(12 nodes) Inflammatory response, and NAD+ nucleosidase activity network (Sinocyclocheilus grahami)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107576986	Toll-like receptor 4. (550 aa)
	LOC107566285	Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. (234 aa)
	irak1	Interleukin-1 receptor-associated kinase 1 isoform X1. (704 aa)
	LOC107590711	Toll-like receptor 2 type-2 isoform X1. (790 aa)
	irak4	Interleukin-1 receptor-associated kinase 4. (492 aa)
	myd88	Myeloid differentiation primary response protein MyD88. (284 aa)
	ENSSGRP00000059767	Toll-interacting protein-like. (278 aa)
	LOC107550181	Toll-interacting protein. (279 aa)
	LOC107584943	Myeloid differentiation primary response protein MyD88-like. (284 aa)
	LOC107597981	Toll-like receptor 2. (841 aa)
	ENSSGRP00000096223	Toll-like receptor 4. (760 aa)
	LOC107559615	Toll-like receptor 1. (797 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000059767	ENSSGRP00000096223	ENSSGRP00000059767	ENSSGRP00000096223	Toll-interacting protein-like.	Toll-like receptor 4.	0.453
ENSSGRP00000059767	LOC107550181	ENSSGRP00000059767	ENSSGRP00000063175	Toll-interacting protein-like.	Toll-interacting protein.	0.900
ENSSGRP00000059767	LOC107566285	ENSSGRP00000059767	ENSSGRP00000029298	Toll-interacting protein-like.	Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein.	0.861
ENSSGRP00000059767	LOC107576986	ENSSGRP00000059767	ENSSGRP00000002901	Toll-interacting protein-like.	Toll-like receptor 4.	0.453
ENSSGRP00000059767	LOC107584943	ENSSGRP00000059767	ENSSGRP00000082576	Toll-interacting protein-like.	Myeloid differentiation primary response protein MyD88-like.	0.969
ENSSGRP00000059767	LOC107590711	ENSSGRP00000059767	ENSSGRP00000037361	Toll-interacting protein-like.	Toll-like receptor 2 type-2 isoform X1.	0.936
ENSSGRP00000059767	LOC107597981	ENSSGRP00000059767	ENSSGRP00000091104	Toll-interacting protein-like.	Toll-like receptor 2.	0.926
ENSSGRP00000059767	irak1	ENSSGRP00000059767	ENSSGRP00000036935	Toll-interacting protein-like.	Interleukin-1 receptor-associated kinase 1 isoform X1.	0.925
ENSSGRP00000059767	irak4	ENSSGRP00000059767	ENSSGRP00000044806	Toll-interacting protein-like.	Interleukin-1 receptor-associated kinase 4.	0.927
ENSSGRP00000059767	myd88	ENSSGRP00000059767	ENSSGRP00000057314	Toll-interacting protein-like.	Myeloid differentiation primary response protein MyD88.	0.969
ENSSGRP00000096223	ENSSGRP00000059767	ENSSGRP00000096223	ENSSGRP00000059767	Toll-like receptor 4.	Toll-interacting protein-like.	0.453
ENSSGRP00000096223	LOC107550181	ENSSGRP00000096223	ENSSGRP00000063175	Toll-like receptor 4.	Toll-interacting protein.	0.453
ENSSGRP00000096223	LOC107559615	ENSSGRP00000096223	ENSSGRP00000103255	Toll-like receptor 4.	Toll-like receptor 1.	0.713
ENSSGRP00000096223	LOC107566285	ENSSGRP00000096223	ENSSGRP00000029298	Toll-like receptor 4.	Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein.	0.978
ENSSGRP00000096223	LOC107576986	ENSSGRP00000096223	ENSSGRP00000002901	Toll-like receptor 4.	Toll-like receptor 4.	0.900
ENSSGRP00000096223	LOC107584943	ENSSGRP00000096223	ENSSGRP00000082576	Toll-like receptor 4.	Myeloid differentiation primary response protein MyD88-like.	0.991
ENSSGRP00000096223	LOC107590711	ENSSGRP00000096223	ENSSGRP00000037361	Toll-like receptor 4.	Toll-like receptor 2 type-2 isoform X1.	0.641
ENSSGRP00000096223	LOC107597981	ENSSGRP00000096223	ENSSGRP00000091104	Toll-like receptor 4.	Toll-like receptor 2.	0.641
ENSSGRP00000096223	irak1	ENSSGRP00000096223	ENSSGRP00000036935	Toll-like receptor 4.	Interleukin-1 receptor-associated kinase 1 isoform X1.	0.646
ENSSGRP00000096223	irak4	ENSSGRP00000096223	ENSSGRP00000044806	Toll-like receptor 4.	Interleukin-1 receptor-associated kinase 4.	0.731