(82 nodes) T cell receptor signaling pathway network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSSGRP00000002444	RING finger and CCCH-type zinc finger domain-containing protein. (975 aa)
	Lcp2	Lymphocyte cytosolic protein 2. (389 aa)
	ENSSGRP00000002744	Ring finger and CCCH-type domains 1a. (983 aa)
	ENSSGRP00000002815	Receptor-interacting serine/threonine-protein kinase 2-like. (80 aa)
	ENSSGRP00000002817	Receptor-interacting serine/threonine-protein kinase 2-like. (392 aa)
	ENSSGRP00000004228	Immune costimulatory protein B7-H3. (302 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C-like. (1106 aa)
	zc3h12a	Bifunctional endoribonuclease and deubiquitinase ZC3H12A. (643 aa)
	ENSSGRP00000009137	annotation not available (71 aa)
	LOC107567864	Translation initiation factor eIF-2B subunit epsilon-like. (698 aa)
	ENSSGRP00000011614	Ribonuclease ZC3H12A-like. (567 aa)
	ENSSGRP00000012751	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta. (458 aa)
	ENSSGRP00000012795	annotation not available (147 aa)
	ENSSGRP00000014694	Roquin-2-like. (951 aa)
	Skap1	Src kinase associated phosphoprotein 1. (383 aa)
	LOC107573567	RanBP-type and C3HC4-type zinc finger-containing protein 1-like. (510 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain isoform X1. (197 aa)
	LOC107595546	RING finger and CCCH-type zinc finger domain-containing protein. (1041 aa)
	ENSSGRP00000019426	Protein THEMIS-like. (203 aa)
	LOC107568457	CDP-diacylglycerol--serine O-phosphatidyltransferase-like isoform X1. (249 aa)
	Plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2. (1147 aa)
	ENSSGRP00000030777	Uncharacterized protein LOC107602534. (529 aa)
	ENSSGRP00000030778	Si:dkey-181m9.8. (344 aa)
	LOC107560775	RING finger and CCCH-type zinc finger domain-containing protein. (1096 aa)
	ENSSGRP00000031584	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like. (582 aa)
	NFKBID	NF-kappa-B inhibitor delta-like. (318 aa)
	ENSSGRP00000037392	annotation not available (910 aa)
	ENSSGRP00000038441	Signal peptide peptidase-like 3. (372 aa)
	ENSSGRP00000042990	Zinc finger CCCH-type containing 12A. (167 aa)
	LOC107599900	Translation initiation factor eIF-2B subunit gamma-like isoform X1. (470 aa)
	LOC107561932	Translation initiation factor eIF-2B subunit delta-like isoform X1. (538 aa)
	ENSSGRP00000045128	Signal peptide peptidase-like 3. (388 aa)
	stoml2	Stomatin-like protein 2, mitochondrial. (359 aa)
	ENSSGRP00000048275	RanBP-type and C3HC4-type zinc finger-containing protein 1-like. (497 aa)
	ENSSGRP00000048411	Tumor necrosis factor receptor superfamily, member 21. (585 aa)
	ENSSGRP00000052722	Receptor-interacting serine/threonine-protein kinase 2-like. (554 aa)
	ENSSGRP00000052869	FYN binding protein b. (530 aa)
	LOC107592879	FYN-binding protein-like. (512 aa)
	LOC107589057	Translation initiation factor eIF-2B subunit delta-like. (537 aa)
	ENSSGRP00000057899	Translation initiation factor eIF-2B subunit alpha-like. (250 aa)
	ENSSGRP00000061204	annotation not available (1046 aa)
	ENSSGRP00000061224	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like. (1074 aa)
	ENSSGRP00000061272	Phospholipase C, gamma 1. (1258 aa)
	LOC107558289	Translation initiation factor eIF-2B subunit gamma-like. (441 aa)
	STK11	Serine/threonine kinase 11. (340 aa)
	PTPRC-2	Protein tyrosine phosphatase receptor type C. (1160 aa)
	ENSSGRP00000063914	Uncharacterized protein LOC107589851 isoform X1. (279 aa)
	ENSSGRP00000067345	annotation not available (118 aa)
	vtcn1	V-set domain-containing T-cell activation inhibitor 1. (285 aa)
	LOC107553479	Tumor necrosis factor receptor superfamily member 21-like. (654 aa)
	LOC107583469	Tyrosine-protein kinase fyna. (537 aa)
	ENSSGRP00000068556	CD247 antigen like. (131 aa)
	ENSSGRP00000069389	annotation not available (179 aa)
	ENSSGRP00000069392	annotation not available (159 aa)
	Malt1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (255 aa)
	ENSSGRP00000069702	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like. (720 aa)
	LOC107564973	Tyrosine-protein kinase fyna-like. (490 aa)
	ENSSGRP00000072665	Eukaryotic translation initiation factor 2B, subunit 1 alpha. (288 aa)
	LOC107588069	RING finger and CCCH-type zinc finger domain-containing protein. (1090 aa)
	LOC107588074	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog. (801 aa)
	ENSSGRP00000075445	FYN proto-oncogene, Src family tyrosine kinase b. (530 aa)
	ENSSGRP00000077961	Protein THEMIS2-like. (538 aa)
	ENSSGRP00000079357	annotation not available (261 aa)
