(12 nodes) Mixed, incl. 5-flap endonuclease activity, and This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain PUBMED:16530788. network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107554014	Exonuclease 1-like. (779 aa)
	LOC107583534	Exonuclease 1-like. (806 aa)
	RAD51	DNA repair protein RAD51 homolog A-like. (130 aa)
	ENSSGRP00000016326	DNA polymerase delta catalytic subunit-like. (831 aa)
	LOC107577751	Replication factor C subunit 3-like. (357 aa)
	LOC107554955	DNA repair protein RAD52 homolog isoform X1. (458 aa)
	ENSSGRP00000083488	WRN RecQ like helicase. (898 aa)
	ENSSGRP00000086521	RAD50 homolog, double strand break repair protein. (1178 aa)
	ENSSGRP00000089578	BLM RecQ like helicase. (1302 aa)
	ENSSGRP00000094094	annotation not available (752 aa)
	DNA2	DNA replication ATP-dependent helicase/nuclease DNA2-like. (1360 aa)
	LOC107589973	Flap endonuclease 1-like. (302 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNA2	ENSSGRP00000016326	ENSSGRP00000101742	ENSSGRP00000016326	DNA replication ATP-dependent helicase/nuclease DNA2-like.	DNA polymerase delta catalytic subunit-like.	0.896
DNA2	ENSSGRP00000083488	ENSSGRP00000101742	ENSSGRP00000083488	DNA replication ATP-dependent helicase/nuclease DNA2-like.	WRN RecQ like helicase.	0.993
DNA2	ENSSGRP00000086521	ENSSGRP00000101742	ENSSGRP00000086521	DNA replication ATP-dependent helicase/nuclease DNA2-like.	RAD50 homolog, double strand break repair protein.	0.794
DNA2	ENSSGRP00000089578	ENSSGRP00000101742	ENSSGRP00000089578	DNA replication ATP-dependent helicase/nuclease DNA2-like.	BLM RecQ like helicase.	0.976
DNA2	ENSSGRP00000094094	ENSSGRP00000101742	ENSSGRP00000094094	DNA replication ATP-dependent helicase/nuclease DNA2-like.	annotation not available	0.905
DNA2	LOC107554014	ENSSGRP00000101742	ENSSGRP00000000492	DNA replication ATP-dependent helicase/nuclease DNA2-like.	Exonuclease 1-like.	0.977
DNA2	LOC107554955	ENSSGRP00000101742	ENSSGRP00000050743	DNA replication ATP-dependent helicase/nuclease DNA2-like.	DNA repair protein RAD52 homolog isoform X1.	0.927
DNA2	LOC107577751	ENSSGRP00000101742	ENSSGRP00000041272	DNA replication ATP-dependent helicase/nuclease DNA2-like.	Replication factor C subunit 3-like.	0.830
DNA2	LOC107583534	ENSSGRP00000101742	ENSSGRP00000000564	DNA replication ATP-dependent helicase/nuclease DNA2-like.	Exonuclease 1-like.	0.977
DNA2	LOC107589973	ENSSGRP00000101742	ENSSGRP00000109626	DNA replication ATP-dependent helicase/nuclease DNA2-like.	Flap endonuclease 1-like.	0.928
DNA2	RAD51	ENSSGRP00000101742	ENSSGRP00000004376	DNA replication ATP-dependent helicase/nuclease DNA2-like.	DNA repair protein RAD51 homolog A-like.	0.909
ENSSGRP00000016326	DNA2	ENSSGRP00000016326	ENSSGRP00000101742	DNA polymerase delta catalytic subunit-like.	DNA replication ATP-dependent helicase/nuclease DNA2-like.	0.896
ENSSGRP00000016326	ENSSGRP00000083488	ENSSGRP00000016326	ENSSGRP00000083488	DNA polymerase delta catalytic subunit-like.	WRN RecQ like helicase.	0.973
ENSSGRP00000016326	ENSSGRP00000086521	ENSSGRP00000016326	ENSSGRP00000086521	DNA polymerase delta catalytic subunit-like.	RAD50 homolog, double strand break repair protein.	0.797
ENSSGRP00000016326	ENSSGRP00000089578	ENSSGRP00000016326	ENSSGRP00000089578	DNA polymerase delta catalytic subunit-like.	BLM RecQ like helicase.	0.828
ENSSGRP00000016326	ENSSGRP00000094094	ENSSGRP00000016326	ENSSGRP00000094094	DNA polymerase delta catalytic subunit-like.	annotation not available	0.826
ENSSGRP00000016326	LOC107554014	ENSSGRP00000016326	ENSSGRP00000000492	DNA polymerase delta catalytic subunit-like.	Exonuclease 1-like.	0.923
ENSSGRP00000016326	LOC107554955	ENSSGRP00000016326	ENSSGRP00000050743	DNA polymerase delta catalytic subunit-like.	DNA repair protein RAD52 homolog isoform X1.	0.774
ENSSGRP00000016326	LOC107577751	ENSSGRP00000016326	ENSSGRP00000041272	DNA polymerase delta catalytic subunit-like.	Replication factor C subunit 3-like.	0.861
ENSSGRP00000016326	LOC107583534	ENSSGRP00000016326	ENSSGRP00000000564	DNA polymerase delta catalytic subunit-like.	Exonuclease 1-like.	0.923