(21 nodes) Arginine and proline metabolism network (Azoarcus sp. KH32C)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AZKH_0139	Aminotransferase class-IV. (285 aa)
	rocD	Bifunctional arginase/ornithine aminotransferase; Belongs to the arginase family. (717 aa)
	AZKH_0865	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1219 aa)
	proB	Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa)
	proA	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (425 aa)
	adiA	Orn/Lys/Arg decarboxylase. (750 aa)
	speE	Spermidine synthase. (273 aa)
	AZKH_1526	Proline iminopeptidase; Belongs to the peptidase S33 family. (338 aa)
	AZKH_1568	Arginine N-succinyltransferase. (338 aa)
	AZKH_1569	Arginine N-succinyltransferase. (341 aa)
	AZKH_1598	Arginase; Belongs to the arginase family. (310 aa)
	AZKH_2078	Aldehyde dehydrogenase. (506 aa)
	AZKH_2437	Hypothetical protein. (251 aa)
	aldH	Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
	AZKH_2544	Hypothetical protein. (102 aa)
	apc-2	Subunit of acetophenone carboxylase. (711 aa)
	apc-4	Subunit of acetophenone carboxylase. (645 aa)
	ocd-2	Ornithine cyclodeaminase. (358 aa)
	betB	Betaine aldehyde dehydrogenase (BADH) oxidoreductase protein; Belongs to the aldehyde dehydrogenase family. (476 aa)
	proC	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa)
	speE-2	Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (287 aa)

Your Current Organism:

Azoarcus sp. KH32C

NCBI taxonomy Id: 748247
Other names: A. sp. KH32C

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZKH_0139	AZKH_0865	AZKH_0139	AZKH_0865	Aminotransferase class-IV.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.929
AZKH_0139	proA	AZKH_0139	AZKH_1271	Aminotransferase class-IV.	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.450
AZKH_0865	AZKH_0139	AZKH_0865	AZKH_0139	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Aminotransferase class-IV.	0.929
AZKH_0865	AZKH_1526	AZKH_0865	AZKH_1526	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Proline iminopeptidase; Belongs to the peptidase S33 family.	0.902
AZKH_0865	AZKH_1598	AZKH_0865	AZKH_1598	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Arginase; Belongs to the arginase family.	0.537
AZKH_0865	AZKH_2078	AZKH_0865	AZKH_2078	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase.	0.882
AZKH_0865	aldH	AZKH_0865	AZKH_2534	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Putative aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.888
AZKH_0865	betB	AZKH_0865	AZKH_3333	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Betaine aldehyde dehydrogenase (BADH) oxidoreductase protein; Belongs to the aldehyde dehydrogenase family.	0.888
AZKH_0865	ocd-2	AZKH_0865	AZKH_3290	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Ornithine cyclodeaminase.	0.944
AZKH_0865	proA	AZKH_0865	AZKH_1271	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.	0.946
AZKH_0865	proB	AZKH_0865	AZKH_1106	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.	0.950
AZKH_0865	proC	AZKH_0865	AZKH_3847	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.963
AZKH_0865	rocD	AZKH_0865	AZKH_0493	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	Bifunctional arginase/ornithine aminotransferase; Belongs to the arginase family.	0.963
AZKH_1526	AZKH_0865	AZKH_1526	AZKH_0865	Proline iminopeptidase; Belongs to the peptidase S33 family.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.902
AZKH_1526	ocd-2	AZKH_1526	AZKH_3290	Proline iminopeptidase; Belongs to the peptidase S33 family.	Ornithine cyclodeaminase.	0.900
AZKH_1526	proC	AZKH_1526	AZKH_3847	Proline iminopeptidase; Belongs to the peptidase S33 family.	Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.	0.906
AZKH_1568	AZKH_1569	AZKH_1568	AZKH_1569	Arginine N-succinyltransferase.	Arginine N-succinyltransferase.	0.976
AZKH_1568	AZKH_1598	AZKH_1568	AZKH_1598	Arginine N-succinyltransferase.	Arginase; Belongs to the arginase family.	0.903
AZKH_1568	adiA	AZKH_1568	AZKH_1294	Arginine N-succinyltransferase.	Orn/Lys/Arg decarboxylase.	0.914
AZKH_1568	rocD	AZKH_1568	AZKH_0493	Arginine N-succinyltransferase.	Bifunctional arginase/ornithine aminotransferase; Belongs to the arginase family.	0.622