	STOML2	Stomatin-like protein 2, mitochondrial. (354 aa)
	ENSSGRP00000083468	CD247 antigen like. (143 aa)
	LOC107554148	Protein THEMIS-like. (581 aa)
	rnf31	E3 ubiquitin-protein ligase RNF31. (1055 aa)
	themis	Protein THEMIS. (684 aa)
	ENSSGRP00000088263	Si:dkey-181m9.8. (536 aa)
	LOC107551774	Ribonuclease ZC3H12A-like. (643 aa)
	eif2b2	Translation initiation factor eIF-2B subunit beta. (355 aa)
	ENSSGRP00000092169	FYN binding protein b. (592 aa)
	ENSSGRP00000098197	Thymocyte selection associated family member 2. (553 aa)
	ENSSGRP00000100713	annotation not available (121 aa)
	LOC107570193	CDP-diacylglycerol--serine O-phosphatidyltransferase-like isoform X1. (241 aa)
	LOC107592114	Raftlin-like isoform X1. (614 aa)
	ENSSGRP00000107030	Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (552 aa)
	ENSSGRP00000107384	FYN proto-oncogene, Src family tyrosine kinase b. (537 aa)
	ENSSGRP00000107667	HERV-H LTR-associating 2b, tandem duplicate 2. (352 aa)
	LOC107593258	Translation initiation factor eIF-2B subunit beta-like. (344 aa)
	ENSSGRP00000109206	Phospholipase C, gamma 1. (1252 aa)
	LOC107596557	T-cell-specific surface glycoprotein CD28-like. (229 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	ENSSGRP00000002815	ENSSGRP00000018699	ENSSGRP00000002815	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Receptor-interacting serine/threonine-protein kinase 2-like.	0.524
CD247	ENSSGRP00000002817	ENSSGRP00000018699	ENSSGRP00000002817	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Receptor-interacting serine/threonine-protein kinase 2-like.	0.524
CD247	ENSSGRP00000004228	ENSSGRP00000018699	ENSSGRP00000004228	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Immune costimulatory protein B7-H3.	0.459
CD247	ENSSGRP00000009137	ENSSGRP00000018699	ENSSGRP00000009137	T-cell surface glycoprotein CD3 zeta chain isoform X1.	annotation not available	0.524
CD247	ENSSGRP00000052722	ENSSGRP00000018699	ENSSGRP00000052722	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Receptor-interacting serine/threonine-protein kinase 2-like.	0.524
CD247	ENSSGRP00000061204	ENSSGRP00000018699	ENSSGRP00000061204	T-cell surface glycoprotein CD3 zeta chain isoform X1.	annotation not available	0.497
CD247	ENSSGRP00000061224	ENSSGRP00000018699	ENSSGRP00000061224	T-cell surface glycoprotein CD3 zeta chain isoform X1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like.	0.497
CD247	ENSSGRP00000061272	ENSSGRP00000018699	ENSSGRP00000061272	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Phospholipase C, gamma 1.	0.497
CD247	ENSSGRP00000075445	ENSSGRP00000018699	ENSSGRP00000075445	T-cell surface glycoprotein CD3 zeta chain isoform X1.	FYN proto-oncogene, Src family tyrosine kinase b.	0.459
CD247	ENSSGRP00000107384	ENSSGRP00000018699	ENSSGRP00000107384	T-cell surface glycoprotein CD3 zeta chain isoform X1.	FYN proto-oncogene, Src family tyrosine kinase b.	0.459
CD247	ENSSGRP00000109206	ENSSGRP00000018699	ENSSGRP00000109206	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Phospholipase C, gamma 1.	0.497
CD247	LOC107564973	ENSSGRP00000018699	ENSSGRP00000071109	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein kinase fyna-like.	0.459
CD247	LOC107583469	ENSSGRP00000018699	ENSSGRP00000067789	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein kinase fyna.	0.459
CD247	Lcp2	ENSSGRP00000018699	ENSSGRP00000002720	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Lymphocyte cytosolic protein 2.	0.833
CD247	PTPRC	ENSSGRP00000018699	ENSSGRP00000008251	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Receptor-type tyrosine-protein phosphatase C-like.	0.632
CD247	PTPRC-2	ENSSGRP00000018699	ENSSGRP00000063515	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Protein tyrosine phosphatase receptor type C.	0.632
CD247	Plcg2	ENSSGRP00000018699	ENSSGRP00000024097	T-cell surface glycoprotein CD3 zeta chain isoform X1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2.	0.497
ENSSGRP00000002444	ENSSGRP00000014694	ENSSGRP00000002444	ENSSGRP00000014694	RING finger and CCCH-type zinc finger domain-containing protein.	Roquin-2-like.	0.591
ENSSGRP00000002444	LOC107595546	ENSSGRP00000002444	ENSSGRP00000018764	RING finger and CCCH-type zinc finger domain-containing protein.	RING finger and CCCH-type zinc finger domain-containing protein.	0.589
ENSSGRP00000002744	ENSSGRP00000011614	ENSSGRP00000002744	ENSSGRP00000011614	Ring finger and CCCH-type domains 1a.	Ribonuclease ZC3H12A-like.	0.585