(35 nodes) Regulation of tumor necrosis factor-mediated signaling pathway network (Sinocyclocheilus grahami)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	LOC107549102	Disintegrin and metalloproteinase domain-containing protein 17-like isoform X1. (842 aa)
	ENSSGRP00000048607	Growth arrest-specific protein 6-like. (105 aa)
	ENSSGRP00000048601	Growth arrest-specific 6. (396 aa)
	ENSSGRP00000045382	OTU deubiquitinase with linear linkage specificity b. (309 aa)
	ENSSGRP00000044854	Bile acid receptor-like isoform X1. (479 aa)
	ube2k-2	Ubiquitin-conjugating enzyme E2 K. (200 aa)
	LOC107570978	Bile acid receptor-like isoform X1. (482 aa)
	ube2k	Ubiquitin-conjugating enzyme (huntingtin interacting protein 2). (200 aa)
	ENSSGRP00000026203	Disintegrin and metalloproteinase domain-containing protein 17-like. (745 aa)
	ENSSGRP00000057067	Tumor necrosis factor receptor superfamily member 1A-like. (388 aa)
	LOC107574178	Ubiquitin carboxyl-terminal hydrolase CYLD-like. (575 aa)
	nr1h4	Farnesoid X receptor. (483 aa)
	LOC107562628	Spermatogenesis-associated protein 2-like. (554 aa)
	prkn	E3 ubiquitin-protein ligase parkin. (438 aa)
	ENSSGRP00000064893	Ubiquitin thioesterase otulin-like. (288 aa)
	LOC107551493	Ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1. (963 aa)
	LOC107568662	Ubiquitin-conjugating enzyme (huntingtin interacting protein 2). (200 aa)
	LOC107583817	Bile acid receptor-like. (345 aa)
	ENSSGRP00000079686	Ubiquitin carboxyl-terminal hydrolase CYLD-like. (925 aa)
	LOC107566714	Adiponectin-like. (276 aa)
	LOC107601850	Disintegrin and metalloproteinase domain-containing protein 17-like isoform X1. (842 aa)
	ENSSGRP00000110934	Parkin RBR E3 ubiquitin protein ligase. (455 aa)
	LOC107550806	Tumor necrosis factor receptor superfamily member 1A-like. (395 aa)
	LOC107589953	Neurofilament medium polypeptide-like isoform X1. (974 aa)
	LOC107551786	E3 ubiquitin-protein ligase TRAIP-like. (469 aa)
	LOC107570539	Coiled-coil domain-containing protein 3-like. (269 aa)
	LOC107564424	E3 ubiquitin-protein ligase TRIM32-like. (661 aa)
	LOC107563405	E3 ubiquitin-protein ligase TRIM32-like. (661 aa)
	ENSSGRP00000102835	ADAM metallopeptidase domain 17a. (847 aa)
	LOC107559588	Ubiquitin-conjugating enzyme E2 K-like. (216 aa)
	ENSSGRP00000106672	Cylindromatosis (turban tumor syndrome), b. (616 aa)
	LOC107556989	Ubiquitin carboxyl-terminal hydrolase CYLD-like. (772 aa)
	ENSSGRP00000109066	Spermatogenesis-associated protein 2-like. (563 aa)
	ENSSGRP00000007826	Growth arrest-specific protein 6-like. (598 aa)
	LOC107575380	E3 ubiquitin-protein ligase TRAIP-like. (452 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000026203	LOC107549102	ENSSGRP00000026203	ENSSGRP00000053473	Disintegrin and metalloproteinase domain-containing protein 17-like.	Disintegrin and metalloproteinase domain-containing protein 17-like isoform X1.	0.902
ENSSGRP00000026203	LOC107601850	ENSSGRP00000026203	ENSSGRP00000086805	Disintegrin and metalloproteinase domain-containing protein 17-like.	Disintegrin and metalloproteinase domain-containing protein 17-like isoform X1.	0.902
