STRINGSTRING
mqnD mqnD nnrD nnrD FAD_0080 FAD_0080 cobD cobD FAD_0099 FAD_0099 FAD_0100 FAD_0100 FAD_0101 FAD_0101 FAD_0102 FAD_0102 FAD_0105 FAD_0105 trpB trpB FAD_0125 FAD_0125 FAD_0198 FAD_0198 FAD_0279 FAD_0279 pdaD pdaD fbp fbp eno eno FAD_0431 FAD_0431 hemE hemE hemH hemH glyFa2 glyFa2 FAD_0525 FAD_0525 FAD_0579 FAD_0579 FAD_0580 FAD_0580 FAD_0581 FAD_0581 FAD_0582 FAD_0582 FAD_0584 FAD_0584 speH speH FAD_0614 FAD_0614 FAD_0637 FAD_0637 FAD_0700 FAD_0700 pdxS pdxS pdxT pdxT queE queE ptps ptps FAD_0757 FAD_0757 FAD_0762 FAD_0762 FAD_0783 FAD_0783 FAD_0824 FAD_0824 FAD_0874 FAD_0874 uxuA uxuA ppcA ppcA pckG pckG FAD_1121 FAD_1121 FAD_1122 FAD_1122 moaA moaA purK purK FAD_1173 FAD_1173 FAD_1196 FAD_1196 FAD_1201 FAD_1201 FAD_1206 FAD_1206 FAD_1235 FAD_1235 ilvD ilvD FAD_1299 FAD_1299 FAD_1314 FAD_1314 FAD_1345 FAD_1345 FAD_1368 FAD_1368 hutU hutU FAD_1395 FAD_1395 FAD_1413 FAD_1413 FAD_1417 FAD_1417 mptD mptD FAD_1438 FAD_1438 FAD_1447 FAD_1447 hisF hisF hisH hisH FAD_1452 FAD_1452 FAD_1475 FAD_1475 taw1 taw1 aroC aroC FAD_1556 FAD_1556 FAD_1605 FAD_1605 FAD_1630 FAD_1630 FAD_1643 FAD_1643 FAD_1709 FAD_1709 FAD_1716 FAD_1716 FAD_1775 FAD_1775 FAD_1789 FAD_1789 FAD_1790 FAD_1790 ogg ogg FAD_1816 FAD_1816 lysT lysT lysU lysU FAD_1849 FAD_1849
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mqnDHypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (271 aa)
nnrDCarbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (457 aa)
FAD_0080Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (227 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (318 aa)
FAD_00993-deoxy-7-phosphoheptulonate synthase. (260 aa)
FAD_0100Indole-3-glycerol-phosphate synthase. (237 aa)
FAD_0101Anthranilate synthase component II. (186 aa)
FAD_0102Anthranilate synthase component I. (383 aa)
FAD_0105Tryptophan synthase alpha chain. (244 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
FAD_01253-dehydroquinate dehydratase. (229 aa)
FAD_0198uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (239 aa)
FAD_0279Cystathionine gamma-lyase. (381 aa)
pdaDPyruvoyl-dependent arginine decarboxylase; Belongs to the PdaD family. (179 aa)
fbpDihydroorotate dehydrogenase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (381 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa)
FAD_0431Hypothetical protein. (631 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (335 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (294 aa)
glyFa2alpha-D-glucoside glucohydrolase 2; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (361 aa)
FAD_0525Hypothetical protein. (288 aa)
FAD_0579Hydrogenase 4 subunit B. (581 aa)
FAD_0580Ni,Fe-hydrogenase III small subunit. (199 aa)
FAD_0581Ni,Fe-hydrogenase III large subunit. (384 aa)
FAD_0582Hydrogenase 4 subunit F. (441 aa)
FAD_0584Formate hydrogenlyase, subunit 4. (313 aa)
speHS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (130 aa)
FAD_0614Siroheme synthase, putative. (164 aa)
FAD_0637Diaminopimelate decarboxylase. (421 aa)
FAD_07002-keto-3-deoxy gluconate aldolase. (290 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (330 aa)
pdxTGlutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (190 aa)
queE7-cyano-7-deazaguanosine biosynthesis protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (229 aa)
ptps6-pyruvoyltetrahydrobiopterin synthase. (157 aa)
FAD_0757Molybdenum cofactor biosynthesis protein C. (146 aa)
FAD_0762Hypothetical protein. (364 aa)
FAD_0783Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (387 aa)
FAD_0824Glutamate decarboxylase. (466 aa)
FAD_0874dTDP-glucose 4,6-dehydratase. (327 aa)
uxuAD-mannonate dehydratase. (329 aa)
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (503 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (598 aa)
FAD_1121Carboxyvinyl-carboxyphosphonate phosphorylmutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (264 aa)
FAD_11222-methylisocitrate synthase. (429 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (315 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (359 aa)
FAD_1173L-fuculose phosphate aldolase. (218 aa)
FAD_11963,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (230 aa)
FAD_1201Putative translaldolase; Multipass membrane protein with frameshifts and 400 bp insertion. (225 aa)
FAD_1206Prephenate dehydratase. (270 aa)
FAD_1235Nucleotide sugar epimerase related protein. (306 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
FAD_1299Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase. (405 aa)
FAD_13143-octaprenyl-4-hydroxybenzoate carboxy-lyase. (481 aa)
FAD_1345Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (322 aa)
FAD_1368Hypothetical protein. (242 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (552 aa)
FAD_1395Histidine ammonia-lyase. (503 aa)
FAD_1413Mandelate racemase subfamily protein. (396 aa)
FAD_1417Mandelate racemase subfamily protein. (409 aa)
mptDHypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD). (118 aa)
FAD_1438Adenylosuccinate lyase. (455 aa)
FAD_1447Glutamate decarboxylase. (459 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (189 aa)
FAD_1452Imidazoleglycerol-phosphate dehydratase. (176 aa)
FAD_1475Putative translaldolase. (223 aa)
taw1tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (325 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (356 aa)
FAD_1556Threonine dehydratase. (401 aa)
FAD_16053-dehydroquinate synthase. (357 aa)
FAD_1630Aspartate ammonia-lyase. (455 aa)
FAD_1643Threonine synthase. (337 aa)
FAD_1709Solute-binding protein. (240 aa)
FAD_1716Threonine synthase. (311 aa)
FAD_1775tRNA splicing endonuclease. (288 aa)
FAD_17893-isopropylmalate dehydratase large subunit. (416 aa)
FAD_17903-isopropylmalate dehydratase small subunit. (175 aa)
oggN-glycosylase/DNA lyase; Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites); Belongs to the type-2 OGG1 family. (209 aa)
FAD_1816Mandelate racemase subfamily protein. (391 aa)
lysTHomoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
lysUHomoaconitase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa)
FAD_1849Argininosuccinate lyase. (438 aa)
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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