(38 nodes) Cytoskeleton-nuclear membrane anchor activity, and Breakdown of the nuclear lamina network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lemd3	Inner nuclear membrane protein Man1. (844 aa)
	ENSSGRP00000004801	Lamin-L(II)-like. (84 aa)
	LOC107579078	Barrier-to-autointegration factor-like. (90 aa)
	LOC107587813	Lamin-A-like. (657 aa)
	ENSSGRP00000010974	Spectrin repeat containing, nuclear envelope 2b. (372 aa)
	ENSSGRP00000017647	annotation not available (4491 aa)
	ENSSGRP00000023012	SUN domain-containing protein 1-like. (390 aa)
	ENSSGRP00000029842	Lamin-B2-like. (563 aa)
	DST	Dystonin. (6144 aa)
	LOC107570199	Lamin-L(III)-like isoform X1. (622 aa)
	ENSSGRP00000044183	SUN domain-containing protein 2-like isoform X1. (558 aa)
	LOC107551414	Lamina-associated polypeptide 2-like isoform X1. (366 aa)
	ENSSGRP00000044997	annotation not available (1435 aa)
	ENSSGRP00000047987	Spectrin repeat containing, nuclear envelope 2b. (398 aa)
	LOC107560939	Emerin-like. (190 aa)
	LOC107569195	SUN domain-containing protein 1-like. (850 aa)
	ENSSGRP00000049964	Nesprin-1-like. (6634 aa)
	LOC107570273	Emerin-like. (190 aa)
	ENSSGRP00000061920	Si:dkey-211g8.4. (99 aa)
	ENSSGRP00000061923	Si:dkey-211g8.4. (97 aa)
	ENSSGRP00000066302	Sad1 and UNC84 domain containing 1. (989 aa)
	ENSSGRP00000069183	Lamin B1. (564 aa)
	ENSSGRP00000069196	Nesprin-3-like. (1054 aa)
	LOC107590013	Lamina-associated polypeptide 2-like isoform X1. (682 aa)
	ENSSGRP00000070866	Nesprin-3-like. (1027 aa)
	ENSSGRP00000075164	Plectin-like. (4595 aa)
	LOC107569350	Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma-like. (408 aa)
	CASP6	Caspase-6-like. (300 aa)
	ENSSGRP00000082733	Nesprin-1-like. (8640 aa)
	syne4	Nesprin-4 isoform X1. (622 aa)
	ENSSGRP00000085110	annotation not available (243 aa)
	ENSSGRP00000086438	LEM domain containing 3. (781 aa)
	LOC107548595	Uncharacterized protein LOC107548595 isoform X1. (653 aa)
	LOC107565618	SUN domain-containing protein 1-like isoform X1. (959 aa)
	LOC107598000	Lamin-A-like. (673 aa)
	ENSSGRP00000092775	Nesprin-1-like. (8558 aa)
	ENSSGRP00000102890	Lamin-B2-like. (631 aa)
	LOC107548237	Barrier-to-autointegration factor. (90 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP6	ENSSGRP00000004801	ENSSGRP00000082653	ENSSGRP00000004801	Caspase-6-like.	Lamin-L(II)-like.	0.657
CASP6	ENSSGRP00000029842	ENSSGRP00000082653	ENSSGRP00000029842	Caspase-6-like.	Lamin-B2-like.	0.964
CASP6	ENSSGRP00000069183	ENSSGRP00000082653	ENSSGRP00000069183	Caspase-6-like.	Lamin B1.	0.657
CASP6	ENSSGRP00000102890	ENSSGRP00000082653	ENSSGRP00000102890	Caspase-6-like.	Lamin-B2-like.	0.964
CASP6	LOC107570199	ENSSGRP00000082653	ENSSGRP00000038733	Caspase-6-like.	Lamin-L(III)-like isoform X1.	0.964
CASP6	LOC107587813	ENSSGRP00000082653	ENSSGRP00000010935	Caspase-6-like.	Lamin-A-like.	0.966
CASP6	LOC107598000	ENSSGRP00000082653	ENSSGRP00000091756	Caspase-6-like.	Lamin-A-like.	0.966
DST	ENSSGRP00000017647	ENSSGRP00000035368	ENSSGRP00000017647	Dystonin.	annotation not available	0.499
DST	ENSSGRP00000075164	ENSSGRP00000035368	ENSSGRP00000075164	Dystonin.	Plectin-like.	0.499
ENSSGRP00000004801	CASP6	ENSSGRP00000004801	ENSSGRP00000082653	Lamin-L(II)-like.	Caspase-6-like.	0.657
ENSSGRP00000004801	ENSSGRP00000023012	ENSSGRP00000004801	ENSSGRP00000023012	Lamin-L(II)-like.	SUN domain-containing protein 1-like.	0.582
ENSSGRP00000004801	ENSSGRP00000044183	ENSSGRP00000004801	ENSSGRP00000044183	Lamin-L(II)-like.	SUN domain-containing protein 2-like isoform X1.	0.582
ENSSGRP00000004801	ENSSGRP00000044997	ENSSGRP00000004801	ENSSGRP00000044997	Lamin-L(II)-like.	annotation not available	0.681
ENSSGRP00000004801	ENSSGRP00000061920	ENSSGRP00000004801	ENSSGRP00000061920	Lamin-L(II)-like.	Si:dkey-211g8.4.	0.794
ENSSGRP00000004801	ENSSGRP00000061923	ENSSGRP00000004801	ENSSGRP00000061923	Lamin-L(II)-like.	Si:dkey-211g8.4.	0.794
ENSSGRP00000004801	ENSSGRP00000066302	ENSSGRP00000004801	ENSSGRP00000066302	Lamin-L(II)-like.	Sad1 and UNC84 domain containing 1.	0.714
ENSSGRP00000004801	ENSSGRP00000082733	ENSSGRP00000004801	ENSSGRP00000082733	Lamin-L(II)-like.	Nesprin-1-like.	0.570
ENSSGRP00000004801	ENSSGRP00000085110	ENSSGRP00000004801	ENSSGRP00000085110	Lamin-L(II)-like.	annotation not available	0.582
ENSSGRP00000004801	ENSSGRP00000086438	ENSSGRP00000004801	ENSSGRP00000086438	Lamin-L(II)-like.	LEM domain containing 3.	0.749
ENSSGRP00000004801	ENSSGRP00000092775	ENSSGRP00000004801	ENSSGRP00000092775	Lamin-L(II)-like.	Nesprin-1-like.	0.570