(11 nodes) Ripoptosome network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107600928	Proprotein convertase subtilisin/kexin type 1. (765 aa)
	ENSSGRP00000005841	CASP8 and FADD-like apoptosis regulator b. (187 aa)
	ENSSGRP00000012313	annotation not available (215 aa)
	ENSSGRP00000018945	annotation not available (555 aa)
	ENSSGRP00000034880	CASP8 and FADD-like apoptosis regulator. (475 aa)
	ENSSGRP00000051562	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (574 aa)
	Ripk1	Receptor-interacting serine/threonine-protein kinase 1. (640 aa)
	ENSSGRP00000086633	CASP8 and FADD-like apoptosis regulator. (221 aa)
	Mlkl	Mixed lineage kinase domain-like protein isoform X1. (468 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1. (765 aa)
	LOC107570294	CASP8 and FADD-like apoptosis regulator. (494 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000005841	ENSSGRP00000018945	ENSSGRP00000005841	ENSSGRP00000018945	CASP8 and FADD-like apoptosis regulator b.	annotation not available	0.745
ENSSGRP00000005841	ENSSGRP00000051562	ENSSGRP00000005841	ENSSGRP00000051562	CASP8 and FADD-like apoptosis regulator b.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.745
ENSSGRP00000005841	Mlkl	ENSSGRP00000005841	ENSSGRP00000093378	CASP8 and FADD-like apoptosis regulator b.	Mixed lineage kinase domain-like protein isoform X1.	0.484
ENSSGRP00000005841	Ripk1	ENSSGRP00000005841	ENSSGRP00000080869	CASP8 and FADD-like apoptosis regulator b.	Receptor-interacting serine/threonine-protein kinase 1.	0.745
ENSSGRP00000012313	ENSSGRP00000018945	ENSSGRP00000012313	ENSSGRP00000018945	annotation not available	annotation not available	0.745
ENSSGRP00000012313	ENSSGRP00000051562	ENSSGRP00000012313	ENSSGRP00000051562	annotation not available	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.745
ENSSGRP00000012313	Mlkl	ENSSGRP00000012313	ENSSGRP00000093378	annotation not available	Mixed lineage kinase domain-like protein isoform X1.	0.484
ENSSGRP00000012313	Ripk1	ENSSGRP00000012313	ENSSGRP00000080869	annotation not available	Receptor-interacting serine/threonine-protein kinase 1.	0.745
ENSSGRP00000018945	ENSSGRP00000005841	ENSSGRP00000018945	ENSSGRP00000005841	annotation not available	CASP8 and FADD-like apoptosis regulator b.	0.745
ENSSGRP00000018945	ENSSGRP00000012313	ENSSGRP00000018945	ENSSGRP00000012313	annotation not available	annotation not available	0.745
ENSSGRP00000018945	ENSSGRP00000034880	ENSSGRP00000018945	ENSSGRP00000034880	annotation not available	CASP8 and FADD-like apoptosis regulator.	0.745
ENSSGRP00000018945	ENSSGRP00000086633	ENSSGRP00000018945	ENSSGRP00000086633	annotation not available	CASP8 and FADD-like apoptosis regulator.	0.745
ENSSGRP00000018945	LOC107570294	ENSSGRP00000018945	ENSSGRP00000111074	annotation not available	CASP8 and FADD-like apoptosis regulator.	0.745
ENSSGRP00000018945	Mlkl	ENSSGRP00000018945	ENSSGRP00000093378	annotation not available	Mixed lineage kinase domain-like protein isoform X1.	0.850
ENSSGRP00000034880	ENSSGRP00000018945	ENSSGRP00000034880	ENSSGRP00000018945	CASP8 and FADD-like apoptosis regulator.	annotation not available	0.745
ENSSGRP00000034880	ENSSGRP00000051562	ENSSGRP00000034880	ENSSGRP00000051562	CASP8 and FADD-like apoptosis regulator.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.745
ENSSGRP00000034880	LOC107570294	ENSSGRP00000034880	ENSSGRP00000111074	CASP8 and FADD-like apoptosis regulator.	CASP8 and FADD-like apoptosis regulator.	0.901
ENSSGRP00000034880	Mlkl	ENSSGRP00000034880	ENSSGRP00000093378	CASP8 and FADD-like apoptosis regulator.	Mixed lineage kinase domain-like protein isoform X1.	0.484
ENSSGRP00000034880	Ripk1	ENSSGRP00000034880	ENSSGRP00000080869	CASP8 and FADD-like apoptosis regulator.	Receptor-interacting serine/threonine-protein kinase 1.	0.745
ENSSGRP00000051562	ENSSGRP00000005841	ENSSGRP00000051562	ENSSGRP00000005841	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	CASP8 and FADD-like apoptosis regulator b.	0.745