STRINGSTRING
FAD_0067 FAD_0067 FAD_0099 FAD_0099 FAD_0100 FAD_0100 FAD_0101 FAD_0101 FAD_0102 FAD_0102 trpF trpF FAD_0104 FAD_0104 FAD_0105 FAD_0105 trpB trpB FAD_0125 FAD_0125 FAD_0273 FAD_0273 FAD_0274 FAD_0274 FAD_0279 FAD_0279 FAD_0378 FAD_0378 proC proC FAD_0428 FAD_0428 FAD_0437 FAD_0437 lysW lysW lysY lysY lysZ lysZ lysJ lysJ lysX lysX lysK lysK FAD_0529 FAD_0529 FAD_0530 FAD_0530 FAD_0543 FAD_0543 FAD_0637 FAD_0637 FAD_0751 FAD_0751 FAD_0783 FAD_0783 cysK cysK FAD_1078 FAD_1078 FAD_1080 FAD_1080 FAD_1132 FAD_1132 FAD_1133 FAD_1133 FAD_1135 FAD_1135 ilvD ilvD FAD_1250 FAD_1250 ilvC ilvC metF metF FAD_1384 FAD_1384 hisI hisI hisF hisF FAD_1450 FAD_1450 hisH hisH FAD_1452 FAD_1452 hisD hisD hisG hisG FAD_1455 FAD_1455 FAD_1523 FAD_1523 aroC aroC FAD_1533 FAD_1533 FAD_1556 FAD_1556 FAD_1589 FAD_1589 FAD_1605 FAD_1605 FAD_1607 FAD_1607 FAD_1608 FAD_1608 aroA aroA FAD_1643 FAD_1643 FAD_1679 FAD_1679 FAD_1789 FAD_1789 FAD_1790 FAD_1790 FAD_1797 FAD_1797 thrB thrB FAD_1809 FAD_1809 hcs hcs lysT lysT lysU lysU hicdh hicdh FAD_1849 FAD_1849 argG argG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAD_0067Carbamate kinase. (253 aa)
FAD_00993-deoxy-7-phosphoheptulonate synthase. (260 aa)
FAD_0100Indole-3-glycerol-phosphate synthase. (237 aa)
FAD_0101Anthranilate synthase component II. (186 aa)
FAD_0102Anthranilate synthase component I. (383 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa)
FAD_0104Anthranilate phosphoribosyltransferase. (324 aa)
FAD_0105Tryptophan synthase alpha chain. (244 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
FAD_01253-dehydroquinate dehydratase. (229 aa)
FAD_0273Methionine synthase. (342 aa)
FAD_0274Hypothetical protein. (293 aa)
FAD_0279Cystathionine gamma-lyase. (381 aa)
FAD_0378Homoserine dehydrogenase. (327 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (261 aa)
FAD_0428Arginine deiminase. (415 aa)
FAD_0437S-adenosyl-L-homocysteine hydrolase; Belongs to the adenosylhomocysteinase family. (409 aa)
lysWAlpha-aminoadipate carrier protein. (57 aa)
lysYN-acetyl-alpha-aminoadipate-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa)
lysZN-acetylaminoadipate kinase. (254 aa)
lysJN2-acetyl-alpha-aminoadipate semialdehyde transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (393 aa)
lysXalpha-aminoadipate--LysW ligase. (282 aa)
lysKN2-acetyl-L-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (355 aa)
FAD_0529Prephenate dehydrogenase. (212 aa)
FAD_0530Chorismate mutase. (184 aa)
FAD_0543Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (513 aa)
FAD_0637Diaminopimelate decarboxylase. (421 aa)
FAD_0751Benzoylformate decarboxylase; Belongs to the TPP enzyme family. (507 aa)
FAD_0783Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (387 aa)
cysKCysteine synthase. (317 aa)
FAD_1078Ferredoxin. (69 aa)
FAD_1080Pyruvate dehydrogenase; Belongs to the TPP enzyme family. (549 aa)
FAD_1132Aspartokinase (akH). (348 aa)
FAD_1133Aspartate-semialdehyde dehydrogenase. (339 aa)
FAD_1135Phosphoserine phosphatase. (212 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
FAD_1250Acetolactate synthase catalytic subunit. (576 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa)
metF5,10-methylenetetrahydrofolate reductase. (224 aa)
FAD_1384Histidinol-phosphate aminotransferase. (316 aa)
hisIBifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa)
FAD_14501-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Belongs to the HisA/HisF family. (229 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (189 aa)
FAD_1452Imidazoleglycerol-phosphate dehydratase. (176 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa)
hisGATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)
FAD_1455ATP phosphoribosyltransferase. (250 aa)
FAD_1523Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (356 aa)
FAD_1533Phosphoserine phosphatase. (229 aa)
FAD_1556Threonine dehydratase. (401 aa)
FAD_15892-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (345 aa)
FAD_16053-dehydroquinate synthase. (357 aa)
FAD_1607Shikimate 5-dehydrogenase. (262 aa)
FAD_1608Shikimate kinase. (272 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa)
FAD_1643Threonine synthase. (337 aa)
FAD_1679Proline racemase. (330 aa)
FAD_17893-isopropylmalate dehydratase large subunit. (416 aa)
FAD_17903-isopropylmalate dehydratase small subunit. (175 aa)
FAD_17972-isopropylmalate synthase. (377 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
FAD_1809Hypothetical protein. (362 aa)
hcsHomocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (388 aa)
lysTHomoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
lysUHomoaconitase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa)
hicdhHomoisocitrate dehydrogenase. (356 aa)
FAD_1849Argininosuccinate lyase. (438 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa)
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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