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NH8B_0679 NH8B_0679 NH8B_0680 NH8B_0680 fumC fumC fumA fumA mdh mdh NH8B_1006 NH8B_1006 NH8B_1007 NH8B_1007 NH8B_1008 NH8B_1008 NH8B_1009 NH8B_1009 NH8B_1011 NH8B_1011 NH8B_1012 NH8B_1012 NH8B_1013 NH8B_1013 NH8B_1014 NH8B_1014 sucC sucC sucD sucD NH8B_2214 NH8B_2214 pdhA pdhA NH8B_2259 NH8B_2259 aceF aceF NH8B_2292 NH8B_2292 acnB acnB acnA-2 acnA-2 NH8B_2459 NH8B_2459 ach ach NH8B_3878 NH8B_3878 NH8B_3879 NH8B_3879 NH8B_3880 NH8B_3880
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NH8B_0679Isocitrate dehydrogenase, NADP-dependent; K00031. (414 aa)
NH8B_0680Isocitrate dehydrogenase, NADP-dependent; K00031; Belongs to the monomeric-type IDH family. (745 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (460 aa)
fumAFumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
NH8B_1006Succinate dehydrogenase, cytochrome b556 subunit; K00241. (124 aa)
NH8B_1007Succinate dehydrogenase, hydrophobic membrane anchor protein; K00242. (114 aa)
NH8B_1008Succinate dehydrogenase, flavoprotein subunit; K00239; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
NH8B_1009Succinate dehydrogenase and fumarate reductase iron-sulfur protein; K00240; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (234 aa)
NH8B_1011Type II citrate synthase; K01647; Belongs to the citrate synthase family. (429 aa)
NH8B_10122-oxoglutarate dehydrogenase, E1 subunit; K00164. (938 aa)
NH8B_10132-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (417 aa)
NH8B_1014Dihydrolipoamide dehydrogenase; K00382. (477 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
NH8B_2214Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1145 aa)
pdhAPyruvate dehydrogenase, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (347 aa)
NH8B_2259Pyruvate dehydrogenase, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (324 aa)
aceFBranched-chain alpha-keto acid dehydrogenase subunit E2; K00627. (363 aa)
NH8B_2292Dihydrolipoamide dehydrogenase; K00382. (463 aa)
acnBAconitate hydratase 2; K01682; Belongs to the aconitase/IPM isomerase family. (861 aa)
acnA-2Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (935 aa)
NH8B_2459Dihydrolipoamide acetyltransferase; K00627. (233 aa)
achacetyl-CoA hydrolase; K01067. (497 aa)
NH8B_3878Dihydrolipoamide dehydrogenase; K00382. (589 aa)
NH8B_3879Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (539 aa)
NH8B_3880Pyruvate dehydrogenase, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (888 aa)
Your Current Organism:
Pseudogulbenkiania sp. NH8B
NCBI taxonomy Id: 748280
Other names: P. sp. NH8B
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