(49 nodes) Thyroid gland development network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107550651	Endothelin-1 receptor-like isoform X1. (422 aa)
	ENSSGRP00000023188	annotation not available (127 aa)
	ENSSGRP00000023709	annotation not available (432 aa)
	HESX1	HESX homeobox 1. (118 aa)
	ENSSGRP00000026683	annotation not available (1038 aa)
	TG	Thyroglobulin-like. (2711 aa)
	ENSSGRP00000035643	Jagged canonical Notch ligand 2b. (1222 aa)
	ENSSGRP00000035653	Paired box protein Pax-5-like. (385 aa)
	ENSSGRP00000037202	Protein jagged-2-like. (1142 aa)
	ENSSGRP00000038634	Endothelin receptor type Ab. (341 aa)
	ENSSGRP00000039338	Paired box 5. (370 aa)
	ENSSGRP00000040047	Jagged canonical Notch ligand 2a. (1133 aa)
	ENSSGRP00000040363	Paired box 2b. (270 aa)
	LOC107567477	Homeobox protein Nkx-2.5-like. (309 aa)
	LOC107598375	Homeobox protein Nkx-2.5-like. (315 aa)
	LOC107551382	Serum response factor-like. (524 aa)
	ENSSGRP00000044449	Heart- and neural crest derivatives-expressed protein 2-like. (208 aa)
	LOC107588637	Paired box protein Pax-2a. (418 aa)
	ENSSGRP00000053827	Fibroblast growth factor 8a. (206 aa)
	ENSSGRP00000055176	Serum response factor-like. (238 aa)
	ENSSGRP00000056586	Protein jagged-2-like. (144 aa)
	ENSSGRP00000061257	Endothelin receptor type Ab. (353 aa)
	LOC107552491	Heart- and neural crest derivatives-expressed protein 2. (208 aa)
	LOC107595156	Hematopoietically-expressed homeobox protein hhex-like. (226 aa)
	ENSSGRP00000068386	Hematopoietically-expressed homeobox protein hhex-like. (243 aa)
	ENSSGRP00000071108	T-cell acute lymphocytic leukemia 1. (324 aa)
	ENSSGRP00000073078	Paired box 2a. (409 aa)
	LOC107585503	Protein jagged-2-like. (1236 aa)
	LOC107585528	Protein jagged-1b-like. (1103 aa)
	ENSSGRP00000078393	Vascular endothelial growth factor A-A-like isoform X1. (139 aa)
	LOC107568266	Serum response factor-like isoform X1. (285 aa)
	LOC107588741	Fibroblast growth factor 8-like. (210 aa)
	LOC107551767	Endothelin-1-like. (189 aa)
	ENSSGRP00000098207	annotation not available (204 aa)
	LOC107550773	Vascular endothelial growth factor receptor kdr-like. (1312 aa)
	ENSSGRP00000000967	annotation not available (220 aa)
	ENSSGRP00000000972	annotation not available (828 aa)
	ENSSGRP00000003434	Protein jagged-1a. (1244 aa)
	ENSSGRP00000005880	T-cell acute lymphocytic leukemia protein 1 homolog. (183 aa)
	LOC107559691	Endothelin-1-like. (226 aa)
	ENSSGRP00000010257	annotation not available (145 aa)
	Pax8	Paired box protein Pax-8. (455 aa)
	ENSSGRP00000011869	Protein jagged-1b. (1161 aa)
	LOC107598731	Endothelin receptor type A. (422 aa)
	ENSSGRP00000018198	Serum response factor-like. (238 aa)
	ENSSGRP00000019188	annotation not available (83 aa)
	ENSSGRP00000021869	annotation not available (89 aa)
	ENSSGRP00000021870	Paired box protein Pax-8-like. (147 aa)
