(27 nodes) Mixed, incl. AP-2 adaptor complex, and Clathrin-dependent synaptic vesicle endocytosis network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000002340	annotation not available (52 aa)
	LOC107599798	Epidermal growth factor receptor substrate 15-like isoform X1. (1036 aa)
	ENSSGRP00000006224	AP-2 complex subunit sigma-like. (109 aa)
	ENSSGRP00000007358	AP-2 complex subunit beta-like. (925 aa)
	ENSSGRP00000008599	Epidermal growth factor receptor pathway substrate 15-like 1a. (908 aa)
	ENSSGRP00000012934	Intersectin 2a. (566 aa)
	LOC107574125	Adaptin ear-binding coat-associated protein 2-like. (261 aa)
	LOC107598387	Epsin-1-like isoform X1. (645 aa)
	LOC107599542	Adaptin ear-binding coat-associated protein 1-like. (260 aa)
	ENSSGRP00000063770	Intersectin 1 (SH3 domain protein). (1620 aa)
	ENSSGRP00000064613	AP-2 complex subunit mu-like. (418 aa)
	ENSSGRP00000070211	LOW QUALITY PROTEIN: intersectin-1-like. (1581 aa)
	ENSSGRP00000074134	Intersectin-2-like. (1586 aa)
	ap2b1	AP-2 complex subunit beta-1. (959 aa)
	ENSSGRP00000079554	annotation not available (557 aa)
	LOC107554102	AP-2 complex subunit alpha-2-like isoform X1. (983 aa)
	ENSSGRP00000081174	Adaptor related protein complex 2 subunit sigma 1. (148 aa)
	ENSSGRP00000084141	Intersectin 2b. (1577 aa)
	LOC107594821	Intersectin-2-like isoform X1. (1827 aa)
	ENSSGRP00000088719	AP-2 complex subunit mu-A-like isoform X1. (434 aa)
	LOC107588275	Stonin-2-like isoform X1. (859 aa)
	ENSSGRP00000106142	AP-2 complex subunit mu-B-like. (372 aa)
	Ap2s1	AP-2 complex subunit sigma isoform X1. (152 aa)
	ENSSGRP00000106577	Adaptor related protein complex 2 subunit sigma 1. (151 aa)
	LOC107593770	AP-2 complex subunit mu-A isoform X1. (436 aa)
	LOC107589372	Adaptin ear-binding coat-associated protein 1-like. (260 aa)
	ENSSGRP00000111852	Adaptor related protein complex 2 subunit alpha 1. (956 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ap2s1	ENSSGRP00000002340	ENSSGRP00000106573	ENSSGRP00000002340	AP-2 complex subunit sigma isoform X1.	annotation not available	0.908
Ap2s1	ENSSGRP00000006224	ENSSGRP00000106573	ENSSGRP00000006224	AP-2 complex subunit sigma isoform X1.	AP-2 complex subunit sigma-like.	0.901
Ap2s1	ENSSGRP00000007358	ENSSGRP00000106573	ENSSGRP00000007358	AP-2 complex subunit sigma isoform X1.	AP-2 complex subunit beta-like.	0.990
Ap2s1	ENSSGRP00000008599	ENSSGRP00000106573	ENSSGRP00000008599	AP-2 complex subunit sigma isoform X1.	Epidermal growth factor receptor pathway substrate 15-like 1a.	0.783
Ap2s1	ENSSGRP00000012934	ENSSGRP00000106573	ENSSGRP00000012934	AP-2 complex subunit sigma isoform X1.	Intersectin 2a.	0.994
Ap2s1	ENSSGRP00000063770	ENSSGRP00000106573	ENSSGRP00000063770	AP-2 complex subunit sigma isoform X1.	Intersectin 1 (SH3 domain protein).	0.989
Ap2s1	ENSSGRP00000064613	ENSSGRP00000106573	ENSSGRP00000064613	AP-2 complex subunit sigma isoform X1.	AP-2 complex subunit mu-like.	0.950
Ap2s1	ENSSGRP00000070211	ENSSGRP00000106573	ENSSGRP00000070211	AP-2 complex subunit sigma isoform X1.	LOW QUALITY PROTEIN: intersectin-1-like.	0.989
Ap2s1	ENSSGRP00000074134	ENSSGRP00000106573	ENSSGRP00000074134	AP-2 complex subunit sigma isoform X1.	Intersectin-2-like.	0.994
Ap2s1	ENSSGRP00000079554	ENSSGRP00000106573	ENSSGRP00000079554	AP-2 complex subunit sigma isoform X1.	annotation not available	0.783
Ap2s1	ENSSGRP00000084141	ENSSGRP00000106573	ENSSGRP00000084141	AP-2 complex subunit sigma isoform X1.	Intersectin 2b.	0.994
Ap2s1	ENSSGRP00000088719	ENSSGRP00000106573	ENSSGRP00000088719	AP-2 complex subunit sigma isoform X1.	AP-2 complex subunit mu-A-like isoform X1.	0.994
Ap2s1	ENSSGRP00000106142	ENSSGRP00000106573	ENSSGRP00000106142	AP-2 complex subunit sigma isoform X1.	AP-2 complex subunit mu-B-like.	0.994
Ap2s1	ENSSGRP00000111852	ENSSGRP00000106573	ENSSGRP00000111852	AP-2 complex subunit sigma isoform X1.	Adaptor related protein complex 2 subunit alpha 1.	0.976
Ap2s1	LOC107554102	ENSSGRP00000106573	ENSSGRP00000080837	AP-2 complex subunit sigma isoform X1.	AP-2 complex subunit alpha-2-like isoform X1.	0.997
Ap2s1	LOC107574125	ENSSGRP00000106573	ENSSGRP00000018678	AP-2 complex subunit sigma isoform X1.	Adaptin ear-binding coat-associated protein 2-like.	0.818
Ap2s1	LOC107588275	ENSSGRP00000106573	ENSSGRP00000102326	AP-2 complex subunit sigma isoform X1.	Stonin-2-like isoform X1.	0.782
Ap2s1	LOC107589372	ENSSGRP00000106573	ENSSGRP00000109495	AP-2 complex subunit sigma isoform X1.	Adaptin ear-binding coat-associated protein 1-like.	0.818
Ap2s1	LOC107593770	ENSSGRP00000106573	ENSSGRP00000108622	AP-2 complex subunit sigma isoform X1.	AP-2 complex subunit mu-A isoform X1.	0.994
Ap2s1	LOC107594821	ENSSGRP00000106573	ENSSGRP00000087700	AP-2 complex subunit sigma isoform X1.	Intersectin-2-like isoform X1.	0.994