(14 nodes) Activation of caspases through apoptosome-mediated cleavage, and Second Mitochondria-derived Activator of Caspases network (Sinocyclocheilus grahami)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000005498	Apoptotic protease-activating factor 1-like. (1031 aa)
	LOC107561284	E3 ubiquitin-protein ligase XIAP-like isoform X1. (452 aa)
	LOC107593914	Caspase-9-like isoform X1. (436 aa)
	casp3	Caspase 3. (282 aa)
	LOC107582616	Diablo homolog, mitochondrial-like isoform X1. (264 aa)
	apaf1	Apoptotic protease-activating factor 1. (1215 aa)
	LOC107584771	Cytochrome c. (104 aa)
	LOC107562747	Caspase-3-like. (276 aa)
	LOC107601340	Baculoviral IAP repeat-containing protein 7-like isoform X1. (455 aa)
	LOC107588772	Diablo homolog, mitochondrial-like isoform X1. (267 aa)
	LOC107589300	Diablo homolog, mitochondrial-like. (235 aa)
	LOC107600151	E3 ubiquitin-protein ligase XIAP-like isoform X1. (447 aa)
	casp9	Caspase-9 isoform X1. (436 aa)
	LOC107581377	Cytochrome c-like. (104 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000005498	LOC107561284	ENSSGRP00000005498	ENSSGRP00000018963	Apoptotic protease-activating factor 1-like.	E3 ubiquitin-protein ligase XIAP-like isoform X1.	0.874
ENSSGRP00000005498	LOC107562747	ENSSGRP00000005498	ENSSGRP00000077939	Apoptotic protease-activating factor 1-like.	Caspase-3-like.	0.836
ENSSGRP00000005498	LOC107581377	ENSSGRP00000005498	ENSSGRP00000108697	Apoptotic protease-activating factor 1-like.	Cytochrome c-like.	0.999
ENSSGRP00000005498	LOC107582616	ENSSGRP00000005498	ENSSGRP00000028866	Apoptotic protease-activating factor 1-like.	Diablo homolog, mitochondrial-like isoform X1.	0.807
ENSSGRP00000005498	LOC107584771	ENSSGRP00000005498	ENSSGRP00000054104	Apoptotic protease-activating factor 1-like.	Cytochrome c.	0.999
ENSSGRP00000005498	LOC107588772	ENSSGRP00000005498	ENSSGRP00000093007	Apoptotic protease-activating factor 1-like.	Diablo homolog, mitochondrial-like isoform X1.	0.807
ENSSGRP00000005498	LOC107589300	ENSSGRP00000005498	ENSSGRP00000094706	Apoptotic protease-activating factor 1-like.	Diablo homolog, mitochondrial-like.	0.807
ENSSGRP00000005498	LOC107593914	ENSSGRP00000005498	ENSSGRP00000024180	Apoptotic protease-activating factor 1-like.	Caspase-9-like isoform X1.	0.997
ENSSGRP00000005498	LOC107600151	ENSSGRP00000005498	ENSSGRP00000097879	Apoptotic protease-activating factor 1-like.	E3 ubiquitin-protein ligase XIAP-like isoform X1.	0.874
ENSSGRP00000005498	LOC107601340	ENSSGRP00000005498	ENSSGRP00000086034	Apoptotic protease-activating factor 1-like.	Baculoviral IAP repeat-containing protein 7-like isoform X1.	0.765
ENSSGRP00000005498	apaf1	ENSSGRP00000005498	ENSSGRP00000051457	Apoptotic protease-activating factor 1-like.	Apoptotic protease-activating factor 1.	0.954
ENSSGRP00000005498	casp3	ENSSGRP00000005498	ENSSGRP00000025831	Apoptotic protease-activating factor 1-like.	Caspase 3.	0.836
ENSSGRP00000005498	casp9	ENSSGRP00000005498	ENSSGRP00000098105	Apoptotic protease-activating factor 1-like.	Caspase-9 isoform X1.	0.997
LOC107561284	ENSSGRP00000005498	ENSSGRP00000018963	ENSSGRP00000005498	E3 ubiquitin-protein ligase XIAP-like isoform X1.	Apoptotic protease-activating factor 1-like.	0.874
LOC107561284	LOC107562747	ENSSGRP00000018963	ENSSGRP00000077939	E3 ubiquitin-protein ligase XIAP-like isoform X1.	Caspase-3-like.	0.957
LOC107561284	LOC107581377	ENSSGRP00000018963	ENSSGRP00000108697	E3 ubiquitin-protein ligase XIAP-like isoform X1.	Cytochrome c-like.	0.797
LOC107561284	LOC107582616	ENSSGRP00000018963	ENSSGRP00000028866	E3 ubiquitin-protein ligase XIAP-like isoform X1.	Diablo homolog, mitochondrial-like isoform X1.	0.987
LOC107561284	LOC107584771	ENSSGRP00000018963	ENSSGRP00000054104	E3 ubiquitin-protein ligase XIAP-like isoform X1.	Cytochrome c.	0.797
LOC107561284	LOC107588772	ENSSGRP00000018963	ENSSGRP00000093007	E3 ubiquitin-protein ligase XIAP-like isoform X1.	Diablo homolog, mitochondrial-like isoform X1.	0.987
LOC107561284	LOC107589300	ENSSGRP00000018963	ENSSGRP00000094706	E3 ubiquitin-protein ligase XIAP-like isoform X1.	Diablo homolog, mitochondrial-like.	0.987