STRINGSTRING
NH8B_0637 NH8B_0637 aroE aroE aroC aroC NH8B_1247 NH8B_1247 NH8B_1478 NH8B_1478 trpF trpF trpB trpB trpA trpA trpD trpD trpG trpG pheA1 pheA1 NH8B_2237 NH8B_2237 NH8B_2503 NH8B_2503 aroQ aroQ NH8B_2532 NH8B_2532 trpE trpE trpC trpC NH8B_2658 NH8B_2658 aroA aroA NH8B_3231 NH8B_3231 trpE-2 trpE-2 aroQ-2 aroQ-2 aroK aroK aroB aroB hisC hisC hisC-2 hisC-2 NH8B_3999 NH8B_3999 NH8B_4017 NH8B_4017
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NH8B_0637Phenylalanine 4-monooxygenase; K00500. (261 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa)
NH8B_1247Endoribonuclease L-PSP. (330 aa)
NH8B_1478Aromatic-amino-acid transaminase; K00832. (402 aa)
trpFPhosphoribosylanthranilate isomerase; K01817; Belongs to the TrpF family. (207 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa)
trpGAnthranilate synthase component II; K01658. (186 aa)
pheA1Chorismate mutase/prephenate dehydratase; K04093 K04518. (357 aa)
NH8B_22373-deoxy-7-phosphoheptulonate synthase; K03856. (338 aa)
NH8B_2503Shikimate dehydrogenase substrate binding domain protein; K00014. (277 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
NH8B_2532Shikimate dehydrogenase substrate binding domain protein; K00014. (292 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (487 aa)
trpCIndole-3-glycerol-phosphate synthase; K01609; Belongs to the TrpC family. (264 aa)
NH8B_2658Aromatic-amino-acid transaminase; K00832. (402 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa)
NH8B_3231Prephenate dehydrogenase; K00210. (294 aa)
trpE-2Anthranilate synthase component I; K01657. (431 aa)
aroQ-23-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (182 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
hisCHistidinol-phosphate aminotransferase; K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (352 aa)
hisC-2Histidinol-phosphate aminotransferase; K00817; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
NH8B_3999Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (377 aa)
NH8B_4017Histidinol-phosphate aminotransferase; K00817. (365 aa)
Your Current Organism:
Pseudogulbenkiania sp. NH8B
NCBI taxonomy Id: 748280
Other names: P. sp. NH8B
Server load: low (22%) [HD]