(36 nodes) Activation of the pre-replicative complex network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000000538	Origin recognition complex subunit 6-like. (274 aa)
	LOC107551039	Origin recognition complex subunit 1-like isoform X1. (909 aa)
	ENSSGRP00000003239	Cell division cycle 7-related protein kinase-like. (336 aa)
	ENSSGRP00000003693	DNA replication licensing factor mcm7-B-like. (656 aa)
	ENSSGRP00000007487	Cell division control protein 6 homolog. (381 aa)
	Orc4	Origin recognition complex subunit 4. (316 aa)
	LOC107564569	Origin recognition complex subunit 2-like. (494 aa)
	LOC107600340	Chromatin licensing and DNA replication factor 1. (677 aa)
	ENSSGRP00000016744	MCM6 minichromosome maintenance deficient 6, like. (675 aa)
	LOC107559729	Maternal DNA replication licensing factor mcm3-like. (651 aa)
	ENSSGRP00000018479	annotation not available (474 aa)
	ENSSGRP00000021599	LOW QUALITY PROTEIN: DNA replication licensing factor mcm4-like. (833 aa)
	LOC107592324	Protein DBF4 homolog A-like isoform X1. (615 aa)
	Cdc45	Cell division control protein 45 homolog. (518 aa)
	mcm6	DNA replication licensing factor MCM6. (845 aa)
	ENSSGRP00000032040	Deoxyribonuclease-1-like protein. (83 aa)
	ENSSGRP00000032120	DNA replication licensing factor mcm2-like. (579 aa)
	LOC107561457	Chromatin licensing and DNA replication factor 1. (667 aa)
	mcm5	DNA replication licensing factor MCM5. (713 aa)
	ENSSGRP00000038718	Origin recognition complex, subunit 4. (225 aa)
	ENSSGRP00000044520	Origin recognition complex, subunit 1. (878 aa)
	ENSSGRP00000055287	Origin recognition complex, subunit 3. (581 aa)
	ENSSGRP00000062138	Cell division cycle 6 homolog (S. cerevisiae). (554 aa)
	MCM7	DNA replication licensing factor MCM7. (656 aa)
	ENSSGRP00000068507	Origin recognition complex, subunit 3. (619 aa)
	mcm3	DNA replication licensing factor MCM3. (808 aa)
	ENSSGRP00000082957	Zygotic DNA replication licensing factor mcm3-like. (635 aa)
	ENSSGRP00000085063	Origin recognition complex subunit 5-like. (400 aa)
	ENSSGRP00000086251	DNA replication licensing factor mcm5-A-like. (645 aa)
	Orc5	Origin recognition complex subunit 5. (456 aa)
	LOC107592429	Activator of S phase kinase. (611 aa)
	LOC107599677	DNA replication licensing factor mcm4-like. (852 aa)
	LOC107591028	Origin recognition complex subunit 6-like. (257 aa)
	mcm10	Minichromosome maintenance protein 10. (834 aa)
	ENSSGRP00000104957	MCM6 minichromosome maintenance deficient 6, like. (642 aa)
	Cdc7	Cell division cycle 7-related protein kinase. (356 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdc45	Cdc7	ENSSGRP00000024209	ENSSGRP00000111020	Cell division control protein 45 homolog.	Cell division cycle 7-related protein kinase.	0.929
Cdc45	ENSSGRP00000000538	ENSSGRP00000024209	ENSSGRP00000000538	Cell division control protein 45 homolog.	Origin recognition complex subunit 6-like.	0.927
Cdc45	ENSSGRP00000003239	ENSSGRP00000024209	ENSSGRP00000003239	Cell division control protein 45 homolog.	Cell division cycle 7-related protein kinase-like.	0.929
Cdc45	ENSSGRP00000003693	ENSSGRP00000024209	ENSSGRP00000003693	Cell division control protein 45 homolog.	DNA replication licensing factor mcm7-B-like.	0.999
Cdc45	ENSSGRP00000007487	ENSSGRP00000024209	ENSSGRP00000007487	Cell division control protein 45 homolog.	Cell division control protein 6 homolog.	0.970
Cdc45	ENSSGRP00000016744	ENSSGRP00000024209	ENSSGRP00000016744	Cell division control protein 45 homolog.	MCM6 minichromosome maintenance deficient 6, like.	0.993
Cdc45	ENSSGRP00000018479	ENSSGRP00000024209	ENSSGRP00000018479	Cell division control protein 45 homolog.	annotation not available	0.993
Cdc45	ENSSGRP00000021599	ENSSGRP00000024209	ENSSGRP00000021599	Cell division control protein 45 homolog.	LOW QUALITY PROTEIN: DNA replication licensing factor mcm4-like.	0.999
Cdc45	ENSSGRP00000032040	ENSSGRP00000024209	ENSSGRP00000032040	Cell division control protein 45 homolog.	Deoxyribonuclease-1-like protein.	0.993
Cdc45	ENSSGRP00000032120	ENSSGRP00000024209	ENSSGRP00000032120	Cell division control protein 45 homolog.	DNA replication licensing factor mcm2-like.	0.999
Cdc45	ENSSGRP00000038718	ENSSGRP00000024209	ENSSGRP00000038718	Cell division control protein 45 homolog.	Origin recognition complex, subunit 4.	0.911
Cdc45	ENSSGRP00000044520	ENSSGRP00000024209	ENSSGRP00000044520	Cell division control protein 45 homolog.	Origin recognition complex, subunit 1.	0.991
Cdc45	ENSSGRP00000055287	ENSSGRP00000024209	ENSSGRP00000055287	Cell division control protein 45 homolog.	Origin recognition complex, subunit 3.	0.953
Cdc45	ENSSGRP00000062138	ENSSGRP00000024209	ENSSGRP00000062138	Cell division control protein 45 homolog.	Cell division cycle 6 homolog (S. cerevisiae).	0.969
Cdc45	ENSSGRP00000068507	ENSSGRP00000024209	ENSSGRP00000068507	Cell division control protein 45 homolog.	Origin recognition complex, subunit 3.	0.953
Cdc45	ENSSGRP00000082957	ENSSGRP00000024209	ENSSGRP00000082957	Cell division control protein 45 homolog.	Zygotic DNA replication licensing factor mcm3-like.	0.998
Cdc45	ENSSGRP00000085063	ENSSGRP00000024209	ENSSGRP00000085063	Cell division control protein 45 homolog.	Origin recognition complex subunit 5-like.	0.964
Cdc45	ENSSGRP00000086251	ENSSGRP00000024209	ENSSGRP00000086251	Cell division control protein 45 homolog.	DNA replication licensing factor mcm5-A-like.	0.999
Cdc45	ENSSGRP00000104957	ENSSGRP00000024209	ENSSGRP00000104957	Cell division control protein 45 homolog.	MCM6 minichromosome maintenance deficient 6, like.	0.993
Cdc45	LOC107551039	ENSSGRP00000024209	ENSSGRP00000002844	Cell division control protein 45 homolog.	Origin recognition complex subunit 1-like isoform X1.	0.991