(34 nodes) Positive regulation of isotype switching network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000013485	annotation not available (223 aa)
	LOC107596557	T-cell-specific surface glycoprotein CD28-like. (229 aa)
	ENSSGRP00000110678	Replication timing regulatory factor 1. (2339 aa)
	ENSSGRP00000106263	5-hydroxymethylcytosine binding, ES cell specific. (290 aa)
	ENSSGRP00000106262	annotation not available (85 aa)
	ENSSGRP00000105593	[histone H4]-N-methyl-L-lysine20 N-methyltransferase. (491 aa)
	ENSSGRP00000104050	Tumor protein p53 binding protein, 1. (1687 aa)
	ENSSGRP00000101205	Protein FAM35A-like. (257 aa)
	ENSSGRP00000101202	annotation not available (397 aa)
	LOC107596936	[histone H4]-N-methyl-L-lysine20 N-methyltransferase. (809 aa)
	ENSSGRP00000096801	[histone H3]-lysine36 N-dimethyltransferase NSD2. (1462 aa)
	LOC107589304	Transforming growth factor beta-1-like. (381 aa)
	ENSSGRP00000094094	annotation not available (752 aa)
	LOC107563776	T-box brain protein 1-like isoform X1. (608 aa)
	LOC107582784	DNA mismatch repair protein Msh2-like. (946 aa)
	ENSSGRP00000077132	Tumor necrosis factor receptor superfamily member 5-like. (213 aa)
	EXOSC3	Exosome complex component RRP40. (275 aa)
	hmces	Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein. (353 aa)
	Rif1	Telomere-associated protein RIF1. (2189 aa)
	PTPRC-2	Protein tyrosine phosphatase receptor type C. (1160 aa)
	LOC107598564	Transforming growth factor beta-1-like. (376 aa)
	mlh1	DNA mismatch repair protein MLH1. (724 aa)
	LOC107573058	Transforming growth factor beta-1. (380 aa)
	LOC107599738	Tumor necrosis factor receptor superfamily member 5-like. (296 aa)
	LOC107550043	DNA mismatch repair protein Msh2-like. (936 aa)
	ENSSGRP00000037912	Transforming growth factor beta-1-like. (376 aa)
	ENSSGRP00000037665	Histone-lysine N-methyltransferase NSD2-like isoform X1. (1463 aa)
	LOC107583742	[histone H4]-N-methyl-L-lysine20 N-methyltransferase. (810 aa)
	LOC107565723	T-box brain protein 1-like. (608 aa)
	LOC107600464	Tumor suppressor p53-binding protein 1-like. (1634 aa)
	ENSSGRP00000014856	ATPase family AAA domain containing 5a. (971 aa)
	LOC107583067	[histone H4]-N-methyl-L-lysine20 N-methyltransferase. (2112 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C-like. (1106 aa)
	LOC107573342	Uncharacterized protein LOC107573342. (251 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000014856	LOC107550043	ENSSGRP00000014856	ENSSGRP00000041943	ATPase family AAA domain containing 5a.	DNA mismatch repair protein Msh2-like.	0.484
ENSSGRP00000014856	LOC107582784	ENSSGRP00000014856	ENSSGRP00000087509	ATPase family AAA domain containing 5a.	DNA mismatch repair protein Msh2-like.	0.484
ENSSGRP00000014856	mlh1	ENSSGRP00000014856	ENSSGRP00000059287	ATPase family AAA domain containing 5a.	DNA mismatch repair protein MLH1.	0.467
ENSSGRP00000037665	ENSSGRP00000104050	ENSSGRP00000037665	ENSSGRP00000104050	Histone-lysine N-methyltransferase NSD2-like isoform X1.	Tumor protein p53 binding protein, 1.	0.737
ENSSGRP00000037665	ENSSGRP00000110678	ENSSGRP00000037665	ENSSGRP00000110678	Histone-lysine N-methyltransferase NSD2-like isoform X1.	Replication timing regulatory factor 1.	0.608
ENSSGRP00000037665	LOC107600464	ENSSGRP00000037665	ENSSGRP00000026454	Histone-lysine N-methyltransferase NSD2-like isoform X1.	Tumor suppressor p53-binding protein 1-like.	0.737
ENSSGRP00000037665	Rif1	ENSSGRP00000037665	ENSSGRP00000067914	Histone-lysine N-methyltransferase NSD2-like isoform X1.	Telomere-associated protein RIF1.	0.608
ENSSGRP00000077132	LOC107599738	ENSSGRP00000077132	ENSSGRP00000053408	Tumor necrosis factor receptor superfamily member 5-like.	Tumor necrosis factor receptor superfamily member 5-like.	0.901
ENSSGRP00000077132	PTPRC	ENSSGRP00000077132	ENSSGRP00000008251	Tumor necrosis factor receptor superfamily member 5-like.	Receptor-type tyrosine-protein phosphatase C-like.	0.471
ENSSGRP00000077132	PTPRC-2	ENSSGRP00000077132	ENSSGRP00000063515	Tumor necrosis factor receptor superfamily member 5-like.	Protein tyrosine phosphatase receptor type C.	0.471
ENSSGRP00000094094	LOC107550043	ENSSGRP00000094094	ENSSGRP00000041943	annotation not available	DNA mismatch repair protein Msh2-like.	0.484
ENSSGRP00000094094	LOC107582784	ENSSGRP00000094094	ENSSGRP00000087509	annotation not available	DNA mismatch repair protein Msh2-like.	0.484
ENSSGRP00000094094	mlh1	ENSSGRP00000094094	ENSSGRP00000059287	annotation not available	DNA mismatch repair protein MLH1.	0.467
ENSSGRP00000096801	ENSSGRP00000104050	ENSSGRP00000096801	ENSSGRP00000104050	[histone H3]-lysine36 N-dimethyltransferase NSD2.	Tumor protein p53 binding protein, 1.	0.737
ENSSGRP00000096801	ENSSGRP00000110678	ENSSGRP00000096801	ENSSGRP00000110678	[histone H3]-lysine36 N-dimethyltransferase NSD2.	Replication timing regulatory factor 1.	0.608
ENSSGRP00000096801	LOC107600464	ENSSGRP00000096801	ENSSGRP00000026454	[histone H3]-lysine36 N-dimethyltransferase NSD2.	Tumor suppressor p53-binding protein 1-like.	0.737
ENSSGRP00000096801	Rif1	ENSSGRP00000096801	ENSSGRP00000067914	[histone H3]-lysine36 N-dimethyltransferase NSD2.	Telomere-associated protein RIF1.	0.608
ENSSGRP00000101202	ENSSGRP00000104050	ENSSGRP00000101202	ENSSGRP00000104050	annotation not available	Tumor protein p53 binding protein, 1.	0.488
ENSSGRP00000101202	ENSSGRP00000110678	ENSSGRP00000101202	ENSSGRP00000110678	annotation not available	Replication timing regulatory factor 1.	0.413
ENSSGRP00000101202	LOC107573342	ENSSGRP00000101202	ENSSGRP00000000596	annotation not available	Uncharacterized protein LOC107573342.	0.956