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NH8B_0020 NH8B_0020 NH8B_0214 NH8B_0214 NH8B_0250 NH8B_0250 NH8B_0449 NH8B_0449 NH8B_0450 NH8B_0450 NH8B_0679 NH8B_0679 NH8B_0680 NH8B_0680 aceK aceK NH8B_0698 NH8B_0698 NH8B_0700 NH8B_0700 NH8B_0701 NH8B_0701 ackA ackA NH8B_0722 NH8B_0722 glcB glcB NH8B_0837 NH8B_0837 fumC fumC fumA fumA mdh mdh NH8B_1006 NH8B_1006 NH8B_1007 NH8B_1007 NH8B_1008 NH8B_1008 NH8B_1009 NH8B_1009 NH8B_1011 NH8B_1011 NH8B_1012 NH8B_1012 NH8B_1013 NH8B_1013 NH8B_1014 NH8B_1014 sucC sucC sucD sucD NH8B_1071 NH8B_1071 ilvD ilvD NH8B_1225 NH8B_1225 leuC leuC leuD leuD leuB leuB NH8B_1597 NH8B_1597 ackA-2 ackA-2 NH8B_1626 NH8B_1626 NH8B_1634 NH8B_1634 NH8B_1635 NH8B_1635 ilvE ilvE NH8B_1762 NH8B_1762 NH8B_1763 NH8B_1763 NH8B_1850 NH8B_1850 NH8B_2063 NH8B_2063 acs acs NH8B_2214 NH8B_2214 acs-2 acs-2 pdhA pdhA NH8B_2259 NH8B_2259 aceF aceF NH8B_2292 NH8B_2292 acnB acnB acnA-2 acnA-2 lplA lplA NH8B_2459 NH8B_2459 NH8B_2460 NH8B_2460 NH8B_2461 NH8B_2461 NH8B_2462 NH8B_2462 NH8B_2538 NH8B_2538 mmsB-3 mmsB-3 NH8B_2827 NH8B_2827 mmsB-4 mmsB-4 acs-3 acs-3 NH8B_3005 NH8B_3005 NH8B_3049 NH8B_3049 ach ach NH8B_3380 NH8B_3380 NH8B_3453 NH8B_3453 NH8B_3619 NH8B_3619 leuA leuA ilvC ilvC NH8B_3852 NH8B_3852 NH8B_3853 NH8B_3853 NH8B_3878 NH8B_3878 NH8B_3879 NH8B_3879 NH8B_3880 NH8B_3880
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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NH8B_0020Malate dehydrogenase; K00029. (553 aa)
NH8B_0214propionyl-CoA synthetase; K01908. (633 aa)
NH8B_0250Pyruvate kinase; K00873; Belongs to the pyruvate kinase family. (478 aa)
NH8B_0449Succinic semialdehyde dehydrogenase; K00135; Belongs to the aldehyde dehydrogenase family. (486 aa)
NH8B_04504-aminobutyrate aminotransferase; K00823; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
NH8B_0679Isocitrate dehydrogenase, NADP-dependent; K00031. (414 aa)
NH8B_0680Isocitrate dehydrogenase, NADP-dependent; K00031; Belongs to the monomeric-type IDH family. (745 aa)
aceKBifunctional isocitrate dehydrogenase kinase/phosphatase protein; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (600 aa)
NH8B_0698Beta-alanine--pyruvate transaminase; K00822; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa)
NH8B_0700Methylmalonate-semialdehyde dehydrogenase; K00140. (497 aa)
NH8B_0701L-lactate dehydrogenase (cytochrome); K00101. (406 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (384 aa)
NH8B_0722Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; K00625. (311 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (721 aa)
NH8B_0837Isocitrate lyase; K01637. (432 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (460 aa)
fumAFumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
NH8B_1006Succinate dehydrogenase, cytochrome b556 subunit; K00241. (124 aa)
NH8B_1007Succinate dehydrogenase, hydrophobic membrane anchor protein; K00242. (114 aa)
NH8B_1008Succinate dehydrogenase, flavoprotein subunit; K00239; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
NH8B_1009Succinate dehydrogenase and fumarate reductase iron-sulfur protein; K00240; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (234 aa)
NH8B_1011Type II citrate synthase; K01647; Belongs to the citrate synthase family. (429 aa)
NH8B_10122-oxoglutarate dehydrogenase, E1 subunit; K00164. (938 aa)
NH8B_10132-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (417 aa)
NH8B_1014Dihydrolipoamide dehydrogenase; K00382. (477 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
