(66 nodes) Negative regulation of I-kappaB kinase/NF-kappaB signaling network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107597346	Caspase-8-like isoform X1. (383 aa)
	LOC107551331	Nuclear receptor subfamily 1 group D member 1-like. (579 aa)
	LOC107570978	Bile acid receptor-like isoform X1. (482 aa)
	LOC107561506	Ubiquitin carboxyl-terminal hydrolase 10-like. (799 aa)
	LOC107586761	Zinc finger MYND domain-containing protein 11-like. (641 aa)
	LOC107597710	Tumor necrosis factor alpha-induced protein 3-like. (780 aa)
	ENSSGRP00000034839	Caspase 10, apoptosis-related cysteine peptidase. (471 aa)
	LOC107593977	Nuclear receptor subfamily 1 group D member 1-like. (571 aa)
	ENSSGRP00000031485	Caspase-8-like. (140 aa)
	LOC107555418	Caspase-8-like. (324 aa)
	ENSSGRP00000031237	Caspase-8-like. (477 aa)
	LOC107560378	Protein phosphatase 1A-like. (333 aa)
	ENSSGRP00000030622	annotation not available (92 aa)
	ENSSGRP00000030621	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative). (184 aa)
	LOC107566313	Caspase-8-like. (350 aa)
	ENSSGRP00000029537	annotation not available (218 aa)
	ENSSGRP00000029534	Caspase-8-like. (202 aa)
	LOC107596620	[histone H3]-lysine4 N-trimethyltransferase ASH1L. (1702 aa)
	riok3	Serine/threonine-protein kinase RIO3. (507 aa)
	LOC107562394	NAD-dependent protein deacetylase sirtuin-1-like. (642 aa)
	LOC107601877	Inhibitor of nuclear factor kappa-B kinase subunit alpha-like. (759 aa)
	ENSSGRP00000011614	Ribonuclease ZC3H12A-like. (567 aa)
	ENSSGRP00000010868	Caspase-8-like. (240 aa)
	zc3h12a	Bifunctional endoribonuclease and deubiquitinase ZC3H12A. (643 aa)
	ENSSGRP00000006828	[histone H3]-lysine4 N-trimethyltransferase ASH1L. (67 aa)
	ENSSGRP00000006151	Caspase-8-like isoform X1. (152 aa)
	LOC107592144	OTU domain-containing protein 7B-like isoform X1. (912 aa)
	LOC107602505	Protein phosphatase 1B-like. (390 aa)
	ENSSGRP00000110564	Ash1 (absent, small, or homeotic)-like (Drosophila). (2606 aa)
	ENSSGRP00000104985	annotation not available (146 aa)
	LOC107565065	NAD-dependent protein deacetylase sirtuin-1-like isoform X1. (501 aa)
	LOC107594924	TNFAIP3-interacting protein 1-like isoform X1. (653 aa)
	LOC107563834	TRAF family member-associated NF-kappa-B activator-like isoform X1. (349 aa)
	ENSSGRP00000099267	Nuclear receptor subfamily 1 group D member 1-like isoform X1. (631 aa)
	ENSSGRP00000096567	OTU domain-containing protein 7B-like. (869 aa)
	ENSSGRP00000096415	RIO kinase 3 (yeast). (333 aa)
	LOC107594886	TNFAIP3-interacting protein 1-like isoform X1. (650 aa)
	LOC107590252	Zinc finger MYND domain-containing protein 11-like. (638 aa)
	LOC107585045	Nuclear receptor subfamily 1 group D member 1-like isoform X1. (613 aa)
	LOC107551774	Ribonuclease ZC3H12A-like. (643 aa)
	LOC107548624	Protein phosphatase 1A-like. (450 aa)
	ENSSGRP00000087331	Caspase-8-like. (228 aa)
	ENSSGRP00000087301	annotation not available (286 aa)
	LOC107582773	Protein phosphatase 1B-like. (527 aa)
	LOC107566714	Adiponectin-like. (276 aa)
	ENSSGRP00000080859	Protein phosphatase 1A-like. (156 aa)
	ENSSGRP00000080858	annotation not available (70 aa)
	LOC107601693	NLR family member X1-like. (757 aa)
	nlrx1	NLR family member X1 isoform X1. (1009 aa)
	LOC107583817	Bile acid receptor-like. (345 aa)
	LOC107550219	OTU domain-containing protein 7A-like. (941 aa)
	LOC107588600	Protein phosphatase 1A isoform X1. (390 aa)
	LOC107589071	Protein phosphatase 1A-like. (372 aa)
	ENSSGRP00000059316	Histone-lysine N-methyltransferase ASH1L-like isoform X1. (2475 aa)
	nr1h4	Farnesoid X receptor. (483 aa)
	LOC107561568	TRAF family member-associated NF-kappa-B activator-like isoform X1. (349 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase 10. (896 aa)
	ENSSGRP00000052147	Component of inhibitor of nuclear factor kappa B kinase complex. (803 aa)
