STRINGSTRING
rbsK rbsK pgk2 pgk2 thrB thrB FAD_1802 FAD_1802 FAD_1798 FAD_1798 mptE mptE FAD_1608 FAD_1608 FAD_1603 FAD_1603 FAD_1602 FAD_1602 FAD_1574 FAD_1574 FAD_1409 FAD_1409 FAD_1350 FAD_1350 FAD_1233 FAD_1233 FAD_1211 FAD_1211 FAD_1183 FAD_1183 FAD_1169 FAD_1169 FAD_1132 FAD_1132 FAD_1072 FAD_1072 FAD_0831 FAD_0831 FAD_0818 FAD_0818 FAD_0817 FAD_0817 FAD_0810 FAD_0810 FAD_0787 FAD_0787 FAD_0776 FAD_0776 FAD_0692 FAD_0692 FAD_0648 FAD_0648 FAD_0599 FAD_0599 ndk ndk FAD_0571 FAD_0571 gap gap FAD_0541 FAD_0541 thiL thiL lysZ lysZ FAD_0459 FAD_0459 apgM apgM FAD_0425 FAD_0425 pgk pgk FAD_0353 FAD_0353 eno eno FAD_0329 FAD_0329 FAD_0300 FAD_0300 FAD_0298 FAD_0298 FAD_0277 FAD_0277 nadK nadK FAD_0201 FAD_0201 FAD_0185 FAD_0185 adkA adkA FAD_0134 FAD_0134 FAD_0107 FAD_0107 FAD_0067 FAD_0067 tdk tdk tmk tmk FAD_0008 FAD_0008
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (298 aa)
pgk22-phosphoglycerate kinase. (198 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
FAD_1802Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa)
FAD_1798N-acetylglucosamine kinase. (330 aa)
mptEHypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (224 aa)
FAD_1608Shikimate kinase. (272 aa)
FAD_1603Pyruvate kinase; Belongs to the pyruvate kinase family. (559 aa)
FAD_1602Succinate-semialdehyde dehydrogenase (NADP+); Belongs to the aldehyde dehydrogenase family. (493 aa)
FAD_1574Hypothetical protein. (326 aa)
FAD_1409NAD-dependent aldehyde dehydrogenase. (437 aa)
FAD_1350Phosphoglycerate mutase family protein. (199 aa)
FAD_1233Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (787 aa)
FAD_1211Kinase related to galactokinase and mevalonate kinase. (322 aa)
FAD_1183Riboflavin kinase. (220 aa)
FAD_1169Phosphoglycerate mutase. (203 aa)
FAD_1132Aspartokinase (akH). (348 aa)
FAD_1072Gamma-aminobutyraldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa)
FAD_0831Glycerate kinase; COG2379. (423 aa)
FAD_0818Membrane protein. (174 aa)
FAD_0817Hypothetical protein. (137 aa)
FAD_0810Glycerol kinase. (489 aa)
FAD_0787Diphosphomevalonate decarboxylase. (322 aa)
FAD_0776Hypothetical protein. (329 aa)
FAD_0692Pantothenate kinase. (320 aa)
FAD_0648Cytidylyltransferase family protein. (314 aa)
FAD_0599Phosphomethylpyrimidine kinase. (262 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (139 aa)
FAD_0571Hypothetical protein. (150 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (344 aa)
FAD_0541NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
lysZN-acetylaminoadipate kinase. (254 aa)
FAD_0459Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (168 aa)
apgMCofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (402 aa)
FAD_0425Phosphoglycerate mutase/fructose-2,6-bisphosphatase. (189 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
FAD_03536-phosphofructokinase. (296 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa)
FAD_0329Hypothetical protein. (181 aa)
FAD_0300Hypothetical protein. (314 aa)
FAD_0298Ubiquione biosynthesis protein. (501 aa)
FAD_0277ROK family glucokinase. (311 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (271 aa)
FAD_0201Serine/threonine protein kinase. (254 aa)
FAD_0185Cytidylate kinase. (180 aa)
adkAAdenylate kinase; Belongs to the archaeal adenylate kinase family. (180 aa)
FAD_0134O-sialoglycoprotein endopeptidase/protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. (531 aa)
FAD_0107Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (216 aa)
FAD_0067Carbamate kinase. (253 aa)
tdkThymidine kinase related protein. (216 aa)
tmkThymidylate kinase. (206 aa)
FAD_0008Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (287 aa)
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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