	LOC107566871	Paired box protein Pax-2a-like. (410 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000003434	ENSSGRP00000011869	ENSSGRP00000003434	ENSSGRP00000011869	Protein jagged-1a.	Protein jagged-1b.	0.901
ENSSGRP00000003434	LOC107550773	ENSSGRP00000003434	ENSSGRP00000110651	Protein jagged-1a.	Vascular endothelial growth factor receptor kdr-like.	0.471
ENSSGRP00000003434	LOC107585528	ENSSGRP00000003434	ENSSGRP00000075601	Protein jagged-1a.	Protein jagged-1b-like.	0.901
ENSSGRP00000005880	ENSSGRP00000068386	ENSSGRP00000005880	ENSSGRP00000068386	T-cell acute lymphocytic leukemia protein 1 homolog.	Hematopoietically-expressed homeobox protein hhex-like.	0.444
ENSSGRP00000005880	LOC107595156	ENSSGRP00000005880	ENSSGRP00000064588	T-cell acute lymphocytic leukemia protein 1 homolog.	Hematopoietically-expressed homeobox protein hhex-like.	0.444
ENSSGRP00000011869	ENSSGRP00000003434	ENSSGRP00000011869	ENSSGRP00000003434	Protein jagged-1b.	Protein jagged-1a.	0.901
ENSSGRP00000011869	LOC107550773	ENSSGRP00000011869	ENSSGRP00000110651	Protein jagged-1b.	Vascular endothelial growth factor receptor kdr-like.	0.429
ENSSGRP00000011869	LOC107585528	ENSSGRP00000011869	ENSSGRP00000075601	Protein jagged-1b.	Protein jagged-1b-like.	0.900
ENSSGRP00000018198	LOC107567477	ENSSGRP00000018198	ENSSGRP00000041521	Serum response factor-like.	Homeobox protein Nkx-2.5-like.	0.503
ENSSGRP00000018198	LOC107598375	ENSSGRP00000018198	ENSSGRP00000041746	Serum response factor-like.	Homeobox protein Nkx-2.5-like.	0.503
ENSSGRP00000023188	LOC107550773	ENSSGRP00000023188	ENSSGRP00000110651	annotation not available	Vascular endothelial growth factor receptor kdr-like.	0.471
ENSSGRP00000023709	LOC107567477	ENSSGRP00000023709	ENSSGRP00000041521	annotation not available	Homeobox protein Nkx-2.5-like.	0.503
ENSSGRP00000023709	LOC107598375	ENSSGRP00000023709	ENSSGRP00000041746	annotation not available	Homeobox protein Nkx-2.5-like.	0.503
ENSSGRP00000026683	LOC107550773	ENSSGRP00000026683	ENSSGRP00000110651	annotation not available	Vascular endothelial growth factor receptor kdr-like.	0.471
ENSSGRP00000038634	LOC107551767	ENSSGRP00000038634	ENSSGRP00000088481	Endothelin receptor type Ab.	Endothelin-1-like.	0.970
ENSSGRP00000038634	LOC107559691	ENSSGRP00000038634	ENSSGRP00000008726	Endothelin receptor type Ab.	Endothelin-1-like.	0.970
ENSSGRP00000044449	ENSSGRP00000053827	ENSSGRP00000044449	ENSSGRP00000053827	Heart- and neural crest derivatives-expressed protein 2-like.	Fibroblast growth factor 8a.	0.503
ENSSGRP00000044449	LOC107551767	ENSSGRP00000044449	ENSSGRP00000088481	Heart- and neural crest derivatives-expressed protein 2-like.	Endothelin-1-like.	0.776
ENSSGRP00000044449	LOC107559691	ENSSGRP00000044449	ENSSGRP00000008726	Heart- and neural crest derivatives-expressed protein 2-like.	Endothelin-1-like.	0.776
ENSSGRP00000044449	LOC107567477	ENSSGRP00000044449	ENSSGRP00000041521	Heart- and neural crest derivatives-expressed protein 2-like.	Homeobox protein Nkx-2.5-like.	0.751