(142 nodes) Negative regulation of cellular response to growth factor stimulus network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	lemd3	Inner nuclear membrane protein Man1. (844 aa)
	SPRY4	Protein sprouty homolog 4-like. (311 aa)
	LOC107586261	Transcription elongation factor SPT5-like isoform X1. (1080 aa)
	ENSSGRP00000029006	annotation not available (56 aa)
	ENSSGRP00000029005	annotation not available (67 aa)
	LOC107551190	Growth/differentiation factor 6-A-like. (405 aa)
	LOC107574881	Protein sprouty homolog 1-like. (298 aa)
	LOC107597177	Interleukin 17 receptor D. (743 aa)
	ENSSGRP00000024684	LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like. (702 aa)
	ENSSGRP00000022692	Inositol polyphosphate phosphatase-like 1a. (835 aa)
	LOC107568470	Secreted frizzled-related protein 2-like. (308 aa)
	LOC107581671	Noggin-3-like. (223 aa)
	ENSSGRP00000020793	CTD small phosphatase-like protein 2. (280 aa)
	LOC107548407	Ski oncogene-like. (726 aa)
	LOC107574503	Gremlin-2-like. (166 aa)
	LOC107586965	Sclerostin domain-containing protein 1-like isoform X1. (196 aa)
	ENSSGRP00000019431	annotation not available (257 aa)
	ENSSGRP00000017277	PR domain zinc finger protein 14-like. (561 aa)
	LOC107582091	Cell adhesion molecule 4-like isoform X1. (419 aa)
	ENSSGRP00000014976	HtrA serine peptidase 3a. (419 aa)
	LOC107599811	Ski oncogene-like. (726 aa)
	ENSSGRP00000012485	annotation not available (95 aa)
	ENSSGRP00000012469	SKI family transcriptional corepressor 1 homolog-B-like. (259 aa)
	LOC107570133	Dickkopf-related protein 1-like isoform X1. (245 aa)
	Sorl1	Sortilin-related receptor. (2185 aa)
	LOC107580985	Noggin-2-like. (216 aa)
	LOC107580862	BMP and activin membrane-bound inhibitor homolog. (148 aa)
	smad6	Mothers against decapentaplegic homolog 6. (450 aa)
	LOC107557528	Ski-like protein. (728 aa)
	ENSSGRP00000003188	Sulfatase 1. (1069 aa)
	LOC107591759	E3 ubiquitin-protein ligase SMURF1 isoform X1. (768 aa)
	LOC107549411	BMP and activin membrane-bound inhibitor homolog. (261 aa)
	LOC107563488	SKI family transcriptional corepressor 1 homolog-B-like isoform X1. (755 aa)
	ENSSGRP00000002073	Ski-like protein. (610 aa)
	LOC107556646	Noggin-2. (211 aa)
	LOC107563047	Multimerin-2-like. (1069 aa)
	LOC107561905	Glypican-1-like isoform X1. (554 aa)
	LOC107587642	Growth/differentiation factor 5-like. (499 aa)
	ENSSGRP00000041345	Chordin-like. (861 aa)
	LOC107552950	Angiotensinogen-like. (455 aa)
	ENSSGRP00000041855	Interleukin-12 subunit beta-like. (335 aa)
	ENSSGRP00000039950	Interleukin-17 receptor D-like. (408 aa)
	LOC107554912	CTD small phosphatase-like protein 2-B isoform X1. (460 aa)
	ENSSGRP00000044677	Spartin-like. (575 aa)
	LOC107581717	E3 ubiquitin-protein ligase SMURF1-like isoform X1. (768 aa)
	ENSSGRP00000044940	Gremlin-1-like. (168 aa)
	ENSSGRP00000045214	Multimerin 2b. (999 aa)
	LOC107566874	Noggin-3. (223 aa)
	NOG	Noggin-1. (217 aa)
	ENSSGRP00000047289	Tumor necrosis factor receptor superfamily member 16-like. (310 aa)
	LOC107583910	SKI family transcriptional corepressor 1 homolog-B. (749 aa)
	LOC107584374	BMP and activin membrane-bound inhibitor homolog. (261 aa)
	ENSSGRP00000048284	Dickkopf-related protein 1-like. (243 aa)
	LOC107591231	Protein shisa-2-like. (294 aa)
	LOC107583766	Mothers against decapentaplegic homolog 6-like. (487 aa)
	Smad7	Mothers against decapentaplegic homolog 7. (182 aa)
	LOC107600621	Growth/differentiation factor 6-A. (405 aa)
	LOC107569933	Follistatin-related protein 3-like. (246 aa)
	LOC107597161	Ski oncogene-like. (705 aa)
	LOC107601571	Noggin-1-like. (217 aa)
	GREM1	Gremlin-1-like. (177 aa)
	Sfrp2	Secreted frizzled-related protein 2. (308 aa)
	LOC107592269	Type-2 angiotensin II receptor-like isoform X1. (387 aa)
	ENSSGRP00000057383	39S ribosomal protein L12, mitochondrial-like. (657 aa)