ENSSGRP00000057067	ENSSGRP00000079686	ENSSGRP00000057067	ENSSGRP00000079686	Tumor necrosis factor receptor superfamily member 1A-like.	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	0.956
ENSSGRP00000057067	ENSSGRP00000106672	ENSSGRP00000057067	ENSSGRP00000106672	Tumor necrosis factor receptor superfamily member 1A-like.	Cylindromatosis (turban tumor syndrome), b.	0.956
ENSSGRP00000057067	LOC107550806	ENSSGRP00000057067	ENSSGRP00000111843	Tumor necrosis factor receptor superfamily member 1A-like.	Tumor necrosis factor receptor superfamily member 1A-like.	0.901
ENSSGRP00000057067	LOC107551493	ENSSGRP00000057067	ENSSGRP00000068842	Tumor necrosis factor receptor superfamily member 1A-like.	Ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1.	0.956
ENSSGRP00000057067	LOC107556989	ENSSGRP00000057067	ENSSGRP00000108389	Tumor necrosis factor receptor superfamily member 1A-like.	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	0.956
ENSSGRP00000057067	LOC107574178	ENSSGRP00000057067	ENSSGRP00000019636	Tumor necrosis factor receptor superfamily member 1A-like.	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	0.946
ENSSGRP00000079686	ENSSGRP00000057067	ENSSGRP00000079686	ENSSGRP00000057067	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	Tumor necrosis factor receptor superfamily member 1A-like.	0.956
ENSSGRP00000079686	ENSSGRP00000109066	ENSSGRP00000079686	ENSSGRP00000109066	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	Spermatogenesis-associated protein 2-like.	0.877
ENSSGRP00000079686	LOC107550806	ENSSGRP00000079686	ENSSGRP00000111843	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	Tumor necrosis factor receptor superfamily member 1A-like.	0.956
ENSSGRP00000079686	LOC107551786	ENSSGRP00000079686	ENSSGRP00000088786	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	E3 ubiquitin-protein ligase TRAIP-like.	0.411
ENSSGRP00000079686	LOC107562628	ENSSGRP00000079686	ENSSGRP00000061309	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	Spermatogenesis-associated protein 2-like.	0.877
ENSSGRP00000079686	LOC107575380	ENSSGRP00000079686	ENSSGRP00000015074	Ubiquitin carboxyl-terminal hydrolase CYLD-like.	E3 ubiquitin-protein ligase TRAIP-like.	0.411
ENSSGRP00000106672	ENSSGRP00000057067	ENSSGRP00000106672	ENSSGRP00000057067	Cylindromatosis (turban tumor syndrome), b.	Tumor necrosis factor receptor superfamily member 1A-like.	0.956
ENSSGRP00000106672	ENSSGRP00000109066	ENSSGRP00000106672	ENSSGRP00000109066	Cylindromatosis (turban tumor syndrome), b.	Spermatogenesis-associated protein 2-like.	0.663
ENSSGRP00000106672	LOC107550806	ENSSGRP00000106672	ENSSGRP00000111843	Cylindromatosis (turban tumor syndrome), b.	Tumor necrosis factor receptor superfamily member 1A-like.	0.956
ENSSGRP00000106672	LOC107551786	ENSSGRP00000106672	ENSSGRP00000088786	Cylindromatosis (turban tumor syndrome), b.	E3 ubiquitin-protein ligase TRAIP-like.	0.411
ENSSGRP00000106672	LOC107562628	ENSSGRP00000106672	ENSSGRP00000061309	Cylindromatosis (turban tumor syndrome), b.	Spermatogenesis-associated protein 2-like.	0.663
ENSSGRP00000106672	LOC107575380	ENSSGRP00000106672	ENSSGRP00000015074	Cylindromatosis (turban tumor syndrome), b.	E3 ubiquitin-protein ligase TRAIP-like.	0.411