STRINGSTRING
FAD_0008 FAD_0008 FAD_0026 FAD_0026 FAD_0050 FAD_0050 FAD_0051 FAD_0051 mqnD mqnD FAD_0090 FAD_0090 FAD_0099 FAD_0099 FAD_0100 FAD_0100 FAD_0101 FAD_0101 FAD_0102 FAD_0102 trpF trpF FAD_0104 FAD_0104 FAD_0105 FAD_0105 trpB trpB FAD_0107 FAD_0107 gcvH gcvH FAD_0117 FAD_0117 FAD_0125 FAD_0125 ctaB ctaB adkA adkA purF purF hemL hemL FAD_0197 FAD_0197 FAD_0198 FAD_0198 ubiA ubiA FAD_0242 FAD_0242 ubiX ubiX FAD_0273 FAD_0273 FAD_0274 FAD_0274 FAD_0277 FAD_0277 FAD_0279 FAD_0279 ispA ispA FAD_0295 FAD_0295 FAD_0330 FAD_0330 fbp fbp FAD_0339 FAD_0339 eno eno FAD_0364 FAD_0364 glnS glnS FAD_0378 FAD_0378 proC proC pgk pgk FAD_0407 FAD_0407 FAD_0425 FAD_0425 FAD_0428 FAD_0428 apgM apgM FAD_0450 FAD_0450 FAD_0451 FAD_0451 hemE hemE hemH hemH FAD_0466 FAD_0466 glyFa2 glyFa2 FAD_0494 FAD_0494 FAD_0495 FAD_0495 FAD_0502 FAD_0502 lysY lysY lysZ lysZ lysJ lysJ FAD_0513 FAD_0513 FAD_0544 FAD_0544 gap gap FAD_0562 FAD_0562 FAD_0567 FAD_0567 FAD_0568 FAD_0568 FAD_0571 FAD_0571 FAD_0586 FAD_0586 ndk ndk FAD_0602 FAD_0602 FAD_0608 FAD_0608 FAD_0614 FAD_0614 FAD_0637 FAD_0637 FAD_0643 FAD_0643 hemA hemA FAD_0683 FAD_0683 FAD_0696 FAD_0696 FAD_0701 FAD_0701 FAD_0709 FAD_0709 sucD sucD FAD_0712 FAD_0712 FAD_0713 FAD_0713 FAD_0714 FAD_0714 FAD_0715 FAD_0715 FAD_0716 FAD_0716 FAD_0717 FAD_0717 FAD_0718 FAD_0718 deoD deoD FAD_0732 FAD_0732 FAD_0738 FAD_0738 FAD_0762 FAD_0762 FAD_0773 FAD_0773 FAD_0775 FAD_0775 FAD_0783 FAD_0783 FAD_0787 FAD_0787 cysK cysK FAD_0831 FAD_0831 FAD_0873 FAD_0873 FAD_0874 FAD_0874 FAD_0875 FAD_0875 FAD_0876 FAD_0876 FAD_0980 FAD_0980 FAD_1022 FAD_1022 malA malA gdh gdh pckG pckG FAD_1067 FAD_1067 FAD_1085 FAD_1085 FAD_1098 FAD_1098 FAD_1100 FAD_1100 FAD_1110 FAD_1110 FAD_1113 FAD_1113 FAD_1114 FAD_1114 FAD_1130 FAD_1130 FAD_1132 FAD_1132 FAD_1133 FAD_1133 FAD_1135 FAD_1135 surE surE purE purE purK purK FAD_1165 FAD_1165 purC purC FAD_1169 FAD_1169 FAD_1189 FAD_1189 FAD_1196 FAD_1196 FAD_1197 FAD_1197 ribH ribH FAD_1201 FAD_1201 FAD_1206 FAD_1206 FAD_1215 FAD_1215 ribA ribA FAD_1233 FAD_1233 FAD_1242 FAD_1242 FAD_1246 FAD_1246 ilvD ilvD FAD_1250 FAD_1250 ilvC ilvC FAD_1287 FAD_1287 FAD_1293 FAD_1293 FAD_1314 FAD_1314 FAD_1332 FAD_1332 FAD_1338 FAD_1338 FAD_1345 FAD_1345 FAD_1347 FAD_1347 FAD_1350 FAD_1350 FAD_1364 FAD_1364 FAD_1365 FAD_1365 FAD_1373 FAD_1373 FAD_1381 FAD_1381 FAD_1384 FAD_1384 FAD_1419 FAD_1419 purS purS purL purL FAD_1438 FAD_1438 FAD_1447 FAD_1447 hisI hisI hisF hisF FAD_1450 FAD_1450 hisH hisH FAD_1452 FAD_1452 hisD hisD hisG hisG FAD_1455 FAD_1455 FAD_1475 FAD_1475 FAD_1476 FAD_1476 FAD_1477 FAD_1477 FAD_1511 FAD_1511 ispB ispB FAD_1523 FAD_1523 aroC aroC FAD_1533 FAD_1533 FAD_1550 FAD_1550 FAD_1556 FAD_1556 FAD_1577 FAD_1577 FAD_1589 FAD_1589 FAD_1603 FAD_1603 FAD_1605 FAD_1605 FAD_1607 FAD_1607 FAD_1608 FAD_1608 aroA aroA FAD_1632 FAD_1632 FAD_1643 FAD_1643 FAD_1664 FAD_1664 FAD_1704 FAD_1704 FAD_1708 FAD_1708 FAD_1709 FAD_1709 FAD_1710 FAD_1710 glyA glyA FAD_1716 FAD_1716 FAD_1725 FAD_1725 FAD_1732 FAD_1732 rpiA rpiA FAD_1758 FAD_1758 FAD_1759 FAD_1759 lysN lysN guaB guaB FAD_1789 FAD_1789 FAD_1790 FAD_1790 thrB thrB FAD_1809 FAD_1809 pgk2 pgk2 fni fni FAD_1830 FAD_1830 FAD_1832 FAD_1832 hcs hcs lysT lysT lysU lysU hicdh hicdh FAD_1849 FAD_1849 argG argG purM purM
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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FAD_0008Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (287 aa)
FAD_0026Peptidase M48. (334 aa)
FAD_0050Hypothetical protein; Belongs to the thiolase-like superfamily. UPF0219 family. (351 aa)
FAD_0051acetyl-CoA acetyltransferase. (387 aa)
mqnDHypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (271 aa)
FAD_0090Mannose-1-phosphate guanyltransferase. (367 aa)
FAD_00993-deoxy-7-phosphoheptulonate synthase. (260 aa)
