(62 nodes) Endocrine pancreas development network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107554285	Transcription factor 2, hepatocyte nuclear factor 1-beta. (558 aa)
	ENSSGRP00000002710	NK2 homeobox 2b. (166 aa)
	INSM1	INSM transcriptional repressor 1. (400 aa)
	ENSSGRP00000053282	annotation not available (97 aa)
	ENSSGRP00000053283	Glucagon-1-like. (115 aa)
	LOC107548428	Insulinoma-associated protein 1a. (398 aa)
	LOC107602011	Insulin gene enhancer protein isl-1-like isoform X1. (349 aa)
	ENSSGRP00000054792	Neuronal differentiation 1. (303 aa)
	LOC107591753	Homeobox protein Nkx-6.1-like. (318 aa)
	ENSSGRP00000059054	Aristaless-related homeobox protein-like. (449 aa)
	Nkx2-2	Homeobox protein Nkx-2.2. (269 aa)
	LOC107556063	Sonic hedgehog protein A. (418 aa)
	LOC107556057	Motor neuron and pancreas homeobox protein 1-like. (322 aa)
	Rfx6	DNA-binding protein RFX6. (835 aa)
	ENSSGRP00000065033	Insulin. (175 aa)
	ENSSGRP00000067161	Homeobox protein Nkx-6.2-like. (274 aa)
	LOC107548416	Homeobox protein Nkx-2.2a-like. (230 aa)
	ENSSGRP00000051879	Achaete-scute complex protein. (176 aa)
	LOC107572035	Wingless-type MMTV integration site family, member 5. (380 aa)
	LOC107553896	Wingless-type MMTV integration site family, member 5. (374 aa)
	ENSSGRP00000046849	Pancreatic and duodenal homeobox 1. (189 aa)
	ENSSGRP00000044424	Homeobox protein Hox-C8a-like isoform X1. (257 aa)
	ENSSGRP00000040415	Aristaless-related homeobox protein-like. (424 aa)
	LOC107564660	Fat storage-inducing transmembrane protein 2-like isoform X1. (260 aa)
	LOC107593970	Homeobox protein HoxB/C/D8. (256 aa)
	ENSSGRP00000052561	Islet1, like. (177 aa)
	LOC107593098	Glucagon. (176 aa)
	ENSSGRP00000108991	Transcription factor 2, hepatocyte nuclear factor 1-beta. (538 aa)
	ENSSGRP00000106720	Smoothened homolog. (662 aa)
	LOC107586699	Aristaless-related homeobox protein. (453 aa)
	ENSSGRP00000104497	Regulatory factor X, 3 (influences HLA class II expression). (697 aa)
	LOC107596434	Achaete-scute complex protein. (198 aa)
	LOC107564444	Insulinoma-associated protein 1b. (442 aa)
	LOC107591009	Sonic hedgehog protein A-like. (418 aa)
	LOC107591052	Motor neuron and pancreas homeobox protein 1-like. (314 aa)
	ENSSGRP00000093665	Achaete-scute complex protein. (175 aa)
	ENSSGRP00000092902	Pancreatic and duodenal homeobox 1. (248 aa)
	ENSSGRP00000092794	Aristaless related homeobox b. (259 aa)
	LOC107599231	Insulin-like. (108 aa)
	LOC107581926	Transcription factor 2, hepatocyte nuclear factor 1-beta. (535 aa)
	nkx6-1	Homeobox protein Nkx-6.1. (317 aa)
	ENSSGRP00000088042	Homeobox protein Nkx-2.2a. (269 aa)
	LOC107558475	Insulinoma-associated protein 1b-like. (445 aa)
	LOC107599171	Insulin gene enhancer protein isl-1 isoform X1. (349 aa)
	LOC107594820	Interleukin-6 receptor subunit alpha-like isoform X1. (621 aa)
	ENSSGRP00000007029	Betaine--homocysteine S-methyltransferase 1-like. (142 aa)
	ENSSGRP00000006097	annotation not available (108 aa)
	ENSSGRP00000005580	Homeobox protein HTR-A2-like. (158 aa)
	ENSSGRP00000005423	annotation not available (202 aa)
	ENSSGRP00000029253	annotation not available (168 aa)
	LOC107582604	Transcription factor 2, hepatocyte nuclear factor 1-beta. (563 aa)
	ENSSGRP00000022448	Regulatory factor X 1/2/3. (698 aa)
	LOC107600448	Achaete-scute complex protein. (198 aa)
	Cdkal1	Threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1. (573 aa)
