(32 nodes) Mixed, incl. Negative regulation of phosphatidylinositol 3-kinase signaling, and Positive regulation of early endosome to late endosome transport network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000000377	annotation not available (233 aa)
	Prkce	Novel protein kinase C epsilon type. (211 aa)
	ENSSGRP00000004162	Radixin-like. (122 aa)
	ENSSGRP00000010558	Basic proline-rich protein-like isoform X1. (326 aa)
	LOC107564092	Solute carrier family 9 (sodium/hydrogen exchanger), member 1. (782 aa)
	LOC107574818	Solute carrier family 9 (sodium/hydrogen exchanger), member 1. (736 aa)
	chp1	Calcineurin B homologous protein 1. (195 aa)
	LOC107581587	Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (365 aa)
	ENSSGRP00000029009	Moesin-like. (612 aa)
	LOC107549516	Villin 2 (ezrin). (592 aa)
	LOC107583749	Cystic fibrosis transmembrane conductance regulator-like. (1485 aa)
	ENSSGRP00000043007	Moesin-like. (586 aa)
	LOC107565796	Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (365 aa)
	LOC107550054	Novel protein kinase C epsilon type. (743 aa)
	LOC107559900	Radixin-like. (605 aa)
	ENSSGRP00000047131	Moesin-like. (593 aa)
	ENSSGRP00000047238	Neurofibromin 2a (merlin). (547 aa)
	LOC107598530	Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like. (359 aa)
	MME-2	Neprilysin. (740 aa)
	ENSSGRP00000064723	annotation not available (355 aa)
	LOC107549678	Golgi-associated PDZ and coiled-coil motif-containing protein-like. (459 aa)
	ENSSGRP00000066321	Na(+)/H(+) exchange regulatory cofactor NHE-RF2-like. (188 aa)
	ENSSGRP00000072702	CD44 antigen-like. (84 aa)
	ENSSGRP00000076578	SLC9A3 regulator 1b. (318 aa)
	slc9a3r2	Sodium/hydrogen exchange regulatory cofactor NHE-RF2. (305 aa)
	LOC107573310	Merlin-like. (614 aa)
	ENSSGRP00000084728	Crumbs cell polarity complex component 1. (1351 aa)
	LOC107562318	Villin 2 (ezrin). (566 aa)
	ENSSGRP00000098157	annotation not available (368 aa)
	LOC107588847	Radixin. (582 aa)
	LOC107596947	Cystic fibrosis transmembrane conductance regulator-like. (1485 aa)
	LOC107552533	Solute carrier family 9 (sodium/hydrogen exchanger), member 1. (780 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000000377	ENSSGRP00000004162	ENSSGRP00000000377	ENSSGRP00000004162	annotation not available	Radixin-like.	0.488
ENSSGRP00000000377	ENSSGRP00000010558	ENSSGRP00000000377	ENSSGRP00000010558	annotation not available	Basic proline-rich protein-like isoform X1.	0.699
ENSSGRP00000000377	ENSSGRP00000029009	ENSSGRP00000000377	ENSSGRP00000029009	annotation not available	Moesin-like.	0.488
ENSSGRP00000000377	ENSSGRP00000047131	ENSSGRP00000000377	ENSSGRP00000047131	annotation not available	Moesin-like.	0.488
ENSSGRP00000000377	ENSSGRP00000047238	ENSSGRP00000000377	ENSSGRP00000047238	annotation not available	Neurofibromin 2a (merlin).	0.511
ENSSGRP00000000377	ENSSGRP00000064723	ENSSGRP00000000377	ENSSGRP00000064723	annotation not available	annotation not available	0.488
ENSSGRP00000000377	LOC107549516	ENSSGRP00000000377	ENSSGRP00000037151	annotation not available	Villin 2 (ezrin).	0.488
ENSSGRP00000000377	LOC107559900	ENSSGRP00000000377	ENSSGRP00000046647	annotation not available	Radixin-like.	0.488
ENSSGRP00000000377	LOC107562318	ENSSGRP00000000377	ENSSGRP00000089709	annotation not available	Villin 2 (ezrin).	0.488
ENSSGRP00000000377	LOC107573310	ENSSGRP00000000377	ENSSGRP00000083804	annotation not available	Merlin-like.	0.511
ENSSGRP00000000377	LOC107583749	ENSSGRP00000000377	ENSSGRP00000038147	annotation not available	Cystic fibrosis transmembrane conductance regulator-like.	0.735
ENSSGRP00000000377	LOC107588847	ENSSGRP00000000377	ENSSGRP00000103869	annotation not available	Radixin.	0.488
ENSSGRP00000000377	LOC107596947	ENSSGRP00000000377	ENSSGRP00000103984	annotation not available	Cystic fibrosis transmembrane conductance regulator-like.	0.735
ENSSGRP00000004162	ENSSGRP00000000377	ENSSGRP00000004162	ENSSGRP00000000377	Radixin-like.	annotation not available	0.488
ENSSGRP00000004162	ENSSGRP00000010558	ENSSGRP00000004162	ENSSGRP00000010558	Radixin-like.	Basic proline-rich protein-like isoform X1.	0.408
ENSSGRP00000004162	ENSSGRP00000029009	ENSSGRP00000004162	ENSSGRP00000029009	Radixin-like.	Moesin-like.	0.408
ENSSGRP00000004162	ENSSGRP00000047131	ENSSGRP00000004162	ENSSGRP00000047131	Radixin-like.	Moesin-like.	0.408
ENSSGRP00000004162	ENSSGRP00000066321	ENSSGRP00000004162	ENSSGRP00000066321	Radixin-like.	Na(+)/H(+) exchange regulatory cofactor NHE-RF2-like.	0.488
ENSSGRP00000004162	ENSSGRP00000072702	ENSSGRP00000004162	ENSSGRP00000072702	Radixin-like.	CD44 antigen-like.	0.512
ENSSGRP00000004162	ENSSGRP00000076578	ENSSGRP00000004162	ENSSGRP00000076578	Radixin-like.	SLC9A3 regulator 1b.	0.511