	ENSSGRP00000057678	SKI family transcriptional corepressor 2-like. (264 aa)
	LOC107589828	Spartin-like isoform X1. (568 aa)
	ENSSGRP00000059550	Calcium/calmodulin-dependent serine protein kinase. (921 aa)
	LOC107589630	EMILIN-1-like isoform X1. (1069 aa)
	LOC107591339	Ski-like protein isoform X1. (727 aa)
	ENSSGRP00000064648	Calcium/calmodulin-dependent serine protein kinase b. (891 aa)
	ENSSGRP00000064974	Noggin-2-like. (211 aa)
	LOC107549726	Serine protease HTRA3-like. (467 aa)
	LOC107599073	EMILIN-1-like. (1010 aa)
	tnfaip6	Tumor necrosis factor-inducible gene 6 protein. (263 aa)
	LOC107570400	Gremlin-2-like. (166 aa)
	ENSSGRP00000069199	LOW QUALITY PROTEIN: extracellular sulfatase Sulf-2-like. (875 aa)
	LOC107553092	SKI family transcriptional corepressor 1 homolog-B-like. (744 aa)
	ENSSGRP00000070226	Mothers against decapentaplegic homolog 6-like isoform X1. (454 aa)
	skil	Ski-like protein. (645 aa)
	ENSSGRP00000071840	Serine protease HTRA3-like. (480 aa)
	ENSSGRP00000072798	Sulfatase 2b. (689 aa)
	ENSSGRP00000073720	Sortilin-related receptor-like. (1959 aa)
	ENSSGRP00000074011	Extracellular sulfatase Sulf-2-like. (864 aa)
	ENSSGRP00000074693	Serine protease HTRA3-like. (168 aa)
	LOC107583498	Gremlin-2-like. (194 aa)
	ENSSGRP00000078178	Dickkopf-related protein 1-like. (244 aa)
	LOC107588081	Glypican 1. (556 aa)
	cadm4	Cell adhesion molecule 4. (414 aa)
	sulf1	Extracellular sulfatase Sulf-1 isoform X1. (1135 aa)
	LOC107556164	Protein Churchill-like. (116 aa)
	LOC107566715	BMP and activin membrane-bound inhibitor homolog. (257 aa)
	LOC107553495	EMILIN-1-like. (1011 aa)
	ENSSGRP00000082393	Gremlin 2, DAN family BMP antagonist a. (151 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (160 aa)
	LOC107581901	Protein sprouty homolog 4-like. (311 aa)
	ENSSGRP00000084442	Multimerin-2-like. (953 aa)
	ENSSGRP00000085341	U3 small nucleolar RNA-associated protein 24. (154 aa)
	LOC107553546	CTD small phosphatase-like protein 2. (345 aa)
	ENSSGRP00000086438	LEM domain containing 3. (781 aa)
	ENSSGRP00000087465	Bardet-Biedl syndrome 9 protein. (673 aa)
	GREM1-2	Gremlin-1-like. (174 aa)
	ENSSGRP00000088111	Glypican-1-like. (513 aa)
	LOC107548158	Chordin-like protein 2. (463 aa)
	LOC107555763	Protein Churchill isoform X1. (130 aa)
	ENSSGRP00000091401	Von Willebrand factor C domain containing 2 like. (154 aa)
	LOC107584966	Protein shisa-2-like. (294 aa)
	ENSSGRP00000092304	Glypican-1-like. (511 aa)
	SPRY3	Protein sprouty homolog 3-like. (281 aa)
	LOC107585655	Mothers against decapentaplegic homolog 7-like. (371 aa)
	ENSSGRP00000094346	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b. (162 aa)
	ENSSGRP00000096002	Peripheral plasma membrane protein CASK-like. (820 aa)
	ENSSGRP00000097145	annotation not available (206 aa)
	LOC107597543	Transcription elongation factor SPT5 isoform X1. (1077 aa)
	LOC107586607	EMILIN-1-like isoform X1. (1072 aa)
	LOC107565944	Calcium/calmodulin-dependent serine protein kinase. (951 aa)
	LOC107595463	Growth/differentiation factor 5-like. (491 aa)
	LOC107554822	Follistatin-related protein 3-like. (246 aa)
	LOC107568801	Sclerostin domain-containing protein 1-like isoform X1. (202 aa)
	LOC107589331	CTD small phosphatase-like protein 2-A. (469 aa)
	LOC107601848	Angiotensinogen-like. (485 aa)
	chrd	Chordin. (938 aa)
	ENSSGRP00000106475	Extracellular sulfatase Sulf-2-like. (740 aa)
	LOC107557418	Interleukin-17 receptor D-like. (739 aa)
	LOC107565209	Ski oncogene-like isoform X1. (706 aa)
	LOC107596967	Mothers against decapentaplegic homolog 6-like. (488 aa)
	ENSSGRP00000108375	PR domain zinc finger protein 14-like. (569 aa)
	ENSSGRP00000108729	annotation not available (87 aa)
	smurf2	E3 ubiquitin-protein ligase SMURF2 isoform X1. (765 aa)
	LOC107557540	Retinoic acid receptor gamma-like isoform X1. (491 aa)
	LOC107555349	Tumor necrosis factor-inducible gene 6 protein-like. (267 aa)
