(55 nodes) Sterol biosynthetic process, and Synthesis of bile acids and bile salts via 27-hydroxycholesterol network (Sinocyclocheilus grahami)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000002511	Squalene epoxidase b. (371 aa)
	LOC107548864	Delta(14)-sterol reductase-like. (421 aa)
	ENSSGRP00000006069	annotation not available (131 aa)
	SDR42E1	Short-chain dehydrogenase/reductase family 42E member 1. (353 aa)
	ebp	3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase. (232 aa)
	LOC107580338	5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like. (510 aa)
	fdft1	Farnesyl-diphosphate farnesyltransferase. (451 aa)
	ENSSGRP00000013239	annotation not available (43 aa)
	ENSSGRP00000013630	7-dehydrocholesterol reductase-like isoform X1. (470 aa)
	LOC107567893	Cholesterol 25-hydroxylase-like protein 1, member 2. (276 aa)
	LOC107548349	Methylsterol monooxygenase 1-like. (291 aa)
	LOC107584736	7-dehydrocholesterol reductase. (457 aa)
	LOC107568024	Lanosterol 14-alpha demethylase. (503 aa)
	ENSSGRP00000034181	Sigma non-opioid intracellular receptor 1-like. (201 aa)
	LOC107555490	3-hydroxy-3-methylglutaryl-coenzyme A reductase-like. (906 aa)
	ENSSGRP00000040335	Prostaglandin I2 (prostacyclin) synthase. (482 aa)
	ENSSGRP00000042886	Lanosterol synthase-like. (386 aa)
	LOC107566988	25-hydroxycholesterol 7-alpha-hydroxylase-like. (505 aa)
	LOC107552346	Phosphoethanolamine N-methyltransferase 3-like isoform X1. (500 aa)
	LOC107601526	Delta14-sterol reductase (lamin-B receptor). (609 aa)
	ENSSGRP00000052387	Coiled-coil domain-containing protein 160 homolog. (329 aa)
	ENSSGRP00000052410	Squalene synthase-like. (294 aa)
	LOC107602637	25-hydroxycholesterol 7-alpha-hydroxylase-like isoform X1. (509 aa)
	LOC107592851	R3H domain-containing protein 4-like. (254 aa)
	LOC107594211	Cholesterol 25-hydroxylase-like protein. (251 aa)
	LOC107573076	Sigma non-opioid intracellular receptor 1. (222 aa)
	hmgcs1	Hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1. (580 aa)
	LOC107553478	Delta14-sterol reductase (lamin-B receptor). (611 aa)
	ENSSGRP00000069837	Si:ch1073-429i10.1. (401 aa)
	ENSSGRP00000072389	Short chain dehydrogenase/reductase family 42E, member 1. (376 aa)
	LOC107555157	Delta(14)-sterol reductase-like. (421 aa)
	ENSSGRP00000074943	annotation not available (88 aa)
	LOC107596167	Cholesterol 25-hydroxylase-like protein. (264 aa)
	ENSSGRP00000076525	Cholesterol 25-hydroxylase like 1, tandem duplicate 2. (276 aa)
	ENSSGRP00000076529	Cholesterol 25-hydroxylase like 1, tandem duplicate 1. (232 aa)
	LOC107554123	3 beta-hydroxysteroid dehydrogenase type 7-like isoform X1. (367 aa)
	Faxdc2	Fatty acid hydroxylase domain-containing protein 2. (236 aa)
	nsdhl	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating. (383 aa)
	LOC107561054	Delta7-sterol 5-desaturase. (298 aa)
	ENSSGRP00000095124	Cytochrome P450, family 39, subfamily A, polypeptide 1. (392 aa)
	LOC107596343	Phosphoethanolamine N-methyltransferase 3-like isoform X1. (498 aa)
	ENSSGRP00000096012	Squalene monooxygenase-like. (535 aa)
	LOC107558014	5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like. (510 aa)
	ENSSGRP00000097275	annotation not available (175 aa)
	ERG28	Probable ergosterol biosynthetic protein 28. (143 aa)
	LOC107591587	Methylsterol monooxygenase 1. (291 aa)
	LOC107548136	Delta7-sterol 5-desaturase. (362 aa)
	LOC107584572	Cholesterol 25-hydroxylase-like protein 2. (290 aa)
	LOC107556968	Squalene monooxygenase-like. (557 aa)
