STRINGSTRING
FAD_0008 FAD_0008 FAD_0099 FAD_0099 FAD_0100 FAD_0100 FAD_0101 FAD_0101 FAD_0102 FAD_0102 trpF trpF FAD_0104 FAD_0104 FAD_0105 FAD_0105 trpB trpB FAD_0107 FAD_0107 FAD_0117 FAD_0117 FAD_0125 FAD_0125 FAD_0273 FAD_0273 FAD_0274 FAD_0274 FAD_0279 FAD_0279 FAD_0295 FAD_0295 fbp fbp eno eno FAD_0378 FAD_0378 proC proC pgk pgk FAD_0425 FAD_0425 apgM apgM lysY lysY lysZ lysZ lysJ lysJ lysX lysX lysK lysK gap gap FAD_0637 FAD_0637 FAD_0643 FAD_0643 FAD_0701 FAD_0701 FAD_0782 FAD_0782 FAD_0783 FAD_0783 cysK cysK FAD_1043 FAD_1043 FAD_1098 FAD_1098 FAD_1100 FAD_1100 FAD_1132 FAD_1132 FAD_1133 FAD_1133 FAD_1135 FAD_1135 FAD_1165 FAD_1165 FAD_1169 FAD_1169 FAD_1201 FAD_1201 FAD_1206 FAD_1206 ilvD ilvD FAD_1250 FAD_1250 ilvC ilvC FAD_1287 FAD_1287 FAD_1338 FAD_1338 FAD_1350 FAD_1350 FAD_1364 FAD_1364 FAD_1383 FAD_1383 FAD_1384 FAD_1384 hisI hisI hisF hisF FAD_1450 FAD_1450 hisH hisH FAD_1452 FAD_1452 hisD hisD hisG hisG FAD_1455 FAD_1455 FAD_1475 FAD_1475 FAD_1476 FAD_1476 FAD_1477 FAD_1477 FAD_1523 FAD_1523 aroC aroC FAD_1533 FAD_1533 FAD_1556 FAD_1556 FAD_1589 FAD_1589 FAD_1603 FAD_1603 FAD_1605 FAD_1605 FAD_1607 FAD_1607 FAD_1608 FAD_1608 aroA aroA FAD_1632 FAD_1632 FAD_1643 FAD_1643 glyA glyA FAD_1716 FAD_1716 rpiA rpiA FAD_1789 FAD_1789 FAD_1790 FAD_1790 thrB thrB FAD_1809 FAD_1809 hcs hcs lysT lysT lysU lysU hicdh hicdh FAD_1847 FAD_1847 FAD_1849 FAD_1849 argG argG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAD_0008Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (287 aa)
FAD_00993-deoxy-7-phosphoheptulonate synthase. (260 aa)
FAD_0100Indole-3-glycerol-phosphate synthase. (237 aa)
FAD_0101Anthranilate synthase component II. (186 aa)
FAD_0102Anthranilate synthase component I. (383 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa)
FAD_0104Anthranilate phosphoribosyltransferase. (324 aa)
FAD_0105Tryptophan synthase alpha chain. (244 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
FAD_0107Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (216 aa)
FAD_0117D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (305 aa)
FAD_01253-dehydroquinate dehydratase. (229 aa)
FAD_0273Methionine synthase. (342 aa)
FAD_0274Hypothetical protein. (293 aa)
FAD_0279Cystathionine gamma-lyase. (381 aa)
FAD_0295Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (213 aa)
fbpDihydroorotate dehydrogenase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (381 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (402 aa)
FAD_0378Homoserine dehydrogenase. (327 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (261 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa)
FAD_0425Phosphoglycerate mutase/fructose-2,6-bisphosphatase. (189 aa)
apgMCofactor-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (402 aa)
lysYN-acetyl-alpha-aminoadipate-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa)
lysZN-acetylaminoadipate kinase. (254 aa)
lysJN2-acetyl-alpha-aminoadipate semialdehyde transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (393 aa)
lysXalpha-aminoadipate--LysW ligase. (282 aa)
lysKN2-acetyl-L-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (355 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (344 aa)
FAD_0637Diaminopimelate decarboxylase. (421 aa)
FAD_0643Serine hydroxymethyltransferase. (387 aa)
FAD_0701Aconitate hydratase. (830 aa)
FAD_0782Diaminopimelate aminotransferase. (397 aa)
FAD_0783Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (387 aa)
cysKCysteine synthase. (317 aa)
FAD_1043Glutamine synthetase. (441 aa)
FAD_1098Aspartate aminotransferase. (379 aa)
FAD_1100Citrate synthase. (372 aa)
FAD_1132Aspartokinase (akH). (348 aa)
FAD_1133Aspartate-semialdehyde dehydrogenase. (339 aa)
FAD_1135Phosphoserine phosphatase. (212 aa)
FAD_1165Citrate synthase. (374 aa)
FAD_1169Phosphoglycerate mutase. (203 aa)
FAD_1201Putative translaldolase; Multipass membrane protein with frameshifts and 400 bp insertion. (225 aa)
FAD_1206Prephenate dehydratase. (270 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa)
FAD_1250Acetolactate synthase catalytic subunit. (576 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa)
FAD_1287Isocitrate dehydrogenase. (392 aa)
FAD_1338S-adenosylmethionine synthetase. (404 aa)
FAD_1350Phosphoglycerate mutase family protein. (199 aa)
FAD_1364Glutamine-hydrolyzing asparagine synthase. (242 aa)
FAD_1383RimK family protein. (274 aa)
FAD_1384Histidinol-phosphate aminotransferase. (316 aa)
hisIBifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa)
FAD_14501-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Belongs to the HisA/HisF family. (229 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (189 aa)
FAD_1452Imidazoleglycerol-phosphate dehydratase. (176 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa)
hisGATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)
FAD_1455ATP phosphoribosyltransferase. (250 aa)
FAD_1475Putative translaldolase. (223 aa)
FAD_1476Transketolase subunit B. (317 aa)
FAD_1477Transketolase subunit A. (275 aa)
FAD_1523Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (301 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (356 aa)
FAD_1533Phosphoserine phosphatase. (229 aa)
FAD_1556Threonine dehydratase. (401 aa)
FAD_15892-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (345 aa)
FAD_1603Pyruvate kinase; Belongs to the pyruvate kinase family. (559 aa)
FAD_16053-dehydroquinate synthase. (357 aa)
FAD_1607Shikimate 5-dehydrogenase. (262 aa)
FAD_1608Shikimate kinase. (272 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa)
FAD_1632Isocitrate dehydrogenase. (369 aa)
FAD_1643Threonine synthase. (337 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
FAD_1716Threonine synthase. (311 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa)
FAD_17893-isopropylmalate dehydratase large subunit. (416 aa)
FAD_17903-isopropylmalate dehydratase small subunit. (175 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
FAD_1809Hypothetical protein. (362 aa)
hcsHomocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (388 aa)
lysTHomoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (413 aa)
lysUHomoaconitase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (160 aa)
hicdhHomoisocitrate dehydrogenase. (356 aa)
FAD_1847Glutamine synthetase. (441 aa)
FAD_1849Argininosuccinate lyase. (438 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa)
Your Current Organism:
Ferroplasma acidiphilum
NCBI taxonomy Id: 74969
Other names: DSM 12658, F. acidiphilum, Ferromonas metallovorans, Ferroplasma acidiphilum Golyshina et al. 2000, JCM 10970
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