FAD_0100Indole-3-glycerol-phosphate synthase. (237 aa)
FAD_0101Anthranilate synthase component II. (186 aa)
FAD_0102Anthranilate synthase component I. (383 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa)
FAD_0104Anthranilate phosphoribosyltransferase. (324 aa)
FAD_0105Tryptophan synthase alpha chain. (244 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
FAD_0107Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (216 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa)
FAD_0117D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (305 aa)
FAD_01253-dehydroquinate dehydratase. (229 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (288 aa)
adkAAdenylate kinase; Belongs to the archaeal adenylate kinase family. (180 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (465 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (420 aa)
FAD_0197Porphobilinogen deaminase. (285 aa)
FAD_0198uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (239 aa)
ubiAPrenyltransferase UbiA family protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (297 aa)
FAD_0242Putative CaaX prenyl protease 1. (328 aa)
ubiXAromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (184 aa)
FAD_0273Methionine synthase. (342 aa)
FAD_0274Hypothetical protein. (293 aa)
FAD_0277ROK family glucokinase. (311 aa)
FAD_0279Cystathionine gamma-lyase. (381 aa)
ispAGeranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (351 aa)
FAD_0295Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (213 aa)
FAD_0330Phosphoribosylformylglycinamidine synthase I. (248 aa)
fbpDihydroorotate dehydrogenase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (381 aa)
FAD_0339uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (429 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa)
FAD_0364Alpha-amylase. (377 aa)
glnSglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (547 aa)
FAD_0378Homoserine dehydrogenase. (327 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (261 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
FAD_0407Phosphoglycolate phosphatase. (223 aa)
FAD_0425Phosphoglycerate mutase/fructose-2,6-bisphosphatase. (189 aa)
FAD_0428Arginine deiminase. (415 aa)
apgMCofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (402 aa)
FAD_0450Glycine dehydrogenase subunit 1. (429 aa)
FAD_0451Glycine dehydrogenase subunit 2. (477 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (335 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (294 aa)
FAD_0466Phosphoribosylamine--glycine ligase. (425 aa)
glyFa2alpha-D-glucoside glucohydrolase 2; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (361 aa)
FAD_0494Alpha, alpha-trehalose-phosphate synthase (UDP-forming) related protein. (445 aa)
FAD_0495Trehalose-phosphatase; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (227 aa)
FAD_05023-oxoacyl-[acyl-carrier-protein] reductase. (261 aa)
lysYN-acetyl-alpha-aminoadipate-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa)
lysZN-acetylaminoadipate kinase. (254 aa)
lysJN2-acetyl-alpha-aminoadipate semialdehyde transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (393 aa)
FAD_0513acetyl-CoA acetyltransferase. (391 aa)
FAD_05442-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (312 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (344 aa)
FAD_0562Bifunctional phosphoglucose/phosphomannose isomerase. (305 aa)
FAD_05672-oxoacid--ferredoxin oxidoreductase, alpha subunit. (582 aa)
FAD_05682-oxoacid ferredoxin oxidoreductase subunit beta. (285 aa)
FAD_0571Hypothetical protein. (150 aa)
FAD_0586Protoporphyrin IX magnesium chelatase related protein. (612 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (139 aa)
FAD_0602Phosphoglucomutase/phosphomannomutase; Belongs to the phosphohexose mutase family. (446 aa)
FAD_0608Hypothetical protein. (232 aa)