	TNFAIP3	TNF alpha induced protein 3. (688 aa)
	LOC107585253	Protein phosphatase 1B-like. (390 aa)
	ENSSGRP00000046716	Histone-lysine N-methyltransferase ASH1L-like isoform X1. (161 aa)
	ENSSGRP00000044854	Bile acid receptor-like isoform X1. (479 aa)
	ENSSGRP00000044387	Nuclear receptor subfamily 1 group D member 1-like. (519 aa)
	ENSSGRP00000042990	Zinc finger CCCH-type containing 12A. (167 aa)
	LOC107550052	Protein phosphatase 1B-like isoform X1. (476 aa)
	LOC107598848	OTU domain-containing protein 7A-like. (941 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000010868	ENSSGRP00000031237	ENSSGRP00000010868	ENSSGRP00000031237	Caspase-8-like.	Caspase-8-like.	0.669
ENSSGRP00000010868	LOC107555418	ENSSGRP00000010868	ENSSGRP00000031239	Caspase-8-like.	Caspase-8-like.	0.677
ENSSGRP00000010868	LOC107566313	ENSSGRP00000010868	ENSSGRP00000029538	Caspase-8-like.	Caspase-8-like.	0.654
ENSSGRP00000010868	LOC107597346	ENSSGRP00000010868	ENSSGRP00000039385	Caspase-8-like.	Caspase-8-like isoform X1.	0.675
ENSSGRP00000011614	LOC107561568	ENSSGRP00000011614	ENSSGRP00000054633	Ribonuclease ZC3H12A-like.	TRAF family member-associated NF-kappa-B activator-like isoform X1.	0.592
ENSSGRP00000011614	LOC107563834	ENSSGRP00000011614	ENSSGRP00000101479	Ribonuclease ZC3H12A-like.	TRAF family member-associated NF-kappa-B activator-like isoform X1.	0.592
ENSSGRP00000031237	ENSSGRP00000010868	ENSSGRP00000031237	ENSSGRP00000010868	Caspase-8-like.	Caspase-8-like.	0.669
ENSSGRP00000042990	LOC107561568	ENSSGRP00000042990	ENSSGRP00000054633	Zinc finger CCCH-type containing 12A.	TRAF family member-associated NF-kappa-B activator-like isoform X1.	0.592
ENSSGRP00000042990	LOC107563834	ENSSGRP00000042990	ENSSGRP00000101479	Zinc finger CCCH-type containing 12A.	TRAF family member-associated NF-kappa-B activator-like isoform X1.	0.592
ENSSGRP00000052147	ENSSGRP00000096567	ENSSGRP00000052147	ENSSGRP00000096567	Component of inhibitor of nuclear factor kappa B kinase complex.	OTU domain-containing protein 7B-like.	0.463
ENSSGRP00000052147	LOC107550219	ENSSGRP00000052147	ENSSGRP00000067500	Component of inhibitor of nuclear factor kappa B kinase complex.	OTU domain-containing protein 7A-like.	0.463
ENSSGRP00000052147	LOC107561568	ENSSGRP00000052147	ENSSGRP00000054633	Component of inhibitor of nuclear factor kappa B kinase complex.	TRAF family member-associated NF-kappa-B activator-like isoform X1.	0.608
ENSSGRP00000052147	LOC107563834	ENSSGRP00000052147	ENSSGRP00000101479	Component of inhibitor of nuclear factor kappa B kinase complex.	TRAF family member-associated NF-kappa-B activator-like isoform X1.	0.608
ENSSGRP00000052147	LOC107592144	ENSSGRP00000052147	ENSSGRP00000002575	Component of inhibitor of nuclear factor kappa B kinase complex.	OTU domain-containing protein 7B-like isoform X1.	0.463
ENSSGRP00000052147	LOC107597710	ENSSGRP00000052147	ENSSGRP00000035382	Component of inhibitor of nuclear factor kappa B kinase complex.	Tumor necrosis factor alpha-induced protein 3-like.	0.652
ENSSGRP00000052147	LOC107598848	ENSSGRP00000052147	ENSSGRP00000041572	Component of inhibitor of nuclear factor kappa B kinase complex.	OTU domain-containing protein 7A-like.	0.463
ENSSGRP00000052147	LOC107601693	ENSSGRP00000052147	ENSSGRP00000077644	Component of inhibitor of nuclear factor kappa B kinase complex.	NLR family member X1-like.	0.622
ENSSGRP00000052147	TNFAIP3	ENSSGRP00000052147	ENSSGRP00000049280	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF alpha induced protein 3.	0.652
ENSSGRP00000052147	nlrx1	ENSSGRP00000052147	ENSSGRP00000076968	Component of inhibitor of nuclear factor kappa B kinase complex.	NLR family member X1 isoform X1.	0.622
ENSSGRP00000096567	ENSSGRP00000052147	ENSSGRP00000096567	ENSSGRP00000052147	OTU domain-containing protein 7B-like.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.463