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| | ADV47306.1 | Aminotransferase class IV; InterPro IPR001544; KEGG: sun:SUN_0387 hypothetical protein; PFAM: aminotransferase class IV; SPTR: Putative uncharacterized protein; PFAM: Aminotransferase class IV. (194 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (255 aa) |
| | ilvD | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR004404: IPR020558: IPR000581; KEGG: sun:SUN_2427 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (122 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (397 aa) |
| | trpF | COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: sun:SUN_2155 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (196 aa) |
| | ADV45426.1 | COGs: COG0031 Cysteine synthase; InterPro IPR005856: IPR005859: IPR001216: IPR001926; KEGG: mta:Moth_1971 cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (284 aa) |
| | ADV45485.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (335 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (246 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (270 aa) |
| | ADV45540.1 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645: IPR018109; KEGG: sun:SUN_2042 folylpolyglutamate synthase; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase. (416 aa) |
| | ADV45551.1 | COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099; KEGG: sun:SUN_1998 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; SPTR: Prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (276 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (223 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (407 aa) |
| | ADV45565.1 | Chorismate mutase; COGs: COG0077 Prephenate dehydratase; InterProIPR010957: IPR020822: IPR001086: IPR002912: IPR 008242: IPR002701; KEGG: sun:SUN_2057 chorismate mutase/prephenate dehydratase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; SPTR: Chorismate mutase/prephenate dehydratase; TIGRFAM: chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase type II; TIGRFAM: chorismate mutase domain of proteobacterial P-protein, clade 2. (355 aa) |
| | hisC | COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR005861: IPR001917: IPR004839; KEGG: sun:SUN_2056 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (364 aa) |
| | plsX | Phosphate:acyl-(acyl carrier protein) acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (339 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (338 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (344 aa) |
| | argH | COGs: COG0165 Argininosuccinate lyase; InterPro IPR003031: IPR000362: IPR009049: IPR020557; KEGG: sun:SUN_0544 argininosuccinate lyase; PFAM: fumarate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (465 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | ADV45603.1 | COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006236: IPR006140: IPR006139: IPR002912; KEGG: sun:SUN_0551 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; SPTR: D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM [...] (530 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (248 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (414 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa) |
| | ADV45668.1 | COGs: COG0498 Threonine synthase; InterPro IPR004450: IPR000634: IPR001926; KEGG: sun:SUN_1624 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (488 aa) |
| | ADV45697.1 | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235: IPR000277; KEGG: sun:SUN_1791 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. (421 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (368 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (263 aa) |
| | ADV45747.1 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR012846: IPR000399: IPR012001: IPR012000: IPR 011766; KEGG: sun:SUN_1823 acetolactate synthase 3 catalytic subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-ter [...] (564 aa) |
| | ADV45748.1 | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789: IPR002912; KEGG: sun:SUN_1822 acetolactate synthase 3 regulatory subunit; PFAM: amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. (156 aa) |
| | ADV45752.1 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1168 aa) |
| | ADV45759.1 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | ADV45767.1 | Periplasmic copper-binding protein; COGs: COG3420 Nitrous oxidase accessory protein; InterPro IPR006626: IPR007742; KEGG: sun:SUN_2177 nitrous oxidase accessory protein NosD; PFAM: periplasmic copper-binding; SPTR: Nitrous oxidase accessory protein NosD; PFAM: Periplasmic copper-binding protein (NosD); TIGRFAM: parallel beta-helix repeat (two copies). (413 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | ADV45794.1 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (405 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (313 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (207 aa) |