FAD_0614Siroheme synthase, putative. (164 aa)
FAD_0637Diaminopimelate decarboxylase. (421 aa)
FAD_0643Serine hydroxymethyltransferase. (387 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (402 aa)
FAD_0683Coenzyme PQQ synthesis protein E. (365 aa)
FAD_0696Short-chain dehydrogenase/reductase SDR. (239 aa)
FAD_0701Aconitate hydratase. (830 aa)
FAD_0709succinyl-CoA synthetase subunit beta. (366 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (284 aa)
FAD_07122-oxoglutarate synthase, alpha chain. (632 aa)
FAD_07132-oxoglutarate ferredoxin oxidoreductase subunit beta. (316 aa)
FAD_0714Succinate dehydrogenase, subunit D. (120 aa)
FAD_0715Succinate dehydrogenase, subunit C. (291 aa)
FAD_0716Succinate dehydrogenase iron-sulfur subunit. (313 aa)
FAD_0717Succinate dehydrogenase flavoprotein subunit. (564 aa)
FAD_0718Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (322 aa)
deoDPurine nucleoside phosphorylase. (233 aa)
FAD_0732HAD family hydrolase. (221 aa)
FAD_0738Aldose 1-epimerase. (268 aa)
FAD_0762Hypothetical protein. (364 aa)
FAD_0773FAD-dependent pyridine nucleotide-disulfide oxidoreductase. (341 aa)
FAD_0775L-asparaginase related protein. (272 aa)
FAD_0783Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (387 aa)
FAD_0787Diphosphomevalonate decarboxylase. (322 aa)
cysKCysteine synthase. (317 aa)
FAD_0831Glycerate kinase; COG2379. (423 aa)
FAD_0873dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (179 aa)
FAD_0874dTDP-glucose 4,6-dehydratase. (327 aa)
FAD_0875dTDP-4-dehydrorhamnose reductase. (275 aa)
FAD_0876Glucose-1-phosphate thymidylyltransferase (graD-2). (351 aa)
FAD_0980acetyl-CoA acetyltransferase. (386 aa)
FAD_1022Acetyl-coenzyme A synthetase. (639 aa)
malAAlpha-glucosidase; Belongs to the glycosyl hydrolase 31 family. (618 aa)
gdhGlucose-1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. (358 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (598 aa)
FAD_1067Fe-S oxidoreductase. (532 aa)
FAD_1085Short-chain alcohol dehydrogenase. (234 aa)
FAD_1098Aspartate aminotransferase. (379 aa)
FAD_1100Citrate synthase. (372 aa)
FAD_1110Purine nucleoside phosphorylase; COG0299. (228 aa)
FAD_1113Hypothetical protein. (297 aa)
FAD_11143-ketoacyl-(acyl-carrier-protein) reductase. (253 aa)
FAD_1130(S)-2-hydroxy-acid oxidase chain D. (470 aa)
FAD_1132Aspartokinase (akH). (348 aa)
FAD_1133Aspartate-semialdehyde dehydrogenase. (339 aa)
FAD_1135Phosphoserine phosphatase. (212 aa)
surEAcid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (269 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (155 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (359 aa)
FAD_1165Citrate synthase. (374 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (296 aa)
FAD_1169Phosphoglycerate mutase. (203 aa)
FAD_11893-hydroxy-3-methylglutaryl-coenzyme A reductase. (401 aa)
FAD_11963,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (230 aa)
FAD_1197Riboflavin synthase. (162 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (134 aa)
FAD_1201Putative translaldolase; Multipass membrane protein with frameshifts and 400 bp insertion. (225 aa)
FAD_1206Prephenate dehydratase. (270 aa)
FAD_1215Glucose-1-dehydrogenase. (362 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (192 aa)
FAD_1233Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (787 aa)
FAD_1242acetyl-CoA acetyltransferase. (387 aa)
FAD_1246Acetyl-CoA acetyltransferase; Frameshift and an internal stop codon in nucleotidyltransferase gene. (393 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
FAD_1250Acetolactate synthase catalytic subunit. (576 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa)
FAD_1287Isocitrate dehydrogenase. (392 aa)
FAD_1293enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
FAD_13143-octaprenyl-4-hydroxybenzoate carboxy-lyase. (481 aa)