	CYP8B1	Cytochrome P450 family 8 subfamily B member 1. (492 aa)
	LOC107581458	Delta(24)-sterol reductase-like. (516 aa)
	LOC107555356	Sterol 26-hydroxylase, mitochondrial-like. (563 aa)
	LOC107582995	Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase. (367 aa)
	LOC107566150	Delta(24)-sterol reductase-like isoform X1. (516 aa)
	LOC107551038	17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase. (359 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP8B1	ENSSGRP00000002511	ENSSGRP00000107144	ENSSGRP00000002511	Cytochrome P450 family 8 subfamily B member 1.	Squalene epoxidase b.	0.747
CYP8B1	ENSSGRP00000006069	ENSSGRP00000107144	ENSSGRP00000006069	Cytochrome P450 family 8 subfamily B member 1.	annotation not available	0.710
CYP8B1	ENSSGRP00000013239	ENSSGRP00000107144	ENSSGRP00000013239	Cytochrome P450 family 8 subfamily B member 1.	annotation not available	0.710
CYP8B1	ENSSGRP00000013630	ENSSGRP00000107144	ENSSGRP00000013630	Cytochrome P450 family 8 subfamily B member 1.	7-dehydrocholesterol reductase-like isoform X1.	0.623
CYP8B1	ENSSGRP00000034181	ENSSGRP00000107144	ENSSGRP00000034181	Cytochrome P450 family 8 subfamily B member 1.	Sigma non-opioid intracellular receptor 1-like.	0.795
CYP8B1	ENSSGRP00000042886	ENSSGRP00000107144	ENSSGRP00000042886	Cytochrome P450 family 8 subfamily B member 1.	Lanosterol synthase-like.	0.936
CYP8B1	ENSSGRP00000052410	ENSSGRP00000107144	ENSSGRP00000052410	Cytochrome P450 family 8 subfamily B member 1.	Squalene synthase-like.	0.710
CYP8B1	ENSSGRP00000069837	ENSSGRP00000107144	ENSSGRP00000069837	Cytochrome P450 family 8 subfamily B member 1.	Si:ch1073-429i10.1.	0.623
CYP8B1	ENSSGRP00000072389	ENSSGRP00000107144	ENSSGRP00000072389	Cytochrome P450 family 8 subfamily B member 1.	Short chain dehydrogenase/reductase family 42E, member 1.	0.694
CYP8B1	ENSSGRP00000074943	ENSSGRP00000107144	ENSSGRP00000074943	Cytochrome P450 family 8 subfamily B member 1.	annotation not available	0.623
CYP8B1	ENSSGRP00000076525	ENSSGRP00000107144	ENSSGRP00000076525	Cytochrome P450 family 8 subfamily B member 1.	Cholesterol 25-hydroxylase like 1, tandem duplicate 2.	0.756
CYP8B1	ENSSGRP00000076529	ENSSGRP00000107144	ENSSGRP00000076529	Cytochrome P450 family 8 subfamily B member 1.	Cholesterol 25-hydroxylase like 1, tandem duplicate 1.	0.756
CYP8B1	ENSSGRP00000096012	ENSSGRP00000107144	ENSSGRP00000096012	Cytochrome P450 family 8 subfamily B member 1.	Squalene monooxygenase-like.	0.747
CYP8B1	ENSSGRP00000097275	ENSSGRP00000107144	ENSSGRP00000097275	Cytochrome P450 family 8 subfamily B member 1.	annotation not available	0.529
CYP8B1	ERG28	ENSSGRP00000107144	ENSSGRP00000101122	Cytochrome P450 family 8 subfamily B member 1.	Probable ergosterol biosynthetic protein 28.	0.882
CYP8B1	Faxdc2	ENSSGRP00000107144	ENSSGRP00000082382	Cytochrome P450 family 8 subfamily B member 1.	Fatty acid hydroxylase domain-containing protein 2.	0.756
CYP8B1	LOC107548136	ENSSGRP00000107144	ENSSGRP00000103611	Cytochrome P450 family 8 subfamily B member 1.	Delta7-sterol 5-desaturase.	0.718
CYP8B1	LOC107548349	ENSSGRP00000107144	ENSSGRP00000024478	Cytochrome P450 family 8 subfamily B member 1.	Methylsterol monooxygenase 1-like.	0.756
CYP8B1	LOC107548864	ENSSGRP00000107144	ENSSGRP00000003542	Cytochrome P450 family 8 subfamily B member 1.	Delta(14)-sterol reductase-like.	0.623
CYP8B1	LOC107551038	ENSSGRP00000107144	ENSSGRP00000113050	Cytochrome P450 family 8 subfamily B member 1.	17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase.	0.881