	ENSSGRP00000018936	annotation not available (562 aa)
	ENSSGRP00000018602	Betaine--homocysteine S-methyltransferase 1-like isoform X1. (226 aa)
	ENSSGRP00000017318	Insulin gene enhancer protein ISL-2A-like isoform X1. (286 aa)
	LOC107594474	Apoptosis regulator BAX-like. (241 aa)
	LOC107601389	Neurogenic differentiation factor 1-like. (348 aa)
	LOC107568407	Fat storage-inducing transmembrane protein 2-like. (248 aa)
	ENSSGRP00000011219	Homeobox protein Nkx-6.2-like. (274 aa)
	ENSSGRP00000009164	Insulin gene enhancer protein isl-1-like. (140 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdkal1	ENSSGRP00000018936	ENSSGRP00000020298	ENSSGRP00000018936	Threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1.	annotation not available	0.524
Cdkal1	Rfx6	ENSSGRP00000020298	ENSSGRP00000064769	Threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1.	DNA-binding protein RFX6.	0.524
ENSSGRP00000002710	ENSSGRP00000054792	ENSSGRP00000002710	ENSSGRP00000054792	NK2 homeobox 2b.	Neuronal differentiation 1.	0.512
ENSSGRP00000002710	ENSSGRP00000065033	ENSSGRP00000002710	ENSSGRP00000065033	NK2 homeobox 2b.	Insulin.	0.562
ENSSGRP00000002710	LOC107556063	ENSSGRP00000002710	ENSSGRP00000063780	NK2 homeobox 2b.	Sonic hedgehog protein A.	0.420
ENSSGRP00000002710	LOC107591009	ENSSGRP00000002710	ENSSGRP00000094493	NK2 homeobox 2b.	Sonic hedgehog protein A-like.	0.420
ENSSGRP00000002710	LOC107599231	ENSSGRP00000002710	ENSSGRP00000091706	NK2 homeobox 2b.	Insulin-like.	0.516
ENSSGRP00000002710	LOC107601389	ENSSGRP00000002710	ENSSGRP00000013249	NK2 homeobox 2b.	Neurogenic differentiation factor 1-like.	0.512
ENSSGRP00000005423	ENSSGRP00000007029	ENSSGRP00000005423	ENSSGRP00000007029	annotation not available	Betaine--homocysteine S-methyltransferase 1-like.	0.488
ENSSGRP00000005580	ENSSGRP00000011219	ENSSGRP00000005580	ENSSGRP00000011219	Homeobox protein HTR-A2-like.	Homeobox protein Nkx-6.2-like.	0.422
ENSSGRP00000005580	ENSSGRP00000065033	ENSSGRP00000005580	ENSSGRP00000065033	Homeobox protein HTR-A2-like.	Insulin.	0.754
ENSSGRP00000005580	ENSSGRP00000067161	ENSSGRP00000005580	ENSSGRP00000067161	Homeobox protein HTR-A2-like.	Homeobox protein Nkx-6.2-like.	0.422
ENSSGRP00000005580	LOC107591753	ENSSGRP00000005580	ENSSGRP00000054897	Homeobox protein HTR-A2-like.	Homeobox protein Nkx-6.1-like.	0.431
ENSSGRP00000005580	LOC107599231	ENSSGRP00000005580	ENSSGRP00000091706	Homeobox protein HTR-A2-like.	Insulin-like.	0.679
ENSSGRP00000005580	nkx6-1	ENSSGRP00000005580	ENSSGRP00000088394	Homeobox protein HTR-A2-like.	Homeobox protein Nkx-6.1.	0.431
ENSSGRP00000007029	ENSSGRP00000005423	ENSSGRP00000007029	ENSSGRP00000005423	Betaine--homocysteine S-methyltransferase 1-like.	annotation not available	0.488
ENSSGRP00000007029	ENSSGRP00000018602	ENSSGRP00000007029	ENSSGRP00000018602	Betaine--homocysteine S-methyltransferase 1-like.	Betaine--homocysteine S-methyltransferase 1-like isoform X1.	0.484
ENSSGRP00000009164	ENSSGRP00000054792	ENSSGRP00000009164	ENSSGRP00000054792	Insulin gene enhancer protein isl-1-like.	Neuronal differentiation 1.	0.420
ENSSGRP00000009164	LOC107556057	ENSSGRP00000009164	ENSSGRP00000063793	Insulin gene enhancer protein isl-1-like.	Motor neuron and pancreas homeobox protein 1-like.	0.400
ENSSGRP00000009164	LOC107591052	ENSSGRP00000009164	ENSSGRP00000094447	Insulin gene enhancer protein isl-1-like.	Motor neuron and pancreas homeobox protein 1-like.	0.400