(67 nodes) Negative regulation of ERK1 and ERK2 cascade network (Sinocyclocheilus grahami)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107549459	Folliculin-like isoform X1. (560 aa)
	LOC107587364	Disabled homolog 2-like isoform X1. (783 aa)
	ENSSGRP00000029869	SMAD family member 4b. (484 aa)
	LOC107586040	Inactive serine/threonine-protein kinase VRK3-like. (530 aa)
	ENSSGRP00000042714	Chromosome 3 open reading frame 33. (229 aa)
	LOC107552315	Tyrosine-protein phosphatase non-receptor type 2-like. (393 aa)
	LOC107550085	Mothers against decapentaplegic homolog 4-like isoform X1. (571 aa)
	ENSSGRP00000046593	Folliculin-like isoform X1. (560 aa)
	LOC107559105	Dual specificity protein phosphatase 10-like. (464 aa)
	ENSSGRP00000085009	annotation not available (141 aa)
	LOC107581901	Protein sprouty homolog 4-like. (311 aa)
	LOC107553495	EMILIN-1-like. (1011 aa)
	LOC107566714	Adiponectin-like. (276 aa)
	ENSSGRP00000078094	Serine/threonine-protein kinase WNK2-like. (651 aa)
	ENSSGRP00000076363	Mothers against decapentaplegic homolog 4-like isoform X1. (573 aa)
	TIMP4-2	TIMP metallopeptidase inhibitor 4. (196 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1. (159 aa)
	LOC107599073	EMILIN-1-like. (1010 aa)
	LOC107566583	Protein C3orf33-like. (252 aa)
	LOC107569206	Metalloproteinase inhibitor 3-like. (213 aa)
	ENSSGRP00000051674	annotation not available (727 aa)
	TIMP3	Metalloproteinase inhibitor 3-like. (212 aa)
	ENSSGRP00000056880	Inactive serine/threonine-protein kinase VRK3-like. (517 aa)
	LOC107592857	ERBB receptor feedback inhibitor 1-like. (460 aa)
	ENSSGRP00000060507	Prohibitin. (247 aa)
	ENSSGRP00000061637	Sprouty-related, EVH1 domain-containing protein 3-like. (510 aa)
	LOC107589630	EMILIN-1-like isoform X1. (1069 aa)
	LOC107561610	Disabled homolog 2-like isoform X1. (684 aa)
	PTPRC-2	Protein tyrosine phosphatase receptor type C. (1160 aa)
	ENSSGRP00000063830	Receptor-type tyrosine-protein phosphatase alpha-like. (258 aa)
	DUSP10	Dual specificity protein phosphatase 10-like. (456 aa)
	LOC107553464	Cyclic AMP-dependent transcription factor ATF-3-like. (202 aa)
	ENSSGRP00000066076	Tyrosine-protein phosphatase non-receptor type 2-like. (426 aa)
	LOC107558948	Cyclic AMP-dependent transcription factor ATF-3-like. (202 aa)
	ENSSGRP00000108729	annotation not available (87 aa)
	ENSSGRP00000104891	Mothers against decapentaplegic homolog 4-like. (571 aa)
	LOC107594924	TNFAIP3-interacting protein 1-like isoform X1. (653 aa)
	Itgb1bp1	Integrin beta-1-binding protein 1. (185 aa)
	LOC107586607	EMILIN-1-like isoform X1. (1072 aa)
	ENSSGRP00000098989	Mothers against decapentaplegic homolog 4-like. (169 aa)
	LOC107556311	Tyrosine-protein phosphatase non-receptor type 1-like. (433 aa)
	LOC107594886	TNFAIP3-interacting protein 1-like isoform X1. (650 aa)
	LOC107556294	Protein sprouty homolog 2-like. (301 aa)
	SPRY3	Protein sprouty homolog 3-like. (281 aa)
	LOC107553608	Disabled homolog 2-like isoform X1. (683 aa)
	phb	Prohibitin 1. (271 aa)
	ENSSGRP00000089762	Si:dkey-222b8.1. (527 aa)
	SPRY4	Protein sprouty homolog 4-like. (311 aa)
	ENSSGRP00000003426	annotation not available (414 aa)
	LOC107549433	Protein sprouty homolog 2-like. (307 aa)
	ENSSGRP00000005397	Integrin beta-1-binding protein 1-like. (185 aa)
	LOC107559658	Mothers against decapentaplegic homolog 4 isoform X1. (550 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C-like. (1106 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1-like. (500 aa)