NH8B_1071Acylphosphatase; K01512. (137 aa)
ilvDDihydroxy-acid dehydratase; K01687; Belongs to the IlvD/Edd family. (618 aa)
NH8B_1225Pyruvate kinase; K00873; Belongs to the pyruvate kinase family. (476 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (354 aa)
NH8B_1597Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (695 aa)
ackA-2Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
NH8B_1626Sulfoacetaldehyde acetyltransferase; K03852; Belongs to the TPP enzyme family. (603 aa)
NH8B_1634Phosphate acetyltransferase; K00625. (339 aa)
NH8B_1635Sulfoacetaldehyde acetyltransferase; K03852; Belongs to the TPP enzyme family. (603 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa)
NH8B_1762AMP-dependent synthetase and ligase; K01895. (567 aa)
NH8B_1763Methylmalonate-semialdehyde dehydrogenase; K00140. (502 aa)
NH8B_1850Acetolactate synthase 2 catalytic subunit; K01652; Belongs to the TPP enzyme family. (527 aa)
NH8B_2063Glu/Leu/Phe/Val dehydrogenase dimerisation region; K00263; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (344 aa)
acsacetyl-CoA synthetase; K01895. (551 aa)
NH8B_2214Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1145 aa)
acs-2acetyl-CoA synthetase; K01895. (592 aa)
pdhAPyruvate dehydrogenase, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (347 aa)
NH8B_2259Pyruvate dehydrogenase, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (324 aa)
aceFBranched-chain alpha-keto acid dehydrogenase subunit E2; K00627. (363 aa)
NH8B_2292Dihydrolipoamide dehydrogenase; K00382. (463 aa)
acnBAconitate hydratase 2; K01682; Belongs to the aconitase/IPM isomerase family. (861 aa)
acnA-2Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (935 aa)
lplABiotin/lipoate A/B protein ligase, putative; K03800. (244 aa)
NH8B_2459Dihydrolipoamide acetyltransferase; K00627. (233 aa)
NH8B_2460Biotin/lipoyl attachment domain-containing protein. (81 aa)
NH8B_2461Pyruvate dehydrogenase, E1 component, beta subunit; K00162. (345 aa)
NH8B_2462Pyruvate dehydrogenase, E1 component, alpha subunit; K00161. (336 aa)
NH8B_2538Succinic semialdehyde dehydrogenase; K00135; Belongs to the aldehyde dehydrogenase family. (483 aa)
mmsB-33-hydroxyisobutyrate dehydrogenase; K00020. (290 aa)
NH8B_2827Methylmalonate-semialdehyde dehydrogenase; K00140. (500 aa)
mmsB-43-hydroxyisobutyrate dehydrogenase; K00020; Belongs to the HIBADH-related family. (295 aa)
acs-3acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa)
NH8B_3005Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions. (159 aa)
NH8B_3049Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); Phosphate acetyltransferase, K00029. (760 aa)
achacetyl-CoA hydrolase; K01067. (497 aa)
NH8B_3380Aminotransferase class I and II. (435 aa)
NH8B_3453Aldehyde dehydrogenase; K00128; Belongs to the aldehyde dehydrogenase family. (506 aa)
NH8B_3619Aldehyde dehydrogenase. (451 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (597 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
NH8B_3852Acetolactate synthase, small subunit; K01653. (163 aa)
NH8B_3853Acetolactate synthase, large subunit, biosynthetic type; K01652. (586 aa)
NH8B_3878Dihydrolipoamide dehydrogenase; K00382. (589 aa)
NH8B_3879Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (539 aa)
NH8B_3880Pyruvate dehydrogenase, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (888 aa)
Your Current Organism:
Pseudogulbenkiania sp. NH8B
NCBI taxonomy Id: 748280
Other names: P. sp. NH8B
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