	LOC107595072	CTD small phosphatase-like protein 2-B. (463 aa)
	LOC107602578	Interleukin-12 subunit beta-like. (325 aa)
	spart	Spartin isoform X1. (601 aa)
	ENSSGRP00000035487	annotation not available (245 aa)
	LOC107582239	Sclerostin domain-containing protein 1-like. (196 aa)
	bmper	BMP-binding endothelial regulator protein. (687 aa)
	LOC107597233	Type-2 angiotensin II receptor-like. (365 aa)
	ENSSGRP00000034229	Chordin-like 2. (421 aa)
	ENSSGRP00000033930	SKI family transcriptional corepressor 2-like isoform X1. (264 aa)
	inppl1	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1279 aa)
	LOC107584353	Sclerostin domain-containing protein 1-like. (202 aa)
	ENSSGRP00000029007	E3 ubiquitin-protein ligase SMURF2-like. (359 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DKK1	LOC107568470	ENSSGRP00000082626	ENSSGRP00000022680	Dickkopf WNT signaling pathway inhibitor 1.	Secreted frizzled-related protein 2-like.	0.429
DKK1	Sfrp2	ENSSGRP00000082626	ENSSGRP00000053156	Dickkopf WNT signaling pathway inhibitor 1.	Secreted frizzled-related protein 2.	0.429
ENSSGRP00000002073	ENSSGRP00000070226	ENSSGRP00000002073	ENSSGRP00000070226	Ski-like protein.	Mothers against decapentaplegic homolog 6-like isoform X1.	0.473
ENSSGRP00000002073	LOC107548407	ENSSGRP00000002073	ENSSGRP00000020651	Ski-like protein.	Ski oncogene-like.	0.615
ENSSGRP00000002073	LOC107583766	ENSSGRP00000002073	ENSSGRP00000049337	Ski-like protein.	Mothers against decapentaplegic homolog 6-like.	0.473
ENSSGRP00000002073	LOC107585655	ENSSGRP00000002073	ENSSGRP00000094207	Ski-like protein.	Mothers against decapentaplegic homolog 7-like.	0.473
ENSSGRP00000002073	LOC107596967	ENSSGRP00000002073	ENSSGRP00000108175	Ski-like protein.	Mothers against decapentaplegic homolog 6-like.	0.473
ENSSGRP00000002073	LOC107599811	ENSSGRP00000002073	ENSSGRP00000013140	Ski-like protein.	Ski oncogene-like.	0.615
ENSSGRP00000002073	Smad7	ENSSGRP00000002073	ENSSGRP00000050201	Ski-like protein.	Mothers against decapentaplegic homolog 7.	0.473
ENSSGRP00000002073	smad6	ENSSGRP00000002073	ENSSGRP00000004658	Ski-like protein.	Mothers against decapentaplegic homolog 6.	0.473
ENSSGRP00000012485	LOC107568470	ENSSGRP00000012485	ENSSGRP00000022680	annotation not available	Secreted frizzled-related protein 2-like.	0.417
ENSSGRP00000012485	Sfrp2	ENSSGRP00000012485	ENSSGRP00000053156	annotation not available	Secreted frizzled-related protein 2.	0.417
ENSSGRP00000020793	LOC107586261	ENSSGRP00000020793	ENSSGRP00000022984	CTD small phosphatase-like protein 2.	Transcription elongation factor SPT5-like isoform X1.	0.620
ENSSGRP00000020793	LOC107597543	ENSSGRP00000020793	ENSSGRP00000098405	CTD small phosphatase-like protein 2.	Transcription elongation factor SPT5 isoform X1.	0.620
ENSSGRP00000022692	inppl1	ENSSGRP00000022692	ENSSGRP00000033332	Inositol polyphosphate phosphatase-like 1a.	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2.	0.458
ENSSGRP00000024684	ENSSGRP00000029005	ENSSGRP00000024684	ENSSGRP00000029005	LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like.	annotation not available	0.550
ENSSGRP00000024684	ENSSGRP00000029006	ENSSGRP00000024684	ENSSGRP00000029006	LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like.	annotation not available	0.550
ENSSGRP00000024684	ENSSGRP00000029007	ENSSGRP00000024684	ENSSGRP00000029007	LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like.	E3 ubiquitin-protein ligase SMURF2-like.	0.550
ENSSGRP00000024684	ENSSGRP00000108729	ENSSGRP00000024684	ENSSGRP00000108729	LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like.	annotation not available	0.442
ENSSGRP00000024684	LOC107581717	ENSSGRP00000024684	ENSSGRP00000044739	LOW QUALITY PROTEIN: hepatocyte growth factor-regulated tyrosine kinase substrate-like.	E3 ubiquitin-protein ligase SMURF1-like isoform X1.	0.550