(22 nodes) Drug-mediated inhibition of ERBB2 signaling, and Hsp90 protein binding network (Sinocyclocheilus grahami)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000002367	AHA1, activator of heat shock protein ATPase homolog 1a. (330 aa)
	LOC107557012	Heat shock protein HSP 90-alpha 1 isoform X1. (769 aa)
	ENSSGRP00000006368	annotation not available (105 aa)
	LOC107564585	Heat shock protein HSP 90-alpha 1 isoform X1. (728 aa)
	ENSSGRP00000012813	Heat shock protein HSP 90-alpha. (115 aa)
	ENSSGRP00000012815	annotation not available (115 aa)
	LOC107564074	Stress-induced-phosphoprotein 1-like. (552 aa)
	ENSSGRP00000028234	Heat shock protein 75 kDa, mitochondrial-like. (716 aa)
	cdc37	Cell division cycle protein 37. (384 aa)
	ENSSGRP00000034429	Cell division cycle 37 homolog (S. cerevisiae). (352 aa)
	ENSSGRP00000037894	Serine/threonine-protein phosphatase 5. (430 aa)
	ahsa1	Activator of 90 kDa heat shock protein ATPase homolog 1. (338 aa)
	Trap1	Heat shock protein 75 kDa, mitochondrial. (495 aa)
	LOC107571522	Stress-induced-phosphoprotein 1-like. (551 aa)
	ppp5c	Serine/threonine-protein phosphatase 5. (489 aa)
	LOC107582322	Peptidyl-prolyl cis-trans isomerase G-like isoform X1. (697 aa)
	fkbp5	Peptidyl-prolyl cis-trans isomerase FKBP5. (481 aa)
	LOC107564896	Peptidyl-prolyl cis-trans isomerase FKBP4-like. (465 aa)
	LOC107566702	Peptidyl-prolyl cis-trans isomerase D-like. (373 aa)
	ENSSGRP00000083814	annotation not available (84 aa)
	ENSSGRP00000088787	annotation not available (1031 aa)
	ENSSGRP00000111800	annotation not available (124 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000002367	ENSSGRP00000006368	ENSSGRP00000002367	ENSSGRP00000006368	AHA1, activator of heat shock protein ATPase homolog 1a.	annotation not available	0.729
ENSSGRP00000002367	ENSSGRP00000012813	ENSSGRP00000002367	ENSSGRP00000012813	AHA1, activator of heat shock protein ATPase homolog 1a.	Heat shock protein HSP 90-alpha.	0.854
ENSSGRP00000002367	ENSSGRP00000012815	ENSSGRP00000002367	ENSSGRP00000012815	AHA1, activator of heat shock protein ATPase homolog 1a.	annotation not available	0.854
ENSSGRP00000002367	ENSSGRP00000028234	ENSSGRP00000002367	ENSSGRP00000028234	AHA1, activator of heat shock protein ATPase homolog 1a.	Heat shock protein 75 kDa, mitochondrial-like.	0.792
ENSSGRP00000002367	ENSSGRP00000034429	ENSSGRP00000002367	ENSSGRP00000034429	AHA1, activator of heat shock protein ATPase homolog 1a.	Cell division cycle 37 homolog (S. cerevisiae).	0.581
ENSSGRP00000002367	ENSSGRP00000037894	ENSSGRP00000002367	ENSSGRP00000037894	AHA1, activator of heat shock protein ATPase homolog 1a.	Serine/threonine-protein phosphatase 5.	0.635
ENSSGRP00000002367	ENSSGRP00000083814	ENSSGRP00000002367	ENSSGRP00000083814	AHA1, activator of heat shock protein ATPase homolog 1a.	annotation not available	0.743
ENSSGRP00000002367	ENSSGRP00000088787	ENSSGRP00000002367	ENSSGRP00000088787	AHA1, activator of heat shock protein ATPase homolog 1a.	annotation not available	0.915
ENSSGRP00000002367	ENSSGRP00000111800	ENSSGRP00000002367	ENSSGRP00000111800	AHA1, activator of heat shock protein ATPase homolog 1a.	annotation not available	0.729
ENSSGRP00000002367	LOC107557012	ENSSGRP00000002367	ENSSGRP00000004227	AHA1, activator of heat shock protein ATPase homolog 1a.	Heat shock protein HSP 90-alpha 1 isoform X1.	0.854
ENSSGRP00000002367	LOC107564074	ENSSGRP00000002367	ENSSGRP00000014996	AHA1, activator of heat shock protein ATPase homolog 1a.	Stress-induced-phosphoprotein 1-like.	0.954
ENSSGRP00000002367	LOC107564585	ENSSGRP00000002367	ENSSGRP00000010700	AHA1, activator of heat shock protein ATPase homolog 1a.	Heat shock protein HSP 90-alpha 1 isoform X1.	0.854
ENSSGRP00000002367	LOC107564896	ENSSGRP00000002367	ENSSGRP00000067975	AHA1, activator of heat shock protein ATPase homolog 1a.	Peptidyl-prolyl cis-trans isomerase FKBP4-like.	0.611
ENSSGRP00000002367	LOC107566702	ENSSGRP00000002367	ENSSGRP00000079284	AHA1, activator of heat shock protein ATPase homolog 1a.	Peptidyl-prolyl cis-trans isomerase D-like.	0.915
ENSSGRP00000002367	LOC107571522	ENSSGRP00000002367	ENSSGRP00000053009	AHA1, activator of heat shock protein ATPase homolog 1a.	Stress-induced-phosphoprotein 1-like.	0.954
ENSSGRP00000002367	LOC107582322	ENSSGRP00000002367	ENSSGRP00000062019	AHA1, activator of heat shock protein ATPase homolog 1a.	Peptidyl-prolyl cis-trans isomerase G-like isoform X1.	0.915
ENSSGRP00000002367	Trap1	ENSSGRP00000002367	ENSSGRP00000048970	AHA1, activator of heat shock protein ATPase homolog 1a.	Heat shock protein 75 kDa, mitochondrial.	0.792
ENSSGRP00000002367	cdc37	ENSSGRP00000002367	ENSSGRP00000034013	AHA1, activator of heat shock protein ATPase homolog 1a.	Cell division cycle protein 37.	0.581
ENSSGRP00000002367	fkbp5	ENSSGRP00000002367	ENSSGRP00000067966	AHA1, activator of heat shock protein ATPase homolog 1a.	Peptidyl-prolyl cis-trans isomerase FKBP5.	0.611
ENSSGRP00000002367	ppp5c	ENSSGRP00000002367	ENSSGRP00000060392	AHA1, activator of heat shock protein ATPase homolog 1a.	Serine/threonine-protein phosphatase 5.	0.635