(33 nodes) Heteromeric SMAD protein complex, and Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000002073	Ski-like protein. (610 aa)
	smad3	Mothers against decapentaplegic homolog 3. (425 aa)
	LOC107557528	Ski-like protein. (728 aa)
	LOC107559658	Mothers against decapentaplegic homolog 4 isoform X1. (550 aa)
	ENSSGRP00000010396	SMAD family member 4b. (464 aa)
	LOC107599811	Ski oncogene-like. (726 aa)
	ENSSGRP00000013976	SMAD family member 1. (442 aa)
	LOC107548407	Ski oncogene-like. (726 aa)
	ENSSGRP00000021965	Zinc finger FYVE domain-containing protein 9-like isoform X1. (1167 aa)
	ENSSGRP00000022575	SMAD family member 4a. (499 aa)
	ENSSGRP00000029005	annotation not available (67 aa)
	ENSSGRP00000029006	annotation not available (56 aa)
	ENSSGRP00000029007	E3 ubiquitin-protein ligase SMURF2-like. (359 aa)
	smad2	Mothers against decapentaplegic homolog 2. (468 aa)
	ENSSGRP00000036217	annotation not available (113 aa)
	ENSSGRP00000036219	Mothers against decapentaplegic homolog 1-like. (181 aa)
	SMAD9	Mothers against decapentaplegic homolog 9-like isoform X1. (434 aa)
	LOC107550085	Mothers against decapentaplegic homolog 4-like isoform X1. (571 aa)
	LOC107583760	Mothers against decapentaplegic homolog 3-like. (453 aa)
	LOC107583766	Mothers against decapentaplegic homolog 6-like. (487 aa)
	Smad7	Mothers against decapentaplegic homolog 7. (182 aa)
	LOC107563595	Mothers against decapentaplegic homolog 5 isoform X1. (464 aa)
	ENSSGRP00000062617	Mothers against decapentaplegic homolog 1. (458 aa)
	LOC107591339	Ski-like protein isoform X1. (727 aa)
	LOC107553101	Mothers against decapentaplegic homolog 3. (439 aa)
	skil	Ski-like protein. (645 aa)
	ENSSGRP00000076363	Mothers against decapentaplegic homolog 4-like isoform X1. (573 aa)
	ENSSGRP00000089762	Si:dkey-222b8.1. (527 aa)
	ENSSGRP00000098989	Mothers against decapentaplegic homolog 4-like. (169 aa)
	ENSSGRP00000100725	MAD, mothers against decapentaplegic interacting protein. (1347 aa)
	ENSSGRP00000104891	Mothers against decapentaplegic homolog 4-like. (571 aa)
	ENSSGRP00000108174	Mothers against decapentaplegic homolog 3-like. (68 aa)
	LOC107596967	Mothers against decapentaplegic homolog 6-like. (488 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000002073	ENSSGRP00000010396	ENSSGRP00000002073	ENSSGRP00000010396	Ski-like protein.	SMAD family member 4b.	0.775
ENSSGRP00000002073	ENSSGRP00000013976	ENSSGRP00000002073	ENSSGRP00000013976	Ski-like protein.	SMAD family member 1.	0.696
ENSSGRP00000002073	ENSSGRP00000022575	ENSSGRP00000002073	ENSSGRP00000022575	Ski-like protein.	SMAD family member 4a.	0.775
ENSSGRP00000002073	ENSSGRP00000036217	ENSSGRP00000002073	ENSSGRP00000036217	Ski-like protein.	annotation not available	0.696
ENSSGRP00000002073	ENSSGRP00000036219	ENSSGRP00000002073	ENSSGRP00000036219	Ski-like protein.	Mothers against decapentaplegic homolog 1-like.	0.696
ENSSGRP00000002073	ENSSGRP00000062617	ENSSGRP00000002073	ENSSGRP00000062617	Ski-like protein.	Mothers against decapentaplegic homolog 1.	0.696
ENSSGRP00000002073	ENSSGRP00000076363	ENSSGRP00000002073	ENSSGRP00000076363	Ski-like protein.	Mothers against decapentaplegic homolog 4-like isoform X1.	0.775
ENSSGRP00000002073	ENSSGRP00000089762	ENSSGRP00000002073	ENSSGRP00000089762	Ski-like protein.	Si:dkey-222b8.1.	0.775
ENSSGRP00000002073	ENSSGRP00000098989	ENSSGRP00000002073	ENSSGRP00000098989	Ski-like protein.	Mothers against decapentaplegic homolog 4-like.	0.775
ENSSGRP00000002073	ENSSGRP00000104891	ENSSGRP00000002073	ENSSGRP00000104891	Ski-like protein.	Mothers against decapentaplegic homolog 4-like.	0.775
ENSSGRP00000002073	ENSSGRP00000108174	ENSSGRP00000002073	ENSSGRP00000108174	Ski-like protein.	Mothers against decapentaplegic homolog 3-like.	0.814
ENSSGRP00000002073	LOC107548407	ENSSGRP00000002073	ENSSGRP00000020651	Ski-like protein.	Ski oncogene-like.	0.615
ENSSGRP00000002073	LOC107550085	ENSSGRP00000002073	ENSSGRP00000045624	Ski-like protein.	Mothers against decapentaplegic homolog 4-like isoform X1.	0.775
ENSSGRP00000002073	LOC107553101	ENSSGRP00000002073	ENSSGRP00000070223	Ski-like protein.	Mothers against decapentaplegic homolog 3.	0.814
ENSSGRP00000002073	LOC107559658	ENSSGRP00000002073	ENSSGRP00000007947	Ski-like protein.	Mothers against decapentaplegic homolog 4 isoform X1.	0.775
ENSSGRP00000002073	LOC107563595	ENSSGRP00000002073	ENSSGRP00000051610	Ski-like protein.	Mothers against decapentaplegic homolog 5 isoform X1.	0.696
ENSSGRP00000002073	LOC107583760	ENSSGRP00000002073	ENSSGRP00000049287	Ski-like protein.	Mothers against decapentaplegic homolog 3-like.	0.814
ENSSGRP00000002073	LOC107583766	ENSSGRP00000002073	ENSSGRP00000049337	Ski-like protein.	Mothers against decapentaplegic homolog 6-like.	0.473
ENSSGRP00000002073	LOC107596967	ENSSGRP00000002073	ENSSGRP00000108175	Ski-like protein.	Mothers against decapentaplegic homolog 6-like.	0.473
ENSSGRP00000002073	LOC107599811	ENSSGRP00000002073	ENSSGRP00000013140	Ski-like protein.	Ski oncogene-like.	0.615