(23 nodes) (2022) Arctigenin: pharmacology, total synthesis, and progress in structure modification. network (Sinocyclocheilus grahami)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC107563452	Oxysterols receptor LXR-alpha-like isoform X1. (438 aa)
	ENSSGRP00000019793	ATP-binding cassette, subfamily G (WHITE), member 1. (690 aa)
	LOC107552079	Forkhead box protein O3-like. (640 aa)
	LOC107558583	Cyclin-dependent kinase 6-like. (324 aa)
	LOC107594963	Serine/threonine-protein kinase mTOR-like. (2549 aa)
	LOC107590469	Proto-oncogene tyrosine-protein kinase Src isoform X1. (553 aa)
	casp9	Caspase-9 isoform X1. (436 aa)
	ENSSGRP00000085654	Signal transducer and activator of transcription 3-like. (811 aa)
	LOC107553099	Oxysterols receptor LXR-alpha-like. (441 aa)
	LOC107562747	Caspase-3-like. (276 aa)
	LOC107556843	Caspase-3-like isoform X1. (275 aa)
	ENSSGRP00000072783	Caspase-3-like. (283 aa)
	tyr	Tyrosinase. (541 aa)
	LOC107564227	Serine/threonine-protein kinase mTOR. (2552 aa)
	foxo3	Forkhead box protein O3. (640 aa)
	ENSSGRP00000051188	Thyroid hormone receptor beta. (489 aa)
	THRB	Thyroid hormone receptor beta. (394 aa)
	ENSSGRP00000039366	Proto-oncogene tyrosine-protein kinase Src-like isoform X1. (505 aa)
	ENSSGRP00000037074	ATP-binding cassette, sub-family G (WHITE), member 1. (663 aa)
	LOC107567973	Cyclin-dependent kinase 6-like. (324 aa)
	casp3	Caspase 3. (282 aa)
	stat3	Signal transducer and activator of transcription 3. (773 aa)
	LOC107593914	Caspase-9-like isoform X1. (436 aa)

Your Current Organism:

Sinocyclocheilus grahami

NCBI taxonomy Id: 75366
Other names: S. grahami

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSGRP00000019793	LOC107553099	ENSSGRP00000019793	ENSSGRP00000082396	ATP-binding cassette, subfamily G (WHITE), member 1.	Oxysterols receptor LXR-alpha-like.	0.583
ENSSGRP00000019793	LOC107563452	ENSSGRP00000019793	ENSSGRP00000020449	ATP-binding cassette, subfamily G (WHITE), member 1.	Oxysterols receptor LXR-alpha-like isoform X1.	0.583
ENSSGRP00000037074	LOC107553099	ENSSGRP00000037074	ENSSGRP00000082396	ATP-binding cassette, sub-family G (WHITE), member 1.	Oxysterols receptor LXR-alpha-like.	0.583
ENSSGRP00000037074	LOC107563452	ENSSGRP00000037074	ENSSGRP00000020449	ATP-binding cassette, sub-family G (WHITE), member 1.	Oxysterols receptor LXR-alpha-like isoform X1.	0.583
ENSSGRP00000039366	ENSSGRP00000085654	ENSSGRP00000039366	ENSSGRP00000085654	Proto-oncogene tyrosine-protein kinase Src-like isoform X1.	Signal transducer and activator of transcription 3-like.	0.627
ENSSGRP00000039366	LOC107590469	ENSSGRP00000039366	ENSSGRP00000110911	Proto-oncogene tyrosine-protein kinase Src-like isoform X1.	Proto-oncogene tyrosine-protein kinase Src isoform X1.	0.900
ENSSGRP00000039366	stat3	ENSSGRP00000039366	ENSSGRP00000025008	Proto-oncogene tyrosine-protein kinase Src-like isoform X1.	Signal transducer and activator of transcription 3.	0.627
ENSSGRP00000072783	LOC107593914	ENSSGRP00000072783	ENSSGRP00000024180	Caspase-3-like.	Caspase-9-like isoform X1.	0.970
ENSSGRP00000072783	casp9	ENSSGRP00000072783	ENSSGRP00000098105	Caspase-3-like.	Caspase-9 isoform X1.	0.971
ENSSGRP00000085654	ENSSGRP00000039366	ENSSGRP00000085654	ENSSGRP00000039366	Signal transducer and activator of transcription 3-like.	Proto-oncogene tyrosine-protein kinase Src-like isoform X1.	0.627
ENSSGRP00000085654	LOC107552079	ENSSGRP00000085654	ENSSGRP00000112737	Signal transducer and activator of transcription 3-like.	Forkhead box protein O3-like.	0.707
ENSSGRP00000085654	LOC107590469	ENSSGRP00000085654	ENSSGRP00000110911	Signal transducer and activator of transcription 3-like.	Proto-oncogene tyrosine-protein kinase Src isoform X1.	0.627
ENSSGRP00000085654	foxo3	ENSSGRP00000085654	ENSSGRP00000052483	Signal transducer and activator of transcription 3-like.	Forkhead box protein O3.	0.707
ENSSGRP00000085654	stat3	ENSSGRP00000085654	ENSSGRP00000025008	Signal transducer and activator of transcription 3-like.	Signal transducer and activator of transcription 3.	0.900
LOC107552079	ENSSGRP00000085654	ENSSGRP00000112737	ENSSGRP00000085654	Forkhead box protein O3-like.	Signal transducer and activator of transcription 3-like.	0.707
LOC107552079	stat3	ENSSGRP00000112737	ENSSGRP00000025008	Forkhead box protein O3-like.	Signal transducer and activator of transcription 3.	0.707
LOC107553099	ENSSGRP00000019793	ENSSGRP00000082396	ENSSGRP00000019793	Oxysterols receptor LXR-alpha-like.	ATP-binding cassette, subfamily G (WHITE), member 1.	0.583
LOC107553099	ENSSGRP00000037074	ENSSGRP00000082396	ENSSGRP00000037074	Oxysterols receptor LXR-alpha-like.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.583
LOC107553099	LOC107563452	ENSSGRP00000082396	ENSSGRP00000020449	Oxysterols receptor LXR-alpha-like.	Oxysterols receptor LXR-alpha-like isoform X1.	0.900
LOC107556843	LOC107593914	ENSSGRP00000077464	ENSSGRP00000024180	Caspase-3-like isoform X1.	Caspase-9-like isoform X1.	0.970