	LOC107597220	Disabled homolog 2-like isoform X1. (805 aa)
	ENSSGRP00000010396	SMAD family member 4b. (464 aa)
	ENSSGRP00000011352	annotation not available (340 aa)
	LOC107571794	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-like. (159 aa)
	ENSSGRP00000015031	annotation not available (165 aa)
	ENSSGRP00000020162	annotation not available (134 aa)
	PTPN2	Protein tyrosine phosphatase non-receptor type 2. (247 aa)
	ENSSGRP00000022575	SMAD family member 4a. (499 aa)
	ENSSGRP00000022860	Si:dkey-175m17.7. (464 aa)
	LOC107594510	Tyrosine-protein phosphatase non-receptor type 1-like isoform X1. (434 aa)
	ENSSGRP00000024608	Serine/threonine-protein kinase WNK2-like. (593 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1-like. (130 aa)
	LOC107574881	Protein sprouty homolog 1-like. (298 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000046593	LOC107549459	ENSSGRP00000046593	ENSSGRP00000026300	Folliculin-like isoform X1.	Folliculin-like isoform X1.	0.900
ENSSGRP00000108729	LOC107574881	ENSSGRP00000108729	ENSSGRP00000026777	annotation not available	Protein sprouty homolog 1-like.	0.662
LOC107549433	LOC107574881	ENSSGRP00000003730	ENSSGRP00000026777	Protein sprouty homolog 2-like.	Protein sprouty homolog 1-like.	0.663
LOC107549459	ENSSGRP00000046593	ENSSGRP00000026300	ENSSGRP00000046593	Folliculin-like isoform X1.	Folliculin-like isoform X1.	0.900
LOC107556294	LOC107574881	ENSSGRP00000096201	ENSSGRP00000026777	Protein sprouty homolog 2-like.	Protein sprouty homolog 1-like.	0.662
LOC107556311	LOC107594510	ENSSGRP00000096327	ENSSGRP00000023111	Tyrosine-protein phosphatase non-receptor type 1-like.	Tyrosine-protein phosphatase non-receptor type 1-like isoform X1.	0.900
LOC107571794	pin1	ENSSGRP00000015028	ENSSGRP00000068864	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-like.	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.	0.900
LOC107574881	ENSSGRP00000108729	ENSSGRP00000026777	ENSSGRP00000108729	Protein sprouty homolog 1-like.	annotation not available	0.662
LOC107574881	LOC107549433	ENSSGRP00000026777	ENSSGRP00000003730	Protein sprouty homolog 1-like.	Protein sprouty homolog 2-like.	0.663
LOC107574881	LOC107556294	ENSSGRP00000026777	ENSSGRP00000096201	Protein sprouty homolog 1-like.	Protein sprouty homolog 2-like.	0.662
LOC107574881	LOC107581901	ENSSGRP00000026777	ENSSGRP00000083316	Protein sprouty homolog 1-like.	Protein sprouty homolog 4-like.	0.709
LOC107574881	SPRY3	ENSSGRP00000026777	ENSSGRP00000093298	Protein sprouty homolog 1-like.	Protein sprouty homolog 3-like.	0.676
LOC107574881	SPRY4	ENSSGRP00000026777	ENSSGRP00000000643	Protein sprouty homolog 1-like.	Protein sprouty homolog 4-like.	0.709
LOC107581901	LOC107574881	ENSSGRP00000083316	ENSSGRP00000026777	Protein sprouty homolog 4-like.	Protein sprouty homolog 1-like.	0.709
LOC107594510	LOC107556311	ENSSGRP00000023111	ENSSGRP00000096327	Tyrosine-protein phosphatase non-receptor type 1-like isoform X1.	Tyrosine-protein phosphatase non-receptor type 1-like.	0.900
SPRY3	LOC107574881	ENSSGRP00000093298	ENSSGRP00000026777	Protein sprouty homolog 3-like.	Protein sprouty homolog 1-like.	0.676
SPRY4	LOC107574881	ENSSGRP00000000643	ENSSGRP00000026777	Protein sprouty homolog 4-like.	Protein sprouty homolog 1-like.	0.709
pin1	LOC107571794	ENSSGRP00000068864	ENSSGRP00000015028	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1.	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1-like.	0.900