| | hisI | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; InterPro IPR008179: IPR002496: IPR021130; KEGG: sun:SUN_0237 histidine biosynthesis bifunctional protein HisI; PFAM: phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; SPTR: Histidine biosynthesis bifunctional protein HisI; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (221 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (226 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (165 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | ADV45906.1 | COGs: COG0527 Aspartokinase; InterProIPR005260: IPR001341: IPR018042: IPR001048: IPR 002912; KEGG: sun:SUN_0456 aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (401 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; InterPro IPR006269: IPR006218; KEGG: sun:SUN_1920 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; SPTR: 2-dehydro-3-deoxyphosphooctonate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase. (266 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (255 aa) |
| | ADV45942.1 | KEGG: nis:NIS_1406 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF540). (327 aa) |
| | ADV45955.1 | COGs: COG0174 Glutamine synthetase; InterPro IPR004809: IPR008147: IPR008146: IPR022272; KEGG: sun:SUN_0353 glutamine synthase; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (476 aa) |
| | ADV45956.1 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR010140: IPR004013; KEGG: nis:NIS_1518 PHP family histidinol phosphatase/hydrolase; PFAM: PHP domain protein; SPTR: Histidinol phosphate phosphatase, HisJ; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (259 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (266 aa) |
| | ADV46059.1 | COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR004410: IPR014043; KEGG: sun:SUN_1756 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase. (313 aa) |
| | ADV46060.1 | Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (229 aa) |
| | trpC | COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468: IPR013798; KEGG: sun:SUN_1695 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (268 aa) |
| | ADV46178.1 | Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198: IPR002347; KEGG: sun:SUN_0808 7-alpha-hydroxysteroid dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: 7-alpha-hydroxysteroid dehydrogenase; PFAM: short chain dehydrogenase. (260 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | hisB | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR020565: IPR000807; KEGG: sun:SUN_1227 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (190 aa) |
| | ADV46204.1 | COGs: COG1246 N-acetylglutamate synthase and related acetyltransferase; InterPro IPR000182; KEGG: sun:SUN_1222 acetyltransferase; PFAM: GCN5-related N-acetyltransferase; SPTR: Acetyltransferase, GNAT family; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (157 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (276 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (335 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (280 aa) |
| | ADV46299.1 | COGs: COG1045 Serine acetyltransferase; InterPro IPR005881: IPR018357: IPR002097: IPR001451; KEGG: sun:SUN_1361 serine O-acetyltransferase; SPTR: Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase. (234 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (767 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (410 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | ADV46388.1 | Enoyl-(acyl-carrier-protein) reductase (NADH); COGs: COG0623 Enoyl-(acyl-carrier-protein); InterPro IPR002198: IPR002347; KEGG: sun:SUN_0717 enoyl-(acyl carrier protein) reductase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Enoyl-[acyl-carrier protein] reductase (NADH); PFAM: short chain dehydrogenase. (275 aa) |
| | argG | COGs: COG0137 Argininosuccinate synthase; InterPro IPR001518: IPR018223; KEGG: sun:SUN_1685 argininosuccinate synthase; PFAM: argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (443 aa) |
| | fabZ | 3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | carB | COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005481: IPR005479: IPR005480: IPR011607: IPR 005483: IPR006275: IPR011761; KEGG: sun:SUN_1107 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: Carbamoylphosphate synthase, large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS- [...] (1089 aa) |
| | ADV46493.1 | COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: nam:NAMH_1777 metal-dependent hydrolase of the beta-lactamase superfamily; SPTR: Metal-dependent hydrolase of the beta-lactamase superfamily; PFAM: Metallo-beta-lactamase superfamily. (235 aa) |
| | ADV46514.1 | COGs: COG0560 Phosphoserine phosphatase; InterPro IPR005834: IPR004469: IPR006383; KEGG: sun:SUN_0642 phosphoserine phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Phosphoserine phosphatase; SPTR: Phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (216 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (350 aa) |
| | ADV46577.1 | Chorismate mutase, type II; InterPro IPR020822: IPR002701; KEGG: sun:SUN_1870 chorismate mutase; PFAM: Chorismate mutase, type II; SPTR: Chorismate mutase; PFAM: Chorismate mutase type II. (99 aa) |
| | ADV46580.1 | Periplasmic copper-binding protein; COGs: COG3420 Nitrous oxidase accessory protein; InterPro IPR007742: IPR006626; KEGG: nis:NIS_0096 nitrous oxidase accessory protein NosD; PFAM: periplasmic copper-binding; SPTR: Nitrous oxidase accessory protein NosD; PFAM: Periplasmic copper-binding protein (NosD). (420 aa) |