FAD_1332Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (500 aa)
FAD_1338S-adenosylmethionine synthetase. (404 aa)
FAD_1345Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (322 aa)
FAD_1347Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (311 aa)
FAD_1350Phosphoglycerate mutase family protein. (199 aa)
FAD_1364Glutamine-hydrolyzing asparagine synthase. (242 aa)
FAD_1365Glycerol-3-phosphate cytidylyltransferase. (135 aa)
FAD_1373Glucose-1-phosphate thymidylyltransferase. (240 aa)
FAD_1381Anaerobic glycerol-3-phosphate dehydrogenase subunit A. (418 aa)
FAD_1384Histidinol-phosphate aminotransferase. (316 aa)
FAD_1419Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (80 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (749 aa)
FAD_1438Adenylosuccinate lyase. (455 aa)
FAD_1447Glutamate decarboxylase. (459 aa)
hisIBifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa)
FAD_14501-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Belongs to the HisA/HisF family. (229 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (189 aa)
FAD_1452Imidazoleglycerol-phosphate dehydratase. (176 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa)
hisGATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)
FAD_1455ATP phosphoribosyltransferase. (250 aa)
FAD_1475Putative translaldolase. (223 aa)
FAD_1476Transketolase subunit B. (317 aa)
FAD_1477Transketolase subunit A. (275 aa)
FAD_15113-ketoacyl-(acyl-carrier-protein) reductase. (255 aa)
ispBPolyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (330 aa)
FAD_1523Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (356 aa)
FAD_1533Phosphoserine phosphatase. (229 aa)
FAD_1550acetyl-CoA acetyltransferase. (410 aa)
FAD_1556Threonine dehydratase. (401 aa)
FAD_1577Hypothetical protein. (284 aa)
FAD_15892-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (345 aa)
FAD_1603Pyruvate kinase; Belongs to the pyruvate kinase family. (559 aa)
FAD_16053-dehydroquinate synthase. (357 aa)
FAD_1607Shikimate 5-dehydrogenase. (262 aa)
FAD_1608Shikimate kinase. (272 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa)
FAD_1632Isocitrate dehydrogenase. (369 aa)
FAD_1643Threonine synthase. (337 aa)
FAD_1664acyl-CoA dehydrogenase. (385 aa)
FAD_1704Phosphoribosylglycinamide formyltransferase. (202 aa)
FAD_1708Hypothetical protein. (368 aa)
FAD_1709Solute-binding protein. (240 aa)
FAD_1710Hypothetical protein. (365 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
FAD_1716Threonine synthase. (311 aa)
FAD_1725Prenyltransferase. (281 aa)
FAD_1732Prenyltransferase. (298 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa)
FAD_1758Branched-chain alpha-keto acid dehydrogenase subunit E2. (384 aa)
FAD_1759Dihydrolipoamide dehydrogenase. (429 aa)
lysNAlpha-aminoadipate aminotransferase. (400 aa)
guaBInosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
FAD_17893-isopropylmalate dehydratase large subunit. (416 aa)
FAD_17903-isopropylmalate dehydratase small subunit. (175 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
FAD_1809Hypothetical protein. (362 aa)
pgk22-phosphoglycerate kinase. (198 aa)
fniIsopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (349 aa)
FAD_1830Kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (242 aa)
FAD_1832Aminomethyltransferase. (368 aa)
hcsHomocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (388 aa)
lysTHomoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
lysUHomoaconitase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa)
hicdhHomoisocitrate dehydrogenase. (356 aa)
FAD_1849Argininosuccinate lyase. (438 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa)
purMPhosphoribosylaminoimidazole synthetase. (335 aa)
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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