(45 nodes) Intracellular steroid hormone receptor signaling pathway network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107585142	Ubiquitin-protein ligase E3A-like. (912 aa)
	LOC107554345	Death domain-associated protein 6-like. (699 aa)
	trip4	Activating signal cointegrator 1 isoform X1. (564 aa)
	LOC107552826	RWD domain-containing protein 1-like. (240 aa)
	LOC107583258	Probable ATP-dependent RNA helicase DDX5 isoform X1. (613 aa)
	LOC107563516	Progesterone receptor-like. (636 aa)
	ENSSGRP00000036259	Ubiquitin protein ligase E3 component n-recognin 5. (2237 aa)
	LOC107598327	Peroxisome proliferator-activated receptor gamma coactivator 1-beta-like isoform X1. (817 aa)
	esr2	Estrogen receptor beta. (573 aa)
	ENSSGRP00000039325	annotation not available (77 aa)
	ENSSGRP00000039366	Proto-oncogene tyrosine-protein kinase Src-like isoform X1. (505 aa)
	LOC107553338	Glucocorticoid receptor-like isoform X1. (763 aa)
	LOC107566988	25-hydroxycholesterol 7-alpha-hydroxylase-like. (505 aa)
	ENSSGRP00000045226	E3 ubiquitin-protein ligase EDD1. (2413 aa)
	ENSSGRP00000046167	annotation not available (434 aa)
	ENSSGRP00000047981	Estrogen receptor 2b. (471 aa)
	ENSSGRP00000052855	Transcriptional-regulating factor 1-like. (777 aa)
	LOC107602637	25-hydroxycholesterol 7-alpha-hydroxylase-like isoform X1. (509 aa)
	ENSSGRP00000060507	Prohibitin. (247 aa)
	ppargc1b	Peroxisome proliferator-activated receptor gamma coactivator 1-beta. (838 aa)
	LOC107558889	TATA element modulatory factor-like isoform X1. (1136 aa)
	LOC107582722	Ubiquitin-protein ligase E3 A. (876 aa)
	ENSSGRP00000074243	Androgen receptor-like. (862 aa)
	ENSSGRP00000079391	Progesterone receptor-like. (617 aa)
	ENSSGRP00000081056	Thyroid hormone receptor interactor 4. (487 aa)
	LOC107587776	RWD domain-containing protein 1-like. (240 aa)
	LOC107556167	Estrogen receptor alpha. (653 aa)
	NR3C1-2	Glucocorticoid receptor-like isoform X1. (733 aa)
	LOC107559446	Homeobox protein Nkx-3.1-like. (185 aa)
	LOC107596701	Androgen receptor-like. (852 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1 isoform X1. (1776 aa)
	LOC107549841	Death domain-associated protein 6-like isoform X1. (698 aa)
	phb	Prohibitin 1. (271 aa)
	ENSSGRP00000092892	LOW QUALITY PROTEIN: estrogen receptor-like. (611 aa)
	LOC107554699	Glucocorticoid receptor-like. (390 aa)
	ENSSGRP00000101880	annotation not available (652 aa)
	LOC107602339	Probable ATP-dependent RNA helicase DDX5 isoform X1. (611 aa)
	LOC107600287	TATA element modulatory factor-like. (1163 aa)
	LOC107590469	Proto-oncogene tyrosine-protein kinase Src isoform X1. (553 aa)
	ENSSGRP00000112766	annotation not available (958 aa)
	NR3C1	Glucocorticoid receptor-like isoform X1. (736 aa)
	LOC107579146	E3 ubiquitin-protein ligase UBR5-like. (302 aa)
	ENSSGRP00000009722	annotation not available (546 aa)
	LOC107553222	Estrogen receptor beta-2. (668 aa)
	ENSSGRP00000011352	annotation not available (340 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000009722	ENSSGRP00000039325	ENSSGRP00000009722	ENSSGRP00000039325	annotation not available	annotation not available	0.518
ENSSGRP00000009722	ENSSGRP00000039366	ENSSGRP00000009722	ENSSGRP00000039366	annotation not available	Proto-oncogene tyrosine-protein kinase Src-like isoform X1.	0.518
ENSSGRP00000009722	ENSSGRP00000046167	ENSSGRP00000009722	ENSSGRP00000046167	annotation not available	annotation not available	0.657
ENSSGRP00000009722	ENSSGRP00000074243	ENSSGRP00000009722	ENSSGRP00000074243	annotation not available	Androgen receptor-like.	0.401
ENSSGRP00000009722	ENSSGRP00000079391	ENSSGRP00000009722	ENSSGRP00000079391	annotation not available	Progesterone receptor-like.	0.840
ENSSGRP00000009722	ENSSGRP00000092892	ENSSGRP00000009722	ENSSGRP00000092892	annotation not available	LOW QUALITY PROTEIN: estrogen receptor-like.	0.594
ENSSGRP00000009722	ENSSGRP00000101880	ENSSGRP00000009722	ENSSGRP00000101880	annotation not available	annotation not available	0.657
ENSSGRP00000009722	LOC107556167	ENSSGRP00000009722	ENSSGRP00000082815	annotation not available	Estrogen receptor alpha.	0.593
ENSSGRP00000009722	LOC107563516	ENSSGRP00000009722	ENSSGRP00000036199	annotation not available	Progesterone receptor-like.	0.840
ENSSGRP00000009722	LOC107582722	ENSSGRP00000009722	ENSSGRP00000070216	annotation not available	Ubiquitin-protein ligase E3 A.	0.533
ENSSGRP00000009722	LOC107583258	ENSSGRP00000009722	ENSSGRP00000030482	annotation not available	Probable ATP-dependent RNA helicase DDX5 isoform X1.	0.657
ENSSGRP00000009722	LOC107585142	ENSSGRP00000009722	ENSSGRP00000011461	annotation not available	Ubiquitin-protein ligase E3A-like.	0.533
ENSSGRP00000009722	LOC107590469	ENSSGRP00000009722	ENSSGRP00000110911	annotation not available	Proto-oncogene tyrosine-protein kinase Src isoform X1.	0.518
ENSSGRP00000009722	LOC107596701	ENSSGRP00000009722	ENSSGRP00000086179	annotation not available	Androgen receptor-like.	0.401
ENSSGRP00000009722	LOC107602339	ENSSGRP00000009722	ENSSGRP00000109462	annotation not available	Probable ATP-dependent RNA helicase DDX5 isoform X1.	0.657
ENSSGRP00000009722	med1	ENSSGRP00000009722	ENSSGRP00000087272	annotation not available	Mediator of RNA polymerase II transcription subunit 1 isoform X1.	0.857
ENSSGRP00000036259	LOC107579146	ENSSGRP00000036259	ENSSGRP00000009574	Ubiquitin protein ligase E3 component n-recognin 5.	E3 ubiquitin-protein ligase UBR5-like.	0.418
ENSSGRP00000039325	ENSSGRP00000009722	ENSSGRP00000039325	ENSSGRP00000009722	annotation not available	annotation not available	0.518
ENSSGRP00000039325	ENSSGRP00000047981	ENSSGRP00000039325	ENSSGRP00000047981	annotation not available	Estrogen receptor 2b.	0.518
ENSSGRP00000039325	ENSSGRP00000074243	ENSSGRP00000039325	ENSSGRP00000074243	annotation not available	Androgen receptor-like.	0.413