| | ADV46597.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550: IPR002052; KEGG: nis:NIS_0432 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosp [...] (186 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (159 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (436 aa) |
| | ADV46699.1 | Glutamate synthase (NADPH) small subunit; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR013027: IPR000759: IPR006006; KEGG: nis:NIS_1200 glutamate synthase subunit beta; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Glutamate synthase (NADPH), small chain; TIGRFAM: glutamate synthase, small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthase small subunit family protein, proteobacterial; glutamate synthases, NADH/NADPH, small subunit. (462 aa) |
| | ADV46700.1 | Glutamate synthase (NADPH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583: IPR006982: IPR002932: IPR002489: IPR 013838: IPR017932; KEGG: nis:NIS_1201 glutamate synthase (NADPH), large chain; PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (NADPH), large chain; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II. (1475 aa) |
| | ADV46780.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa) |
| | ADV47347.1 | Methyltransferase type 12; InterPro IPR013217; KEGG: sun:SUN_0038 methyl transferase; PFAM: Methyltransferase type 12; SPTR: Methyl transferase; PFAM: Methyltransferase domain. (241 aa) |
| | ADV46784.1 | Hypothetical protein; InterPro IPR011761; KEGG: nam:NAMH_0703 hypothetical protein; SPTR: Putative uncharacterized protein. (340 aa) |
| | ADV46785.1 | Orn/DAP/Arg decarboxylase 2; COGs: COG0019 Diaminopimelate decarboxylase; InterPro IPR000183; KEGG: nam:NAMH_0704 Orn/DAP/Arg decarboxylase, family 2; PFAM: Orn/DAP/Arg decarboxylase 2; SPTR: Orn/DAP/Arg decarboxylase, family 2; PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: diaminopimelate decarboxylase. (447 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (118 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (275 aa) |
| | ADV46860.1 | Radical SAM domain protein; COGs: COG0535 Fe-S oxidoreductase; InterPro IPR006638: IPR017200: IPR007197; KEGG: nis:NIS_1792 heme d1 biosynthesis protein NirJ; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Heme d1 biosynthesis protein NirJ; PFAM: Radical SAM superfamily. (376 aa) |
| | ADV46863.1 | Nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR006066: IPR005117: IPR006067; KEGG: sun:SUN_0312 ferredoxin--nitrite reductase; PFAM: nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; SPTR: Ferredoxin--nitrite reductase; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain. (552 aa) |
| | ADV46877.1 | COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814: IPR004636; KEGG: sun:SUN_0591 acetylornithine aminotransferase; PFAM: aminotransferase class-III; SPTR: Acetylornithine/succinylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases. (395 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (364 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062: IPR006063; KEGG: sun:SUN_1951 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide [...] (239 aa) |
| | ADV47095.1 | COGs: COG0460 Homoserine dehydrogenase; InterProIPR019811: IPR016204: IPR005106: IPR001342: IPR 002912; KEGG: sun:SUN_0225 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; SPTR: Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (420 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (520 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (326 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (397 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (294 aa) |
| | ADV47149.1 | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (331 aa) |
| | carA | COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR006274: IPR017926: IPR002474: IPR000991: IPR 001317: IPR011702: IPR006220; KEGG: sun:SUN_0176 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Carbamoylphosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (372 aa) |
| | ADV47189.1 | tRNA synthetase class II (G H P and S); COGs: COG0124 Histidyl-tRNA synthetase; InterPro IPR002314; KEGG: sun:SUN_0173 ATP phosphoribosyltransferase regulatory subunit; PFAM: tRNA synthetase class II (G H P and S); SPTR: Putative uncharacterized protein. (283 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (191 aa) |
| | ADV47242.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | ADV47243.1 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | ADV47275.1 | COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766; KEGG: sun:SUN_2140 acetolactate synthase, large subunit; PFAM: thiamine pyrophosphate central domain-containing protein; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (603 aa) |
| | ADV47293.1 | KEGG: sun:SUN_2150 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF540). (222 aa) |
| | ADV47299.1 | COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR006426: IPR017932: IPR000583: IPR001962; KEGG: tdn:Suden_0163 asparagine synthase, glutamine-hydrolyzing; PFAM: asparagine synthase; glutamine amidotransferase class-II; SPTR: Asparagine synthase, glutamine-hydrolyzing; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (605 aa) |
