(13 nodes) Mixed, incl. Mre11 complex, and BRCA1-BARD1 complex network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107582084	Nibrin-like. (858 aa)
	Rbbp8	DNA endonuclease RBBP8 isoform X1. (641 aa)
	LOC107557067	PWWP domain-containing protein 2A-like. (1003 aa)
	ENSSGRP00000030630	BRCA1-associated RING domain protein 1-like. (135 aa)
	LOC107551678	Mediator of DNA damage checkpoint protein 1-like isoform X1. (1963 aa)
	ENSSGRP00000038462	Checkpoint kinase 2. (471 aa)
	mre11	Double-strand break repair protein MRE11A isoform X1. (717 aa)
	rtel1	Regulator of telomere elongation helicase 1 isoform X1. (1180 aa)
	LOC107595095	Nibrin-like isoform X1. (842 aa)
	ENSSGRP00000091406	annotation not available (102 aa)
	ENSSGRP00000104050	Tumor protein p53 binding protein, 1. (1687 aa)
	Topbp1	DNA topoisomerase 2-binding protein 1 isoform X1. (1494 aa)
	rad50	DNA repair protein RAD50 isoform X1. (1312 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000030630	ENSSGRP00000038462	ENSSGRP00000030630	ENSSGRP00000038462	BRCA1-associated RING domain protein 1-like.	Checkpoint kinase 2.	0.938
ENSSGRP00000030630	ENSSGRP00000091406	ENSSGRP00000030630	ENSSGRP00000091406	BRCA1-associated RING domain protein 1-like.	annotation not available	0.744
ENSSGRP00000030630	ENSSGRP00000104050	ENSSGRP00000030630	ENSSGRP00000104050	BRCA1-associated RING domain protein 1-like.	Tumor protein p53 binding protein, 1.	0.940
ENSSGRP00000030630	LOC107551678	ENSSGRP00000030630	ENSSGRP00000036415	BRCA1-associated RING domain protein 1-like.	Mediator of DNA damage checkpoint protein 1-like isoform X1.	0.911
ENSSGRP00000030630	LOC107557067	ENSSGRP00000030630	ENSSGRP00000024675	BRCA1-associated RING domain protein 1-like.	PWWP domain-containing protein 2A-like.	0.972
ENSSGRP00000030630	LOC107582084	ENSSGRP00000030630	ENSSGRP00000015571	BRCA1-associated RING domain protein 1-like.	Nibrin-like.	0.988
ENSSGRP00000030630	LOC107595095	ENSSGRP00000030630	ENSSGRP00000079047	BRCA1-associated RING domain protein 1-like.	Nibrin-like isoform X1.	0.988
ENSSGRP00000030630	Rbbp8	ENSSGRP00000030630	ENSSGRP00000020506	BRCA1-associated RING domain protein 1-like.	DNA endonuclease RBBP8 isoform X1.	0.998
ENSSGRP00000030630	Topbp1	ENSSGRP00000030630	ENSSGRP00000110347	BRCA1-associated RING domain protein 1-like.	DNA topoisomerase 2-binding protein 1 isoform X1.	0.999
ENSSGRP00000030630	mre11	ENSSGRP00000030630	ENSSGRP00000051217	BRCA1-associated RING domain protein 1-like.	Double-strand break repair protein MRE11A isoform X1.	0.999
ENSSGRP00000030630	rad50	ENSSGRP00000030630	ENSSGRP00000110721	BRCA1-associated RING domain protein 1-like.	DNA repair protein RAD50 isoform X1.	0.966
ENSSGRP00000030630	rtel1	ENSSGRP00000030630	ENSSGRP00000069677	BRCA1-associated RING domain protein 1-like.	Regulator of telomere elongation helicase 1 isoform X1.	0.950
ENSSGRP00000038462	ENSSGRP00000030630	ENSSGRP00000038462	ENSSGRP00000030630	Checkpoint kinase 2.	BRCA1-associated RING domain protein 1-like.	0.938
ENSSGRP00000038462	ENSSGRP00000091406	ENSSGRP00000038462	ENSSGRP00000091406	Checkpoint kinase 2.	annotation not available	0.938
ENSSGRP00000038462	ENSSGRP00000104050	ENSSGRP00000038462	ENSSGRP00000104050	Checkpoint kinase 2.	Tumor protein p53 binding protein, 1.	0.980
ENSSGRP00000038462	LOC107551678	ENSSGRP00000038462	ENSSGRP00000036415	Checkpoint kinase 2.	Mediator of DNA damage checkpoint protein 1-like isoform X1.	0.728
ENSSGRP00000038462	LOC107557067	ENSSGRP00000038462	ENSSGRP00000024675	Checkpoint kinase 2.	PWWP domain-containing protein 2A-like.	0.956
ENSSGRP00000038462	LOC107582084	ENSSGRP00000038462	ENSSGRP00000015571	Checkpoint kinase 2.	Nibrin-like.	0.878
ENSSGRP00000038462	LOC107595095	ENSSGRP00000038462	ENSSGRP00000079047	Checkpoint kinase 2.	Nibrin-like isoform X1.	0.878
ENSSGRP00000038462	Rbbp8	ENSSGRP00000038462	ENSSGRP00000020506	Checkpoint kinase 2.	DNA endonuclease RBBP8 isoform X1.	0.648