STRINGSTRING
FAD_1849 FAD_1849 FAD_0050 FAD_0050 FAD_0059 FAD_0059 FAD_0070 FAD_0070 FAD_0086 FAD_0086 FAD_0100 FAD_0100 FAD_0102 FAD_0102 trpF trpF FAD_0104 FAD_0104 FAD_0105 FAD_0105 trpB trpB FAD_0117 FAD_0117 FAD_0118 FAD_0118 FAD_0125 FAD_0125 argG argG FAD_0198 FAD_0198 FAD_0210 FAD_0210 FAD_0273 FAD_0273 FAD_0274 FAD_0274 serS serS FAD_0378 FAD_0378 proC proC FAD_0491 FAD_0491 lysW lysW lysY lysY lysZ lysZ lysJ lysJ lysX lysX lysK lysK FAD_0529 FAD_0529 FAD_0538 FAD_0538 FAD_0544 FAD_0544 gap gap FAD_0637 FAD_0637 FAD_0643 FAD_0643 FAD_0700 FAD_0700 FAD_0752 FAD_0752 FAD_0782 FAD_0782 FAD_0783 FAD_0783 cysK cysK FAD_1041 FAD_1041 FAD_1043 FAD_1043 FAD_1133 FAD_1133 FAD_1135 FAD_1135 carA carA FAD_1155 FAD_1155 FAD_1206 FAD_1206 folD folD ilvD ilvD ilvC ilvC mtnP mtnP FAD_1364 FAD_1364 FAD_1383 FAD_1383 FAD_1384 FAD_1384 FAD_1398 FAD_1398 hisI hisI hisF hisF FAD_1450 FAD_1450 hisH hisH FAD_1452 FAD_1452 hisD hisD hisG hisG aroC aroC FAD_1533 FAD_1533 FAD_1556 FAD_1556 FAD_1579 FAD_1579 FAD_1605 FAD_1605 FAD_1607 FAD_1607 FAD_1608 FAD_1608 aroA aroA FAD_1643 FAD_1643 FAD_1679 FAD_1679 glyA glyA FAD_1716 FAD_1716 lipA lipA FAD_1789 FAD_1789 FAD_1790 FAD_1790 thrB thrB lysT lysT lysU lysU hicdh hicdh FAD_1847 FAD_1847
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAD_1849Argininosuccinate lyase. (438 aa)
FAD_0050Hypothetical protein; Belongs to the thiolase-like superfamily. UPF0219 family. (351 aa)
FAD_0059Hypothetical protein. (69 aa)
FAD_00704-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa)
FAD_0086Phosphoserine phosphatase. (294 aa)
FAD_0100Indole-3-glycerol-phosphate synthase. (237 aa)
FAD_0102Anthranilate synthase component I. (383 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa)
FAD_0104Anthranilate phosphoribosyltransferase. (324 aa)
FAD_0105Tryptophan synthase alpha chain. (244 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
FAD_0117D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (305 aa)
FAD_0118Serine--pyruvate aminotransferase. (371 aa)
FAD_01253-dehydroquinate dehydratase. (229 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa)
FAD_0198uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (239 aa)
FAD_0210Translation initiation factor IF-2B subunit alpha; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (338 aa)
FAD_0273Methionine synthase. (342 aa)
FAD_0274Hypothetical protein. (293 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (443 aa)
FAD_0378Homoserine dehydrogenase. (327 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (261 aa)
FAD_0491Carboxypeptidase G2 precursor. (376 aa)
lysWAlpha-aminoadipate carrier protein. (57 aa)
lysYN-acetyl-alpha-aminoadipate-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa)
lysZN-acetylaminoadipate kinase. (254 aa)
lysJN2-acetyl-alpha-aminoadipate semialdehyde transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (393 aa)
lysXalpha-aminoadipate--LysW ligase. (282 aa)
lysKN2-acetyl-L-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (355 aa)
FAD_0529Prephenate dehydrogenase. (212 aa)
FAD_0538Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (437 aa)
FAD_05442-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (312 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (344 aa)
FAD_0637Diaminopimelate decarboxylase. (421 aa)
FAD_0643Serine hydroxymethyltransferase. (387 aa)
FAD_07002-keto-3-deoxy gluconate aldolase. (290 aa)
FAD_0752Allantoate amidohydrolase. (399 aa)
FAD_0782Diaminopimelate aminotransferase. (397 aa)
FAD_0783Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (387 aa)
cysKCysteine synthase. (317 aa)
FAD_1041Glutamate synthase (NADPH). (694 aa)
FAD_1043Glutamine synthetase. (441 aa)
FAD_1133Aspartate-semialdehyde dehydrogenase. (339 aa)
FAD_1135Phosphoserine phosphatase. (212 aa)
carACarbamoyl phosphate synthase small subunit; Belongs to the CarA family. (350 aa)
FAD_1155Carbamoyl phosphate synthase large subunit. (1051 aa)
FAD_1206Prephenate dehydratase. (270 aa)
folDMethylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa)
mtnP5'-methylthioadenosine phosphorylase II; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (257 aa)
FAD_1364Glutamine-hydrolyzing asparagine synthase. (242 aa)
FAD_1383RimK family protein. (274 aa)
FAD_1384Histidinol-phosphate aminotransferase. (316 aa)
FAD_1398Allantoate amidohydrolase. (416 aa)
hisIBifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa)
FAD_14501-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Belongs to the HisA/HisF family. (229 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (189 aa)
FAD_1452Imidazoleglycerol-phosphate dehydratase. (176 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa)
hisGATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (356 aa)
FAD_1533Phosphoserine phosphatase. (229 aa)
FAD_1556Threonine dehydratase. (401 aa)
FAD_1579Hypothetical protein. (364 aa)
FAD_16053-dehydroquinate synthase. (357 aa)
FAD_1607Shikimate 5-dehydrogenase. (262 aa)
FAD_1608Shikimate kinase. (272 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa)
FAD_1643Threonine synthase. (337 aa)
FAD_1679Proline racemase. (330 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
FAD_1716Threonine synthase. (311 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (284 aa)
FAD_17893-isopropylmalate dehydratase large subunit. (416 aa)
FAD_17903-isopropylmalate dehydratase small subunit. (175 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
lysTHomoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
lysUHomoaconitase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa)
hicdhHomoisocitrate dehydrogenase. (356 aa)
FAD_1847Glutamine synthetase. (441 aa)
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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