaX | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (244 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (366 aa) |
| | clsB | Phospholipase D/transphosphatidylase protein; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (385 aa) |
| | AZKH_0687 | Glycosyltransferase family protein. (332 aa) |
| | prsA | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | ipk | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (284 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | AZKH_0719 | Thioesterase superfamily protein. (163 aa) |
| | AZKH_0730 | Hypothetical protein. (281 aa) |
| | nlaB | Phospholipid/glycerol acyltransferase. (255 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (418 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (436 aa) |
| | AZKH_0827 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (281 aa) |
| | acsB-2 | acetyl-CoA synthetase. (562 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (425 aa) |
| | purH | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (530 aa) |
| | pdxA | Pyridoxal phosphate biosynthesis protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (324 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (311 aa) |
| | fbaA | Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (482 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | suhB1 | Myo-inositol-1(or 4)-monophosphatase. (269 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa) |
| | moeA | Molybdopterin biosynthesis MOEA protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (415 aa) |
| | gpsA | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (334 aa) |
| | thiF | Adenylyltransferase. (251 aa) |
| | gpmB | Phosphoglycerate mutase 2; Belongs to the phosphoglycerate mutase family. (221 aa) |
| | mogA | Molybdenum cofactor biosynthesis protein. (196 aa) |
| | prpE | propionyl-CoA synthetase. (630 aa) |
| | folE2 | Putative GTP cyclohydrolase; Converts GTP to 7,8-dihydroneopterin triphosphate. (269 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (311 aa) |
| | ribF | Riboflavin biosynthesis protein; Belongs to the ribF family. (314 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (497 aa) |
| | AZKH_1207 | Glycerol-3-phosphate dehydrogenase. (521 aa) |
| | fliI | Flagellar-specific ATP synthase. (467 aa) |
| | pykA-3 | Pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa) |
| | AZKH_3306 | 3-demethylubiquinone-9,3-methyltransferase. (137 aa) |
| | pdhC-2 | Pyruvate dehydrogenase E2 component. (366 aa) |
| | AZKH_3280 | acetoacetyl-CoA synthetase. (662 aa) |
| | talA | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (359 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (337 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (418 aa) |
| | AZKH_3223 | Hypothetical protein. (201 aa) |
| | nadE | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (541 aa) |
| | thiS | Thiamine biosynthesis protein. (69 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (273 aa) |
| | accD | acetyl-CoA carboxylase carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (508 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (242 aa) |
| | ppnK | Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (294 aa) |
| | carA | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. (380 aa) |
| | carB | Carbamoyl phosphate synthase, large subunit; Belongs to the CarB family. (1075 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | AZKH_3052 | ADP-ribose pyrophosphatase. (198 aa) |
| | AZKH_3007 | Hypothetical protein. (180 aa) |
| | AZKH_2973 | Ap4A phosphorylase II. (279 aa) |
| | nadC | Nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. (282 aa) |
| | nnrE | Hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (502 aa) |
| | padA | phenylacetyl-CoA acceptor oxidoreductase; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (265 aa) |
| | padF | Phenylglyoxylate acceptor oxidoreductase. (99 aa) |
| | padG | Phenylglyoxylate acceptor oxidoreductase. (417 aa) |
| | padI | Phenylglyoxylate:acceptor oxidoreductase. (421 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (359 aa) |
| | yceF-2 | Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (194 aa) |
| | plsX | Glycerol-3-phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (338 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (532 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphatidyltrans ferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (199 aa) |
| | suhB1-2 | Myo-inositol-1(or 4)-monophosphatase. (265 aa) |
| | AZKH_2794 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (459 aa) |
| | AZKH_2793 | Isochorismatase hydrolase. (199 aa) |
| | moeB-2 | Molybdopterin biosynthesis protein. (483 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (233 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (165 aa) |
| | relA | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (738 aa) |
| | AZKH_2724 | Glyoxylase I family protein. (132 aa) |
| | eno-2 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | pykA-2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | zwf-2 | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa) |
| | pgl | Hypothetical protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (246 aa) |
| | AZKH_2713 | Transcriptional regulator, RpiR family. (305 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (545 aa) |
| | AZKH_2694 | Glyoxalase/bleomycin resistance protein/dioxygenase. (181 aa) |
| | acsA | acetoacetyl-CoA synthetase. (658 aa) |
| | glk | Glucokinase; Belongs to the bacterial glucokinase family. (327 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (486 aa) |
| | glk-2 | Glucokinase/transcriptional regulator, RpiR family, fusion; Belongs to the bacterial glucokinase family. (630 aa) |
| | cls2 | Putative cardiolipin synthetase. (459 aa) |
| | AZKH_2641 | Hypothetical protein. (762 aa) |
| | dnaJ-2 | Chaperone protein. (351 aa) |
